Rehabilitation after bone marrow transplant compared with usual care to improve patient outcomes (REBOOT): protocol for a randomised controlled trial by Linda Denehy, Shaza Abo, Christopher Swain, Camille E. Short, Nicole Kiss, Amit Khot, Eric Wong, Duncan Purtill, Clare O’Donnell, Marlena Klaic, Catherine L. Granger, Michelle Tew, Tim Spelman, Vinicius Cavalheri, Lara Edbrooke, on behalf on the REBOOT research team

“…Abstract Background Haematological cancer affects more than 1.3 million people around the world annually and accounted for almost 800,000 deaths globally in 2020. …”
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The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population. by Nathalie Chami, Michael Preuss, Ryan W Walker, Arden Moscati, Ruth J F Loos

“…<h4>Background</h4>Melanocortin 4 receptor (MC4R) deficiency, caused by mutations in MC4R, is the most common cause of monogenic forms of obesity. …”
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Effect of screw pressing temperature on yield, bioactive compounds, and quality of hemp (Cannabis sativa L.) seed oil by Aymane Allay, Abdessamad Ben Moumen, Youssef Rbah, Marie-Laure Fauconnier, Jacques Nkengurutse, Hana Serghini Caid, Ahmed Elamrani, Farid Mansouri

“…This study aims to assess the effects of different screw press extraction temperatures on hemp oil yield, composition and quality. Methods The study was conducted to examine the influence of screw press extraction temperatures (30, 60, 80, 100, 120 and 140 °C) on hemp oil yield and quality. …”
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A1 protein free milk benefits mood and subjective cognition in free-living Australian adults: a pragmatic, exploratory, open label randomised controlled trial by Carlene Starck, Michelle Blumfield, Peter Petocz, Emily Duve, Lucy Downey, Kylie Abbott, Flavia Fayet-Moore, Flavia Fayet-Moore

“…BackgroundAdverse effects of milk containing A1-type β-casein on digestion, immune response, and cognition have been identified in milk-intolerant individuals, but health effects in healthy individuals without symptoms of milk intolerance are yet to be examined.ObjectiveThe objective was to explore the impact of reducing A1 type β-casein intake via switching milk type from conventional A1/A2-type β-casein milk (A1/A2 milk) to A1-type β-casein protein free milk (A1PF) on brain, immune response, gastrointestinal, and skin (BIGS) outcomes in a real-world setting.MethodsAn open-label, pragmatic, exploratory randomised controlled trial was conducted in 997 healthy, free-living Australian older adolescents and adults (16–65 years) who regularly consume A1/A2 protein-containing milk and milk products. …”
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A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics by Zhengjie Wu, Zhiping Liu, Yukun Wang, Geling Teng, Xiaodong Li, Tong Lu, Fangning Hu, Shuo Wu, Guanqiang Ma, Hua Zhang

“…BackgroundTryptophan (Trp) metabolism plays a vital role in tumor development and outcomes. …”
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Enhancement of oxaliplatin efficacy and amelioration of intestinal epithelial damage by Lactobacillus rhamnosus GG through modulation of gut microbiota by Zijie Zhang, Zijie Zhang, Rui Li, Yilin Ren, Yilin Ren, Yalan Ni, Yalan Ni, Xiaoyu Shen, Xiaoyu Shen, Deli Yi, Deli Yi, Zheng-hong Xu, Yan Geng, Yan Geng, Qingjun You, Qingjun You

“…BackgroundNon-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide, necessitating extensive research into effective treatment strategies. …”
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GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…BackgroundThe exploration of genetic signatures within the ovarian cancer (OC) tumor microenvironment (TME) remains limited. …”
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Intranasal Transplantation of Microbiota Derived from Parkinson’s Disease Mice Induced Astrocyte Activation and Neurodegenerative Pathology from Nose to Brain by Yi-Meng Xia, Mei-Xuan Zhang, Xiao-Yu Ma, Lu-Lu Tan, Ting Li, Jian Wu, Ming-An Li, Wei-Jiang Zhao, Chen-Meng Qiao, Xue-Bing Jia, Yan-Qin Shen, Chun Cui

“…Background: Parkinson’s disease (PD) is characterized by early-onset olfactory dysfunction preceding motor symptoms, yet its mechanisms remain elusive. …”
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Exploring the impact of chronic intermittent EU-GMP certified Cannabis sativa L. therapy and its relevance in a rat model of aging by Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carmen Solcan, Mitica Ciorpac, Andrei Szilagyi, Daniela-Carmen Ababei, Raluca-Maria Gogu, Bogdan-Ionel Tamba

“…Abstract Background Aging is a multifaceted process marked by the progressive accumulation of cellular damage in various tissues, resulting in a decline in physiological functions. …”
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Success Factors of Growth-Stage Digital Health Companies: Systematic Literature Review by Estelle Pfitzer, Laura Bitomsky, Marcia Nißen, Christoph Kausch, Tobias Kowatsch

