Spatial transcriptomics and multi-omics reveal relapse and resistance mechanisms of EndMT-derived CAFs mediated by TNC and FLNC in glioblastoma by Li Ji, Die Xia, Yu Zhou, Yaling Hu, Zhenkun Yang, Ying Yin, Jingjing Wang, Bo Zhang, Lingli Gong, Koukou Li, Jian Zou, Mei Wang

“…Nevertheless, the role and source of CAFs in recurrent and chemotherapy-resistant GBMs still remain ambiguous. Methods Spatial transcriptome (ST) sequencing was conducted on the tissue microarray encompassing primary and recurrent glioma samples in order to characterize the cellular composition. …”
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The human milk bacteriome and mycobiome and their inter-kingdom interactions viewed across geography by Haipeng Sun, Brett Finlay, Brett Finlay, Meghan B. Azad, Meghan B. Azad, Christina A. Cuomo, Christina A. Cuomo, Leah E. Cowen, Leah E. Cowen, Brittany Berdy, Jonathan Livny, Terrance Shea, Edna E. Aquino, Filipa Godoy-Vitorino, Melissa A. Woortman, Margot Shumaker, Claudio Alba, Claudio Alba, Juan M. Rodríguez, Juan M. Rodríguez, María G. Domínguez-Bello, María G. Domínguez-Bello, María G. Domínguez-Bello

“…Here we assessed the bacterial, archaeal and fungal composition of human milk and the potential inter-kingdom interactions in milk collected from women living in a wide spectrum of countries, environments, and socio-economical settings.Materials and methodsAbout 518 human milk samples were collected in 16 countries. …”
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The Influence of the Seasonal Variability of <i>Candida</i> spp. Bloodstream Infections and Antifungal Treatment: A Mediterranean Pilot Study by Paola Di Carlo, Nicola Serra, Ornella Collotta, Claudia Colomba, Alberto Firenze, Luigi Aprea, Salvatore Antonino Distefano, Andrea Cortegiani, Giovanni Giammanco, Teresa Maria Assunta Fasciana, Roberta Virruso, Angela Capuano, Consolato M. Sergi, Antonio Cascio

“…<b>Background/Objectives</b>: Various factors associated with seasonality, including temperature, humidity, geographical composition, and seasonal fluctuations, can influence the trends of microbes responsible for hospital infections, such as <i>Candida</i> spp. …”
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Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites by Sui Li, Sui Li, Li Wang, MingYu Han, Huali Fan, Hailin Tang, Huile Gao, Guobo Li, Zheng Xu, Zhaokai Zhou, JunRong Du, Cheng Peng, Fu Peng, Fu Peng

“…BackgroundRecent studies have highlighted the importance of cross-talk along the gut-brain axis in regulating inflammatory nociception, inflammatory responses, and immune homeostasis. …”
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Trajectory correction enables free-running chemical shift encoded imaging for accurate cardiac proton-density fat fraction quantification at 3T by Pierre Daudé, Thomas Troalen, Adèle L.C. Mackowiak, Emilien Royer, Davide Piccini, Jérôme Yerly, Josef Pfeuffer, Frank Kober, Sylviane Confort Gouny, Monique Bernard, Matthias Stuber, Jessica A.M. Bastiaansen, Stanislas Rapacchi

“…ABSTRACT: Background: Metabolic diseases can negatively alter epicardial fat accumulation and composition, which can be probed using quantitative cardiac chemical shift encoded (CSE) cardiovascular magnetic resonance (CMR) by mapping proton-density fat fraction (PDFF). …”
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Restructuring of small-scale constructed wetland systems and treatability of individual household wastewater through natural process by S. Mokatip, K. Chunkao, W. Wararam, S. Bualert, O. Phewnil, T. Pattamapitoon, N. Semvimol, P. Maskulrath, P. Rollap, S. Thaipakdee

“…BACKGROUND AND OBJECTIVES: Domestic wastewater pollution in Thailand presents challenges due to limited space and a high concentration of point source effluents. …”
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Comparative Analysis of Fatty Acid Profiles in Erythrocyte Membranes in Vegetarians Compared to Omnivores by Marta Despotović, Jasmina Debeljak Martačić, Ivana Šarac, Gordana Petrović Oggiano, Slavica Ranković, Petar Jovanović, Marija Takić

