Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes by Sara Gutiérrez Fernández, Cristina Gan Oria, Dieter Petit, Wim Annaert, John M. Ringman, Nick C. Fox, Natalie S. Ryan, Lucía Chávez-Gutiérrez

“…Abstract Background Autosomal Dominant Alzheimer's Disease (ADAD), caused by mutations in Presenilins (PSEN1/2) and Amyloid Precursor Protein (APP) genes, typically manifests with early onset (< 65 years). …”
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Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation... by Huihui Gao, Hangming Bai, Yanyan Su, Yuting Gao, Hui Fang, Donghang Li, Youren Yu, Xing Lu, Dasheng Xia, Daqing Mao, Yi Luo

“…This study aims to characterize BQT-induced gut microbiota alterations in asymptomatic H. pylori carriers and evaluate their effect on an ALD mouse model. Methods Metagenomic sequencing was conducted to assess the gut microbiota composition of individuals before and after BQT. …”
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Depot-specific metabolic and inflammatory profiles in perirenal and renal sinus adipose tissue by Maria J. Pereira, Argyri Mathioudaki, Susanne Hetty, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson

“…Abstract Background Alterations in kidney-associated adipose tissue depots, specifically renal sinus (RSAT) and perirenal adipose tissue (PRAT), may contribute to metabolic, cardiovascular, and chronic kidney diseases. …”
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Pharmacokinetics of levosimendan in critically Ill children on extracorporeal membrane oxygenation: a prospective observational study by Stéphane Bertin, David Haefliger, Maria-Helena Perez, Monia Guidi, Monia Guidi, Laurent A. Decosterd, Vivianne Chanez, Ermindo R. Di Paolo, Thierry Buclin, Françoise Livio

“…BackgroundLevosimendan is used off-label in pediatrics and pharmacokinetic (PK) data in this population are scarce. …”
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Morphofunctional status of parotid salivary glands in three-month-old rats with experimentally induced fetal macrosomia by O. V. Garmash, G. I. Gubina-Vakulyk

“…The aim of the study is to examine experimentally the features of postnatal morphogenesis of salivary glands in three-month-old rats born with macrosomia. Materials and methods. Somatometric data of the animals were examined at birth and after the experiment, which induced macrosomia of rat fetus with four different ways (high-calorie diet for young pregnant female specimens, high-calorie diet for mature pregnant female specimens, high-calorie diet and hypokinesia condition for young pregnant female specimens, increased placental-fetal blood supply on the background of normal living conditions for young pregnant female specimens). …”
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Biliary Microbial Community and Metabolic Potential in Patients with Multiple Common Bile Duct Stones by Xia T, Feng S, Zou Z, Zhou J, Cai X, Ye J, Dai C

“…In this study, we aimed to investigate the characteristics and metabolic potential of biliary microbiota in patients with multiple CBDS.Methods: Eligible patients were prospectively enrolled in this study at First Affiliated Hospital of Soochow University between December 2022 and October 2023. …”
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Fuzi alleviates cold-related rheumatoid arthritis via regulating gut microbiota and microbial bile acid metabolism by Juan Liu, Dandan Zhang, Yaochuan Zhou, Jinlu Wu, Wuwen Feng, Cheng Peng

“…Abstract Background Rheumatoid arthritis (RA) with cold pattern is an important type of RA according to the theory of traditional Chinese medicine. …”
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Is There an Association between Sodium-Based Additives and Total Sodium Content of Foods? by Carla Almeida, Eduarda Lopes, Patrícia Padrão

“…Background and objectives: Excessive sodium intake is a major public health issue. …”
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DMSO-free cryopreservation of hiPSC-derived cardiomyocytes: low temperature characterization and protocol development by Akshat S. Mallya, Tessa Burrows, Jeanne Hsieh, Troy Louwagie, James R. Dutton, Brenda M. Ogle, Allison Hubel

“…Abstract Background Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have attracted significant interest for use in disease modeling, drug discovery and potential therapeutic applications. …”
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Utilization of drug checking services in Austria: a cross-sectional online survey by Alexandra Karden, Tobias Fragner, Cornelia Feichtinger, Julian Strizek, Daragh T. McDermott, Igor Grabovac

