Multi‐Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals by Ryosuke Fujii, Mako Nagayoshi, Masahiro Nakatochi, Shuntaro Sato, Yoshiki Tsuboi, Koji Suzuki, Hiroaki Ikezaki, Yuichiro Nishida, Yoko Kubo, Shiroh Tanoue, Sadao Suzuki, Teruhide Koyama, Kiyonori Kuriki, Naoyuki Takashima, Sakurako Katsuura‐Kamano, Yukihide Momozawa, Kenji Wakai, Keitaro Matsuo

“…Background Although utility of composite trait‐specific polygenic risk score (multi‐trait PRS) has been examined among European ancestries, few studies investigated among East Asians and incorporated modifiable risk factors. …”
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Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank by Zi-Jian Cheng, Yu-feng Luo, Qing-yun Zhu, Yan-fei Wang, Wen-yan Ren, Fei-yan Deng, Lin Bo, Xi-Yuan Jiang, Shu-feng Lei, Long-Fei Wu

“…Abstract Background Glucosamine is a widely used supplement for treating osteoarthritis and joint pain. …”
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Impact of Procedural Success Definitions on Long‐Term Outcomes in Patients With Rheumatic Mitral Stenosis Treated With Percutaneous Balloon Mitral Valvuloplasty: A Multicenter, Ret... by Premanan Manoret, Tasalak Thonghong, Krissada Meemook, Seththawut Kosallavat, Suchart Aroonsiriwattana, Thammarak Songsangjinda, Saranyou Suwanugsorn, Thanapon Nilmoje, Sirichai Cheewatanakornkul, Treechada Wisaratapong, Sunti Limumpornpetch, Watchara Lohawijarn, Metus Thungthienthong, Noppadol Chamnarnphol, Mann Chandavimol, Pannipa Suwannasom, Woravut Jintapakorn, Ply Chichareon

“…Background It is uncertain which percutaneous balloon mitral valvuloplasty (PBMV) success definitions should be used because there are no studies comparing the effects of these definitions on subsequent outcomes. …”
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Integrated machine learning and population attributable fraction analysis of systemic inflammatory indices for mortality risk prediction in diabetes and prediabetes by Zixi Zhang, Chenyang Li, Yichao Xiao, Chan Liu, Xiaoqin Luo, Cancan Wang, Yongguo Dai, Qiuzhen Lin, Zeying Zhang, Cheng Zheng, Jiafeng Lin, Tao Tu, Qiming Liu

“…Background Chronic systemic inflammation is a key contributor to cardiometabolic complications in diabetes mellitus (DM) and prediabetes (PreDM). …”
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Assessing the Fortification Quality of Refined Vegetable Oil with Vitamin A, Wheat Flour with Iron, and Salt with Iodine: Findings from a Market Assessment in Senegal, West Africa by Mane Hélène Faye, Marie-Madeleine A Diémé, Phillip M Nkhoma, Adama Diouf, Dora Panagides, Abdou Badiane, Becky L Tsang, Olouwafemi Mistourath Mama, Marielle A De Souza, Nicole Idohou Dossou

“…Background: Mandatory fortification (MF) of wheat flour (WF) with iron/folic acid, refined edible oil with vitamin A (VA), and salt with iodine is implemented to address micronutrient deficiencies in Senegal. …”
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Stratifying risk outcomes among adult COVID-19 inpatients with high flow oxygen: The R4 score by G.M. Aguirre-García, D. Ramonfaur, G. Torre-Amione, M.T. Ramírez-Elizondo, R. Lara-Medrano, J.F. Moreno-Hoyos, E.S. Velázquez-Ávila, C.A. Diaz-Garza, V.M. Sanchez-Nava, F. Castilleja-Leal, G.M. Rhoades, M.F. Martínez-Reséndez

“…This study aims to provide a simple risk stratification system to predict invasive mechanical ventilation (IMV) or death among COVID-19 inpatients on HFO.Methods Among 529 adult inpatients with COVID-19 pneumonia, we selected unadjusted clinical risk factors for developing the composite endpoint of IMV or death. …”
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Efficacy and safety of direct oral anticoagulants compared with warfarin in antiphospholipid syndrome. Results of a multicenter retrospective cohort study by Maha A.T. Elsebaie, Zoe Wickham, Stephanie DeBragga, Stacey Fedewa, Mohamed Amgad, Jane Jungyoon Park, Allen Li, Ali Eshaghpour, Juan Li, Mark Crowther, Manila Gaddh

