Matrix metalloproteinases and heat shock proteins on extracellular vesicles in colorectal cancer patients: association with metabolic status by N. V. Yunusova, D. A. Svarovsky, E. E. Dandarova, D. N. Kostromitsky, A. A. Dimcha, O. V. Cheremisina, S. G. Afanasiev, A. I. Konovalov, Z. A. Startseva, I. V. Kondakova, M. R. Patysheva, A. E. Grigor'eva, L. V. Spirina

“…In most patients with colorectal cancer (CRC), the tumor develops against the background of metabolically healthy obesity or metabolic syndrome (more than 60 % of patients), the key pathogenetic moment of which is developing hyperinsulinemia. …”
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Adherence to a “MediterrAsian” diet is associated with weight loss-independent improvements in liver fat and lipid profile, but not glucoregulation or inflammation: secondary analy... by Yu Chung Chooi, Faidon Magkos, Jadegoud Yaligar, Navin Michael, Suresh Anand Sadananthan, Yeshe Manuel Kway, Yeshe Manuel Kway, S. Sendhil Velan, Kevin Junliang Lim, Xianning Lai, Long Hui Wong, Yap Seng Chong, Yap Seng Chong, Evelyn Xiu Ling Loo, Evelyn Xiu Ling Loo, Johan G. Eriksson, Johan G. Eriksson, Johan G. Eriksson, Johan G. Eriksson

“…BackgroundGreater adherence to the Mediterranean Diet (MedDiet) has been associated with improved inflammatory biomarkers in Western populations, suggesting that the anti-inflammatory effect is crucial for improvements in body weight, body composition, and cardiometabolic risk factors observed with the MedDiet. …”
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Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial drivers by Claudio Díaz-García, Elena Moreno, Alba Talavera-Rodríguez, Lucía Martín-Fernández, Sara González-Bodí, Laura Martín-Pedraza, José A. Pérez-Molina, Fernando Dronda, María José Gosalbes, Laura Luna, María Jesús Vivancos, Jaime Huerta-Cepas, Santiago Moreno, Sergio Serrano-Villar

“…Abstract Background Despite effective antiretroviral therapy, people with HIV (PWH) experience persistent systemic inflammation and increased morbidity and mortality. …”
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Microbial community profiling for forensic drowning diagnosis across locations and submersion times by Qin Su, Xiaofeng Zhang, Xiaohui Chen, Zhonghao Yu, Weibin Wu, Qingqing Xiang, Chengliang Yang, Jian Zhao, Ling Chen, Quyi Xu, Chao Liu

“…Abstract Background Drowning diagnosis has long been a critical issue in forensic research, influenced by various factors such as the environment and decomposition time. …”
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Software-Based Transformation of White Light Endoscopy Images to Hyperspectral Images for Improved Gastrointestinal Disease Detection by Chien-Wei Huang, Chang-Chao Su, Chu-Kuang Chou, Arvind Mukundan, Riya Karmakar, Tsung-Hsien Chen, Pranav Shukla, Devansh Gupta, Hsiang-Chen Wang

“…<b>Background/Objectives:</b> Gastrointestinal diseases (GID), such as oesophagitis, polyps, and ulcerative colitis, contribute significantly to global morbidity and mortality. …”
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Comparative analysis of corpus callosum lipidome and transcriptome in schizophrenia and healthy brain by Maria S. Osetrova, Olga I. Efimova, Marina D. Zavolskova, Elena A. Stekolschikova, Gleb N. Vladimirov, Dmitry A. Senko, Tatiana A. Zhuravleva, Anna Y. Morozova, Yana A. Zorkina, Denis S. Andreyuk, George P. Kostyuk, Evgeniy N. Nikolaev, Philipp E. Khaitovich

“…BACKGROUND: Functional and structural studies of the brain highlight the importance of white matter alterations in schizophrenia. …”
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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

“…However, complexity of its structural composition poses a greater difficulty for drug design studies.ObjectivesPharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.MethodsFrom the assessment of the ADC action process based on PK/PD, we introduce the main research strategies of ADCs. …”
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Anti-Gastric Cancer Activity of Mixed-Region Iranian Propolis Nanoparticles: Potential Therapeutic Applications by Sara Aravand, MSc, Azam J. Esfahani, PhD, Nematollah Gheibi, PhD, Saeideh G. Khoei, PhD, Shaghayegh P. Dibazar, MSc, Leila Zolghadr, PhD, Hossein Ahmadpour_Yazdi, PhD

“…Background: Propolis holds great potential in therapeutic development due to the presence of flavonoids, phenolic acids, and esters. …”
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Application of single venous approach under echocardiography without angiography in closure of Patent Ductus Arteriosus by Pan Xiong, Quan Chen, Yiwei He

“…Abstract Background The conventional arteriovenous approach closure of patent ductus arteriosus (PDA) may be associated with more complications, especially in young infants. …”
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Saliva Proteome, Metabolome and Microbiome Signatures for Detection of Alzheimer’s Disease by Maxime François, Dana Pascovici, Yanan Wang, Toan Vu, Jian-Wei Liu, David Beale, Maryam Hor, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Wayne Leifert

