Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu

“…Background and Objectives: Rectal cancer management increasingly relies on watch-and-wait strategies after neoadjuvant chemoradiotherapy (nCRT). …”
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Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude by Feng Zeng, Hanxue Li, Yan Ma, Yan Ma, Shuang Ma, Shuang Ma

“…BackgroundLong-term exposure to high-altitude hypoxia can lead to cognitive impairment, yet the role of the gut microbiota in this process remains unclear. …”
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Evaluating Medical Entity Recognition in Health Care: Entity Model Quantitative Study by Shengyu Liu, Anran Wang, Xiaolei Xiu, Ming Zhong, Sizhu Wu

“… BackgroundNamed entity recognition (NER) models are essential for extracting structured information from unstructured medical texts by identifying entities such as diseases, treatments, and conditions, enhancing clinical decision-making and research. …”
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Randomized Clinical Evaluation of the Healing Activity of Green Propolis Ointment in Individuals with Lower Limb Ulcers Resulting from Leprosy: Preliminary Results of a Pilot Study by Cristiano da Rosa, Larissa Kaori Maquedano, Ian Lucas Bueno, Fernando Augusto Lima Marson, Giovanna Barbarini Longato

“…<b>Background/Objectives:</b> Treating chronic wounds incurs substantial costs for Brazil’s Unified Health System. …”
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Determination of pKA of nonvolatile weak acids in plasma of healthy volunteers and critically ill patients by Martin Krbec, Serena Brusatori, Petr Waldauf, Alberto Zanella, Francesco Zadek, Victor van Bochove, František Duška, Thomas Langer, Paul Elbers

“…Abstract Background The dissociation constant of nonvolatile weak acids in plasma (KA), expressed as pKA, is essential for electroneutrality-based acid–base analysis. …”
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Tertiary lymphoid structures correlate with the therapeutic efficacy and prognosis of resectable esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy plus im... by Ke Zhai, Ru Xie, Kun Ru, Miaoqing Zhao

“…We explored TLS characteristics and correlated them with patient survival.MethodsA total of 157 resectable ESCC patients treated with neoadjuvant therapy between September 2020 and May 2023 were divided into NRCI (n=49) and neoadjuvant chemoimmunotherapy (NCI, n=108) groups. …”
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Exploring the bacterial communities in date palm roots in saline versus non-saline environment by Shafeeq Rahman, Manzoor Ahmad, Mughair Abdul Aziz, Taif Ibrahim Alrayssi, Asma Saleh Mohammad, Reem Alothman, Khaled Masmoudi

“…Abstract Background Bacterial communities associated with plant roots significantly influence plant growth and adaptation to environmental stresses, particularly in arid agroecosystems. …”
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Osteogenic and Antibacterial Response of Levofloxacin-Loaded Mesoporous Nanoparticles Functionalized with <i>N</i>-Acetylcysteine by Alberto Polo-Montalvo, Natividad Gómez-Cerezo, Mónica Cicuéndez, Blanca González, Isabel Izquierdo-Barba, Daniel Arcos

“…These nanoparticles would present antibacterial activity able to disintegrate the biofilm and regenerate the peri-implantar osseous tissue. <b>Methods</b>: MBGN of composition 82.5 SiO₂—17.5 CaO have been synthesized, loaded with levofloxacin, and functionalized with NAC (MBGN-L-NAC). …”
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Global burden of gallbladder and biliary diseases (1990–2021) with healthcare workforce analysis and projections to 2035 by Fangyi Dai, Yuzhou Cai, Shangjin Yang, Jingyang Zhang, Yong Dai

“…Abstract Background Gallbladder and biliary tract diseases pose a significant global health burden, yet comprehensive analyses of their long-term epidemiological trends and future projections remain limited. …”
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Evaluation of the Cytotoxicity, Genotoxicity and Acute Oral Toxicity of <i>Thymus longicaulis</i> subsp. <i>chaubardii</i> (Rchb.f.) Jalas by Ayfer Beceren, Ayse Nur Hazar-Yavuz, Ozlem Bingol Ozakpinar, Duygu Taskin, Ismail Senkardes, Turgut Taskin, Ozlem Tugçe Cilingir-Kaya, Ahmad Kado, Elif Caliskan Salihi, Hatice Kubra Elcioglu

“…The aim of this study was to determine its phytochemical profile and to evaluate its cytotoxic, genotoxic and acute oral toxicity effects. <b>Methods</b>: The phenolic composition of the methanolic extract was determined by HPLC-DAD. …”
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Gut microbiota dysbiosis in patients with Alzheimer’s disease and correlation with multiple cognitive domains by Qionglei Chen, Jiayu Shi, Gaojie Yu, Huijia Xie, Shicheng Yu, Jin Xu, Jiaming Liu, Jing Sun

