Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota by Xingduo Liu, Chaoqun Sun, Yuqiong Dai, Feifei Duan, Tianzhen He, Menglu Zhen, Enxi Liang, Shuting Zhang, Yun Xia, Nianchun Hu, Ruoting Zhan, Ruoting Zhan, Dong Deng, Sijun Liu

“…BackgroundAlzheimer’s disease (AD), a neurodegenerative disorders linked to gut microbiota dysbiosis, may benefit from Traditional Chinese Medicine (TCM) interventions.ObjectivesDanggui Shaoyao San (DSS), a classic traditional Chinese Medicine (TCM) formula. …”
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Microbial and clinical disparities in pneumonia: insights from metagenomic next-generation sequencing in patients with community-acquired and severe pneumonia by Wang Luo, Shuhua Zhang, Jinhuan Sun, Jinhuan Sun, Jianhui Xu, Weihua Huang, Ruiqing Hao, Zhao Ou, Zhao Ou, Ziyang Wen, Ziyang Wen, Daiwei Wang, Daiwei Wang, Guanhua Xiao, Hangming Dong

“…BackgroundCommunity-acquired pneumonia (CAP) is a major global cause of death, with its varying symptoms and severity complicating diagnosis and treatment. …”
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Identification of sepsis biomarkers through glutamine metabolism-mediated immune regulation: a comprehensive analysis employing mendelian randomization, multi-omics integration, an... by Zhuang’e Shi, Fuping Wang, Lishun Yang, Lishun Yang, Couwen Li, Bing Gong, Ruanxian Dai, Guobing Chen

“…BackgroundSepsis is a global health challenge associated with high morbidity and mortality rates. …”
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Epigenome-wide analysis reveals potential biomarkers for radiation-induced toxicity risk in prostate cancer by Carlos Lopez-Pleguezuelos, Miguel E. Aguado-Barrera, Ana Carballo-Castro, Paula Peleteiro, Patricia Calvo-Crespo, Begoña Taboada-Valladares, Ramón Lobato-Busto, Olivia Fuentes-Ríos, Javier Galego-Carro, Carla Coedo-Costa, Antonio Gómez-Caamaño, Ana Vega

“…Abstract Background Prostate cancer is the second most common cancer globally, with radiation therapy (RT) being a key treatment for clinically localized and locally advanced cases. …”
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The state of the immunophenotype of blood lymphocytes in patients with newly diagnosed type 2 diabetes in the post-COVID period by V.V. Popova, N.V. Het’man, Ya.I. Labanets, H.V. Kulikovska, O.E. Lavrinenko, O.V. Furmanova, O.I. Kovzun, M.D. Tronko

“…Background. Today, the indicators of the subpopulation blood composition are one of the key characteristics of immune function. …”
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Indirect Fortification of Traditional Nixtamalized Tortillas with Nixtamalized Corn Flours by María Guadalupe Nieves-Hernandez, Brenda Lizbeth Correa-Piña, Oscar Garcia-Chavero, Salomon Lopez-Ramirez, Rosendo Florez-Mejia, Oscar Yael Barrón-García, Elsa Gutierrez-Cortez, Marcela Gaytán-Martínez, Juana Isela Rojas-Molina, Mario E. Rodriguez-Garcia

“…Methods: The chemical proximate values (CPV), ash content, mineral composition by inductively coupled plasma, in vitro protein digestibility (PD), protein digestibility-corrected amino acid score (PDCAAS), the total starch content, the resistant starch (RS) content in nixtamalized corn tortillas (NC-T) and nixtamalized commercial corn flour tortillas (NCCF-T) and the contribution of tortillas prepared with a mixture of NM and NCC-F (75:25 and 50:50, NM:NCC-F) to the recommended dietary intake (RDI) of minerals and vitamins were determined. …”
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Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity by Valentina Salvi, Carolina Gaudenzi, Barbara Mariotti, Gaia Giongrandi, Silvia Alacqua, Veronica Gianello, Tiziana Schioppa, Laura Tiberio, Angela Ceribelli, Carlo Selmi, Paolo Bergese, Stefano Calza, Annalisa Del Prete, Silvano Sozzani, Flavia Bazzoni, Daniela Bosisio