“…<b>Background:</b> As the burden of Alzheimer’s disease (AD) escalates with an ageing population, the demand for early and accessible diagnostic methods becomes increasingly urgent. …”
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Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf... by Rainer Kollmar, Hagen B. Huttner, Yigit Ozpeynirci, Christian Herweh, Jochen A. Sembill, Stefan Gerner, Michael Bender, Patrick Schramm, Ingo Schirotzek, Lisa Maeder, Anisa Myftiu, Marius Hartmann, Juergen Konczalla, Karsten Geletneky, Rainer Kram, Raimund Helbok, Joji B. Kuramatsu, Martin Welte, Amr Abdulazim, Emanuela Keller, Ferdinand Bohmann, Wolf-Rüdiger Schäbitz

“…Conclusion This practical consensus statement provides a standardized approach to aSAH management, balancing guideline-based evidence with expert consensus to address clinical uncertainties. Due to the used methods and composition of the group, the results should be considered as a multi-institutional protocol of an experienced neurointensivist group, but certainly not as evidence based-guidelines. …”
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Mechanisms of Acetate in Alleviating SETDB1-Linked Neuroinflammation and Cognitive Impairment in a Mouse Model of OSA by Zhao Z, Xiang L, Hong JS, Wang Y, Feng J

“…We aimed to investigate roles of acetate (ACE) and SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in neuroinflammation of OSA.Methods: After C57BL/6J mice were exposed to OSA-associated intermittent hypoxia (IH) or normoxia for four weeks, the composition of the gut microbiota (GM) and the levels of serum short-chain fatty acids (SCFAs) were measured by 16S rRNA and GC-MS methods, respectively. …”
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Bioinformatics analysis of ferroptosis-related biomarkers and potential drug predictions in doxorubicin-induced cardiotoxicity by Jian Yu, Jian Yu, Jiangtao Wang, Xinya Liu, Xinya Liu, Cancan Wang, Cancan Wang, Li Wu, Yuanming Zhang, Yuanming Zhang

“…BackgroundDoxorubicin-induced cardiotoxicity (DIC) significantly impacts the survival and prognosis of cancer patients. …”
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Urinary Hippuric Acid as a Sex-Dependent Biomarker for Fruit and Nut Intake Raised from the EAT-Lancet Index and Nuclear Magnetic Resonance Analysis by Edwin Fernández-Cruz, Víctor de la O, Cristina M. Fernández-Diaz, Pilar Matía-Martín, M. Ángel Rubio-Herrera, Nuria Amigó, Alfonso L. Calle-Pascual, J. Alfredo Martínez

“…Traditional methods, such as dietary questionnaires and quality indices, are limited by subjectivity and variability in food composition tables. …”
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Ruminal digestion, gastrointestinal microbial profile, and metabolic pathways after the introduction of silicon-containing ultrafine particles into bull by Elena Sizova, Elena Yausheva, Sergey Miroshnikov, Aina Kamirova, Daniil Shoshin

“…Background and Aim: Nanotechnology offers innovative strategies to enhance livestock productivity and sustainability. …”
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<i>Agave amica</i> (Medik.) Thiede & Govaerts (Asparagaceae)—Insights into Its Valuable Phenolic Profile and <i>In Vitro</i> Antimicrobial, Antibiofilm, Antioxidative, and Antiprol... by Mihaela Niculae, Daniela Hanganu, Ilioara Oniga, Sergiu-Alexandru Burcă, Brîndușa Tiperciuc, Irina Ielciu, Emoke Pall, Timea Bab, Ramona Flavia Burtescu, Mihaela Andreea Sava, Daniela Benedec

“…This study is aimed at assessing the phenolic profile and selected biological properties of ethanolic extracts obtained from the aerial parts and bulbs of <i>A. amica</i> cultivated in Romania. <b>Methods</b>: The phenolic composition was characterized by spectrophotometric methods and LC/MS analysis. …”
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Physical activity interventions in adult kidney transplant recipients: an updated systematic review and meta-analysis of randomized controlled trials by Roseanne E. Billany, Nicolette C. Bishop, Ellen M. Castle, Matthew P. M. Graham-Brown, Sharlene A. Greenwood, Courtney J. Lightfoot, Thomas J. Wilkinson

“…Background Kidney transplant recipients (KTRs) exhibit a high prevalence of cardiovascular disease (CVD) and adverse changes in physical fitness and body composition. …”
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Gut microbiota links to cognitive impairment in bipolar disorder via modulating synaptic plasticity by Anying Tang, Hangyuan Jiang, Jie Li, Yi Chen, Jinyu Zhang, Dandan Wang, Shaohua Hu, Jianbo Lai

“…Abstract Background Cognitive impairment is an intractable clinical manifestation of bipolar disorder (BD), but its underlying mechanisms remain largely unexplored. …”
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High oxidative phosphorylation represented by UQCRFS1 marks CD8 + tumor-infiltrating lymphocytes exhaustion in diffuse large B-cell lymphoma by Yiming Yang, Yaqi Shu, Zujun Qin, Yi Zeng, Kexin Chen, Xin Liu, Shunhai Jian, Qiqi Zhu

“…Abstract Background Metabolic alterations are closely associated with the exhaustion and immune deficiency of CD8+ tumor-infiltrating lymphocytes (TILs), while little is known about diffuse large B-cell lymphoma (DLBCL). …”
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Effect of treadmill walking on cardiometabolic risk factors and liver function markers in older adults with MASLD: a randomized controlled trial by Jiyoun Kim, Sungju Lee, Yong-Seok Jee

“…Abstract Background Regular walking has been reported to improve metabolically-associated steatotic liver disease (MASLD) by altering the metabolic environment. …”
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