Influence of Worsening Renal Function and Baseline Chronic Kidney Disease on Clinical Outcomes in Patients With Chronic Coronary Syndromes: Insights From the REAL‐CAD Study by Yu Yoshiki, Yukio Ozaki, Mitsuru Abe, Tevfik F. Ismail, Hiroshi Takahashi, Masaharu Akao, Hideki Kawai, Takashi Muramatsu, Masahide Harada, Masaya Ohta, Yosuke Hashimoto, Yuichiro Shiki, Masayuki Koshikawa, Keiichi Miyajima, Hidemaro Takatsu, Yudai Niwa, Naoyuki Kawashima, Reina Ozaki, Naotake Tsuboi, Satoshi Iimuro, Hiroshi Iwata, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Hideo Izawa, Takeshi Kimura, Ryozo Nagai

“…Background The effect of worsening renal function and baseline chronic kidney disease (CKD) on outcomes in patients with chronic coronary syndrome in the setting of optimal medical therapy remains unknown. …”
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Outcomes for older people with screening-detected versus existing chronic kidney disease: a cohort study with data linkage by Anna K Forbes, José M Ordóñez-Mena, Winnie Mei, Clare J Taylor, Nicholas Jones, Jennifer A Hirst, FD Richard Hobbs

“…Design & setting: Prospective cohort study of 892 primary care patients aged ≥60 years with CKD (existing and screening detected) in Oxfordshire, with data linkage to civil death registry and secondary care. Method: Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models to compare the risk of all-cause mortality, hospitalisation, CVD, ESKD separately, and as a composite between CKD groups, as well as to identify factors associated with mortality. …”
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Comparison of antimicrobial efficacy and therapeutic index properties for common wound cleansing solutions, focusing on solutions containing PHMB by Watson, Fergus, Chen, Rui, Saint Bezard, Jeanne, Percival, Steven

“…The optimal solution would have minimal cytotoxicity to the patient while maintaining a minimum concentration required for antimicrobial activity necessary to prevent opportunistic pathogens and biofilm formation.Method: A variety of common wound irrigation products, including polyhexanide in various concentrations and compositions, iodine and hypochlorous acid-based solutions, were tested and compared for their activity against pathogens according to the ESKAPE group of nosocomial relevant microbes. …”
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Ability of soluble TREM2 and PRO-C3 as biomarkers to predict changes in MASLD activity by Charlotte Wilhelmina Wernberg, Vineesh Indira Chandran, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Camilla Dalby Hansen, Johanne Kragh Hansen, Lea Ladegaard Grønkjær, Birgitte Gade Jacobsen, Tina Di Caterino, Sönke Detlefsen, Maja Thiele, Alejandro Mayorca Guiliani, Ida Falk Villesen, Diana Julie Leeming, Morten Karsdal, Jonas Heilskov Graversen, Aleksander Krag

“…Background & Aims: Diet and weight loss remain the primary treatment for most patients with metabolic dysfunction-associated fatty liver disease (MASLD), with one recent drug therapy approved for severe cases. …”
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Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review by Minne Van Den Noortgate, Filip Van Den Eede, Violette Coppens, Erik J. Giltay, Livia De Picker, Manuel Morrens

“…Background: Bidirectional interactions between immune and neuroendocrine mechanisms are involved in mood and psychotic disorders, although individual studies report inconsistent and even contradictory findings on the nature of this crosstalk. …”
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Enhancing Patient Safety Education: Cross-Cultural Validation of the APSQ-III in Brazilian Healthcare Students by João Daniel de Souza Menezes, Matheus Querino da Silva, Emerson Roberto dos Santos, Rodrigo Soares Ribeiro, Natália Almeida de Arnaldo Silva Rodriguez Castro, Isabela Amaral de Almeida Bistafa, Alex Bertolazzo Quitério, Eliana Fazuoli Chubaci, Sônia Maria Maciel Lopes, Flávia Cristina Custódio, Stela Regina Pedroso Vilela Torres de Carvalho, Gustavo Schiavinato, Thalissa Catricala, José Nathan Fernandes Rocha, Vânia Maria Sabadoto Brienze, Josimerci Ittavo Lamana Faria, Denise Cristina Mós Vaz Oliani, Antônio Hélio Oliani, Vânia Zaqueu Brandão, Júlio Cesar André, Rita de Cassia Helú Mendonça Ribeiro