“…Background: Direct oral anticoagulants (DOACs) have become firstline treatment for many thrombotic conditions, but their use in antiphospholipid syndrome (APS) patients remains controversial. …”
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Sodium–glucose cotransporter-2 inhibitors improve cardiovascular outcomes post-acute coronary syndrome complicated by acute heart failure by Alaa Rahhal, Tahseen Hamamyh, Ammar Chapra, Khaled J. Zaza, Mostafa Najim, Mohammad Hemadneh, Hazem Faraj, Wael Kanjo, Ahmed Yasin, Haneen Toba, Wafa Mohammed, Mohammad Khair Hamad, Nawras Al-Tikrety, Mhd Baraa Habib, Ahmed Awaisu, Ahmed Mahfouz, Sumaya Alyafei, Abdul Rahman Arabi, Ashfaq Patel, Mohammed Al-Hijji, Mohammed Al-Hijji

“…BackgroundAcute coronary syndrome (ACS) remains a risk factor for heart failure (HF). …”
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Direct Oral Anticoagulants Versus Vitamin K Antagonists After Mitral Valve Transcatheter Edge‐to‐Edge Repair in Patients With Atrial Fibrillation: A Single‐Center Observational Stu... by Jan‐Hendrik Schipper, Anne‐Sophie Sommer, Richard Julius Nies, Clemens Metze, Max Maria Meertens, Jonas Wörmann, Sebastian Dittrich, Jan‐Hendrik van den Bruck, Arian Sultan, Jakob Lüker, Daniel Steven, Christopher Hohmann, Roman Pfister, Stephan Baldus, Ingo Eitel, Christian Frerker, Tobias Schmidt

“…Background Mitral valve transcatheter edge‐to‐edge repair (M‐TEER) has emerged as a viable therapy option in patients with severe mitral regurgitation and high surgical risk. …”
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Optimal Medical Therapy for Heart Failure and Integrated Care in Patients With Atrial Fibrillation: A Report From the ESC‐EHRA EORP Atrial Fibrillation Long‐Term General Registry... by Niccolò Bonini, Marco Proietti, Giulio Francesco Romiti, Marco Vitolo, Ameenathul Mazaya Fawzy, Wern Yew Ding, Jacopo Francesco Imberti, Laurent Fauchier, Francisco Marin, Michael Nabauer, Gheorghe Andrei Dan, Tatjana S. Potpara, Giuseppe Boriani, Gregory Y. H. Lip

“…Background Heart failure (HF) often occurs in patients with atrial fibrillation (AF), with a major impact on prognosis. …”
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Suicide and suicide attempt in users of GLP-1 receptor agonists: a nationwide case-time-control studyResearch in context by Julien Bezin, Anne Bénard-Laribière, Emilie Hucteau, Marie Tournier, François Montastruc, Antoine Pariente, Jean-Luc Faillie

“…Summary: Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are extensively evaluated for the risk of suicidal behaviors or ideation; the influence of psychiatric history or obesity on this potential effect remains to be investigated. …”
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Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

“…Abstract Background Steroid-resistant asthma (SRA) is a form of asthma resistant to corticosteroid therapy, which is characterized by the presence of neutrophil-predominant inflammatory response and neutrophil extracellular traps (NETs) formation. …”
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Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events by Yun‐Jiu Cheng, Zi‐Li Liao, Li‐Juan Liu, Yue‐Dong Ma, Xu‐Miao Chen, Ze‐Xuan Wu, Hui‐Qiang Wei, Wei‐Dong Lin, Yi‐Jian Liao, Su‐Hua Wu, Yu‐Mei Xue, Li‐Chun Wang, Yang Wu

