Exogenous Nucleotides Supplementation Attenuates Age‐Related Sarcopenia by Xin Wu, Rui Liu, Na Zhu, Xiujuan Wang, Chan Wei, Xiaoyang An, Meihong Xu, Yong Li

“…ABSTRACT Background Sarcopenia, an age‐related clinical syndrome characterized by reduced skeletal muscle mass and strength, often leads to a loss of physical function. …”
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Investigation of differential Multi-Mode antibacterial mechanisms of essential oils of Satureja montana L. and Leptospermum scoparium J.R.Forst. & G.Forst. Against Porphyromonas gi... by Yue Yuan, Xiuli Hui, Zixuan Liu, Jinlong Sun, Rifat Nowshin Raka, Junsong Xiao, Zhongwei Zhang, Hua Wu

“…Abstract Background Globally, according to WHO estimates, severe periodontitis affects over 1 billion people. …”
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Immune cell topography of head and neck cancer by Bernard A Fox, Rieneke van de Ven, Carmen Ballesteros-Merino, Tara Muijlwijk, Sonja H Ganzevles, Ruud H Brakenhoff, Jos B Poell, Dennis N L M Nijenhuis, C René Leemans, Laura A N Peferoen, Elisabeth Bloemena, Fatima Ekhlas

“…Background Approximately 50% of head and neck squamous cell carcinomas (HNSCC) recur after treatment with curative intent. …”
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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation by Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

“…However, it remains unknown whether and how FPHA affects the immune microenvironment of the bone defects. Methods FPHA was synthesized and its composition and structural properties were confirmed. …”
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Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study by Xiaobo Liu, Bin Wan, Xi-Han Zhang, Ruifang Cui, Siyu Long, Ruiyang Ge, Lang Liu, Jinming Xiao, Zhen-Qi Liu, Jiadong Yan, Ke Xie, Meng Yao, Xin Wen, Sanwang Wang, Yujun Gao

“…Abstract Background Bipolar disorder (BD) is a heterogeneous psychiatric condition characterized by distinct episodes: manic (BipM), depressive (BipD), mixed (mBD), and remission (rBD). …”
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A study on the mechanism of Bushen Kaiqiao Formula in modulating microglial activation to alleviate neuroinflammation in ADHD by Jiaqi Zhang, Ruxin Sun, Yu Xiong, Yuting Yang, Jing Wang, Kanglin Zhu, Xinqiang Ni, Min Huang

“…Utilizing spontaneously hypertensive rats—a well-validated animal model of ADHD—this study aimed to characterize ADHD-like behavioral phenotypes and prefrontal cortical neuronal development and elucidate the neuroimmunological mechanisms through which the Bushen Kaiqiao Formula (BSKQF) exerts its therapeutic effects by modulating microglial activation states. Methods: Ultra-high-performance liquid chromatography coupled with a tandem mass spectrometer (UHPLC-MS/MS) was used to qualitatively analyze the chemical composition of Bushen Kaiqiao Formula, and network pharmacology was applied to predict its potential therapeutic targets and ADHD-related pathways ADHD-like behaviors, including hyperactivity, impulsivity, spatial memory, and attention, were assessed using the Open Field Test, Elevated Plus Maze, and Y-Maze Test at weeks 2 and 4. …”
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Fermented palm kernel waste with different sugars as substrate for black soldier fly larvae by R.A. Nugroho, R. Aryani, E.H. Hardi, H. Manurung, R. Rudianto, W.N. Jati

“…BACKGROUND AND OBJECTIVES: The palm industry generates several waste products. …”
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Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway by Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu

“…Abstract Background Pancreatic carcinoma (PC) remains one of the most aggressive malignancies that is often referred to as the “king of cancers” in clinic. …”
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Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial. by Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium

“…<h4>Background</h4>Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. …”
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ESTIMATION OF TENDENCIES IN THE HEIGHT OF THE SNOW COVERAT WEATHER STATIONS IN THE NORTHERN CAUCASUS by L. A. Kesheva

“…Introduction. Against the background of global warming observed in recent decades, changes in all climatic characteristics are taking place. …”
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Enhancing treatment outcomes after gynaecological cancer (ACUMEN): a randomised controlled exercise trial protocol by Vivian Chiu, Alexander Boytar, Brent Cunningham, Tina Skinner, Jane Turner, Debra Anderson, Asaduzzaman Khan, Tom Bailey, Janine Porter-Steele, Leonie Young, Haitham Tuffaha, Lewis Perrin, Andrea Garrett, Jeffrey Goh, Grace Rose, Briana Clifford, Sjaan Gomersall, Darren Korbie, Nicolas Constantin, Jackie Li, Alexandra Leigh McCarthy

“…Abstract Background Treatment for gynaecological cancer often entails challenges that negatively affect quality-of-life. …”
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Morphological and molecular monitoring of fishes in the waters of mangrove ecosystems by M. Basyuni, Irmawati , A. Mubaraq, A. Susilowati, A.B. Rangkuti, Desrita , A.A. Aznawi, S.S. Al Mustaniroh, S.H. Larekeng, A.H. Salman, E.R. Ardli, Y. Isowa, T. Kajita

