Expert panel as reference standard procedure in diagnostic accuracy studies: a systematic scoping review and methodological guidance by Bas E. Kellerhuis, Kevin Jenniskens, Mike P. T. Kusters, Ewoud Schuit, Lotty Hooft, Karel G. M. Moons, Johannes B. Reitsma

“…Abstract Background In diagnostic accuracy studies, when no reference standard test is available, a group of experts, combined in an expert panel, is often used to assess the presence of the target condition using multiple relevant pieces of patient information. …”
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Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…Background Chimeric antigen receptor (CAR)-T cells face many obstacles in solid tumor therapy, including heterogeneous antigen expression and inefficient T cell persistence. …”
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Different Level of Carotid-Femoral Pulse Wave Velocity and Related Factors in Different Nationality Group in China by Liu J, Cui X, Wen H, Bai X, Jiang S, Zhao H, Li L, Wang H

“…We chose these three ethnic groups for analysis, to find some similarities or differences in CF-PWV.Methods: We launched early vascular lesion detection technology promotion involving several regions such as the Han (Beijing), Miao (Guizhou Province), and She (Fujian Province) ethnicity. …”
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Visceral adiposity loss is associated with improvement in cardiometabolic markers: findings from a dietary intervention study by Shazana Rifham Abdullah, Ahmad Kamil Nur Zati Iwani, Liyana Ahmad Zamri, Ruziana Mona Wan Mohd Zin, Norhashimah Abu Seman, Nur Azlin Zainal Abidin, Siti Sarah Hamzah, Nur Hayati Azizul, Azahadi Omar, Zamtira Seman, Abqariyah Yahya, Mohd Fairulnizal Md Noh

“…BackgroundVisceral adiposity is closely linked with cardiometabolic disorders, but evidence on the extent of visceral fat loss required for significant improvement in cardiometabolic markers remains limited. …”
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Lactobacillus reuteri DSM 17,938 ameliorates LPS-induced depression-like and anxiety-like behaviors by modulating gut microbiota and brain metabolic function by Xiaolong Mo, Siyi Guo, Dian He, Qisheng Cheng, Yichun Yang, Haiyang Wang, Yikun Ren, Lanxiang Liu, Peng Xie

“…Abstract Background Lactobacillus reuteri DSM 17,938 exhibits antidepressant and anxiolytic potential. …”
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Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota by Li JH, Xu J, Huang C, Hu JX, Xu HM, Guo X, Zhang Y, Xu JK, Peng Y, Zhang Y, Zhu MZ, Zhou YL, Nie YQ

“…This study aims to evaluate the efficacy of HELNs in treating colitis in mice and investigate its potential mechanisms.Methods: HELNs were isolated from H. cordata for characterization, and their safety and stability were evaluated. …”
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Comparison of the Blood–Brain Barrier Penetration Ability and Anti-Neuroinflammatory Activity of Chromones in Two Types of Agarwood by Mengyuan Yang, Yanan Yuan, Jingfan Wei, Yifei Pei, Yuanfei Niu, Yifan Zhao, Xiangying Kong, Zhijie Zhang

“…<b>Background/Objectives</b>: Agarwood has a good neuroprotective effect and is often used to relieve anxiety and treat insomnia. …”
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Dysgeusia in MASLD-related advanced chronic liver disease (ACLD): a silent driver towards the “Bermuda” triangle of malnutrition-sarcopenia-frailty severely affecting prognosis by Marcello Dallio, Mario Romeo, Fiammetta Di Nardo, Carmine Napolitano, Paolo Vaia, Giorgia Iadanza, Simone Olivieri, Annachiara Coppola, Marco Niosi, Alessandro Federico

“…Methods 200 MASLD patients [60 ≤ F3 fibrosis, 70 compensated ACLD (cACLD), and 70 decompensated (dACLD)] were enrolled. …”
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Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study by Sinibaldo Romero Arocha, Kim Han, Rebecca D Huffstutler, Geethika P Thota, Natalie A Macheret, Amber B Courville, Robert J Brychta, Kong Y Chen, Stephanie T Chung, Laura C Coates, Alexander J Clarke, Michael N Sack

“… BackgroundPsoriasis is a chronic inflammatory disease associated with multiple comorbidities, including metabolic syndrome and cardiovascular disease. …”
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A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers by Laurel K. Berry, Ashok K. Pullikuth, Kristen L. Stearns, Yuezhu Wang, Calvin J. Wagner, Jeff W. Chou, Janelle P. Darby, Michael G. Kelly, Raghvendra Mall, Ming Leung, Julia Chifman, Lance D. Miller

“…Abstract Background While high-grade serous ovarian cancer (HGSC) has proven largely resistant to immunotherapy, sporadic incidents of partial and complete response have been observed in clinical trials and case reports. …”
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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…Abstract Background Alzheimer’s disease (AD) remains incurable, yet its long prodromal phase offers a crucial window for early intervention. …”
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Prevalence and Clinical Impact of Obstructive Sleep Apnea in Patients with Severe Aortic Stenosis Undergoing Valve Replacement by Hilary Miranda-Mendoza, Luis M. Amezcua-Guerra, Gustavo Rojas-Velasco, Daniel Manzur-Sandoval, Jennifer Escobar-Alvarado, Luis Chávez-Sánchez, Wendy G. Vázquez-González, Laura L. Rodríguez Chávez, Humberto Martínez Hernández, Malinalli Brianza-Padilla