“…<b>Background:</b> This study aimed to adapt and validate the Attitudes to Patient Safety Questionnaire (APSQ-III) for Brazilian Portuguese and to compare patient safety attitudes between medical and nursing students. …”
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Pathophysiological and Prognostic Importance of an ExtraCardiac Comorbidity Burden in Patients with Heart Failure with Preserved Ejection Fraction by Yuki Saito, MD, PhD, Tomonari Harada, MD, PhD, Naoki Yuasa, MD, Kazuki Kagami, MD, PhD, Yuta Tani, MSc, Ayami Naito, MD, Fumitaka Murakami, MD, Tomoaki Ishii, RS, Toshimitsu Kato, MD, PhD, Naoki Wada, MD, PhD, Yasuo Okumura, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

“…Background: Extracardiac comorbidities are highly prevalent in patients with heart failure with preserved ejection fraction (HFpEF). …”
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First-line vs Second-Line Catheter Ablation Therapy for Patients with Atrial Fibrillation—Data from a National Multicentre Registry by Ranin Hilu, MD, Mahmoud Suleiman, MD, Adi Elias, MD, MPH, Ibrahim Marai, MD, Roy Beinart, MD, Eyal Nof, MD, Yoav Michowitz, MD, Michael Glikson, MD, Yuval Konstantino, MD, Moti Haim, MD, David Luria, MD, David Pereg, MD, Avishag Laish-Farkash, MD, PhD, Alexander Omelchenko, MD

“…Background: An early catheter ablation treatment strategy is effective for rhythm control in patients with atrial fibrillation (AF). …”
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Area-level socioeconomic inequalities in hypertension care cascade in China: a nationwide population-based study based on the ChinaHEART projectResearch in context by Wenyao Peng, Siqi Lin, Xuan Liu, Bowang Chen, Xueke Bai, Chaoqun Wu, Xiaoyan Zhang, Yang Yang, Jianlan Cui, Wei Xu, Lijuan Song, Hao Yang, Wenyan He, Yan Zhang, Xi Li, Jiapeng Lu

“…Summary: Background: Socioeconomic status (SES) is one of key social determinants of health. …”
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Interpreting the clinical significance of multiple large-scale mitochondrial DNA deletions (MLSMD) in skeletal muscle tissue in the diagnostic evaluation of primary mitochondrial d... by Jing Wang, Jing Wang, James T. Peterson, Joaquim Diego D. Santos, Ada J. S. Chan, Maria Alejandra Diaz-Miranda, Imon Rahaman, Jean Flickinger, Amy Goldstein, Amy Goldstein, Emily Bogush, Elizabeth M. McCormick, Colleen C. Muraresku, Vernon E. Anderson, Matthew C. Dulik, Matthew C. Dulik, Douglas C. Wallace, Douglas C. Wallace, Rui Xiao, Marni J. Falk, Marni J. Falk, Angela N. Viaene, Angela N. Viaene, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham

“…We sought to evaluate clinical, biochemical, and histopathological phenotypes of a large clinical cohort harboring MLSMD in muscle to better understand their significance across a range of clinical phenotypes.MethodsA single-site retrospective study was performed of 212 diagnostic muscle biopsies obtained from patients referred for Primary Mitochondrial Disease (PMD) evaluation with muscle mitochondrial (mt)DNA sequencing performed at our institution, including electronic medical record (EMR) review of symptoms, biochemical results, and Mitochondrial Myopathy Composite Assessment Tool (MM-COAST) scores.ResultsMLSMD were identified in 50 of 212 (24%) diagnostic tissue biopsies, and were universally present. in subjects ≥50 years (n = 18/18). …”
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Characterization of Malnutrition in Atrial Functional Mitral Regurgitation by Tsukasa Murakami, MD, PhD, Nobuyuki Kagiyama, MD, PhD, Tomohiro Kaneko, MD, PhD, Kazuki Kagami, MD, PhD, Masashi Amano, MD, PhD, Taiji Okada, MD, PhD, Yukio Sato, MD, PhD, Yohei Ohno, MD, PhD, Kimi Sato, MD, PhD, Kojiro Morita, MPH, PhD, RN, PHN, Tomoko Machino-Ohtsuka, MD, PhD, Yukio Abe, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

