<i>Syzygium aromaticum</i> Phytoconstituents Target SARS-CoV-2: Integrating Molecular Docking, Dynamics, Pharmacokinetics, and <i>miR-21 rs1292037</i> Genotyping by Mustafa Ahmed Muhmood, Faiza Safi, Mohammed Mukhles Ahmed, Safaa Abed Latef Almeani

“…Background and aim: The COVID-19 pandemic, caused by SARS-CoV-2, remains a global health crisis despite vaccination efforts, necessitating novel therapeutic strategies. …”
Get full text

Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion by Fangyan Wang, Xinyu Wang, Chaoyi Wang, Wangxin Yan, Junpeng Xu, Zhengyang Song, Mingli Su, Jingjing Zeng, Qiannian Han, Gaoyi Ruan, Eryao Zhang, Wantie Wang

“…Abstract Background Intestinal ischemia/reperfusion injury (IIRI) is a life-threatening condition caused by multiple organ and system failures induced by dysbiosis and gut leakage. …”
Get full text

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…Abstract Background The modulation of tumor microenvironments through immune checkpoint pathways is pivotal for the development of effective cancer immunotherapies. …”
Get full text

Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health by Iván Artemio Corral-Guerrero, Angela Elena Martínez-Medina, Litzy Yazmin Alvarado-Mata, Ana Cristina Figueroa Chávez, Roberto Muñoz-García, Miriam Paulina Luévanos-Escareño, Jazel Doménica Sosa-Martínez, María José Castro-Alonso, Padma Nimmakayala, Umesh K. Reddy, Nagamani Balagurusamy

“…<b>Background/Objectives:</b> Capsaicin is the principal pungent compound in chili peppers and is increasingly recognized as a multifunctional phytochemical with systemic effects beyond its sensory properties. …”
Get full text

Altered heme metabolism and hemoglobin concentration due to empirical antibiotics-induced gut dysbiosis in preterm infants by Seung Hyun Kim, Min‑Jin Kwak, Jae Kyoon Hwang, Jihyun Keum, Hee Yeon Jin, Chan-Yeong Lee, Rahul Sadashiv Tanpure, Yong Joo Kim, Jeong-Kyu Hoh, Jae Yong Park, Woojin Chung, Byong-Hun Jeon, Hyun-Kyung Park

“…Background: High-risk infants are usually treated with empirical antibiotics after birth, regardless of the evidence of infection; however, their gut microbiome and metabolome have seldom been studied. …”
Get full text

Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy by Lei S, Wu Q, Zhang B, Lu M, Xia Y, Li N

“…The nanoparticle size, chemical structure, and elemental composition were explored. The toxicity, cellular uptake, lysosomal escape, and AR release efficiency of GA-MSe@AR were investigated by in vitro experiments. …”
Get full text

Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism by Yang Yang, Yang Yang, Qing Hong, Qing Hong, Xuehong Zhang, Zhenmin Liu, Zhenmin Liu

“…BackgroundRheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. …”
Get full text

Host-specific effects of Eubacterium species on Rg3-mediated modulation of osteosarcopenia in a genetically diverse mouse population by Soyeon Hong, Bao Ngoc Nguyen, Huitae Min, Hye-Young Youn, Sowoon Choi, Emmanuel Hitayezu, Kwang-Hyun Cha, Young Tae Park, Choong-Gu Lee, GyHye Yoo, Myungsuk Kim

“…Abstract Background Osteosarcopenia, characterized by the simultaneous loss of bone and muscle mass, is a serious health problem in the aging population. …”
Get full text

The dietary inflammation index and body mass index mediate the association between the dietary index for gut microbiota and sarcopenia in older women: evidence from NHANES 2011–201... by Xiaoyan Zhang, Liangzhi Wu, Yutian He, Shuyao Zhang, Wenfeng Hua, Wenfeng Hua

“…BackgroundThe dietary index of gut microbiota (DI-GM) was developed to assess dietary quality by reflecting the diversity of the gut microbiota composition. …”
Get full text

Daily Lactose Supplementation in Lactase Non-Persistent Individuals Induces Colonic Adaptation and Reduces Intolerance Symptoms by Ellen Looijesteijn, Lonneke JanssenDuijghuijsen, Maartje van den Belt, Beatrix Gerhard, Renata Ariens, Reina Tjoelker, Jan Geurts

“…Background and objectives: Globally, about 70% of the adult population is lactase non-persistent (LNP), lacking the enzyme required for lactose digestion. …”
Get full text

Microbiome and metabolome patterns after lung transplantation reflect underlying disease and chronic lung allograft dysfunction by Christian Martin, Kathleen S. Mahan, Talia D. Wiggen, Adam J. Gilbertsen, Marshall I. Hertz, Ryan C. Hunter, Robert A. Quinn

“…Abstract Background Progression of chronic lung disease may lead to the requirement for lung transplant (LTx). …”
Get full text

