Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway by Ana Merino-Vico, Merve Kocyigit, Giulia Frazzei, Lisa Landman, Louis Boon, Ester M. van Leeuwen, Ingrid E. Lundberg, Anneke J. van der Kooi, Joost Raaphorst, Jan Piet van Hamburg, Sander W. Tas

“…Abstract Background Idiopathic inflammatory myopathies (IIM) are autoimmune disorders characterized by muscle inflammation and autoreactive B cell responses. …”
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Immunogenic Activity of Secreted Protein-Based Compounds Staphylococcus aureus № 6 by I. M. Gruber, E. A. Astashkina, O. V. Lebedinskaya, N. B. Egorova, M. V. Kiselevsky, F. V. Donenko, N. E. Yastrebova, O. M. Ignatova, E. A. Kurbatova, L. S. Cherkasova

“…Difficulties in the therapy of infection, caused by S. aureus, depends on the resistance of staphylococci to antibiotics, proceeding to chronicity of the diseases and the development on that background the depression of innate immunity functions and decreasing of the host resistance to the infection. …”
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Gut Microbiota Dysbiosis in Japanese Female Patients with Nontuberculous Mycobacteria-Associated Lung Disease: An Observational Study by Kanako Kono, Yutaka Kozu, Shun Yokota, Kouta Hatayama, Kenji Mizumura, Shuichiro Maruoka, Hiroaki Masuyama, Yasuhiro Gon

“…We aimed to investigate the association between NTM-PD and gut microbiota and determine the impact of antimicrobial therapy on the composition of the gut microbiota. <b>Methods:</b> We analyzed the gut microbiota of 20 Japanese females with NTM-PD (mean age: 67.9 years; range: 50–80 years) at different treatment stages—before, during, and at recurrence—alongside 20 healthy individuals, using 16S rRNA gene amplicon sequencing. …”
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Streptococcus pneumoniae serotype 33H: a novel serotype with frameshift mutations in the acetyltransferase gene wciG by Sam Manna, Belinda D. Ortika, Joel P. Werren, Casey L. Pell, Ilche Gjuroski, Stephanie W. Lo, Jason Hinds, Odgerel Tundev, Eileen M. Dunne, Bradford D. Gessner, Fiona M. Russell, E. Kim Mulholland, Tuya Mungun, Claire von Mollendorf, Stephen D. Bentley, Markus Hilty, Neil Ravenscroft, Catherine Satzke

“…Abstract Background Streptococcus pneumoniae (the pneumococcus) is a leading cause of community-acquired pneumonia. …”
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Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study by Xiaohua Hu, Xianwu Ye, Haimin Chen, Bibo Wu, Qi Guo, Chen Yu, Wei Ding, Jianying Niu, Junli Zhao, Hualin Qi, Suhua Zhang, Cheng Xue, Liming Zhang

“…Despite the prevalence of these conditions, the interrelationships among them remain poorly understood in HD patients. Methods In this multicenter cross-sectional study, 858 HD patients from 7 dialysis centers were recruited. …”
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PM2.5 exposure reprograms cell cycle dynamics in uterine immune cells at single-cell resolution by Lin Zhang, Lin Zhang, Lin Zhang, Jiaqi Tian, Jiaqi Tian, Jiaqi Tian, Yongfei Zheng, Shuyin Duan

“…BackgroundFine particulate matter (PM2.5) exposure has been associated with adverse effects on reproduction, yet the underlying cellular mechanisms remain poorly understood.MethodsUsing single-cell RNA sequencing, we systematically investigated cell cycle dynamics of immune cell populations in the mouse uterus following PM2.5 exposure. …”
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Changes in Cytokines and Fibrotic Growth Factors after Low-Carbohydrate or Low-Fat Low-Energy Diets in Females with Lipedema by Julianne Lundanes, Vilde Fiske Nes, Oda Aakervik, Liv Ryan, Patrik Hansson, Anne Mari Rokstad, Catia Martins, Siren Nymo

“…Background: Lipedema is considered an inflammation-related disease, and low-carbohydrate ketogenic diets may help reduce inflammation. …”
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<i>Cystoseira spinosa</i> Polysaccharide: A Promising Natural Source for Antioxidant, Pro-Angiogenic, and Wound Healing Applications: In Silico Study by Mouhamed Ayad Berfad, Intissar Kammoun, Marwa Lakhrem, Zakaria Boujhoud, Malek Eleroui, Manel Mellouli, Saadia Makni, Majed Kammoun, Riadh Badraoui, Jean Marc Pujo, Hatem Kallel, Ibtissem Ben Amara

“…Collected off the coast of Alkhoms, Libya, PCS was investigated for its wound-healing and pro-angiogenic properties, addressing the need for natural bioactive compounds in therapeutic applications. <b>Methods:</b> The monosaccharide composition of PCS was analyzed using HPLC-RID, identifying glucuronic acid and xylose as major components. …”
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Microbiome multi-omics analysis reveals novel biomarkers and mechanisms linked with CD etiopathology by Gerard Serrano-Gómez, Francisca Yañez, Zaida Soler, Marc Pons-Tarin, Luis Mayorga, Claudia Herrera-deGuise, Natalia Borruel, Antonio Rodriguez-Sinovas, Marta Consegal, Isaac Manjón, Sara Vega-Abellaneda, Chaysavanh Manichanh

