Immediate or delayed initiation of renal replacement therapy in patients with leptospirosis and acute kidney injury: a target trial emulation by Marie Julien, Cédric Rafat, Loïc Raffray, Henri Vacher-Coponat, Nicolas Allou, Jérôme Allyn, Julien Jabot, Yannis Lombardi

“…Conversely, several randomized controlled trials (RCTs) conducted in intensive care units have refuted the positive impact of early RRT on mortality in patients with AKI and other causes of sepsis. Methods In this emulated RCT utilizing a propensity score-weighted logistic regression performed in the two academic centers on the island of La Réunion, France, between 2010 and 2020, we evaluated the impact of the timing of RRT on a composite outcome of mortality or new-onset or worsening chronic kidney disease (CKD) within a year, in patients hospitalized with leptospirosis, Stage 3 AKI, and no immediate need for RRT. …”
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Early Critical Care Unit Outcome with Transcatheter Aortic Valve Intervention Compared to Surgical Aortic Valve Replacement in Severe Aortic Stenosis by Mahmoud K. Nour, Yasser A. Sadek, Ahmed Abdelaziz, El Shazly Abdelaal, Khaled H. Zeineldin

“…Abstract Background Aortic valve stenosis is the most common type of valvular diseases in the elderly population.1 Trans-catheter aortic valve implantation (TAVI) has been developed for minimally invasive treatment for patients considered ineligible for valve surgery. …”
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Characteristics of Wellens’ Syndrome in the Current PCI Era: A Single-Center Retrospective Study by Li Zhou, Xuhe Gong, Hui Chen, Tianhui Dong, He-he Cui, Hongwei Li

“…However, there is still a paucity of available clinical trial data for Wellens’ syndrome even though it is a well-known high-risk ACS. Methods. Among a total of 3528 patients with ACS who underwent angioplasty from 2017 to 2019 at the Cardiovascular Center of Beijing Friendship Hospital, 476 NSTEMI patients with culprit left anterior descending (LAD) vessels were enrolled in this study. …”
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The association of HALP score with low muscle mass in older adults by Suxia Liu, Jiansheng Huang, Xiaolei Hu, Shuaiqing Chen, Mingshen Lin

“…Our investigation aimed to explore the association of this composite score with the prevalence of low muscle mass and associated mortality in the elderly American population.MethodsThe investigation incorporated information from 3,550 individuals aged ≥60 years enrolled in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2004. …”
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Anti-cancer potential of Syzygium cumini and Syzygium Jambolanum extracts against MCF-7 cell line: An in vitro evaluation by Sheikh Muhammad Suhail, Amit Anand, Abu Safana Biswas, Santhepete Nanjundiah Manjula, Kenganora Mruthunjaya

“…Purpose: This study aims to identify the bioactive compounds present in the extracts, assess their in vitro antioxidant and anticancer potential, along with the possible mechanism of action for its anticancer property. Methods: Hydroalcoholic extracts of S. cumini and S. jambolanum fruit pulp, Juice, Seed was subjected to GC–MS to identify its chemical compositions followed by invitro antioxidant cytotoxicity study by DPPH, MTT assay respectively. …”
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Association of ambient temperature and influenza-like illness with acute appendicitis: an ecological study using 22-year data by On Tai Ken Yu, Xiaoting Jiang, Conglu Li, Yawen Wang, Yuchen Wei, Ka Chun Chong

“…Abstract Background While acute appendicitis poses a significant disease burden worldwide, its etiology is not completely known. …”
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Impacts of clinical research units on clinical research — a systematic review of empirical studies by Fan Wang, Xu Wang, Enmei Liu, Fujian Song, Yaolong Chen

“…Abstract Background Clinical research is essential for evidence-based decision-making in healthcare practice, but its conduct is hindered by various barriers. …”
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Fusarium oxysporum assisted green synthesis of small-sized silver nanoparticles for high antibacterial, and photocatalytic decolorization performances by Reyad M. El-Sharkawy, Inas A. Ahmed, Taghrid G. Kharboush

“…The unique characteristics of metal oxide and noble metals nanoparticles make them suitable for different fields including antimicrobial agents, cosmetics, textiles, wound dressings, and anticancer drug carriers. Methods This study focuses on the biosynthesis of small-sized SNPs using exo-metabolites of Fusarium oxysporum via bioprocess optimization using Plackett-Burman (PBD) and central composite designs (CCD) while evaluating their multifaceted bioactivities. …”
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A hybrid fuzzy logic–Random Forest model to predict psychiatric treatment order outcomes: an interpretable tool for legal decision support by Alexandre Hudon, Alexandre Hudon, Alexandre Hudon, Alexandre Hudon

“…BackgroundDecisions surrounding involuntary psychiatric treatment orders often involve complex clinical, legal, and ethical considerations, especially when patients lack decisional capacity and refuse treatment. …”
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The role of CD47 in immune escape of colon cancer and its correlation with heterogeneity of tumor immune microenvironment by Qiu-Si Tian, ChunMei Zhang, Zhi-Jun Bao, ZhiGang Pei

