Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Ind... by Simone Solano, Mingming Yang, Paolo Tolomeo, Toru Kondo, Li Shen, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Jean L. Rouleau, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Milton Packer, Scott D. Solomon, John J. V. McMurray

“…Background The importance of nutritional status is underappreciated in patients with heart failure (HF). …”
Get full text

Neurodevelopment at 10 months and 2–3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (GABA) secondary analysis by Laura Cornelissen, Siobhan Coffman, Isabelle Kim, Ellen Underwood, Alice Tao, Maria G. Maloney, Carolina Donado, Kimberly Lobo, Charles A. Nelson, Takao K. Hensch, Laurel J. Gabard-Durnam, Charles B. Berde

“…Background: Effects of early and prolonged exposure to general anaesthesia on the developing brain are unclear. …”
Get full text

Walking as a viable alternative to moderate-to-vigorous physical activity for improving cardiovascular outcomes in coronary artery disease patients by Zejun Yang, Yunting Liang, Liu He, Le Zhou, Xiaodong Peng, Yiwei Lai, Cong Yuan, Xiaoxia Liu, Ning Zhou, Weihua Zhang, Caihua Sang, Qian Tong, Xin Du, Jianzeng Dong, Changsheng Ma

“…Background: Home-based cardiac rehabilitation is recommended for coronary artery disease (CAD) patients, while exercise is the most important component. …”
Get full text

Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…Background and aims: Patients with acute coronary syndromes (ACS) are at risk for long-term sequelae related to adverse ventricular remodeling including heart failure (HF) and cardiovascular death. …”
Get full text

Full-Blood Inflammatory Ratios Predict Length of Stay but Not Early Death in Romanian Pulmonary Tuberculosis by Ionut-Valentin Stanciu, Ariadna-Petronela Fildan, Barkha Rani Thakur, Adrian Cosmin Ilie, Livia Stanga, Cristian Oancea, Emanuela Tudorache, Felix Bratosin, Ovidiu Rosca, Iulia Bogdan, Anca Chisoi, Ionela Preotesoiu, Viorica Zamfir, Elena Dantes

“…<i>Materials and Methods</i>: Data were drawn from 80 consecutive TB in-patients and 50 community controls. …”
Get full text

Aspirin‐Free Strategy for Percutaneous Coronary Intervention in Patients With Oral Anticoagulation: Prespecified Subgroup Analysis From the STOPDAPT‐3 Trial by Masahiro Natsuaki, Hirotoshi Watanabe, Takeshi Morimoto, Ko Yamamoto, Yuki Obayashi, Ryusuke Nishikawa, Kenji Ando, Satoru Suwa, Tsuyoshi Isawa, Hiroyuki Takenaka, Tetsuya Ishikawa, Minoru Yamada, Tetsuzo Wakatsuki, Yoichi Nozaki, Hideki Kitahara, Ryuichi Kato, Ryoma Kawai, Yohei Kobayashi, Mitsuru Ishii, Yoshitaka Goto, Koh Ono, Takeshi Kimura

“…Background The effects of aspirin‐free strategy on bleeding and cardiovascular events in patients undergoing percutaneous coronary intervention with oral anticoagulation (OAC) have not been fully elucidated. …”
Get full text

Frailty and delirium: A fatal combination in older adults by Jay Acharya, Radcliffe Lisk, Rashid Mahmood, Amir Manzoor, Francesca Young, Mitveer Gill, Keefai Yeong, Kevin Kelly, Jonathan Robin, David Fluck, Christopher Henry Fry, Thang Sieu Han

“…We have developed risk categories based on these scales to predict mortality. Methods: Two-graph ROC curve analysis derived thresholds at 5.5 for CFS and 1 for 4AT for predicting mortality, from which three composite Risk-Categories were created: “Low-Risk” represents low scores for both CFS (1–6) and 4AT (0); Intermediate-Risk” represents either high CFS (7–9) or high 4AT (1–12) scores; and High-Risk” represents both high CFS and 4AT scales. …”
Get full text

Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study by Na Liu, Xiong‐Fei Pan, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li

“…Background Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). …”
Get full text

Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China by Decheng Li, Yunhe Wang, Shuai Guo, Ziyang Ren, Binbin Su, Lichuan Zhang, Zuliyaer Talifu, Xiaoying Zheng

“…Background: Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. …”
Get full text

Clopidogrel Versus Aspirin as Chronic Maintenance Antiplatelet Monotherapy in Patients After Percutaneous Coronary Intervention With Chronic Kidney Disease: A Post Hoc Analysis of... by Jeehoon Kang, Sang‐Hyeon Park, Kyung Woo Park, Bon‐Kwon Koo, Huijin Lee, Minju Han, Doyeon Hwang, Han‐Mo Yang, In‐Ho Chae, Won‐Yong Shin, Ju Hyeon Oh, Yong Hoon Kim, Tae‐Ho Park, Bum Soo Kim, Jung‐Kyu Han, Eun‐Seok Shin, Hyo‐Soo Kim

“…However, it is uncertain whether the beneficial effect of clopidogrel over aspirin is different according to the renal function. Methods and Results We conducted a post hoc analysis of the HOST‐EXAM trial. …”
Get full text

Impact on Outcome of Different Mechanisms, Baseline Degree and Changes of Mitral Regurgitation in Patients With Aortic Stenosis Who Underwent Transcatheter Aortic Valve Replacement by Francesco Melillo, Annamaria Tavernese, Vincenzo Rizza, Francesco Putortì, Alberto Preda, Francesco Ancona, Giacomo Ingallina, Stefano Stella, Antonio Colombo, Marco Ancona, Alaide Chieffo, Nicola Buzzatti, Alessandro Castiglioni, Michele De Bonis, Francesco Maisano, Matteo Montorfano, Eustachio Agricola

“…Background Mitral regurgitation (MR) is frequent in patients with aortic stenosis (AS). …”
Get full text

Predictive value and optimal cut-off level of high-sensitivity troponin T in patients with acute pulmonary embolism by Moojun Kim, Chang-Ok Seo, Yong-Lee Kim, Hangyul Kim, Hye Ree Kim, Yun Ho Cho, Jeong Yoon Jang, Jong-Hwa Ahn, Min Gyu Kang, Kyehwan Kim, Jin-Sin Koh, Seok-Jae Hwang, Jin Yong Hwang, Jeong Rang Park

“…Background/Aims Elevated troponin levels predict in-hospital mortality and influence decisions regarding thrombolytic therapy in patients with acute pulmonary embolism (PE). …”
Get full text

Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia by Sanaz Sedaghat, Saeun Park, Rob F. Walker, Shuo Wang, Jialing Liu, Timothy M. Hughes, Behnam Sabayan, Weihong Tang, Josef Coresh, James S. Pankow, Keenan A. Walker, Ramon Casanova, Ruth Dubin, Rajat Deo, Jerome I. Rotter, Alexis C. Wood, Peter Ganz, Pamela L. Lutsey, Weihua Guan, Anna Prizment

“…Abstract Background: Biological age can be quantified by composite proteomic scores, called proteomics-based aging clocks (PACs). …”
Get full text

Excessive Supraventricular Ectopic Activity in Patients With Acute Ischemic Stroke Is Associated With Atrial Fibrillation Detection Within 24 Months After Stroke: A Predefined Anal... by Karl Georg Haeusler, Serdar Tütüncü, Cornelia Fiessler, Muhammad Jawad‐Ul‐Qamar, Claudia Kunze, Johannes Schurig, Joanna Dietzel, Michael Krämer, Gabor C. Petzold, Georg Royl, Torsten Helberg, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Paulus Kirchhof, Manuel C. Olma, Matthias Endres