The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review by Leila Maghsoumi-Norouzabad, Alireza Bagherzadeh-Karimi, Shabnam Aliakbari Majd, Leila Hosseini, Fatemeh Shahi

“…Background: Modulation of intestinal barrier, which function through zonulin pathway downregulation, represents a promising therapeutic strategy for chronic diseases. …”
Get full text

Thigh muscle features in female patients with severe knee osteoarthritis: a cross-sectional study by Tingting Liu, Hao Xie, Songhua Yan, Jizhou Zeng, Kuan Zhang

“…Abstract Background Muscle function deterioration in female patients with severe knee osteoarthritis (KOA) is linked to alterations in muscle morphology, composition, and mechanical properties. …”
Get full text

High-fat diet impairs microbial metabolite production and aggravates influenza A infection by Franziska Hornung, Harini K. SureshKumar, Laura Klement, Yasmina Reisser, Christoph Wernike, Vivien Nischang, Paul M. Jordan, Oliver Werz, Carsten Hoffmann, Bettina Löffler, Stefanie Deinhardt-Emmer

“…This study investigates alterations in the gut microbiome during a high-fat diet (HFD), particularly short-chain fatty acids (SCFAs), and how these metabolites affect lung infection caused by Influenza A virus (IAV). Methods We used a HFD-mouse model to evaluate gut microbiota composition, SCFA levels, and pulmonary outcomes following IAV infection. …”
Get full text

New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach by Yin Guan, Xiaoqian Zhao, Yun Lu, Yue Zhang, Yan Lu, Yue Wang

“…BackgroundRheumatoid arthritis (RA) is a persistent autoimmune disorder marked by inflammation and joint damage. …”
Get full text

Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells by Barbara Guerra, Kristina Jurcic, Rachelle van der Poel, Samantha Lynn Cousineau, Thomas K. Doktor, Laura M. Buchwald, Scott E. Roffey, Caroline A. Lindegaard, Anna Z. Ferrer, Mohammad A. Siddiqui, Laszlo Gyenis, Brage S. Andresen, David W. Litchfield

“…Abstract Background Clear cell renal cell carcinoma (ccRCC) is a type of cancer characterized by a vast intracellular accumulation of lipids that are critical to sustain growth and viability of the cells in the tumour microenvironment. …”
Get full text

The Effects of Dietary Supplementation of Chestnut Tannic Acid on the Growth Performance, Gut Morphology and Microbiota of Weaned Piglets by Jinzhou Zhang, Yuting Zhang, Yuya Wang, Yanwei Li, Dongyang Liu, Hongbing Xie, Yongqiang Wang, Meinan Chang, Liping Guo, Zhiguo Miao

“…<b>Background/Objectives</b>: This study investigated the effects of chestnut tannic acid (TA) on the growth performance, the expression of tight junction proteins and the composition of the gut microbiota of weaned piglets, which could provide novel insights into the application of TA in swine production. …”
Get full text

Adsorption-induced negative carbon isotope sequence in over-mature coal-type gas from the southwest Ordos Basin by Xiaoming Wu, Qiang Meng, Haiwei Zhu, Heng Zhao, Yu Xiao, Zhuo Guo, Mengting Zhang, Liyu Liu, Luxing Dou, Zhigang Wen

“…Heavier hydrocarbon gases (e.g., ethane), with lighter carbon isotope signatures, preferentially desorb, resulting in a relatively light observed carbon isotope composition. Owing to its high abundance, the isotopic composition of methane is impacted relatively little by adsorption. (2) The anomalous geochemical characteristics of over-mature coal-type gas result in the failure of the negative carbon isotope sequence method for identifying inorganic gas; this also invalidates the criterion for classifying oil-type gas and coal-type gas based on thresholds of δ 13C2 = − 28‰ and δ 13C3 = − 25‰. …”
Get full text

Presenting the model of managerial competencies of women in the industry (case study: Sabah Food Company) by masoomeh samadi, mohammad mohammadi, Hamid Rezaei Far, hossein hakimpour

“…The current research is applicable in terms of purpose, and descriptive-exploratory in terms of nature and method. The statistical population of the present study included 10 female managers in the food industry. …”
Get full text

Advancing neuroprotection and atherosclerosis prevention through familial hypercholesterolemia management: Analyzing comorbidity burden with stroke, coronary heart disease, hyperte... by Jingjia Wang, Sicong Liu, Ming Zhang, Xiangbin Meng, Xuliang Wang, Wenyao Wang, Jun Gao, Jilin Zheng, Zhiyun Yang, Jun Wen, Da Liu, Lin Yang, Chen Wei, Siyan Zhan, Pei Gao, Chunli Shao

“…This study aimed to investigate the comorbidity burden of FH in China and analyze the differences between familial and general hypercholesterolemia (HC) populations. Methods Using a national medical insurance database from 2013 to 2017 including 13,976 patients with FH and 13,976 matched control patients with HC, we utilized case‐control methods to compare the composition ratio, comorbidity rates, medical expenses, and healthcare burden of patients with FH to those of control patients. …”
Get full text