Effects of Intensive Systolic Blood Pressure Lowering on Cardiovascular Events and Mortality in Patients With Type 2 Diabetes Mellitus on Standard Glycemic Control and in Those Wit... by Srinivasan Beddhu, Glenn M. Chertow, Tom Greene, Paul K. Whelton, Walter T. Ambrosius, Alfred K. Cheung, Jeffrey Cutler, Lawrence Fine, Robert Boucher, Guo Wei, Chong Zhang, Holly Kramer, Adam P. Bress, Paul L. Kimmel, Suzanne Oparil, Cora E. Lewis, Mahboob Rahman, William C. Cushman

“…Methods and Results SPRINT tested the effects of intensive (<120 mm Hg) versus standard (<140 mm Hg) SBP goals on CVD events and all‐cause mortality. …”
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Outcomes After Noncardiac Surgery Performed Within 2 Years of Percutaneous Coronary Intervention by Neel M. Butala, Annika Hebbe, Binita Shah, Nathaniel R. Smilowitz, Bilal Aijaz, Anezi Uzendu, Peter Boulos, Stephen W. Waldo

“…Background Limited data exist on noncardiac surgery patients with prior percutaneous coronary intervention (PCI) in the contemporary era. …”
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Trends in Complications Among Patients Undergoing Aortic Valve Replacement in the United States by James E. Harvey, Samir R. Kapadia, David J. Cohen, Ankur Kalra, William Irish, Candace Gunnarsson, Michael Ryan, Soumya G. Chikermane, Christin Thompson, Rishi Puri

“…Methods and Results We performed a retrospective cohort study using Medicare data to evaluate temporal trends in complications among beneficiaries, aged ≥65 years, treated with elective isolated transfemoral TAVR or SAVR between 2012 and 2019. …”
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Proteomics‐Based Soluble Urokinase Plasminogen Activator Receptor Levels and Long‐Term Cardiovascular Outcomes in Survivors of Breast Cancer: A UK Biobank Study by Adithya K. Yadalam, Chang Liu, Yan V. Sun, Anant Mandawat, Arshed A. Quyyumi, Salim S. Hayek

“…We sought to examine whether elevated proteomics‐based suPAR levels are associated with cardiovascular death or incident coronary artery disease in survivors of breast cancer. Methods We leveraged Olink proteomics‐based measurement of suPAR levels in 845 female survivors of breast cancer without cardiovascular disease enrolled in the UK Biobank. …”
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Identification of Plasma Metabolites Responding to Oxycodone Exposure in Rats by Thao Vu, Suneeta Godbole, Lieselot L. G. Carrette, Lisa Maturin, Olivier George, Laura M. Saba, Katerina Kechris

“…Background: Oxycodone has an elevated abuse liability profile compared to other prescription opioid medications. …”
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Prognostic Implications of Resistive Reserve Ratio in Patients With Nonobstructive Coronary Artery Disease With Myocardial Bridging by Negin Mahmoudi Hamidabad, Yoshihisa Kanaji, Ilke Ozcan, Jaskanwal Deep Singh Sara, Ali Ahmad, Lilach O. Lerman, Amir Lerman

“…Background Myocardial bridging (MB) is accompanied by the dynamic extravascular compression of epicardial coronary arteries, leading to intracoronary hemodynamic disturbance with abnormal coronary flow profiles. …”
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Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low‐Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE‐IT Randomized Trial by Rahul Aggarwal, Deepak L. Bhatt, Ph. Gabriel Steg, Michael Miller, Eliot A. Brinton, Richard L. Dunbar, Steven B. Ketchum, Jean‐Claude Tardif, Fabrice M. A. C. Martens, Christie M. Ballantyne, Michael Szarek, R. Preston Mason

“…Background The efficacy of icosapent ethyl among patients with very well‐controlled baseline low‐density lipoprotein cholesterol (LDL‐C) is unknown. …”
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Adverse Childhood Experiences and Cardiovascular Outcomes in Adult Congenital Heart Disease by David J. Harrison, MD, Rania A. Mekary, PhD, MS, MSc, Shilpa Vijayakumar, MD, Erin Lake, ScD, MS, Joseph Kay, MD, Roni M. Jacobsen, MD, Camila Londono-Obregon, MD, Elizabeth Yeung, MD, Sarah Kelly, PsyD, Ann Poteet, NP, MS, Michael J. Landzberg, MD, Molly Wallrich, RN, Amber D. Khanna, MD

“…Background: Adverse childhood experiences (ACEs) are linked with poor physical and psychosocial health outcomes in adulthood, including cardiovascular disease. …”
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Narcolepsy Is Associated With Subclinical Cardiovascular Disease as Early as Childhood: A Big Data Analysis by Christopher N. Kaufmann, Munaza Riaz, Haesuk Park, Wei‐Hsuan Lo‐Ciganic, Debbie Wilson, Emerson M. Wickwire, Atul Malhotra, Rakesh Bhattacharjee

“…Background Narcolepsy is linked to adverse cardiovascular disease (CVD) outcomes, but few studies have examined its associations with subclinical CVD, including in children. …”
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Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes by John E. Brush, Jr., MD, Chungsoo Kim, PharmD, PhD, Yuntian Liu, MPH, Xin Xin, MS, Chenxi Huang, PhD, Iris J. Lundy, BSN, Jordan R. Asher, MD, MS, Mitsuaki Sawano, MD, Patrick Young, PhD, Jacob McPadden, MD, Mark Anderson, AS, John S. Burrows, MBA, Harlan M. Krumholz, MD, SM, Yuan Lu, ScD

