Persistence of Ebola virus in semen among Ebola virus disease survivors in Sierra Leone: A cohort study of frequency, duration, and risk factors. by A E Thorson, G F Deen, K T Bernstein, W J Liu, F Yamba, N Habib, F R Sesay, P Gaillard, T A Massaquoi, S L R McDonald, Y Zhang, K N Durski, S Singaravelu, E Ervin, H Liu, A Coursier, J E Marrinan, A Ariyarajah, M Carino, P Formenty, U Ströher, M Lamunu, G Wu, F Sahr, W Xu, B Knust, N Broutet, Sierra Leone Ebola Virus Persistence Study Group

“…<h4>Background</h4>Sexual transmission chains of Ebola virus (EBOV) have been verified and linked to EBOV RNA persistence in semen, post-recovery. …”
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Therapeutic effects and mechanisms of Fufang Longdan mixture on metabolic syndrome with psoriasis via miR-29a-5p/IGF-1R axis by Guangyun Luo, Guangyun Luo, Xiangyi Kong, Fang Wang, Zhiming Wang, Zhuo Zhang, Huan Cui, Yiwen Zhang, Wen Huang, Xuesong Yang, Jianzhou Ye, Jianzhou Ye

“…However, current treatments have shown limited efficacy in improving the symptoms of both conditions simultaneously.ObjectiveThis study aimed to investigate the therapeutic efficacy of Fufang Longdan Mixture (FLM) in treating MS-P comorbidity, elucidate its mechanism through the miR-29a-5p/IGF-1R axis and evaluate treatment responses between APOE−/− and C57BL/6 mice.MethodsUPLC-Q-exactive-MS/MS analysis was used to characterise FLM’s chemical composition. …”
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Association of bioelectrical impedance phase angle and nutritional status in patients undergoing pancreaticoduodenectomy by Jialing Li, Defu Hu, Yu Yan, Mengyu Yu, Hexing Hang, Hexing Hang, Yudong Qiu, Yudong Qiu, Dayu Chen, Xu Fu

“…BackgroundVarious tools for nutritional assessment are used in individuals undergoing pancreaticoduodenectomy (PD), causing varying prevalence rates of malnutrition. …”
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Gene and genotype frequencies of immunoglobulin-like natural killer cell receptors in the population of Samara region by D. Yu. Klyuchnikov, Yu. Yu. Teterina, O. V. Tyumina, I. L. Davydkin

“…Background. The using of killer-cell immunoglobulin-like receptor (KIR) composition data is of increasing interest in clinical practice to select an optimal donor for allogeneic hematopoietic stem cell transplantation for treatment of hematologic malignancies to reduce graft versus host disease and the risk of relapse. …”
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The Influence of Zn and Ca Addition on the Microstructure, Mechanical Properties, Cytocompatibility, and Electrochemical Behavior of WE43 Alloy Intended for Orthopedic Applications by Mircea Cătălin Ivănescu, Corneliu Munteanu, Ramona Cimpoeșu, Maria Daniela Vlad, Bogdan Istrate, Fabian Cezar Lupu, Eusebiu Viorel Șindilar, Alexandru Vlasa, Cristinel Ionel Stan, Maria Larisa Ivănescu, Georgeta Zegan

“…<i>Background and Objectives</i>: Magnesium (Mg)-based materials, such as the WE43 alloy, show potential in biomedical applications owing to their advantageous mechanical properties and biodegradability; however, their quick corrosion rate and hydrogen release restrict their general clinical utilization. …”
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Characterizing sarcopenia and sarcopenic obesity in patients aged 65 years and over, at risk of mobility disability: a multicenter observational trial (SARA-OBS) by Roger A. Fielding, Yves Rolland, Olivier Bruyere, Moise Desvarieux, Lorenzo M. Donini, Raffaele Antonelli Incalzi, Maurizio Muscaritoli, Achille Tchalla, Marc Bonnefoy, Mariangela Rondanelli, Rob Van Maanen, Jean Mariani, Carole Margalef, Susanna Del Signore, Cendrine Tourette, Waly Dioh, Stanislas Veillet