“…Background Excessive supraventricular ectopic activity (ESVEA) is regarded as a risk marker for later atrial fibrillation (AF) detection. …”
Get full text

Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…BackgroundCanine pneumonia is a serious respiratory disease often associated with Canine Infectious Respiratory Disease (CIRD). …”
Get full text

Association Between Mineralocorticoid Receptor Antagonist Use With Worsening Renal Function and Prognosis in Patients With Acute Heart Failure by Yudai Fujimoto, Yasuyuki Shiraishi, Kazutaka Nogi, Shun Kohsaka, Takashi Kohno, Mitsunobu Kitamura, Yuji Nagatomo, Tomoya Ueda, Maki Nogi, Satomi Ishihara, Yasuki Nakada, Rika Kawakami, Takeshi Kitai, Shogo Oishi, Eiichi Akiyama, Satoshi Suzuki, Masayoshi Yamamoto, Keisuke Kida, Takahiro Okumura, Tsutomu Yoshikawa, Yoshihiko Saito, Yuya Matsue

“…Background Prognostic implications of mineralocorticoid receptor antagonist (MRA) initiation in the context of worsening renal function (WRF) in patients with acute heart failure (AHF) remain unknown. …”
Get full text

Prevalence and correlates of anxiety disorders and depressive disorders among older adults with non-communicable diseases: results from China Mental Health Survey by Hongmin Ge, Zhaorui Liu, Yue Tong, Yueqin Huang, Xiaofei Hou, Minghui Li, Yongping Yan, Shuiyuan Xiao, Lingjiang Li, Tingting Zhang, Jie Yan, Yaqin Yu, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Xiangdong Xu, Limin Wang, Huifang Yin, Guangming Xu

“…BackgroundAnxiety disorders (ADs) and depressive disorders (DDs) are prevalent among older adults with non-communicable diseases (NCDs), yet nationally representative epidemiological data from China remain limited. …”
Get full text

Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumoursResearch in context by Chiel F. Ebbelaar, Anne M.L. Jansen, Leonie C.M. Speet, Frans Schutgens, Sietske Zoetemeyer, Anne-Marie Cleton-Jansen, Marijke R. van Dijk, Gerben E. Breimer, Lourens T. Bloem, Wendy W.J. de Leng, Remco van Doorn, Karijn P.M. Suijkerbuijk, Anne M.R. Schrader, Willeke A.M. Blokx

“…Summary: Background: Primary cutaneous melanocytic tumours harbouring MAP2K1 mutations without second-hit genomic alterations represent a subclass of neoplasms with poorly understood biological behaviour. …”
Get full text

Impact of diabetes on three-year outcome after coronary stenting in patients with polyvascular atherosclerotic disease – a secondary analysis of the randomized TWENTE trials by Daphne van Vliet, Tineke H. Pinxterhuis, Eline H. Ploumen, Marlies M. Kok, Rosaly A. Buiten, Paolo Zocca, Ariel Roguin, Carl E. Schotborgh, Rutger L. Anthonio, Peter W. Danse, Edouard Benit, Adel Aminian, Carine J.M. Doggen, Clemens von Birgelen

“…Background: The presence of polyvascular atherosclerotic disease is associated with a high-risk of adverse events following percutaneous coronary intervention (PCI). …”
Get full text

Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project by Oliwia Janota-Sosińska, Marta Mantovani, Krzysztof Irlik, Hanna Kwiendacz, Anna Olejarz, Patrycja Pabis, Aleksandra Włosowicz-Momot, Julia Piaśnik, Wiktoria Wójcik, Paulina Szromek-Białek, Uazman Alam, Janusz Gumprecht, Gregory Y. H. Lip, Katarzyna Nabrdalik

“…Abstract Background The impact of diabetic kidney disease (DKD) phenotype on the cardiovascular (CV) risk remains ambiguous. …”
Get full text