Plasma and Fecal Metabolites Combined with Gut Microbiome Reveal Systemic Metabolic Shifts in ⁶⁰Co Gamma-Irradiated Rats by Jie Zong, Haiyang Wu, Xuan Hu, Ami Yao, Wenhua Zhu, Guifang Dou, Shuchen Liu, Xiaoxia Zhu, Ruolan Gu, Yunbo Sun, Zhuona Wu, Shanshan Wang, Hui Gan

“…<b>Background</b>: High-dose γ-ray exposure (≥7 Gy) in nuclear emergencies induces life-threatening acute radiation syndrome, characterized by rapid hematopoietic collapse (leukocytes <0.5 × 10⁹/L) and gastrointestinal barrier failure. …”
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Anthropogenic influences on Rhodnius ecuadoriensis populations and nesting behaviors in sylvatic areas of southern Ecuador by Jazive Esparza-Carate, Soledad Santillán-Guayasamín, César A. Yumiseva, Juan José Bustillos, Mario J. Grijalva, Sereno Denis, Anita G. Villacís

“…Abstract Background Chagas disease, caused by the parasite Trypanosoma cruzi, remains a major public health concern. …”
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To MRAs treatment or not? evidence from a meta-analysis of randomized controlled trials of different MRAs on cardiovascular health in heart failure by Jinyu He, Gang Chen, Yujia Huo, Chunyu Zhang, Haojie Xue, Jing Wang, Yi Zhong, Juan Xiao, Hongping Shen, Jian Feng, Jian Feng

“…BackgroundMineralocorticoid receptor antagonists (MRAs) are pivotal in heart failure (HF) management.ObjectivesThis study evaluates their impact on adverse cardiovascular events and left ventricular ejection fraction (LVEF) in HF patients.MethodsA comprehensive literature search was conducted across PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials databases, with a cutoff date of September 30, 2024. …”
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The association of HDL-cholesterol levels with incident major adverse cardiovascular events and mortality in 0.6 million individuals with type 2 diabetes: a population-based retros... by David Tak Wai Lui, Lanlan Li, Xiaodong Liu, Xi Xiong, Eric Ho Man Tang, Chi Ho Lee, Yu Cho Woo, Brian Hung Hin Lang, Carlos King Ho Wong, Kathryn Choon Beng Tan

“…Abstract Background High levels of high-density lipoprotein cholesterol (HDL-C) are previously considered protective against cardiovascular diseases (CVD), but recent studies suggest an increased risk of adverse events at very high HDL-C levels in the general population. …”
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Right Ventricular–Pulmonary Artery Uncoupling and Strain in Acute Heart Failure by Alberto Palazzuoli, Frank Loyd Dini, Nicola Riccardo Pugliese, Gaetano Ruocco, Paolo Severino, Dario Vizza, Rosa Carbonara, Andrea Passantino, Erberto Carluccio

“…Background Assessment of right ventricular–pulmonary artery coupling plays a crucial role in risk stratification, monitoring efficacy, and predicting outcomes in chronic heart failure patients. …”
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Knowledge, Attitudes, and Perceptions of Chronic Patients in Saudi Arabia Regarding the Use of Artificial Intelligence to Improve Medication Adherence by Alsanosi SM, Aldajani AQ, Gheliwi HA, Alotibi MM, Bokhari GS, Almatrafi OA, Alqawlaq AK, Abujamai JZ, Shaikhomer M, Alhindi YZ, Alshanberi AM

“…This study explores knowledge, attitudes, and perceptions (KAP) regarding AI in medication adherence among chronic patients in Makkah region, Saudi Arabia.Methods: A cross-sectional study was conducted among patients with chronic diseases in the Makkah region, Saudi Arabia, from 1 July to 31 December 2024. …”
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Is There a Sex Difference in the Prognosis of Hypertrophic Cardiomyopathy? A Systematic Review and Meta‐Analysis by Huilei Zhao, Ziqi Tan, Menglu Liu, Peng Yu, Jianyong Ma, Xiaozhong Li, Jingfeng Wang, Yujie Zhao, Wengen Zhu, Xiao Liu

“…Background It is still unclear whether there is a sex difference in the prognosis of patients with hypertrophic cardiomyopathy (HCM). …”
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Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated me... by Jane E Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sue Chowdhry, Sarah Cunningham-Burley, Xue W Mei, Joel B E Smith, Andrew Shennan, Stephen C Robson, Steven Thornton, Mark D Kilby, Neil Marlow, Sarah J Stock, Phillip R Bennett, Jane Denton, STOPPIT-2 collaborative group

“…<h4>Background</h4>Preterm-labour-associated preterm birth is a common cause of perinatal mortality and morbidity in twin pregnancy. …”
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Impact of Primary Health Care Data Quality on Infectious Disease Surveillance in Brazil: Case Study by Pilar Tavares Veras Florentino, Juracy Bertoldo Junior, George Caique Gouveia Barbosa, Thiago Cerqueira-Silva, Vinicius de Araújo Oliveira, Marcio Henrique de Oliveira Garcia, Gerson Oliveira Penna, Viviane Boaventura, Pablo Ivan Pereira Ramos, Manoel Barral-Netto, Izabel Marcilio

