Numerical Simulation Study on Stability Control Technology of Large-Area Wall Caving Area (LAWCA) in Large-Inclined Face by Xun Liu, Shihao Tu, Hongsheng Tu, Long Tang, Jieyang Ma, Yan Li, Wenlong Li, Kaijun Miao, Hao Tian

“…The research results show that when the water-cement ratio of the backfill is 3 : 1, the simulation and field trial results are good, and the safe and efficient mining of the large-angle composite roof working face is realized, which verifies the feasibility and correctness of the coupled simulation method. …”
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Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma by Akihiko Kawahara, Jun Akiba, Hirohisa Yano, Ambrogio Fassina, Rocco Cappellesso, Yoshiki Naito, Maria Guido, Paolo Simioni, Giuliana Cortese, Lorenzo Nicolè, Tiziana Sanavia, Valeria Maffeis, Claudia Maria Radu, Davide Serafin, Giacomo Zanus

“…Background Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second leading cause of cancer-related deaths worldwide. …”
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Visceral adiposity loss is associated with improvement in cardiometabolic markers: findings from a dietary intervention study by Shazana Rifham Abdullah, Ahmad Kamil Nur Zati Iwani, Liyana Ahmad Zamri, Ruziana Mona Wan Mohd Zin, Norhashimah Abu Seman, Nur Azlin Zainal Abidin, Siti Sarah Hamzah, Nur Hayati Azizul, Azahadi Omar, Zamtira Seman, Abqariyah Yahya, Mohd Fairulnizal Md Noh

“…BackgroundVisceral adiposity is closely linked with cardiometabolic disorders, but evidence on the extent of visceral fat loss required for significant improvement in cardiometabolic markers remains limited. …”
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Coral microbiome in estuary coral community of Pearl River Estuary: insights into variation in coral holobiont adaptability to low-salinity conditions by Mengling Lan, Kaixiang Gao, Zhenjun Qin, Zhanhong Li, Ru Meng, Lifei Wei, Biao Chen, Xiaopeng Yu, Lijia Xu, Yongzhi Wang, Kefu Yu

“…Abstract Background Low salinity is a crucial environmental stressor that affects estuarine coral ecosystems considerably. …”
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Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus by Jingxuan Qiu, Yiwen Wei, Jiayi Shu, Wenjing Zheng, Yuxi Zhang, Junting Xie, Dong Zhang, Xiaochuan Luo, Xiulan Sun, Xin Wang, Sijie Wang, Xuanyi Wang, Tianyi Qiu

“…Abstract Background Norovirus (NoVs) is a foodborne pathogen that causes acute gastroenteritis. …”
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The effect of amycretin, a unimolecular glucagon-like peptide-1 and amylin receptor agonist, on body weight and metabolic dysfunction in mice and ratsResearch in context by Rune Ehrenreich Kuhre, Borja Ballarín-González, Christian Lehn Brand, Tine Glendorf, Kim Grimstrup Madsen, Karina Rahr Hjøllund, Wouter Frederik Johan Hogendorf, David Højland Ipsen, Sofia Lundh, Thomas Kruse, Signe Beck Petersen, Anna Secher, Andreas Vegge, Kirsten Raun

“…Summary: Background: Amycretin is a novel unimolecular glucagon-like peptide-1 (GLP-1) and amylin receptor agonist. …”
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Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…Background Chimeric antigen receptor (CAR)-T cells face many obstacles in solid tumor therapy, including heterogeneous antigen expression and inefficient T cell persistence. …”
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Prevalence and Clinical Impact of Obstructive Sleep Apnea in Patients with Severe Aortic Stenosis Undergoing Valve Replacement by Hilary Miranda-Mendoza, Luis M. Amezcua-Guerra, Gustavo Rojas-Velasco, Daniel Manzur-Sandoval, Jennifer Escobar-Alvarado, Luis Chávez-Sánchez, Wendy G. Vázquez-González, Laura L. Rodríguez Chávez, Humberto Martínez Hernández, Malinalli Brianza-Padilla

“…<b>Background/Objectives</b>: Aortic stenosis (AS) is the most prevalent valvular disease among older adults. …”
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Orange Peel <i>Lactiplantibacillus plantarum</i>: Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity by Elisa Corazza, Asia Pizzi, Carola Parolin, Barbara Giordani, Angela Abruzzo, Federica Bigucci, Teresa Cerchiara, Barbara Luppi, Beatrice Vitali

“…<b>Background/Objectives:</b> Due to the high frequency and severity of upper respiratory bacterial infections, probiotics could offer a new medical approach. …”
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PD-L1 deficiency exacerbates colitis severity by remodeling gut microbiota in inflammatory bowel disease by Yixian Ma, Yixian Ma, Yixian Ma, Jinshan Suo, Siqi Sheng, Siqi Sheng, Siqi Sheng, Ling Chen, Ling Chen, Ling Chen, Ling Chen