“…<b>Background/Objectives</b>: Aortic stenosis (AS) is the most prevalent valvular disease among older adults. …”
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Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells With Early Antibody-mediated Rejection in Kidney Transplant Recipients by Dania Altulea, MSc, Joost van den Born, MD, PhD, Theo Bijma, BSc, Carlo Bonasia, MSc, Nanthicha Inrueangsri, MSc, Rosa Lammerts, MD, PhD, Stefan Berger, MD, PhD, Peter Heeringa, PhD, Jan-Stephan Sanders, MD, PhD

“…Background. B cells play a crucial role in kidney transplantation through antibody production and cytokine secretion. …”
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Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota by Lingyu Ruan, Zhennan Wang, Mengyun Zheng, Qi Zheng, Qing Qing, Hongyan Lin, Yuheng Tao, Liqun Wang, Junsong Wang, Wenhao Ge, Wenhao Ge

“…Background and purposeIschemic stroke (IS) is the most common type of stroke, known for its high rates of morbidity, disability, mortality, and recurrence. …”
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Heat Adaptation Benefits for Vulnerable groups In Africa (HABVIA): a study protocol for a controlled clinical heat adaptation trial by Michaela Deglon, Chad Africa, Larske Marit Soepnel, Thandi Kapwata, Ama de-Graft Aikins, Kweku Bedu-Addo, Guy Howard, Estelle Victoria Lambert, Dale Elizabeth Rae, Martha Sibanda, Christopher Gordon, Mark New, Lara Ruth Dugas

“…Abstract Background Temperatures across Africa are expected to rise at up to twice the rate of mean global temperatures, posing significant health threats to vulnerable communities. …”
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C-Reactive Protein-to-Serum Chloride Ratio: A Novel Marker of All-Cause Mortality in Maintenance Haemodialysis Patients by Francisco Valga, Tania Monzón, José C. De la Flor, Angelo Santana-del-Pino, Nicanor Vega-Díaz, Ana Yurena Sanchez-Santana, Gloria Antón-Pérez, Sergio Ruiz-Santana, José C. Rodríguez-Pérez, Patricia Perez-Borges

“…Some studies suggest the influence of inflammation as a synergistic factor, so we set out to analyse the association of a novel C-reactive protein-to-serum chloride ratio (CRP/Cl⁻) with the prognosis of maintenance haemodialysis patients and to assess its relationship with fluid status and body composition measured by bioimpedance. <i>Materials and Methods</i>: the present work is a retrospective cohort study of maintenance haemodialysis patients from our chronic outpatient haemodialysis programme between 1 January 2022 and 31 December 2022. …”
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Long‐Term Effects of High‐Intensity Aerobic Training on Metabolic Syndrome: An 8‐Year Follow‐Up Randomized Clinical Trial by Felix Morales‐Palomo, Alfonso Moreno‐Cabañas, Laura Alvarez‐Jimenez, Diego Mora‐Gonzalez, Ricardo Mora‐Rodriguez

“…ABSTRACT Background Metabolic syndrome (MetS) is a set of five cardiometabolic risk factors that typically worsen with age. …”
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Orange Peel <i>Lactiplantibacillus plantarum</i>: Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity by Elisa Corazza, Asia Pizzi, Carola Parolin, Barbara Giordani, Angela Abruzzo, Federica Bigucci, Teresa Cerchiara, Barbara Luppi, Beatrice Vitali

“…<b>Background/Objectives:</b> Due to the high frequency and severity of upper respiratory bacterial infections, probiotics could offer a new medical approach. …”
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AKR1B1 Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance by Seçil Demirkol Canlı, Güneş Güner, Aynur Işık, Branka Sosic‐Jurjevic, Aleksandra Djikic Rom, Esin Gülce Seza, Ömer Dizdar, Sandra Dragicevic, Aleksandra Nikolic, Aytekin Akyol, Sreeparna Banerjee

“…ABSTRACT Background AKR1B1, a member of the aldo‐keto reductase enzyme family involved in the polyol pathway of aldehyde metabolism, is aberrantly expressed in colorectal cancer (CRC). …”
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Youth Uptake of Digital Sexual and Reproductive Health Services Across Sociodemographic Groups (2018-2022): A Total Population Study from Stockholm, Sweden by Lovisa Hellsten, MPH, Viktor H. Ahlqvist, PhD, Anna M. Nielsen, RM, PhD, Gunnar Brandén, PhD, Anna Mia Ekström, MD, PhD, Kyriaki Kosidou, MD, PhD

“…Objective: To examine uptake of in-person and digital sexual and reproductive health (SRH) services among adolescents and young adults, quantify uptake across time, and explore whether the introduction of digital services affected the sociodemographic composition of users. Patients and Methods: This Swedish total population study included all Stockholm residents aged 12-22 years between January 1st 2018 and December 31st 2022. …”
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