“…Objectives: The aim of the study was to examine how the neighborhood-level social vulnerability index (SVI) influences cardiovascular outcomes in a large, diverse cohort of patients with hypertension. Methods: We used electronic health data to examine the association between census tract-level rankings for the SVI with a composite endpoint of incident myocardial infarction, congestive heart failure, or stroke. …”
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Intrapartum Amnioinfusion for Recurrent Variable Decelerations and Neonatal Morbidity: A Systematic Review and Meta-Analysis by Brock E. Polnaszek, Julia Rossen, Katherine H. Bligard, Angela Hardi, Emily S. Miller, Methodius G. Tuuli, Adam K. Lewkowitz

“…Background: The objective was to estimate the effect of intrapartum amnioinfusion (AI) for recurrent variable decelerations on neonatal morbidity. …”
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Change in Dicrotic Notch Index Predicts Outcomes in Patients Undergoing Transcatheter Edge-to-Edge Repair for Mitral Regurgitation by Vishwum Kapadia, Shivabalan Kathavarayan Ramu, MD, Maryam Majeed-Saidan, MD, Rhonda Miyasaka, MD, Serge Harb, MD, Amar Krishnaswamy, MD

“…Background: Changes in the dicrotic notch characteristics in the aortic pressure waveform have not been adequately studied with mitral transcatheter edge-to-edge repair (M-TEER). …”
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Social Vulnerability and Long‐Term Cardiovascular Outcomes After COVID‐19 Hospitalization: An Analysis of the American Heart Association COVID‐19 Registry Linked With Medicare Clai... by Reza Fakhraei, Yang Song, Dhruv S. Kazi, Rishi K. Wadhera, James A. de Lemos, Sandeep R. Das, David A. Morrow, Issa J. Dahabreh, Christine M. Rutan, Kathie Thomas, Robert W. Yeh

“…Background Patients hospitalized with COVID‐19 from socioeconomically vulnerable communities are at risk for in‐hospital cardiovascular events. …”
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Myocardial Work in Children With Hypertrophic Cardiomyopathy by Xander Jacquemyn, BSc, Rebbeca Dryer, MD, Kyla Cordrey, MD, Rita Long, RDCS, David A. Danford, MD, MPH, Shelby Kutty, MD, PhD, MHCM, Benjamin T. Barnes, MD

“…Background: Myocardial work (MW) predicts adverse outcomes in adults with hypertrophic cardiomyopathy (HCM), yet pediatric data are lacking. …”
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Social Determinants of Health and Cardiovascular Risk among Adults with Diabetes: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study by Lisa Zhang, Evgeniya Reshetnyak, Joanna B. Ringel, Laura C. Pinheiro, April Carson, Doyle M. Cummings, Raegan W. Durant, Gargya Malla, Monika M. Safford

“…Background Social determinants of health (SDOH) have been associated with diabetes risk; however, their association with cardiovascular disease (CVD) events in individuals with diabetes is poorly described. …”
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Association Between Caregiver Strain and Self‐Care Among Caregivers With Hypertension: Findings From the REGARDS Study by Asia Gobourne, Joanna Bryan Ringel, Alexandra King, Monika Safford, Catherine Riffin, Ronal Adelman, Adam Bress, Tracy K. Paul, Raegan W. Durant, David L. Roth, Madeline R. Sterling

“…Background Self‐care for adults with hypertension includes adherence to lifestyle behaviors and medication. …”
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Predicting the incidence of depression in adolescence using a sociodemographic risk score: prospective follow-up of the IDEA-RiSCo study by Christian Kieling, Brandon A Kohrt, Anna Viduani, Valeria Mondelli, Helen L Fisher, Jader Piccin, Claudia Buchweitz, Pedro H Manfro, Rivka Barros Pereira, Fernanda Rohrsetzer, Laila Souza, Arthur Caye, Johnna R Swartz

“…Background Adolescence constitutes a critical window for preventing depression, but efforts have mostly targeted single risk factors. …”
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Rationale and Design of the ORCCA (Outcomes Registry for Cardiac Conditions in Athletes) Study by Nathaniel Moulson, Bradley J. Petek, Michael J. Ackerman, Timothy W. Churchill, Sharlene M. Day, Jonathan H. Kim, Stephanie A. Kliethermes, Rachel Lampert, Benjamin D. Levine, Matthew W. Martinez, Manesh R. Patel, Dermot Phelan, Kimberly G. Harmon, Aaron L. Baggish, Jonathan A. Drezner

“…Background Clinical practice recommendations for participation in sports and exercise among young competitive athletes with cardiovascular conditions at risk for sudden death are based largely on expert consensus with a paucity of prospective outcomes data. …”
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Sex Differences in the Association Between Lipoprotein(a) and Cardiovascular Outcomes: The MGB Lp(a) Registry by Gurleen Kaur, Adam N. Berman, David W. Biery, Stephanie A. Besser, Wanda Y. Wu, Brittany Weber, Michael C. Honigberg, Khurram Nasir, Martha Gulati, Marcelo F. Di Carli, Leslee J. Shaw, Deepak L. Bhatt, Ron Blankstein

“…Background Sex‐based differences in the association of lipoprotein(a) with cardiovascular outcomes have not been well established for those without prior atherosclerotic cardiovascular disease. …”
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Construct and Predictive Validity of the Kansas City Cardiomyopathy Questionnaire in Adult Congenital Heart Disease by Ryan D. Byrne, MD, Ajith P. Nair, MD, Stephen J. Dolgner, MD, Swati Choudhry, MD, Edward J. Hickey, MD, Alexis C. Wood, PhD, Savitri Fedson, MD, Biykem Bozkurt, MD, PhD, Christopher R. Broda, MD

“…Objectives: This study evaluates construct and predictive validity of the KCCQ in ambulatory ACHD patients. Methods: We performed cross-sectional and prospective cohort studies of ACHD patients who completed the KCCQ to assess construct and predictive validity, respectively. …”
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