“…Methods: This multicentre, observational study included 802 patients diagnosed with AFMR. …”
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A Standardized Validation Framework for Clinically Actionable Healthcare Machine Learning with Knee Osteoarthritis Grading as a Case Study by Daniel Nasef, Demarcus Nasef, Michael Sher, Milan Toma

“…Background: High in-domain accuracy in healthcare machine learning (ML) models does not guarantee reliable clinical performance, especially when training and validation protocols are insufficiently robust. …”
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Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... by Michael P. MacManus, John F. Seymour, Hennes Tsang, Richard Fisher, Colm Keane, Muhammed B. Sabdia, Soi C. Law, Jay Gunawardana, Karthik Nath, Stephen H. Kazakoff, Mario L. Marques-Piubelli, Daniela E. Duenas, Michael R. Green, Daniel Roos, Peter O'Brien, Andrew McCann, Richard Tsang, Sidney Davis, David Christie, Chan Cheah, Benhur Amanuel, Tara Cochrane, Jason Butler, Anna Johnston, Mohamed Shanavas, Li Li, Claire Vajdic, Robert Kridel, Victoria Shelton, Samantha Hershenfield, Tara Baetz, David Lebrun, Nathalie Johnson, Marianne Brodtkorb, Maja Ludvigsen, Francesco d’Amore, Ella R. Thompson, Piers Blombery, Maher K. Gandhi, Joshua W.D. Tobin

“…Methods: Patients with ESFL were randomised to involved field radiotherapy (IFRT) or IFRT plus 6-cycles cyclophosphamide/vincristine/prednisolone (IFRT + CVP). …”
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Application of a deep learning algorithm for the diagnosis of HCC by Philip Leung Ho Yu, Keith Wan-Hang Chiu, Jianliang Lu, Gilbert C.S. Lui, Jian Zhou, Ho-Ming Cheng, Xianhua Mao, Juan Wu, Xin-Ping Shen, King Ming Kwok, Wai Kuen Kan, Y.C. Ho, Hung Tat Chan, Peng Xiao, Lung-Yi Mak, Vivien W.M. Tsui, Cynthia Hui, Pui Mei Lam, Zijie Deng, Jiaqi Guo, Li Ni, Jinhua Huang, Sarah Yu, Chengzhi Peng, Wai Keung Li, Man-Fung Yuen, Wai-Kay Seto

“…Background &amp; Aims: Hepatocellular carcinoma (HCC) is characterized by a high mortality rate. …”
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The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…Summary: Background: Spinal cord injury (SCI) clinical trials typically rely on a single primary endpoint to assess drug efficacy. …”
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An expert patient program for people living with multiple sclerosis improves knowledge and empowerment: a pre-test, post-test multicenter implementation study by Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Paloma Amil-Bujan, Cristina Bosch-Farré, Clàudia Coll-Martínez, Clàudia Coll-Martínez, María Jesús Arévalo, Elisenda Anglada-Clofent, Rebeca Menéndez-Díaz, Montserrat Aroca-Alsina, Montserrat Aroca-Alsina, Miguel Merchan-Ruiz, Miguel Merchan-Ruiz, Santiago Pérez-Hoyos, Santiago Pérez-Hoyos, Ángel Guillermo Arévalo-Bernabé, Ángel Guillermo Arévalo-Bernabé, Xavier Montalban, Ana Hernando, Sara LLufriú, Silvia Peralta-Moncusí, Lluís Brieva, Cristina Ramo-Tello, Mariona Carabí, Nuria Solà-Valls, Maria Cinta Zabay, Maria Alba Mañé-Martínez, Jaume Sastre-Garriga, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Carmen Bertran-Noguer