“…As an essential immune checkpoint, Programmed death-ligand 1 (PD-L1) has been implicated in modulating gut microbiota composition. However, the precise role of PD-L1 in shaping metagenomic profiles during IBD-associated colitis remains unexplored.MethodsDSS-induced colitis was established in both PD-L1 knockout (Pdcd1lg1-/-) mice and wild-type (wt) control mice. …”
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Progression to fibrosis and hepatocellular carcinoma in DEN CCl4 liver mice, is associated with macrophage and striking regulatory T cells infiltration by Ananya Ajith, Jonathan Evraerts, Caroline Bouzin, Davide Brusa, Makram Merimi, Mehdi Najar, Mehdi Najar, Françoise Smets, Etienne Sokal, Mustapha Najimi

“…This study investigates immune dysregulation that occurs during the progression of CLD to HCC by delineating changes in immune cell composition and distribution within the liver microenvironment.MethodsMice were injected with Diethylnitrosamine (DEN) at 4 weeks of age, followed by continuous tri-weekly injections of carbon tetrachloride (CCl4) for 6 and 21 weeks to induce liver fibrosis and HCC. …”
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Evaluation of the immunomodulatory effects of a novel synbiotic made of combined use of probiotic-prebiotic-Chinese traditional herbs by Deshan Ning, Yiru Huang, Yulong Zhou, Hongwei Zhao, Wenlei Nie, Yu Zheng, Xiaojun Huang

“…Background: Recent studies have discussed the preferred activity of synbiotics, which are a combination of probiotics and prebiotics. …”
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Major Adverse Kidney Events in Hospitalized Older Patients With Acute Kidney Injury: Machine Learning–Based Model Development and Validation Study by Xiao-Qin Luo, Ning-Ya Zhang, Ying-Hao Deng, Hong-Shen Wang, Yi-Xin Kang, Shao-Bin Duan

“… BackgroundAcute kidney injury (AKI) is a common complication in hospitalized older patients, associated with increased morbidity, mortality, and health care costs. …”
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High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy by Hanxiang Xu, Shizhuo Mu, Jingxuan Bao, Christos Davatzikos, Haochang Shou, Li Shen

“…Abstract Background Alzheimer’s disease (AD) is a complex disorder that affects multiple biological systems including cognition, behavior and physical health. …”
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Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells With Early Antibody-mediated Rejection in Kidney Transplant Recipients by Dania Altulea, MSc, Joost van den Born, MD, PhD, Theo Bijma, BSc, Carlo Bonasia, MSc, Nanthicha Inrueangsri, MSc, Rosa Lammerts, MD, PhD, Stefan Berger, MD, PhD, Peter Heeringa, PhD, Jan-Stephan Sanders, MD, PhD

“…Background. B cells play a crucial role in kidney transplantation through antibody production and cytokine secretion. …”
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The evolution of sprinting performance: Technological and regulatory influences from 1976 to 2024 by Dariusz Tadeusz SKALSKI, Magdalena PROŃCZUK, Kinga ŁOSIŃSKA, Ewelina LULIŃSKA, Joanna MOTOWIDŁO, Petr STASTNY, Adam MASZCZYK, Grzegorz TRYBEK

“…Background: This study examines the progression of sprinting performance across the 100m, 200m, and 400m events from 1976 to 2024, highlighting the influence of technological advancements and regulatory changes. …”
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Characteristics of the gut virome in patients with premalignant colorectal adenoma by Pan Zhang, Xiaofeng Tuo, Jiong Jiang, Yue Zhang, Juhui Zhao, Chengzhao Deng, Gang Zhao, Yan Cheng, Lingqin Song, Yan Yang, Ruochun Guo, Huan Zhang, Hongli Zhao, Shiyang Ma, Lu Li, Haitao Shi

“…Methods Based on the Metagenomic Gut Virus catalogue (MGV) containing 54,118 non-redundant gut viral genomes, this study characterized the virome composition and diversity using publicly available metagenomic sequencing data from 419 individuals with premalignant colorectal adenoma and 552 healthy controls. …”
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Fecal profiling reveals a common microbial signature for pancreatic cancer in Finnish and Iranian cohorts by Heidelinde Sammallahti, Sama Rezasoltani, Satu Pekkala, Arto Kokkola, Hamid Asadzadeh Agdaei, Mehdi Azizmohammad Looha, Reza Ghanbari, Farhad Zamani, Amir Sadeghi, Virinder Kaur Sarhadi, Marja Tiirola, Pauli Puolakkainen, Sakari Knuutila

“…The inadequacy of current screening methods has prompted investigations into stool-based assays and microbial classifiers as potential early detection markers. …”
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Enhancement of oxaliplatin efficacy and amelioration of intestinal epithelial damage by Lactobacillus rhamnosus GG through modulation of gut microbiota by Zijie Zhang, Zijie Zhang, Rui Li, Yilin Ren, Yilin Ren, Yalan Ni, Yalan Ni, Xiaoyu Shen, Xiaoyu Shen, Deli Yi, Deli Yi, Zheng-hong Xu, Yan Geng, Yan Geng, Qingjun You, Qingjun You

“…BackgroundNon-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide, necessitating extensive research into effective treatment strategies. …”
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Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation by Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo

“…This study aimed to examine the molecular mechanisms underlying the involvement of NSUN2 in immune evasion and metabolic reprogramming of HCC. Methods Single‐cell transcriptomic sequencing was applied to examine cellular composition changes, particularly immune cell dynamics, in HCC and adjacent normal tissues. …”
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