“…Abstract Background The use of psychoactive substances is a key public health issue due to its impact on mental, physical, and social health. …”
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Using benthos a bioindicator to assess the efficiency constructed wetland community wastewater treatment system by K. Seethong, K. Chunkao, N. Dampin, W. Wararam

“…This study assesses the diversity, species composition, and distribution of benthic organisms in a community wastewater-filter grass system and explores the relationship between water quality and benthos.METHODS: Water samples were collected from plant plots between December 2021 and March 2022. …”
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Ethanol extract of propolis relieves exercise-induced fatigue via modulating the metabolites and gut microbiota in mice by Shan Huang, Xiaofei Yang, Jingxuan Ma, Chen Li, Yajing Wang, Zhaoxia Wu

“…BackgroundPropolis, a natural mixture rich in bioactive compounds, has shown the potential to relieve exercise-induced fatigue. …”
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Exercise Dose Effects on Body Fat 12 Months after an Exercise Intervention: Follow-up from a Randomized Controlled Trial by Christine M. Friedenreich, Yibing Ruan, Aalo Duha, Kerry S. Courneya

“…Background. Exercise interventions can result in weight loss, which is associated with reductions in disease risk. …”
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Effect of Seminal Plasma on the Freezability of Boar Sperm by Kuanfeng Zhu, Yukun Song, Zhi He, Peng Wang, Xuguang Wang, Guoshi Liu

“…Background: Seminal plasma is an important component of semen and has a significant effect on sperm function. …”
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SPECIALIZED PRODUCTS OF PROBIOTIC USE: QUALITY AND FUNCTIONALITY by Lobach E.Y., Gur'yanov Y.G., Poznyakovskiy V.M., Kostin A.N.

“…To achieve this goal we used generally accepted and special research methods determined by technical regulations [9]. The article reflects the prescription composition, organoleptic indices, and nutritional value of the developed products. …”
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Myostatin/Smad2/Smad3 pathway define a differential clinical phenotype in COPD-associated sarcopenia by Adriana Núñez-Robainas, Maria Guitart, Adrián López-Postigo, Antonio Sancho-Muñoz, Esther Barreiro

“…Background Sarcopenia, defined as the loss of muscle mass and function, represents one of the most relevant comorbidities in patients with COPD even at early stages. …”
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The mediating effect of parental monitoring in the association between parent–child relationship harmony and smartphone addiction: findings from a nationwide youth survey in China... by Ziyan Meng, Kaiyuan Min, Runping Ma, Juntao Yang, Hui Zhang, Qing li

“…Abstract Background The increasing prevalence of smartphone addiction among youth has raised concerns. …”
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Atf3 + senescent chondrocytes mediate meniscus degeneration in aging by Jing-Yi Wang, Yao-Hui Liu, Xiao Wang, Min Ma, Zhang-Yi Pan, Ao-Yuan Fan, Lai-Ya Lu, Zheng Liu, Kun Tao, Feng Yin

“…Abstract Background Meniscus degeneration contributes to knee arthritis progression, but the cellular and molecular mechanisms of meniscus aging remain poorly understood. …”
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A metric to measure long-term well-being of people living with HIV in Spain by María José Fuster-RuizdeApodaca, Trenton M. White, Carlos Prats-Silvestre, Francisco P. Holgado-Tello, Jeffrey V. Lazarus

“…Methods This study employs a Delphi consensus process with composite score analysis of cross-sectional survey data from 500 PLHIV in Spain. …”
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Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales’s testis by Jun Yu, Longfei Hu, Huixia Li, Xiaofeng Li, Chaoye Ma, Ting Jiang, Yongxin Liu, Xue Wang, Xia Li, Liandong Zuo, Haocheng Lin, Wenming Xu, Yiwen Zhou, Yang Liu, Hao Chen

“…However, the testicular impacts of feminising hormones present heterogeneity due to the complexity of testicular regulatory mechanisms. Method In this study, we analyzed approximately 49,385 single-cell transcriptomes from transfemale human testicular tissue, comparing cellular composition with that of cisgender male individuals across a range of ages. …”
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