“…Background: The fatty acid profiles in cellular membranes can be influenced by many endogenic and external factors, including diet. …”
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GDF15 Neutralization Ameliorates Muscle Atrophy and Exercise Intolerance in a Mouse Model of Mitochondrial Myopathy by Stephen E. Flaherty III, LouJin Song, Bina Albuquerque, Anthony Rinaldi, Mary Piper, Dinesh Hirenallur Shanthappa, Xian Chen, John Stansfield, Shoh Asano, Evanthia Pashos, Trenton Thomas Ross, Srinath Jagarlapudi, Abdul Sheikh, Bei Zhang, Zhidan Wu

“…ABSTRACT Background Primary mitochondrial myopathies (PMMs) are disorders caused by mutations in genes encoding mitochondrial proteins and proteins involved in mitochondrial function. …”
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The Impact of Vaccination on Disease Course and Outcome in Intensive Care Patients With COVID-19 by B. I. Kurilin, V. Y. Kiselevskaya-Babinina, Y. V. Kuzmicheva, A. V. Shapoval, N. E. Drozdova, K. A. Popugayev

“…BACKGROUND Our study provides a unique opportunity to compare the course of the disease with a new coronavirus infection in seriously ill patients in the groups of vaccinated and unvaccinated patients hospitalized in the infectious intensive care units of N.V. …”
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Regional and aging-specific cellular architecture of non-human primate brains by Yun-Mei Wang, Wen-Chao Wang, Yongzhang Pan, Lin Zeng, Jing Wu, Zheng-Bo Wang, Xiao-Lin Zhuang, Ming-Li Li, David N. Cooper, Sheng Wang, Yong Shao, Li-Min Wang, Ying-Yin Fan, Yonghan He, Xin-Tian Hu, Dong-Dong Wu

“…Abstract Background Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the processes underlying brain pathogenesis. …”
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Effects of a Western Diet on Colonic Dysbiosis, Bile Acid Dysmetabolism and Intestinal Inflammation in Clinically Healthy Dogs by Brandon Mason, Dipak Kumar Sahoo, Chelsea A. Iennarella‐Servantez, Aarti Kathrani, Shannon M. Morgan, Agnes Bourgois‐Mochel, Alex M. Bray, Vojtech Gabriel, Christopher Zdyrski, Jennifer M. Groeltz, Eric Cassmann, Mark R. Ackermann, Jan S. Suchodolski, Jonathan P. Mochel, Karin Allenspach, Albert E. Jergens

“…Animals Ten adult clinically healthy dogs. Methods A dietary trial compared the effects of two home‐prepared diets: a high‐fiber, low‐fat control diet (CD) to a diet containing the macronutrient composition of WD (low‐fiber, high fat). …”
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Oral Hygiene, Dietary Habits, and Saliva Properties in Relation to the Decayed, Missing, and Filled Teeth Index of Dental Students: A Pilot Study by Zoran Mandinić, Jelena Stojanović, Aleksandra Prokić, Miloš Beloica, Svetlana Jovanović, Jovana Kuzmanović Pfićer, Rasa Mladenovic, Dušan Kosanović, Milena Milanović, Miloš Todorović, Maja Milošević Marković, Ivan Dožić

“…<i>Background and Objectives</i>: Caries development is associated with poor oral hygiene, inadequate dietary habits, quantitative and qualitative food content, and a high level of bacterial plaque. …”
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Assessing the impact of an intensive dietitian-led telehealth intervention focusing on nutritional adequacy, symptom control and optional supplemental jejunal feeding, on quality o... by Emma McShane, Kate Furness, Lauren Hanna, Kate Connell, Terrence Haines, Catherine E. Huggins, John Zalcberg, Sharon Carey, Charles H.C. Pilgrim, Joanne Lundy, Andrew Metz, David Kissane, Michael Franco, John Coutsouvelis, Diederick W. De Boo, J Simon Bell, Mahesh Iddawela, Theresa Dodson, Ignatius Pereira, Nina Imad, Jill Kirkpatrick, Cherie Dear, Daniel Croagh

“…Abstract Background Pancreatic cancer is the third leading cause of cancer-related death in Australia, with a persistently poor 5-year survival rate of around 13%. …”
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Usnic acid and tannic acid as inhibitors of coccidia and Clostridium perfringens: alleviating necrotic enteritis and improving intestinal health in broiler chickens by Huiping Xu, Minghao Yang, Jianyang Fu, Huiyuan Lv, Jiang Guo, Changji Lu, Zengpeng Lv, Yuming Guo