“…The aim of this study was to explore microbial signatures associated with global cognition and specific cognitive domains in AD patients and to determine their predictive value as biomarkers.MethodsA total of 64 subjects (18 mild AD, 23 severe AD and 23 healthy control) were recruited in the study. 16 s rDNA sequencing was performed for the gut bacteria composition, followed by liquid chromatography electrospray ionization tandem mass spectrometry (LC/MS/MS) analysis of short-chain fatty acids (SCFAs). …”
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Association analysis-based screening strategy for quality markers of Tengdan capsule in the treatment of hypertensive renal disease by Jing Liu, Jun Li, Wei Zhang, Yu Dong, Fang Wang, Jinzhe Liu, Yong Wang, Qian Zhang, Xiaoli Du

“…This study aimed to identify candidate Q-markers of TDC and elucidate the molecular pathways through which it exerts its renoprotective effects, using an integrative association analysis-based approach.MethodsThe chemical composition of TDC and its potential Q-markers were systematically characterized through in vitro and in vivo profiling using HPLC-Q-Exactive-MS and chromatographic fingerprinting. …”
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Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis by Zulong Sheng, Yi Fan, Zhenjun Ji, Yanru He, Rui Zhang, Yuyu Yao, Genshan Ma

“…Abstract Background Atherosclerosis (AS) is a chronic cardiovascular disease characterized by lipid accumulation and inflammation within arterial walls, leading to plaque formation and cardiovascular events. …”
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CXCL12/CXCR4 axis governs Treg spatial dominance over CD8+ T cells via IL-2 sequestration: a dual therapeutic target in prostate cancer by Junyi Li, Long Zhang, Ruoyang Liu, Changwen Xu, HuiHui Tang, Yunfei Zou, Qingfei Cao, Weichao Huang

“…BackgroundProstate cancer (PCa) is characterized by high incidence and recurrence rates, presenting as an immune ‘cold’ tumor that exhibits a poor response to immunotherapy. …”
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Muscle Mass Index Decline as a Predictor of Lung Function Reduction in the General Population by Joon Young Choi, Chin Kook Rhee, Sang Hyuk Kim, Yong Suk Jo

“…We aimed to clarify this dynamic relationship by examining how changes in muscle mass impact pulmonary function and the development of respiratory symptoms. Methods We utilized the Ansan and Ansung Cohort Study of the Korean Genome and Epidemiology Study (KoGES) database, a large‐scale prospective cohort, enrolling participants aged 40 to 69 years with lung function and body composition measurements. …”
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Relationship between dietary protein intake and serum essential free amino acid concentrations in Japanese pregnant women: an observational study by Takuya Shibasaki, Hirohiko Nakamura, Takuya Kamimura, Fuka Tabata, Satomi Kawakami, Mayumi Inubashiri, Masayoshi Hosaka, Kiwamu Noshiro, Takeshi Umazume, Kazuhiro Miyaji

“…Abstract Background Insufficient protein intake decreases serum free amino acid (FAA) concentrations and worse whole-body nutritional status, leading to poor pregnancy outcomes. …”
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Early and Late Responses of Cultured Human Mesenchymal Stem Cells (MSCs) to Cell-free DNA (cfDNA) in Patients With Acute Myocardial Infarction by Elena M. Malinovskaya, Natalia N. Veiko, Elisaveta S. Ershova, Larisa V. Kameneva, Marina S. Konkova, Svetlana V. Kostyuk

“…Background: Acute myocardial infarction (AMI) is accompanied by damage to heart tissues and some cell death. …”
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The GD3 ganglioside promotes cell growth, plasticity and chemotherapy resistance of human glioblastoma cancer stem cells by Victoria Hein, Nathalie Baeza-Kallee, Raphaël Bergès, Nora Essakhi, Aurélie Soubéran, Carole Colin, Philippe Morando, Romain Appay, Thomas Graillon, Aurélie Tchoghandjian, Dominique Figarella-Branger, Emeline Tabouret

“…Abstract Background Glioblastoma is the most aggressive primary brain tumour with no curative treatment and inevitable relapse. …”
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Evaluating the effects of a resistance exercise intervention for sarcopenia in patients receiving neoadjuvant chemotherapy for breast cancer: study protocol for a randomized contro... by Min Kyeong Jang, Seho Park, Justine Y. Jeon, Min Jae Kang, Chang Park, Ardith Z. Doorenbos, Sue Kim

“…Abstract Background Sarcopenia is highly prevalent among people being treated for various types of cancers and is associated with adverse clinical impacts including postoperative complications, chemotherapy-related toxicities, and poor survival. …”
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Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model by Anna Kamlárová, Monika Kvaková, Ľuboš Ambro, René Link, Izabela Bertková, Zdenka Hertelyová, Martin Janíčko, Emília Hijová, Jana Štofilová

“…Abstract Background Fecal microbiota transplantation (FMT) seems to be a promising approach in ulcerative colitis (UC) management with the aim of repopulating a patient’s dysbiotic microbiota with beneficial bacteria and restore its metabolic activity to its healthy characteristics. …”
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