“…Abstract Background Aging is associated with a progressive change of body composition characterized by muscle mass decline and accumulation of adipose tissue that can lead to sarcopenia and obesity, respectively. …”
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Unraveling the in vitro antioxidant and neuroprotective potential of green amalgamated gold nanoparticles from Chang shuo huang ma (Corchorus olitorius (L)): Insights on SK-N-SH ne... by Basheerahmed Abdulaziz Mannasaheb, Ibrahim Ahmed Shaikh, Gurmeet Kaur Surindar Singh, Noordin Othman, Mohammed M. Ghoneim, Hanish Singh Jayasingh Chellammal

“…Background: The global healthcare management for neurodegenerative disorders is increasing, mandating the need to discover safe and effective medications to manage them. …”
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Bone marrow mesenchymal stem cells transport connexin43 via tunneling nanotubes to alleviate isopreterenol-induced myocardial hypertrophy by Jianghui Zhang, Hongfeng Jiang, Sa Liu, Zhong Xian, Limin Zhao, Yue Li, Wenxiu Lu, Changrong Shao, Sanbao Chai

“…Abstract Background Paracrine signaling plays an important role in stem cell therapy. …”
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Amelioration of Metabolic Syndrome by Co-Administration of <i>Lactobacillus johnsonii</i> CRL1231 and Wheat Bran in Mice via Gut Microbiota and Metabolites Modulation by Matias Russo, Antonela Marquez, Estefanía Andrada, Sebastián Torres, Arlette Santacruz, Roxana Medina, Paola Gauffin-Cano

“…Background/Objectives: <i>Lactobacillus johnsonii</i> CRL1231 (<i>Lj</i> CRL1231) is a strain with feruloyl esterase (FE) activity that enhances ferulic acid (FA) release from wheat bran (WB) and has potential as a probiotic for metabolic syndrome (MS). …”
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Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma by Liu S, Lin Z, Zhou J, Yang X, You L, Yang Q, Li T, Hu Z, Zhan X, Jiang Y, Sun B

“…While allergen triggers are well-known, the role of the airway microbiome and metabolites in asthma exacerbations remains poorly understood.Methods: We recruited 64 participants (24 EA, 20 NEA, 20 healthy controls [HC]) for the discovery cohort, with validation in an external cohort (10 EA, 8 NEA, 8 HC). …”
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Effects of Neuromuscular Training Applied During Ramadan on Physical Fitness and Injury Prevention in Highly-Trained Male Youth Soccer Players by Ali Belamjahad, Claire Tourny, Anthony C. Hackney, Fatiha Laziri, Ayoub Saeidi, Ouafae El Hachimi, Ismail Laher, Urs Granacher, Hassane Zouhal

“…Abstract Background The intermittent fasting period of Ramadan is associated with reductions in training volumes and intensities to maintain physical fitness levels and reduce injury occurrence. …”
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Exploring the Potential of Coix Seeds to Mitigate High Humidity-Induced Gut Inflammation via Microbiota and Metabolite Modulation by Zhao P, Xiao C, Xuan M, Yan S, Yu X, Li W, Han L, Wang H, Zhao J, Zhang S, Zhong X

“…Coix seed (Coix lacryma-jobi L.), widely used in traditional Chinese medicine for eliminating dampness, shows promise; however, its mechanisms require further elucidation.Methods: A Coix seed decoction (CD) was administered to rats exposed to 85% relative humidity (8 h/day) for 30 days. …”
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Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. by Jane L Tarry-Adkins, Catherine E Aiken, Susan E Ozanne

“…<h4>Background</h4>Metformin is increasingly offered as an acceptable and economic alternative to insulin for treatment of gestational diabetes mellitus (GDM) in many countries. …”
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Association between the early or late onset of gestational diabetes mellitus with neonatal adverse outcomes: a retrospective cohort study by Fabiana Vieira Duarte de Souza Reis, Carlos Izaias Sartorão Filho, Luis Sobrevia, Caroline Baldini Prudencio, Bruna Bologna, Luana Favaro Iamundo, Adriely Magyori, Luiz Takano, Raissa Escandiussi Avramidis, Rafael Guilen de Oliveira, Marilza Vieira Cunha Rudge, Angélica Mércia Pascon Barbosa, Diamater Study Group