“…Abstract Background Necrotic enteritis (NE) in broiler chickens leads to significant economic losses in poultry production. …”
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Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulationResearch in context by Xuguang Li, Nobuaki Shiraki, Takami Watanabe, Rikako Fukui, Kyohei Furukawa, Yusuke Kato, Yuri Nakahara, Shoen Kume, Akashi Taguchi, Youichiro Wada, Dwina Juliana Warman, Kenji Saito, Haruyo Nakajima-Adachi, Satoshi Hachimura, Hisanori Kato, Huijuan Jia

“…Summary: Background: Maternal nutrition during critical developmental windows is crucial for offspring metabolic programming. …”
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Muscle‐specific gene editing improves molecular and phenotypic defects in a mouse model of myotonic dystrophy type 1 by Mariapaola Izzo, Jonathan Battistini, Elisabetta Golini, Christine Voellenkle, Claudia Provenzano, Tiziana Orsini, Georgios Strimpakos, Ferdinando Scavizzi, Marcello Raspa, Denisa Baci, Svetlana Frolova, Spyros Tastsoglou, Germana Zaccagnini, Jose Manuel Garcia‐Manteiga, Genevieve Gourdon, Silvia Mandillo, Beatrice Cardinali, Fabio Martelli, Germana Falcone

“…Abstract Background Myotonic dystrophy type 1 (DM1) is a genetic multisystemic disease, characterised by pleiotropic symptoms that exhibit notable variability in severity, nature and age of onset. …”
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Persistence of Ebola virus in semen among Ebola virus disease survivors in Sierra Leone: A cohort study of frequency, duration, and risk factors. by A E Thorson, G F Deen, K T Bernstein, W J Liu, F Yamba, N Habib, F R Sesay, P Gaillard, T A Massaquoi, S L R McDonald, Y Zhang, K N Durski, S Singaravelu, E Ervin, H Liu, A Coursier, J E Marrinan, A Ariyarajah, M Carino, P Formenty, U Ströher, M Lamunu, G Wu, F Sahr, W Xu, B Knust, N Broutet, Sierra Leone Ebola Virus Persistence Study Group

“…<h4>Background</h4>Sexual transmission chains of Ebola virus (EBOV) have been verified and linked to EBOV RNA persistence in semen, post-recovery. …”
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Therapeutic effects and mechanisms of Fufang Longdan mixture on metabolic syndrome with psoriasis via miR-29a-5p/IGF-1R axis by Guangyun Luo, Guangyun Luo, Xiangyi Kong, Fang Wang, Zhiming Wang, Zhuo Zhang, Huan Cui, Yiwen Zhang, Wen Huang, Xuesong Yang, Jianzhou Ye, Jianzhou Ye

“…However, current treatments have shown limited efficacy in improving the symptoms of both conditions simultaneously.ObjectiveThis study aimed to investigate the therapeutic efficacy of Fufang Longdan Mixture (FLM) in treating MS-P comorbidity, elucidate its mechanism through the miR-29a-5p/IGF-1R axis and evaluate treatment responses between APOE−/− and C57BL/6 mice.MethodsUPLC-Q-exactive-MS/MS analysis was used to characterise FLM’s chemical composition. …”
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Treatment of Vitamin D Deficiency in Decompensated Patients with Cirrhosis Is Associated with Improvement in Frailty by Raquel Díaz-Ruíz, Maria Poca, Eva Román, Berta Cuyàs, Irene Bañares, Ángela Morales, Elvira Hernández Martínez-Esparza, Rocío Panadero, Cristina Velasco, Marta Rapado-Castro, Irene Bretón, Rafael Bañares, German Soriano, Rita García-Martínez

“…<b>Background/aim</b>: Frailty is increasingly recognized as a relevant prognostic factor in patients with cirrhosis, regardless of liver failure. …”
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A novel interplay between bacteria and metabolites in different early-stage lung cancer: an integrated microbiome and metabolome analysis by Xiaoqian Zhai, Xiaoqian Zhai, Dongqi Lin, Dongqi Lin, Yi Shen, Yi Shen, Ni Zhai, Fan Yu, Fan Yu, Jiabi Zhang, Yiyun Lin, Yuqing Wang, Qinghua Zhou, Qinghua Zhou, Xi Zheng, Xi Zheng

“…BackgroundThe carcinogenesis mechanism of early-stage lung cancer (ESLC) remains unclear. …”
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