Exploring bladder cancer through urinary microbiota: innovative “urinetypes” classification and establishment of a diagnostic model by Zhaoyang Sheng, Jing Liu, Maoyu Wang, Xiang Chen, Jinshan Xu, Chen Zhang, Yang Xu, Hui Zhang, Jinpeng Zhu, Nan Qin, ShuXiong Zeng, Zhijun Zheng, ZhenSheng Zhang

“…Abstract Background Bladder cancer (BCa) is a prevalent and lethal malignancy of the urinary system. …”
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Process Development for GMP-Grade Full Extract Cannabis Oil: Towards Standardized Medicinal Use by Maria do Céu Costa, Ana Patrícia Gomes, Iva Vinhas, Joana Rosa, Filipe Pereira, Sara Moniz, Elsa M. Gonçalves, Miguel Pestana, Mafalda Silva, Luís Monteiro Rodrigues, Anthony DeMeo, Logan Marynissen, António Marques da Costa, Patrícia Rijo, Michael Sassano

“…<b>Background/Objectives:</b> The industrial extraction and purification processes of <i>Cannabis sativa</i> L. compounds are critical steps in creating formulations with reliable and reproducible therapeutic and sensorial attributes. …”
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Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…Abstract Background Preterm birth (PTB) is a major contributor to neonatal morbidity, mortality, and long-term health complications. …”
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A qualitative exploration of active ingredients and mechanisms of action of an online singing programme with mothers experiencing postnatal depression during the COVID-19 pandemic:... by Alexandra Burton, Rebecca H. Bind, Rachel Davis, Lorna Greenwood, Ching Yin Lee, Carolina Estevao, Katie Hazelgrove, Celeste Miller, Kristi Priestley, Lavinia Rebecchini, Tim Osborn, Hannah Dye, Paola Dazzan, Anthony Woods, Nikki Crane, Carmine M. Pariante, Daisy Fancourt

“…Abstract Background Social distancing restrictions and the suspension of in-person treatment and support contributed to an increase in postnatal depression during the coronavirus disease 2019 (COVID-19) pandemic. …”
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Ecological drivers of malaria vector habitat and transmission over 1 year of long-lasting insecticidal net intervention in Côte d’Ivoire by Benoit Talbot, Ludovic P. Ahoua Alou, Alphonsine A. Koffi, Colette Sih, Edouard Dangbenon, Marius G. Zoh, Soromane Camara, Serge B. Assi, Raphael N’Guessan, Louisa A. Messenger, Natacha Protopopoff, Jackie Cook, Manisha A. Kulkarni

“…Abstract Background Malaria is a mosquito-borne parasitic disease that causes significant morbidity and mortality in at-risk populations, especially in children in sub-Saharan Africa. …”
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Maternal β-carotene addition has long-term effects on intestinal health of offspring chicks by Taiping Wang, Taiping Wang, Da Wan, Da Wan, Tianyu Ren, Ye Tao, Ye Tao, Min Wu, Xin Zheng, Xin Zheng

“…BackgroundMaternal dietary intervention utilizing complex additives rich in β-carotene has demonstrated the capacity to enhance embryonic intestinal development and influence microbial composition in offspring. …”
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Evaluation of seasonal variation, effect of extraction solvent on phytochemicals and antioxidant activity on Rosmarinus officinalis grown in different agro-ecological zones of Kiam... by Zelipha N. Kabubii, James M. Mbaria, Mbaabu P. Mathiu, John M. Wanjohi, Evans N. Nyaboga

“…Abstract Background Rosemary (Rosmarinus officinalis) is a commonly used culinary herb with great potential applications in the pharmaceutical, food, and cosmetics industries because of its reported bioactive phytochemicals and antioxidant properties. …”
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Investigating the Role and Underlying Mechanisms of 18&amp;beta;-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-&amp;gamma;/NF-&amp;kappa;B... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,&amp;ast; Qingqing Qiu,1,&amp;ast; Zhengguang Xu,1,&amp;ast; Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
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Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes by Liping Wang, Ran Zhou, Guanghui Li, Xiaodan Zhang, Yan Li, Yinchen Shen, Junwei Fang

“…Background: Despite optimized blood pressure control and glycemic management reducing the incidence of diabetic nephropathy (DN), significant residual risk remains, suggesting the contribution of pathogenic factors independent of glucose metabolism and hemodynamic disturbances. …”
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Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair by Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer

“…Process improvements that reduce cell heterogeneity while increasing donor cell numbers with improved chondrogenic potential during expansion culture are needed to realize the full potential of MSC therapy. Methods In this study, we investigated the potential of MSC metabolic modulation during expansion to enhance their chondrogenic commitment by varying the nutrient composition, including glucose, pyruvate, glutamine, and ascorbic acid in culture media. …”
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Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes by Wagner S. Dantas, Elizabeth C. Heintz, Elizabeth R. M. Zunica, Jacob T. Mey, Melissa L. Erickson, Kathryn P. Belmont, Analisa L. Taylor, Gangarao Davuluri, Hisashi Fujioka, Ciarán E. Fealy, Charles L. Hoppel, Christopher L. Axelrod, John P. Kirwan