“…BackgroundMultiple sclerosis (MS) is associated with complex needs and demands, which require patient-centered care. …”
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Need for Support: Facilitating Early Transfer of Cardiogenic Shock Patients to Advanced Heart Failure Centres by Vicki N. Wang, MD, Darshan H. Brahmbhatt, MB BChir, MD(Res), Julie K.K. Vishram-Nielsen, MD, PhD, Fernando L. Scolari, MD, PhD, Nicole L. Fung, Madison Otsuki, Vesna Mihajlovic, MD, Narmin Ibrahimova, Filio Billia, MD, PhD, Christopher B. Overgaard, MD, Adriana C. Luk, MD, MSc

“…Background: Cardiogenic shock (CS) is a complex, life-threatening condition that requires timely care of patients. …”
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Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels by Sem A.O.F. Rikken, MD, C. Michael Gibson, MD, MS, M. Cecilia Bahit, MD, Danielle Duffy, MD, Gerald Chi, MD, Serge Korjian, MD, Niekbachsh Mohammadnia, MD, Harvey White, DSc, Gaya Anschuetz, MS, Bronwyn A. Kingwell, PhD, Ton Oude Ophuis, MD, PhD, Jose C. Nicolau, MD, PhD, Renato D. Lopes, MD, PhD, Basil S. Lewis, MD, Saloua El Messaoudi, MD, PhD, Dragos Vinereanu, MD, PhD, Jurriën M. ten Berg, MD, PhD, Shaun G. Goodman, MD, MSc, Christoph Bode, MD, PhD, P. Gabriel Steg, MD, Peter Libby, MD, Kevin R. Bainey, MD, Arnoud W.J. van 't Hof, MD, PhD, Paul M. Ridker, MD, Kenneth W. Mahaffey, MD, Stephen J. Nicholls, MD, Roxana Mehran, MD, Robert A. Harrington, MD, Jan H. Cornel, MD, PhD

“…Background: The AEGIS-II (ApoA-I Event Reducing in Ischemic Syndromes-II; NCT03473223) trial evaluated CSL112, a human plasma-derived apolipoprotein A-I therapy, for reducing cardiovascular events after acute myocardial infarction (AMI). …”
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Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin... by Nam Hoon Kim, Juneyoung Lee, Suk Chon, Jae Myung Yu, In-Kyung Jeong, Soo Lim, Won Jun Kim, Keeho Song, Ho Chan Cho, Hea Min Yu, Kyoung-Ah Kim, Sang Soo Kim, Soon Hee Lee, Chong Hwa Kim, Soo Heon Kwak, Yong‐ho Lee, Choon Hee Chung, Sihoon Lee, Heung Yong Jin, Jae Hyuk Lee, Gwanpyo Koh, Sang-Yong Kim, Jaetaek Kim, Ju Hee Lee, Tae Nyun Kim, Hyun Jeong Jeon, Ji Hyun Lee, Jae-Han Jeon, Hye Jin Yoo, Hee Kyung Kim, Hyeong-Kyu Park, Il Seong Nam-Goong, Seongbin Hong, Chul Woo Ahn, Ji Hee Yu, Jong Heon Park, Keun-Gyu Park, Chan Ho Park, Kyong Hye Joung, Ohk-Hyun Ryu, Keun Yong Park, Eun-Gyoung Hong, Bong-Soo Cha, Kyu Chang Won, Yoon-Sok Chung, Sin Gon Kim

“…Background Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. …”
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Perioperative and Long-Term Outcomes of Acute Stanford Type A Aortic Dissection Repair in Octogenarians by Hannah Masraf, Manoraj Navaratnarajah, Laura Viola, Davorin Sef, Pietro G. Malvindi, Szabolcs Miskolczi, Theodore Velissaris, Suvitesh Luthra

“…Methods: This was a single-centre retrospective study (2007–2021). …”
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