“…Abstract Background The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (sEV-miRNAs) remains debated because of the limiting representativity of specific miRNAs within the extracellular pool. …”
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A scRNA-seq reference contrasting living and early post-mortem human retina across diverse donor states by Luning Yang, Yiwen Tao, Qi Pan, Tengda Cai, Yunyan Ye, Jianhui Liu, Yang Zhou, Yongqing Shao, Quanyong Yi, Zen Huat Lu, Lie Chen, Gareth McKay, Richard Rankin, Weihua Meng

“…Abstract Background Current human retina studies predominantly utilize post-mortem tissue, and the sample accessibility constraints make the characterization of the living human retina at single-cell resolution a challenge. …”
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Factors affecting hematological parameters in Creole goats on the Southern Coast of Peru by Jhony Soca, Emmanuel Alexander Sessarego, Pamela Sarmiento, María José Cevallos-Cardenas, Juan Canchino-Gutierrez, Jose Teran, Jose Antonio Ruiz, Juancarlos Cruz-Luis, Danny Julio Cruz

“…Background and Aim: Hematological parameters are critical indicators of health and physiological status in goats. …”
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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration by Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland, Stephen M. Richardson

“…Abstract Background Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. …”
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Refining Unfavorable Vaginal Microbial Community in Infertile Women Subjected to Precision Probiotic Intervention: An Exploratory Single-Arm, Prospective, Open-Label, Interventiona... by Giovanna Cocomazzi, Viviana Contu, Silvia De Stefani, Lino Del Pup, Matteo Buccheri, Monica Antinori, Lodovico Parmegiani, Daniele De Ruvo, Francesco Marino, Edy Virgili, Christine Allen, Simone Palini, Walter Ciampaglia, Matteo Cerboneschi, Domenico Baldini, Giorgio Maria Baldini, Valerio Pazienza

“…Background and aims: Vaginal microbiomes have been classified into five different general categories, termed Community State Type (CSTs), with CST-III and CST-IV often associated with vaginal dysbiosis which makes women more prone to recurrent infections and assisted reproductive technology (ART) failure. …”
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Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice by Yun-kai Lin, Yu-fei Pan, Tian-yi Jiang, Yi-bin Chen, Tai-yu Shang, Meng-you Xu, Hui-bo Feng, Yun-han Ma, Ye-xiong Tan, Hong-yang Wang, Li-wei Dong

“…Abstract Background Adipose tissue plays a pivotal role in systemic metabolism and maintaining bodily homeostasis. …”
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Association Between Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population by Wenjian Lin, Zixin Liang, Junxuan Fang, Yu Liu, Lei Lei, Jiawen Lin, Bin Xia, Zhihua Zheng, Jingqiu Yuan, Chun Tang

“…<b>Background:</b> Population differences in gut microbiota composition and related metabolites may influence their potential causal relationship with chronic kidney disease (CKD); however, this relationship remains poorly understood in the Chinese population. …”
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Interrelationship between altered metabolites and the gut microbiota in people living with HIV with different immune responses to antiretroviral therapy by Xuebin Tian, Zhongyao Gao, Yiwen Xie, Xiangyun Lu, Yulong Zhao, Peng Yao, Mingqing Dong, Lifeng Yu, Nanping Wu

“…This study explores the connections among immune responses, metabolites, and the gut microbiota in PLWH with differing reactions to ART. Methods: We analyzed the gut microbiota composition, metabolites, and immune markers in 38 PLWH who showed an immunological response (IR) and 32 who did not (INR), as classified according to CD4+ T-cell levels after 24 months of ART. …”
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Prevalence and influencing factors of micronutrient powder adoption among children aged 6–24 months by parental and grandparental caregivers: an analysis from rural China by Yiran Tian, Fangqun Leng, Xinru Zhou, Yadi He, Linhua Li, Ruixue Ye, Andrew Rule, Jieyuan Feng, Scott Rozelle, Yuju Wu, Huan Zhou