“…ABSTRACT Background Activation of mitochondrial fission and quality control occur early in the onset of insulin resistance in human skeletal muscle. …”
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Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early‐Stage Lung Cancer by Tetsuya Isaka, Takuya Nagashima, Kota Washimi, Haruhiro Saito, Hiroto Narimatsu, Shunsuke Shigefuku, Chiaki Kanno, Ryotaro Matsuyama, Naoko Shigeta, Yui Sueishi, Hiroyuki Ito

“…ABSTRACT Background The impact of lobectomy versus segmentectomy on body composition changes, particularly adipose tissue, in patients with early‐stage lung cancer remains unclear. …”
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The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort by Mengqi Wu, Xin Zhou, Saiping Chen, Yuqing Wang, Bin Lu, Aiping Zhang, Yanqin Zhu, Min Huang, Jiarui Wang, Junyi Liu, Fenggui Zhu, Hong Liu, Riyang Lin, Riyang Lin

“…BackgroundDiabetic kidney disease (DKD) exhibits heterogeneous progression, implicating factors beyond hyperglycemia, such as gut microbiota dysbiosis. …”
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Exogenous Nucleotides Supplementation Attenuates Age‐Related Sarcopenia by Xin Wu, Rui Liu, Na Zhu, Xiujuan Wang, Chan Wei, Xiaoyang An, Meihong Xu, Yong Li

“…ABSTRACT Background Sarcopenia, an age‐related clinical syndrome characterized by reduced skeletal muscle mass and strength, often leads to a loss of physical function. …”
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Establishment of a new approach for quality evaluation of Pseudobulbus Cremastrae seu Pleiones (Shancigu) based on multicomponent analysis and anti-liver cancer pharmacological eff... by Yuxin Cao, Zhuangzhuang Hao, Mengmeng Liu, Jingwen Xue, Yuqing Wang, Tingyue Jiang, Ge Zhang, Wenxin Fan, ChunGuo Wang, Jinli Shi

“…Shancigu is classified into two commercial specifications—“Maocigu” and “Bingqiuzi”—which exhibit significant differences in appearance, chemical composition, and price, posing challenges for the quality control of medicinal materials.PurposeThe aim of this study was to clarify the quality evaluation indicators based on the anti-liver cancer active components in Shancigu and to establish a reliable quality evaluation method to preliminarily assess the quality of Shancigu from different commercial specifications and production areas.MethodsTwenty-six batches of Shancigu samples were collected. …”
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A comparative study of the essential oil extracts of Centaurea alexanderina different parts: GC-MS analysis, antimicrobial, antioxidant, and anti-hyperglycemic activities by Hossam A. Abdallah, Naglaa Afifi, Enas I. A. Mohamed, Mohamed Sebak, Rabab Mohammed, Mohamed A. Zaki

“…In this context, essential oil extracts from different parts of C. alexanderina (flowers, stems, leaves, and roots) have been analyzed chemically and tested for their antioxidant, antimicrobial, and anti-hyperglycemic activities. Methods The essential oil extracts from different parts of C. alexanderina have been prepared and their chemical compositions have been analyzed using GC–MS technique. …”
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ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota by Yi-Hsuan Liu, Yueh-Lun Lee, Chia-Li Han, Yu-Chun Lo, Zih-An Liao, Yu-Syuan Shih, Yi-Wen Lin, Syue-Wei Peng, Kang-Yun Lee, Shu-Chuan Ho, Sheng-Ming Wu, Cheng-Wei Lin, Kian Fan Chung, Jer-Hwa Chang, Hsiao-Chi Chuang

“…Abstract Background Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), a Type 2 acute phase protein, is critical for resolving inflammation and promoting tissue repair. …”
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Synergizing population structure, habitat preferences, and ecological drivers for conservation of Cedrus deodara by Syed Waseem Gillani, Mushtaq Ahmad, Muhammad Manzoor, Muhammad Waheed, Andreas Tribsch, Hamayun Shaheen, Abdul Basit Mehmood, Beatrice Ambo Fonge, Abeer Al-Andal

“…Abstract Background Climate change is impacting forest tree species adversely and making the ecological system vulnerable. …”
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Investigation of differential Multi-Mode antibacterial mechanisms of essential oils of Satureja montana L. and Leptospermum scoparium J.R.Forst. & G.Forst. Against Porphyromonas gi... by Yue Yuan, Xiuli Hui, Zixuan Liu, Jinlong Sun, Rifat Nowshin Raka, Junsong Xiao, Zhongwei Zhang, Hua Wu

“…Abstract Background Globally, according to WHO estimates, severe periodontitis affects over 1 billion people. …”
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Modeling regional aboveground carbon stock dynamics affected by land use and land cover changes by A.D. Malik, M.C.W. Arief, S. Withaningsih, P. Parikesit

“…BACKGROUND AND OBJECTIVES: Land use and land cover changes are affected by massive construction, urban expansion, and exploitative agricultural management. …”
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