Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study by Dong Liu, Chun Dou, Chaojie Ye, Lijie Kong, Zheng Zhu, Mingling Chen, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Tiange Wang

“…Abstract Background Delineating the causal chain effects of reproductive traits and fat- and muscle-related traits on cardiovascular disease (CVD) is essential for optimizing precision prevention and control of cardiovascular health in women. …”
Get full text

Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model. by Ernesto Luna, Pankaj Agrawal, Riyaz Mehta, Maria E Boone, Charlotte Vernhes, Colombe Denys, Robert Small, Bhaswati Mukherjee, Norbert Tennagels, Stefan Maerten, Donald R Drake

“…<h4>Background</h4>The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. …”
Get full text

The Role of the Bone Marrow Microenvironment in Physical Function and Quality of Life in Patients with Multiple Myeloma After First-Line Treatment with Novel Agents and Autologous... by Polyxeni Spiliopoulou, Pantelis Rousakis, Chrysanthi Panteli, Evangelos Eleutherakis-Papaiakovou, Magdalini Migkou, Nikolaos Kanellias, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Foteini Theodorakakou, Despina Fotiou, Evangelos Terpos, Vassilios Myrianthopoulos, Maria Gavriatopoulou, Ourania E. Tsitsilonis, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Gerasimos Terzis

“…Background/Objectives: Multiple myeloma is a malignancy of plasma cells detected in the bone marrow, inducing symptoms like anemia, hypercalcemia, renal problems, and bone fractures in multiple myeloma patients, affecting their quality of life. …”
Get full text

Plasma Fatty Acid Profiling and Mathematical Estimation of the Omega-3 Index: Toward Diagnostic Tools in Atherosclerosis and Statin Therapy Monitoring by Nikolay Eroshchenko, Elena Danilova, Anastasiia Lomonosova, Alexey Antonik, Svetlana Lebedeva, Daria Gognieva, Dmitry Shchekochikhin, Tatiana Demura, Marina Krot, Nana Gogiberidze, Abram Syrkin, Philipp Kopylov

“…<b>Background/Objectives:</b> Omega-3 highly unsaturated fatty acids (HUFAs), particularly EPA and DHA, have anti-inflammatory and lipid-modulating properties for treating atherosclerosis. …”
Get full text

Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study by Daina Martínez‐Falguera, Júlia Aranyó, Gemma Ferrer‐Curriu, Albert Teis, Elena Revuelta‐Lopez, Idoia Diaz‐Güemes, Marta Monguió‐Tortajada, Edgar Fadeuilhe, Oriol Rodríguez‐Leor, Francesc Poblador, Borja Montejo, Santiago Roura, Roger Villuendas, Axel Sarrias, Victor Bazan, Esther Jorge, Victoria Delgado, Francisco Rafael Jimenez‐Trinidad, Montserrat Rigol, Neus Martinez‐Micaelo, Núria Amigó, Antoni Bayes‐Genis, Felipe Bisbal, Carolina Gálvez‐Montón

“…Background Empagliflozin and sacubitril/valsartan are established in heart failure treatment, but their effects after myocardial infarction (MI) are less clear. …”
Get full text

TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy by Qiliang Teng, Niu Wang, Hanqi Lei, Tongyu Tong, Yupeng Guan, Mengjun Huang, Fei Cao, Bin Xu, Jia Yang, Yimian Huo, Wenping Chen, Ran Bi, Xuanqi Wang, Zhenyu Wang, Fu-Ying Tian, Bo Zhao, Jun Pang

“…Abstract Background Prostate cancer (PCa) has previously been established as a cold tumor with highly complex tumor environment. …”
Get full text

miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis. by Alberto Del Monte, Ana B Arroyo, María J Andrés-Manzano, Nuria García-Barberá, María S Caleprico, Vicente Vicente, Vanessa Roldán, Rocío González-Conejero, Constantino Martínez, Vicente Andrés

“…<h4>Background</h4>Atherosclerosis involves activation of the IRAK1/TRAF6/NF-κB inflammatory cascade, which is negatively regulated by miR146a. …”
Get full text

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation by Xiaohu Wang, Mengxia Fu, Weiteng Wang, Songren Shu, Ningning Zhang, Ruojin Zhao, Xiao Chen, Xiumeng Hua, Xin Wang, Wei Feng, Xianqiang Wang, Jiangping Song

“…Abstract Background Functional mitral regurgitation (MR) is a common form of mitral valve dysfunction that often persists even after surgical intervention, requiring reoperation in some cases. …”
Get full text

Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model by Daisuke Kitano, Suguru Migita, Yuxin Li, Yutaka Koyama, Katsunori Fukumoto, Sayaka Shimodai-Yamada, Akira Onishi, Daiichiro Fuchimoto, Shunichi Suzuki, Yoshiyuki Nakamura, Atsushi Hirayama, Hiroyuki Hao, Yasuo Okumura

“…Background: The combination of antiplatelet and antithrombotic drugs increases the risk of bleeding in patients with atrial fibrillation after coronary drug-eluting stent (DES) implantation. …”
Get full text

PCI-DB: a novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development by Sven Nahnsen, Hans-Georg Rammensee, Cécile Gouttefangeas, Jonas S Heitmann, Juliane S Walz, Jens Bauer, Marcel Wacker, Annika Nelde, Jonas Scheid, Steffen Lemke, Marissa L Dubbelaar, Patrick Zimmermann, Naomi Hoenisch Gravel, Susanne Jung, Anna Dengler, Yacine Maringer, Sven Fillinger, Tatjana Bilich

“…Background Various cancer immunotherapies rely on the T cell-mediated recognition of peptide antigens presented on human leukocyte antigens (HLA). …”
Get full text

Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial by Xinxing Li, Dae Young Kim, Yunho Sung, Donghyun Kim, Seohyun Ahn, Hyejung Shin, Nur Afiqah Binti Zulkifli, Ji-won Seo, Shu Jiang, Parivash Jamrasi, SoYoung Ahn, Jun Hyun Bae, HeeKyung Yeo, Hayoung Park, Wook Song

“…Methods: Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. …”
Get full text

Legume-based green concentrate alleviates negative energy balance and enhances performance, metabolic health, and profitability in postpartum Holstein Friesian cows by Renny Fatmyah Utamy, Ambo Ako, Zyahrul Ramadan, Yasuyuki Ishii, Mohammad Mijanur Rahman, Kannika Umpuch, Azisah Nurfadilah, Gemal Umar Akmal Alkatiry, Muhammad Akram, Jiant Muthahra Maharani

“…Background and Aim: Negative energy balance (NEB) is a common metabolic disorder in postpartum dairy cows that compromises milk yield, metabolic health, and reproductive function. …”
Get full text

Enhancing the nutritional profile of purple sweet potato flour through fermentation with Lactiplantibacillus plantarum InaCC B157: A functional food perspective by Tiurma Pasaribu, Yati Sudaryati Soeka, Novik Nurhidayat, Suciatmih Suciatmih, Titin Yulinery, Evi Triana, Tri Ratna Sulistiyani, Ninik Setyowati, Desty Dwi Sulistyowati, Dwi Ningsih Susilowati

“…This study aimed to evaluate the ability of Lactiplantibacillus plantarum InaCC B157 to enhance the biochemical and functional composition of purple sweet potato flour. Materials and Methods: Six L. plantarum strains were screened for enzymatic activities. …”
Get full text

Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression by Ludivine Obry, Raissa Medina-Santos, Myriam Rahmouni, Josselin Noirel, Toufik Labib, Pilar Galan, Jean-Louis Spadoni, Gaëlle Gendronneau, Randa Jdid, Sandra Courrèges, Julie Latreille, Nada André, Jean-François Zagury, Sigrid Le Clerc

“…BackgroundSkin aging is characterized by observable major changes in the composition and organization of the skin, including the appearance of wrinkles, tissue sagging, dryness, and pigmentary disorders. …”
Get full text

Salivary mycobiome alterations in HIV-infected MSM: dominance of Pseudogymnoascus and functional shifts across disease stages by Ying Guo, Ying Guo, Lu Lin, Miao Zhang, Yixi Yu, Yan Wang, Jie Cao, Yuchen Li, Xintong Sun, Meilin Guan, Shuo Wen, Xin Wang, Zhen Fang, Wenshan Duan, Junyi Duan, Tao Huang, Wei Xia, Shan Guo, Feili Wei, Dongxiang Zheng, Xiaojie Huang

“…BackgroundOral health is increasingly recognized as a crucial determinant of overall health in people living with HIV/AIDS (PLWHA). …”
Get full text

Adipose tissue content of alpha-linolenic acid and the risk of ischemic stroke and ischemic stroke subtypes: A Danish case-cohort study. by Christian Sørensen Bork, Stine Krogh Venø, Søren Lundbye-Christensen, Marianne Uhre Jakobsen, Anne Tjønneland, Philip C Calder, Kim Overvad, Erik Berg Schmidt

“…<h4>Background</h4>The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) may reduce the risk of cardiovascular disease.…”
Get full text

Detecting wetland encroachment and urban agriculture land classification in Uganda using hyper-temporal remote sensing [version 2; peer review: 1 approved, 2 approved with reservat... by Stella Kabiri, Rebecca Ssabaganzi, Beatrice Akello, Molly Allen, Drake Mubiru, Juduth Toma Okuonzia

“…Background: Urbanization is an important indicator of economic growth and social change but is associated with environmental degradation, which threatens the sustainable growth of African cities. …”
Get full text

Multiplex immunofluorescence assessment of macrophages and IL-23R in inflammatory and malignant diseases of the oral mucosa: a pilot study by Leah Trumet, Leah Trumet, Bettina Grötsch, Abbas Agaimy, Kerstin Galler, Carol Geppert, Linus Winter, Linus Winter, Jutta Ries, Jutta Ries, Marco Kesting, Marco Kesting, Manuel Weber, Manuel Weber

“…BackgroundImmune cells play a major role in the development and progression of inflammatory and malignant diseases of the oral mucosa. …”
Get full text

The Impact of Nanoparticle Coatings on the Color of Teeth Restored Using Dental Adhesives Augmented with Magnetic Nanoparticles by Carina Sonia Neagu, Andreea Codruta Novac, Cristian Zaharia, Meda-Lavinia Negrutiu, Izabell Craciunescu, Vlad Mircea Socoliuc, Catalin Nicolae Marin, Ionela-Amalia Bradu, Luminita Maria Nica, Marius Stef, Virgil-Florin Duma, Mihai Romînu, Cosmin Sinescu

“…<i>Background and Objectives</i>: Dental adhesives augmented with magnetic nanoparticles (MNPs) have been proposed to prevent microleakages. …”
Get full text

Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle by Shunya Sadaki, Ryosuke Tsuji, Takuto Hayashi, Masato Watanabe, Ryoto Iwai, Gu Wenchao, Ekaterina A. Semenova, Rinat I. Sultanov, Andrey V. Zhelankin, Edward V. Generozov, Ildus I. Ahmetov, Iori Sakakibara, Koichi Ojima, Hidetoshi Sakurai, Masafumi Muratani, Takashi Kudo, Satoru Takahashi, Ryo Fujita

“…Abstract Background Small mammals such as mice rely on type IIb myofibers, which express the fast-contracting myosin heavy chain isoform Myh4, to achieve rapid movements. …”
Get full text