Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy by Louis Boon, Matheus H W Crommentuijn, Sjoerd T T Schetters, Laura J W Kruijssen, Yvette van Kooyk, Ernesto Rodriguez, Jan Van den Bossche, Joke M M Den Haan

“…Background PD1 immune checkpoint blockade (αPD1 ICB) has shown unparalleled success in treating many types of cancer. …”
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Metabolic and Structural Consequences of GM3 Synthase Deficiency: Insights from an HEK293-T Knockout Model by Elena Chiricozzi, Giulia Lunghi, Manuela Valsecchi, Emma Veronica Carsana, Rosaria Bassi, Erika Di Biase, Dorina Dobi, Maria Grazia Ciampa, Laura Mauri, Massimo Aureli, Kei-ichiro Inamori, Jin-ichi Inokuchi, Sandro Sonnino, Maria Fazzari

“…<b>Background</b>: GM3 Synthase Deficiency (GM3SD) is a rare autosomal recessive neurodevelopmental disease characterized by recurrent seizures and neurological deficits. …”
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Predicting acute lung injury in infants with congenital heart disease after cardiopulmonary bypass by gut microbiota by Lan Jiang, Yueshuang Cun, Qiang Wang, Kede Wu, Menglong Hu, Zhen Wu, Tianyi Zhu, Zhaocong Yang, Nishant Patel, Nishant Patel, Xinyu Cai, Xinyu Cai, Jirong Qi, Xuming Mo

“…BackgroundAcute lung injury (ALI) is a serious and common complication that occurs in children with congenital heart disease after cardiopulmonary bypass (CPB) surgery, leading to higher mortality rates and poorer prognosis. …”
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Microwave-dried black soldier fly larvae enhance growth, intestinal health, and humoral imm by Osfar Sjofjan, Ari Ardiantoro, Inaayah Novitri Cahyawati, Amalia Iffah Jihana, Muhammad Halim Natsir, Yuli Frita Nuningtyas, Danung Nur Adli

“…Background and Aim: The global demand for sustainable animal protein sources has led to the exploration of insects as alternative feed ingredients. …”
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The effects of a combined recovery strategy during a match-congested period crossing Ramadan: a repeated measurements crossover study among professional male basketball players by Seifeddine Brini, Fatma Hilal Yagin, Julio Calleja Gonzalez, Georgian Badicu, Sarah da Glória Teles, Javier Raya Gonzalez, Safaa M. Elkholi, Hanan Alyami, Anissa Bouassida, Anne Delextrat, Urs Granacher, Luca Paolo Ardigò

“…Background: A good recovery process is a key factor to avoid fatigue and sports-related injuries in Muslim male basketball players, especially during some decisive phases of the sport season, such as the match congestion period coinciding with Ramadan intermittent fasting (RIF). …”
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A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by exceedingly high rates of metastatic progression, with the liver representing the most common site of distant spread. …”
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Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis by Dongsheng Wu, Dongsheng Wu, Yuang Dong, Dongyang Zhang, Tongtong Wang, Haipeng Ye, Wei Zhang

“…BackgroundThe therapeutic application of dietary polyphenols in chronic obstructive pulmonary disease (COPD) management represents an emerging therapeutic paradigm in pulmonary medicine. …”
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Association between birth length, linear growth velocities, and primary school achievement at age 10 years: evidence from the Ethiopian iABC birth cohort by Rahma Ali, Beakal Zinab, Bikila S. Megersa, Daniel Yilma, Tsinuel Girma, Alemseged Abdissa, Melkamu Berhane, Bitiya Admasu, Suzanne Filteau, Dorothea Nitsch, Henrik Friis, Jonathan C. K. Wells, Gregers S. Andersen, Mubarek Abera, Mette F. Olsen, Rasmus Wibaek, Akanksha A. Marphatia

“…We assessed associations between birth length, childhood linear growth velocities, and stunting with school achievement. Methods Newborns were recruited into the Ethiopian infant Anthropometry and Body Composition (iABC) birth cohort and followed from birth to 10 years. …”
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Circulating Microvesicles Enriched in miR–126–5p and miR–223–3p: Potential Biomarkers in Acute Coronary Syndrome by José Rubicel Hernández-López, Mirthala Flores-García, Esbeidy García-Flores, Benny Giovanni Cazarín-Santos, Marco Antonio Peña-Duque, Fausto Sánchez-Muñoz, Martha Alicia Ballinas-Verdugo, Hilda Delgadillo-Rodríguez, Marco Antonio Martínez-Ríos, Eduardo Angles-Cano, Aurora de la Peña-Díaz

“…<b>Methods.</b> Bioinformatic tools identified miRNAs linked to ACS. …”
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Endurance running during late murine adolescence results in a stronger anterior cruciate ligament and flatter posterior tibial slopes compared to controls by Danielle N. Ochocki, Benjamin E. Loflin, Taeyong Ahn, Kaitlyn A. Colglazier, Andrew R. Young, Anna A. Snider, Elizabeth P. Bueckers, Edward M. Wojtys, Stephen H. Schlecht