“…Background The prognostic significance of small left ventricle (LV) in the general population and its association with cardiovascular disease remain elusive. …”
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Prognostic value of global coronary flow reserve before and after elective percutaneous coronary intervention in patients with chronic coronary syndrome by Kai Nogami, Masahiro Hoshino, Eisuke Usui, Yoshihisa Kanaji, Tomoyo Sugiyama, Masahiro Hada, Tatsuhiro Nagamine, Hiroki Ueno, Mirei Setoguchi, Tomohiro Tahara, Tatsuya Sakamoto, Takashi Mineo, Tsunekazu Kakuta

“…ABSTRACT: Background: Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. …”
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Clinical Features and Outcomes of Primary Sclerosing Cholangitis in the Highly Admixed Brazilian Population by Mateus Jorge Nardelli, Paulo Lisboa Bittencourt, Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Cristiane Alves Villela-Nogueira, Vivian Rotman, Eliabe Silva de Abreu, Fernanda Maria Farage Osório, Andreia Silva Evangelista, Liliana Sampaio Costa Mendes, Daniel Ferraz de Campos Mazo, Elodie Bonfim Hyppolito, Adrielly de Souza Martins, Liana Codes, Izabelle Venturini Signorelli, Geisa Perez Medina Gomide, Luciana Agoglia, Claudia Alexandra Pontes Ivantes, Valéria Ferreira de Almeida e Borges, Gabriela Perdomo Coral, Rosamar Eulira Fontes Rezende, Maria Lucia Gomes Ferraz, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Claudia Alves Couto

“…Background. Primary sclerosing cholangitis (PSC) is associated with a broad phenotypic spectrum in different populations from diverse ethnic and racial backgrounds. …”
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Utility of serum cytokine testing to differentiate complicated common variable immunodeficiency in resource limited settings by Aditi Jogdand, BS, Karen M. Gilbert, PhD, Joseph S. Hong, BS, Andrew J. Pak, BS, Katherine Liu, BA, Uhuru Kamau, MS, Neha V. Khairnar, MS, MBA, Henry C. Ssemaganda, MD, MS, Daniel DiGiacomo, MD, MPH, Sara Barmettler, MD, MPH, Mei-Sing Ong, PhD, Jocelyn R. Farmer, MD, PhD

“…Background: Common variable immunodeficiency (CVID) is the most common, symptomatic inborn error of immunity (IEI) worldwide. …”
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α-Glucosidase Inhibition Mechanism and Anti-Hyperglycemic Effects of Flavonoids from Astragali Radix and Their Mixture Effects by Xing Han, Pengpu Wang, Jing Zhang, Yang Lv, Zhigao Zhao, Fengxian Zhang, Mingying Shang, Guangxue Liu, Xuan Wang, Shaoqing Cai, Feng Xu

“…<b>Background</b>: Inhibition of intestinal α-glucosidase is a key strategy for controlling postprandial hyperglycemia in diabetes. …”
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Efficacy of immune checkpoint inhibitors for in-transit melanoma by Victoria Atkinson, Shahneen Sandhu, Georgina V Long, David E Gyorki, George Au-Yeung, Grant A McArthur, Euan Walpole, Mark Smithers, Alexander Menzies, Robyn Saw, Tavis Read, Julia Lai-Kwon, Lumine Na, Emilia Nan Tie, Michael Alexander Rtshiladze, James Bozzi

“…Background The efficacy of immune checkpoint inhibitors (ICI) in metastatic melanoma is well established. …”
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Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial by Hanim Kwon, Jae-Chan Ryu, Jae-Kwan Cha, Sang Min Sung, Tae-Jin Song, Kyung Bok Lee, Eung-Gyu Kim, Yong-Won Kim, Ji Hoe Heo, Man Seok Park, Kyusik Kang, Byung-Chul Lee, Keun-Sik Hong, Oh Young Bang, Jei Kim, Jong S. Kim

“…However, whether these results can be applied to Asian patients with different ischemic stroke subtypes remains unclear. Methods Patients from 14 South Korean centers were analyzed separately. …”
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Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study by Han-Qing Zhao, Han-Qing Zhao, Jia-Le Lv, Jia-Le Lv, Yuan-Zhi Gao, Bo Hu, Zong-Da Du, Zong-Da Du, Zong-Da Du, Yan Wang, Mei-Lin Wang, Mei-Lin Wang, Meng-Di Hou, Fang Li, Xue Xing, Ming-Hui Sun

“…BackgroundThe inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. …”
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