“… BackgroundOver the past decade, digital health technologies (DHTs) have grown rapidly, driven by innovations such as electronic health records and accelerated by the COVID-19 pandemic. …”
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Causal association between gut microbiota and endometrial cancer in European and East Asian populations: a two-sample Mendelian randomization study by Jiaqi Chen, Haiqing Li, Xinrui Long, Hao Tong, Xin Xin, Han Zhang, Yeyao Li, Ping Liu, Xiaolin He, Zhuoyuan Chen

“…The inverse variance-weighted(IVW) method was applied to evaluate the association between gut microbiota composition and EC risk. …”
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Food additive mixtures and type 2 diabetes incidence: Results from the NutriNet-Santé prospective cohort. by Marie Payen de la Garanderie, Anaïs Hasenbohler, Nicolas Dechamp, Guillaume Javaux, Fabien Szabo de Edelenyi, Cédric Agaësse, Alexandre De Sa, Laurent Bourhis, Raphaël Porcher, Fabrice Pierre, Xavier Coumoul, Emmanuelle Kesse-Guyot, Benjamin Allès, Léopold K Fezeu, Emmanuel Cosson, Sopio Tatulashvili, Inge Huybrechts, Serge Hercberg, Mélanie Deschasaux-Tanguy, Benoit Chassaing, Héloïse Rytter, Bernard Srour, Mathilde Touvier

“…<h4>Background</h4>Mixtures of food additives are daily consumed worldwide by billions of people. …”
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Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect by Jie Zheng, Yihui Liu, Yong He, Chen Hu, Di Wu, Tao Peng, Chao He, Rui Han, Conghua Lu, Ziyuan Gao, Daijuan Huang, Caiyu Lin, Yuanyao Dou, Yimin Zhang, Fenfen Sun, Weiling Jiang, Guoqing Yin

“…Background The dynamic interplay between tyrosine kinase inhibitors (TKIs) and the tumor immune microenvironment (TME) plays a crucial role in the therapeutic trajectory of non-small cell lung cancer (NSCLC). …”
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Effect of atrial fibrosis on clot burden score and physicochemical properties of thrombus in patients with ischaemic stroke occurring in non-valvular atrial fibrillation by Juan Zhao, Guangjun Deng, Weijing Wang, Peng Wang, Xinyu Shen, Xiaoxiao Yuan, Haifei Jiang, Zhong-bao Ruan

“…Background To investigate the effect of the degree of atrial fibrosis on the clot burden score (CBS) and physicochemical properties in patients with acute ischaemic stroke (AIS) due to non-valvular atrial fibrillation (NVAF). …”
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Effects of ketogenic diets on polycystic ovary syndrome: a systematic review and meta-analysis by Rossella Cannarella, Michele Rubulotta, Alessia Leonardi, Andrea Crafa, Antonio Calvo, Federica Barbagallo, Sandro La Vignera, Aldo E. Calogero

“…Abstract Background This systematic review and meta-analysis aimed to evaluate the effects of ketogenic diet (KD) and very-low-energy ketogenic therapy (VLEKT) protocols on various health outcomes in patients with polycystic ovary syndrome (PCOS) and increased body weight. …”
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Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapy by Li Zhang, Sergio Rutella, Jongbok Lee, Ismat Khatri, Yoosu Na, Enoch Tin, Karen Fang, Michele Nawata, Juan Arteaga, Mark D Minden

“…Background Allogeneic double-negative T-cell (DNT) therapy has emerged as a novel, off-the-shelf cellular treatment with clinical feasibility, safety, and promising efficacy against leukemia. …”
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Three-dimensional fracture migration evolution law of overburden rock in steeply dipping working face by Panshi XIE, Baofa HUANG, Yongping WU, Shenghu LUO, Mingjian ZHU, Leilei YI, Hui XU, Jianjie CHEN

“…Based on the engineering background of steeply dipping longwall and large mining height working face, the research methods of numerical calculation, field measurement and theoretical analysis are combined. …”
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Plant Dominant Low-Protein Diet, Nutritional Status (Phase Angle) and Progression of Renal Failure: Case-Report Study by Danijela Ristic-Medic, Snjezana Petrovic, Biljana Pokimica, Marija Paunovic, Vesna Vucic

“…Background and Objectives: High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. …”
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Evaluation of the immunomodulatory effects of a novel synbiotic made of combined use of probiotic-prebiotic-Chinese traditional herbs by Deshan Ning, Yiru Huang, Yulong Zhou, Hongwei Zhao, Wenlei Nie, Yu Zheng, Xiaojun Huang

“…Background: Recent studies have discussed the preferred activity of synbiotics, which are a combination of probiotics and prebiotics. …”
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Chronic stress is associated with altered gut microbiota profile and relevant metabolites in adolescents by Li Ying, Wang Yuhao, He Yafang, Lan Jiao, Dang Lina, Song Qinze, Yang Chenghai, Zhao Shaoxiong, Gu Yuexi, Shen Mingwang, Cai Zelin, Wang Chuangchuang, Guo Zihan, Liu Xin, Ma Lu, Zhang Lei

“…Abstract Background Gut microbiota and microbiota-derived metabolites have been implicated in the regulation of stress-related diseases, yet their associations with chronic stress in adolescents remain unclear. …”
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