“…ObjectiveWe aimed to evaluate the impact of data completeness and timeliness on the performance of an EWS for ILI outbreaks and establish optimal thresholds for a suitable DQI, thereby improving the accuracy of outbreak detection and supporting public health surveillance. MethodsA composite DQI was established to measure the completeness and timeliness of PHC data from the Brazilian National Information System on Primary Health Care. …”
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Incidence of eclampsia and related complications across 10 low- and middle-resource geographical regions: Secondary analysis of a cluster randomised controlled trial. by Nicola Vousden, Elodie Lawley, Paul T Seed, Muchabayiwa Francis Gidiri, Shivaprasad Goudar, Jane Sandall, Lucy C Chappell, Andrew H Shennan, CRADLE Trial Collaborative Group

“…<h4>Background</h4>In 2015, approximately 42,000 women died as a result of hypertensive disorders of pregnancy worldwide; over 99% of these deaths occurred in low- and middle-income countries. …”
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Achievement of treatment targets and maintenance of response with upadacitinib in patients with moderate-to-severe rheumatoid arthritis in real-world practice: 1-year outcomes from... by Andrew Östör, Eugen Feist, Prodromos Sidiropoulos, Jérôme Avouac, Martin Rebella, Rajaie Namas, Erin McDearmon-Blondell, Tianming Gao, Ivan Lagunes-Galindo, Sander Strengholt, Devy Zisman, Suzan Attar

“…Abstract Background Upadacitinib (UPA), an oral Janus kinase inhibitor, has shown efficacy with an acceptable safety profile in rheumatoid arthritis (RA) clinical trials. …”
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General ecosystem health indicators – A scoping review by Gillian Penn, Luís Pedro Carmo, Elena Boriani, Michelle Gallagher, Christi Piper, John Berezowski, Barry J. McMahon, Thomas Jaenisch

“…Abstract Background: Assessing the health status of a natural ecosystem is important across all natural fields of study. …”
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Predictive Validity of Hospital-Associated Complications of Older People Identified Using Diagnosis Procedure Combination Data From an Acute Care Hospital in Japan: Observational S... by Seigo Mitsutake, Tatsuro Ishizaki, Shohei Yano, Takumi Hirata, Kae Ito, Ko Furuta, Yoshitomo Shimazaki, Hideki Ito, Alison Mudge, Kenji Toba

“… BackgroundA composite outcome of hospital-associated complications of older people (HAC-OP; comprising functional decline, delirium, incontinence, falls, and pressure injuries) has been proposed as an outcome measure reflecting quality of acute hospital care. …”
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The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study by Yifeng Wang, Li Wang, Zongquan Zhao, Song Yin, Xuejun Tang, Kerui Zhang

“…Abstract Background The high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio, a composite marker of low-grade inflammation and lipid metabolism, is reportedly associated with the occurrence of new cardiovascular diseases (CVDs) in certain people. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…This study investigated the interaction and effects of sEVs derived from low (LNCaP) and moderately metastatic (DU145) prostate cancer (PCa) cell lines with the human brain endothelial cell line hCMEC/D3. Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
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Delta troponin does not distinguish acute coronary syndrome in emergency department patients with renal impairment and an initial positive troponin by Praveen Mital, John Forrester, Samuel Abecassis, John Haverty, Ximena Arata, Margaret Gorlin, Thomas Perera

“…Abstract Background In emergency department (ED) patients with renal impairment, troponin concentrations can be positive without myocardial ischemia. …”
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Sources of risk communication, knowledge and preventive practices toward Lassa fever in Bauchi State, Nigeria by Benjamin Bukky Ilesanmi, Nathanael Afolabi, Olayinka Badmus, Munkail Titilola, Abdulmajid Ahmad, Usman Inuwa, Matthew Okoh, Hajara Aliyu, Shittu Abdu-Aguye, Foyeke Oyedokun-Adebagbo

“…Abstract Background Lassa fever (LF) is a zoonotic disease that persistently threaten public health and Bauchi is among the most affected states in Nigeria. …”
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Slowing fetal growth velocity from the mid-trimester may signal increased risks of perinatal morbidity and mortality: a retrospective cohort study by Chloe Jamieson-Grigg, Pawel Kalinowski, Stephen Tong, Esther Turner, Sarah A. Banting, Susan P. Walker, Teresa M. MacDonald

“…Abstract Background Undetected fetal growth restriction is a major risk factor for stillbirth. …”
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Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. by Jennifer M Kwan, Miles Shen, Narjes Akhlaghi, Jiun-Ruey Hu, Ruben Mora, James L Cross, Matthew Jiang, Michael Mankbadi, Peter Wang, Saif Zaman, Seohyuk Lee, Yunju Im, Attila Feher, Yi-Hwa Liu, Shuangge S Ma, Weiwei Tao, Wei Wei, Lauren A Baldassarre

“…<h4>Background</h4>There is an urgent need to better understand the diverse presentations, risk factors, and outcomes of immune checkpoint inhibitor (ICI)-associated cardiovascular toxicity. …”
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The impact of particulate matter exposure on global and domain-specific cognitive function: evidence from the Chinese Square Dancer Study by Jingyi Zhu, Shuaibo Wang, Peizheng Li, Fengping Li, Benchao Li, Lu Ma, Shuang Rong, Jingling Liao

“…Abstract Background There is growing evidence that exposure to particulate matter (PM) is associated with impaired cognitive function. …”
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