“…Abstract Background Micronutrient powder (MNP or Yingyangbao, a dietary supplement that contains multiple vitamins and minerals) programs can reduce the risk of anemia among children. …”
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Effects of a strength physical exercise program in chronic lymphocytic leukemia patients on quality of life, mental health, and frailty: a randomized controlled trial study protoco... by Juan Luis Sánchez-González, Juan Luis Sánchez-González, Eduardo José Fernández-Rodríguez, Eduardo José Fernández-Rodríguez, Roberto Méndez-Sánchez, Roberto Méndez-Sánchez, Luis Polo-Ferrero, Luis Polo-Ferrero, Ana Silvia Puente-González, Ana Silvia Puente-González, Cristina de Ramón, Cristina de Ramón, Sara Marcos-Asensio, Sara Marcos-Asensio, Patricia Blázquez-Benito, Almudena Navarro-Bailón, Almudena Navarro-Bailón, Almudena Navarro-Bailón, Fermín Sánchez-Guijo, Fermín Sánchez-Guijo, Fermín Sánchez-Guijo, Fermín Sánchez-Guijo, Carlos Martín-Sánchez, Carlos Martín-Sánchez

“…Specifically, strength training may help address some common treatment side effects.ObjectiveThis study aims to evaluate the effects of a therapeutic exercise program, focused on frailty in patients with CLL, along with secondary objectives including impacts on functional capacity, quality of life, psychological status, sleep quality, body composition, anthropometric variables, lipid profile and on proteins related to the immune system and inflammation.MethodsAn open label, randomized controlled trial will be carried out with 36 participants, divided into an intervention group (supervised resistance training twice a week and home exercises) and a control group (home exercise only). …”
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Impact of dairy farming on gut microbiota structure and diversity of practitioners by Zhaojie WANG, Xixiao MA, Xianxia LIU, Yanggui CHEN, Xueying XIANG, Wanting XU, Jiguo JIN, Fan WU, Xiangnan WEI, Jianyong WU, Fuye LI

“…BackgroundAnimal farming may affect the structure and diversity of gut microbiota of farm workers, but it needs more studies to provide solid evidence. …”
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Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease by Shruti Singh Kakan, Sara Abdelhamid, Sara Abdelhamid, Yaping Ju, Yaping Ju, J. Andrew MacKay, J. Andrew MacKay, J. Andrew MacKay, Maria C. Edman, Indu Raman, Chengsong Zhu, Prithvi Raj, Sarah F. Hamm-Alvarez, Sarah F. Hamm-Alvarez

“…The LG produces the protein-rich aqueous component of tears, and SjD-associated autoimmune dacryoadenitis (AD) may thus alter tear autoantibody composition.MethodsThe presence of tertiary lymphoid structures (TLS) in LG from two murine models of SjD-associated AD, male non-obese diabetic (NOD) and male non-obese insulitis resistant (NOR) mice, were evaluated using immunofluorescence. …”
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Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation by Yu Feng, Qian Zhao, Yifan Zhao, Chen Ma, Meiling Tian, Xiaosong Hu, Fang Chen, Daotong Li

“…Abstract Background Inflammatory bowel disease (IBD) is a gastrointestinal inflammatory disorder characterized by disturbed interactions between gut microbiota and host immune response. …”
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Improvement in kidney damage resulting from stanozolol intramuscular injections in rats by Natural Cocoa Powder (NCP) administration by Daniel Odoom, Benjamin Arko-Boham, Kevin Kofi Adutwum-Ofosu, Richard Michael Blay, Saviour Kweku Adjenti, John Ahenkorah, Bismarck Afedo Hottor, Esther Dennis, Nii Koney-Kwaku Koney, Frederick Kwaku Addai

“…Background: Stanozolol, an anabolic steroid, has been shown to induce kidney damage through mechanisms involving oxidative stress and inflammation. …”
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