“…BACKGROUND AND OBJECTIVES: Mangroves are primarily found along Sumatra’s east coast in Aceh and North Sumatra, Indonesia. …”
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Sex differences in metabolic regulation by Gi/o-coupled receptor modulation of exocytosis by Montana Young, Ryan P. Ceddia, Analisa Thompson-Gray, David Reyes, Jackson B. Cassada, Julio E. Ayala, Owen P. McGuinness, Sheila Collins, Sheila Collins, Heidi E. Hamm

“…When male SNAP25Δ3/Δ3 mice were housed at thermoneutrality (30°C), all metabolic protection was abolished, suggesting sympathetic tone is important for the phenotypes.MethodsWe housed male and female mice at either standard room temperature (21°C) or at thermoneutrality (30°C) and fed them a high fat diet (HFD) for 8 weeks. …”
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Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing by Yueling Peng, Yaling Zhang, Yaling Zhang, Rui Wang, Xinyu Wang, Xingwei Liu, Hui Liao, Rongshan Li

“…Inonotus obliquus (Chaga), a traditional medicinal mushroom, has shown promising effects in chronic kidney disease (CKD), yet its cellular and molecular mechanisms remain largely unexplored.MethodsWe analysed the chemical composition of Chaga using UPLC-MS and predicted its biological targets using PubChem and Swiss Target Prediction. …”
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Effects of Fermentation on Proximate, Mineral Elements and Total Antioxidant Activity of Cloves-Cinnamon Formulated Cereal Gruels by T. Ozabor, M. Makanjuola, M. Jejeniwa, I. Adekomi, G. Oni, O. Oluwajide, J. Olaitan

“…The fermenting organisms were isolated from the spontaneously formulated fermented blends using standard microbiological methods. Physicochemical parameters, such as temperature, pH, and Titratable Acidity, as well as proximate and mineral compositions, were assessed using standard procedures. …”
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Silver diamine fluoride alters microbial communities in subsurface dentinWhy Is This Important? by Rosalyn M. Sulyanto, DMD, MS, Clifford J. Beall, MS, PhD, Martin T. Berger, DMD, Christopher P. Goodell, DMD, Stephanie Koo, DMD, Fiorella Candamo, DMD, John R. Dickson, MD, PhD, Misun Kang, PhD, Sunita P. Ho, PhD, Man Wai Ng, DDS, MPH, Shahr B. Hashmi, BS, Eugene J. Leys, PhD, Ann L. Griffen, MS, DDS

“…Background: Silver diamine fluoride (SDF) is a dental biomaterial with cariostatic properties that are thought to be owing to, in part, to its antimicrobial activity. …”
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Protein structural domain-disease association prediction based on heterogeneous networks by Jingpu Zhang, Lianping Deng, Lei Deng

“…Abstract Background Domains can be viewed as portable units of protein structure, folding, function, evolution, and design. …”
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High-Coverage Profiling of Hydroxyl and Amino Compounds in Sauce-Flavor Baijiu Using Bromine Isotope Labeling and Ultra-High Performance Liquid Chromatography–High-Resolution Mass... by Zixuan Wang, Youlan Sun, Tiantian Chen, Lili Jiang, Yuhao Shang, Xiaolong You, Feng Hu, Di Yu, Xinyu Liu, Bo Wan, Chunxiu Hu, Guowang Xu

“…In this study, we developed a novel bromine isotope labeling approach combined with ultra-high performance liquid chromatography–high-resolution mass spectrometry (UHPLC-HRMS) to achieve high-coverage profiling of these compounds in sauce-flavor Baijiu. <b>Methods</b>: The method employs 5-bromonicotinoyl chloride (BrNC) for rapid (30 s) and mild (room temperature) labeling of hydroxyl and amino functional groups, utilizing bromine’s natural isotopic pattern (Δ<i>m</i>/<i>z</i> = 1.998 Da) for efficient screening. …”
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THROMBOLYTIC AND ANTICOAGULANT THERAPY FOR PULMONARY EMBOLISM: AN EFFECT ON PULMONARY PERFUSION (PART 2) by O. V. Nikitina, I. P. Mikhailov, N. Y. Kudryashova, E. V. Migunova, O. A. Alekseyechkina, E. V. Kungurtsev, N. M. Udalova, S. Z. Khusainov, I. B. Kostyuchenko

“…Background. Perfusion scintigraphy reveals perfusion defects in the occlusion of pulmonary vessels of any caliber and makes it possible to quantify pulmonary blood flow disorders, which allows the method to be used for the comparison of the thrombolytic and anticoagulant therapy efficacy in patients with acute pulmonary embolism.Aim of study .To compare the efficacy of thrombolytic and anticoagulant therapy in the treatment of acute pulmonary embolism in the dynamics of pulmonary perfusion disorders.Study Design. …”
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The Application of S-Substituted Pteridine for CCl₄-Induced Acute Hepatitis Treatment in Rats by Natalia Lohvinenko, Volodymyr Shvets, Oleksii Antypenko, Oleksii Voskoboinik, Andrii Bozhkov, Hanna Maslak, Valentyn Oksenych, Oleksandr Kamyshnyi, Sergiy Okovytyy, Serhii Kovalenko

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