“…Abstract Background Anterior cruciate ligament (ACL) injury rates continue to rise among youth involved in recreational and competitive athletics, requiring a better understanding of how the knee structurally and mechanically responds to activity during musculoskeletal growth. …”
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Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement by Natalie Grima, Andrew N. Smith, Claire E. Shepherd, Lyndal Henden, Thiri Zaw, Luke Carroll, Dominic B. Rowe, Matthew C. Kiernan, Ian P. Blair, Kelly L. Williams

“…Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects the motor neurons, causing progressive muscle weakness and paralysis. …”
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Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway by Na Yang, Meiduo Huayu, Shanshan Su, Bin Hou, Zhanting Yang, Xingmei Nan, Zhanqiang Li, Zhanqiang Li

“…Although its active fraction (ACRT) shows therapeutic potential for HAPH, the main pharmacodynamic substances remain unclear due to its complex composition.AimsThis study aimed to identify bioactive equivalent combinatorial components (BECCs) of ACRT that alleviate pulmonary vascular remodeling in HAPH rats and explore the underlying pharmacological mechanisms.MethodsSeventy adult Sprague–Dawley rats were divided into control, hypoxia, hypoxia + ACRT (150 mg/kg), hypoxia + BECCs (25, 50, and 100 mg/kg), and hypoxia + sildenafil (30 mg/kg) groups. …”
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Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants by Jun Qiu, Jun Qiu, Sha Wu, Sha Wu, Ruiwen Huang, Zhenyu Liao, Xiongfeng Pan, Kunyan Zhao, Kunyan Zhao, Yunlong Peng, Yunlong Peng, Shiting Xiang, Yunhui Cao, Yunhui Cao, Ye Ma, Zhenghui Xiao, Zhenghui Xiao

“…BackgroundAntibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. …”
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DENTAL STATUS OF PRESCHOOL CHILDREN WITH MOUTH BREATHING by L.P. Ulasevych

“…The purpose of our study was to assess the dental status of preschool children with oral breathing to develop more effective methods of preventing caries of temporary teeth that can be applied chairside during the dental appointment. …”
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Cancer incidence in young adults aged 20 to 44 years old in the Siberian Federal District by L. D. Zhuikova, E. L. Choynzonov, A. D. Kaprin, A. O. Shakhzadova, O. A. Ananina, G. A. Kononova, L. V. Pikalova, M. Yu. Grishchenko, E. V. Denisov

“…The purpose of the study was to assess the incidence of the most common cancers in young men and women aged 20 to 44 years in the SFD. Material and Methods. The study used data from the state medical statistics reports (form 7, “Information on malignant neoplasms”) of the SFD subjects, as well as data on the age and sex composition of the population of these territories for 2014–2023. …”
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The impact of participation status on the colorectal cancer incidence, stage and survival outcomes in the Shanghai colorectal cancer screening program by PENG Peng, DOU Jianming, WU Chunxiao, PANG Yi, GONG Yangming, WU Mengyin, SHI Yan, GU Kai

“…Background and purpose: The colorectal cancer screening program for community residents in Shanghai has been implemented for 12 years since 2013. …”
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Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study by Yuqin Zhang, Min Zhang, Meili Cai, Xiaowen Shao, Diliqingna Dilimulati, Jiayi Lu, Cuiling Zhu, Haibing Chen, Changbin Li, Shen Qu, Manna Zhang

“…Abstract Background While the specific effects of bedtime on androgen levels and lean muscle mass remain understudied, circadian misalignment and sleep disturbances have been well-established as risk factors for various metabolic disorders. …”
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Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy by Dean G. Campelj, Cara A. Timpani, Guinevere Spiesberger, Luke E. Formosa, Joel R. Steele, Haijian Zhang, Ralf B. Schittenhelm, Lewis Leow, Craig A. Goodman, Emma Rybalka

“…ABSTRACT Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often‐irreversible body‐wasting condition that causes 20%–30% of cancer‐related deaths. …”
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The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers by Anahita Fathi Kazerooni, Hamed Akbari, Xiaoju Hu, Vikas Bommineni, Dimitris Grigoriadis, Erik Toorens, Chiharu Sako, Elizabeth Mamourian, Dominique Ballinger, Robyn Sussman, Ashish Singh, Ioannis I. Verginadis, Nadia Dahmane, Constantinos Koumenis, Zev A. Binder, Stephen J. Bagley, Suyash Mohan, Artemis Hatzigeorgiou, Donald M. O’Rourke, Tapan Ganguly, Subhajyoti De, Spyridon Bakas, MacLean P. Nasrallah, Christos Davatzikos

“…Abstract Background Glioblastoma is a highly heterogeneous brain tumor, posing challenges for precision therapies and patient stratification in clinical trials. …”
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School-based physical activity and health-related fitness in Mediterranean students: findings from the DELICIOUS project by Mohamed Aly, Achraf Ammar, Achraf Ammar, Achraf Ammar, Khaled Trabelsi, Khaled Trabelsi, Khaled Trabelsi, Liwa Masmoudi, Noha El-Gyar, Amira M. Shalaby, Osama Abdelkarim

“…BackgroundPhysical inactivity among children is a growing public health concern, particularly in Mediterranean countries, where lifestyle changes have contributed to declining physical fitness levels. …”
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