“…Abstract Background The literature has been evolving to standardize gestational diabetes mellitus (GDM) diagnosis and terminology. …”
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A Polysorbate-Based Lipid Nanoparticle Vaccine Formulation Induces In Vivo Immune Response Against SARS-CoV-2 by Aishwarya Saraswat, Alireza Nomani, Lin-Kin Yong, Jimmy Chun-Tien Kuo, Heather Brown, Muralikrishna Narayanareddygari, Avery Peace, Rizan Fazily, Timothy Blake, Christopher D. Petro, Bindhu Rayaprolu, Johanna Hansen, Amardeep Singh Bhalla, Mohammed Shameem

“…By leveraging PS-80’s unique structural properties, this study aimed to develop an mRNA-LNP platform with improved extrahepatic delivery and robust freeze/thaw tolerance. <b>Methods</b>: We employed a stepwise optimization to establish both the lipid composition and formulation buffer to yield a stable, high-performing PS-80-based SARS-CoV-2 mRNA-LNP (SC2-PS80 LNP). …”
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In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach by Asmaa Ramzy, Mohammad Abdel-Halim, Tamer Manie, Noha M. Elemam, Samar Mansour, Rana A. Youness, Aya Sebak

“…Background: Triple negative breast cancer (TNBC) is an immunogenic tumor; however, its tumor immune microenvironment (TIME) is densely packed with immune suppressive cytokines and immune checkpoints. …”
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Combination of Essential Oils and Extracts Enriched with Tocopherols in Diet of Holstein Steers and Its Effect on Ruminal Fermentation, Antioxidant and Anti-Inflammatory Response,... by João Gustavo Weschenfelder Wandscheer, Natalia Turcatto, Guilherme Luiz Deolindo, Mateus Henrique Signor, Alexandro Fritzen, Marcelo Vedovatto, Camila Ten Kathen Jung, Gilberto Vilmar Kozloski, Ana Carolina Hadlich Xavier, Roger Wagner, Bianca Fagan Bissacotti, Priscila Marquezan Copetti, Aleksandro Schafer da Silva

“…Methods: The experiment included 24 Holstein steers, divided into two groups, randomly divided (treated = phytogenic mixture (n = 12); control = monensin (n = 12)), undergoing a growth phase of 120 days and 90 days of finishing in individual pens, with a monthly collection of blood, rumen fluid, feces, and feed. …”
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Discovering biomarkers associated with infiltration of CD8+ T cells and tumor-associated fibrosis in colon adenocarcinoma using single-cell RNA sequencing and gene co-expression ne... by Jinning Zhang, Jinning Zhang, Ziquan Sun, Ziquan Sun, Guodong Li, Guodong Li, Lixian Ding, Zitong Wang, Ming Liu, Ming Liu

“…BackgroundColorectal adenocarcinoma (COAD) is a prevalent malignant tumor associated with a high mortality rate. …”
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Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals. by Robert F Hillary, Daniel L McCartney, Hannah M Smith, Elena Bernabeu, Danni A Gadd, Aleksandra D Chybowska, Yipeng Cheng, Lee Murphy, Nicola Wrobel, Archie Campbell, Rosie M Walker, Caroline Hayward, Kathryn L Evans, Andrew M McIntosh, Riccardo E Marioni

“…<h4>Background</h4>DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. …”
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Ranges, temporal trend, and determinants of novel obesity indices in middle-aged and older Chinese population: insights from a nationally representative and longitudinal study by Liufang Huang, Yifan Zhou, Kaiweisa Abuduxukuer, Kaiweisa Abuduxukuer, Chuchu Wang, Chuchu Wang, Chuchu Wang, Ya’nan Hou, Wenming Shi, Jianfeng Luo, Jianfeng Luo, Jianfeng Luo, Jin Wei, Yuhang Yue

“…BackgroundTraditional obesity assessment using body mass index (BMI) fails to adequately capture fat distribution, particularly central obesity, which is closely linked to metabolic dysfunction and obesity-related complications. …”
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