“…Abstract Background The gut microbiome plays a key role in the development of inflammatory bowel disease (IBD), as imbalances in microbial composition are associated with immune dysfunction. …”
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Probiotic supplementation modifies the gut microbiota profile of very low birth weight preterm infants during hospitalization by Hung-Yang Chang, Chia-Ying Lin, Jen-Shiu Chiang Chiau, Jui-Hsing Chang, Chyong-Hsin Hsu, Mary Hsin-Ju Ko, Hung-Chang Lee

“…Background: Probiotic supplementation is increasingly being given to very low birth weight (VLBW) preterm infants. …”
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Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function by Agnieszka Żak-Bochenek, Paulina Żebrowska-Różańska, Joanna Bajzert, Łukasz Łaczmański, Bogumiła Szponar, Natalia Siwińska, Klaudia Gładysz, Katarzyna Sikorska, Anna Chełmońska-Soyta

“…BackgroundOral probiotic dietary supplements are widely used in veterinary medicine, including in horses. …”
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Citrus flavonoid supplement enhances glycemic and metabolic control in prediabetic patients on metformin: a randomized controlled trial by Thais Cesar, Maria Rita Oliveira, Valeria Sandrim, Adriana Mendes, Ricardo Bruder, Rogerio Oliveira, Katia Sivieri, Katia Sivieri, Dragan Milenkovic

“…Background and objectiveCombining natural compounds with conventional drugs is an emerging strategy to improve the management of type 2 diabetes and its precursor, prediabetes. …”
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Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics by Jinhua Chi, Jeffrey S. Patterson, Yan Jin, Kyle Joohyung Kim, Nicole Lalime, Daniella Hawley, Freeman Lewis, Lingjun Li, Xuan Wang, Matthew J. Campen, Julia Yue Cui, Haiwei Gu

“…<b>Background</b>: Microplastics (MPs) are small plastic fragments with diameters less than 5 mm in size and are prevalent in everyday essentials and consumables. …”
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Metagenomic Insights into Microbial Signatures in Thrombi from Acute Ischemic Stroke Patients Undergoing Endovascular Treatment by Kasthuri Thirupathi, Sherief Ghozy, Abdullah Reda, Wasantha K. Ranatunga, Mars A. Ruben, Zarrintan Armin, Oana M. Mereuta, Sekhon Prabhjot, Daying Dai, Waleed Brinjikji, David F. Kallmes, Ramanathan Kadirvel

“…<b>Background:</b> Variability in recanalization success during endovascular treatment for acute ischemic stroke (AIS) has led to increased interests in thrombus composition and associated cellular materials. …”
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Temporal Changes in Epicardial Adipose Tissue and Left Atrial Substrate After Atrial Fibrillation Ablation: Implications for Procedural Success by Ryuta Watanabe, Katsuaki Yokoyama, Koichi Nagashima, Moyuru Hirata, Shu Hirata, Yuji Wakamatsu, Masanaru Sawada, Sayaka Kurokawa, Atsushi Ikeda, Kenta Murotani, Naoya Matsumoto, Yasuo Okumura

“…Methods A prospective 2‐part study was conducted. …”
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Gut microbiota characteristics in neonatal respiratory distress syndrome and the therapeutic potential of probiotics in recovery by Yongcheng Fu, Xiujuan Wang, Lintao Nie, Zhaorui Wang, Xiao Ma, Lijia Wu, Liping Han, Wenjun Fu, Ruoming Wang, Hongyan Ren, Da Zhang, Juan Ding

“…This study aims to investigate the gut microbiota characteristics in NRDS and the potential regulatory role of probiotics in restoring gut microbiota dysbiosis.MethodsThis study enrolled 55 PTIs diagnosed with NRDS and 26 preterm infants without NRDS. …”
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Host-specific effects of Eubacterium species on Rg3-mediated modulation of osteosarcopenia in a genetically diverse mouse population by Soyeon Hong, Bao Ngoc Nguyen, Huitae Min, Hye-Young Youn, Sowoon Choi, Emmanuel Hitayezu, Kwang-Hyun Cha, Young Tae Park, Choong-Gu Lee, GyHye Yoo, Myungsuk Kim

“…Abstract Background Osteosarcopenia, characterized by the simultaneous loss of bone and muscle mass, is a serious health problem in the aging population. …”
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ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…Abstract Background Prostate cancer (PrCa) is a significant health concern, ranking as the second most common cancer in males globally. …”
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Using the Nutri-Score to visualise food reformulation in Germany: the case of breakfast cereals by Corinna Gréa, Anna Dittmann, David Wolff, Hanna Haidar, Silvia Roser, Benedikt Merz, Stefan Storcksdieck genannt Bonsmann

“…Abstract Background The reformulation of commonly consumed foods towards less sugar, fat, and salt is an important public health strategy to improve food choices of consumers and thus address the high prevalence of overweight and obesity. …”
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Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer by Zhe Zhao, Kailun Fei, Hua Bai, Zhijie Wang, Jianchun Duan, Jie Wang

“…Background The gut microbiome is important in the development and immunotherapy efficacy of lung cancer. …”
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