“…Background Cluster of differentiation 47 (CD47), a transmembrane protein, plays a critical role in regulating cellular functions and maintaining immune homeostasis. …”
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Healthcare Resource Utilization and Cost Comparisons of High-Protein Enteral Nutrition Formulas Used in Critically Ill Patients by Matthew C. Bozeman, Laura L. Schott, Amarsinh M. Desai, Mary K. Miranowski, Dorothy L. Baumer, Cynthia C. Lowen, Zhun Cao, Krysmaru Araujo Torres

“…# Background High-protein enteral nutrition is advised for patients who are critically ill. …”
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Compass Fundus-Guided Perimetry in Geographic Atrophy by Roberta Farci, Arturo Carta, Paolo Fogagnolo, Luca Mario Rossetti, Maurizio Fossarello

“…To evaluate compass (CMP), a recently introduced device that combines scanning ophthalmoscopy, automated perimetry, and eye tracking, for fundus-guided perimetry (microperimetry) with the purpose of correlating perimetric retinal sensitivity (PRS) and retinal geographic atrophy (GA) features. Materials and Methods. A retrospective, cross-sectional study was performed in 56 eyes of 43 patients affected by GA. …”
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Health care professionals intention to use digital health data hub working in East Gojjam Hospitals, Northwest Ethiopia: Technology acceptance modeling. by Ayenew Sisay Gebeyew, Sefefe Birhanu Tizie, Bayou Tilahun Assaye, Afework Edmealem, Temesgen Feyu, Habtamu Mekonen, Tirsit Ketsela Zeleke, Melese Getachew, Andualem Fentahun

“…<h4>Background</h4>Digital health data hubs contribute significantly to finding the right solutions to health problems, which forms the basis for achieving sustainable development goals. …”
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Socioeconomic and racial-ethnic disparities in flame retardant exposure and executive function skills in preschool children by Alexis Merculief, Megan McClelland, Stephanie Foster, John Geldhof, Shannon Lipscomb, Kim Anderson, Molly L. Kile

“…Abstract Background Polybrominated diphenyl ethers (PBDEs) and organophosphate esters (OPEs) are commonly used as flame retardants. …”
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Lipid metabolism dysregulation in umbilical cord plasma of newborns from mothers with preeclampsia is associated with neonatal physical parameters at birth by Jing Ding, Yihan Xiao, Jie Fu, Qionghui Huang, Zijun Ma, Chao Zhang, Yan Wang, Guoli Liu, Hongkun Wu, Yifang Yuan

“…Abstract Background Preeclampsia is linked to fetal growth restriction and may have long-term implications for the offspring. …”
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Examining Sex Differences in Visual Reliance During Postural Control in Intercollegiate Athletes by Nicolette Ingel, Victoria Vice, Courtney Dommer, Jennifer Csonka, Tara Moore, Ariel Zaleski, Carolyn Killelea, Mallory Faherty, Jody Feld, Timothy Sell

“…# Background Risk factors for different sports injuries vary between sexes. …”
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Oscillometry Assesses Small Airway Disease and Reveals Peripheral Lung Pathology in Early Pulmonary Fibrosis: A Cross-Sectional Study by Athena Gogali, Georgia Gkrepi, Christos Kyriakopoulos, Konstantinos Tatsis, Konstantinos Katsoulis, Chara Tselepi, Konstantinos Kostikas

“…<b>Background/Objectives:</b> Small airway disease/dysfunction (SAD) is crucial in obstructive airway diseases but is less investigated in interstitial lung disease (ILD). …”
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Evaluation of the marginal fit and fracture resistance of interim restorations fabricated using different techniques: an in vitro study by Mostafa Elashkar, Yehia Aboushady, Merna Ihab, Mohamed T. El Halawani

“…Aim The aim of this in vitro study was to investigate the marginal fit and fracture resistance of manually fabricated, computer-aided design and computer-aided manufacturing (CAD/CAM) milled, and CAD/CAM three-dimensionally (3D) printed 3-unit interim fixed dental prostheses (FDPs). Materials and methods Sixty-four 3-unit interim FDPs were fabricated on epoxy resin models using different fabrication techniques: manual fabrication with poly methyl methacrylate (PMMA) (n = 16), manual fabrication with Bis-acrylic composite resin (n = 16), CAD/CAM milling (n = 16), and CAD/CAM 3D-printing with a digital light processing (DLP) printer (n = 16). …”
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The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study by Yu Li, Yu Li, Meng Yu, Ming Yang, Jingqi Yang

“…BackgroundChronic low-grade inflammation is recognized as a significant factor in various health outcomes, including the development and progression of breast cancer. …”
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Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures by Caitlin C. Clements, Anne-Michelle Engelstad, Carol L. Wilkinson, Carly Hyde, Megan Hartney, Alexandra Simmons, Helen Tager-Flusberg, Shafali Jeste, Charles A. Nelson

“…Abstract Background Tuberous Sclerosis Complex (TSC) is a rare genetic condition caused by mutation to TSC1 or TSC2 genes, with a population prevalence of 1/7000 births. …”
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