Metabolic state uncovers prognosis insights of esophageal squamous cell carcinoma patients by Tingze Feng, Pengfei Li, Siyi Li, Yuhan Wang, Jing Lv, Tian Xia, Hoy-Jong Lee, Hai-Long Piao, Di Chen, Yegang Ma

“…Abstract Background Metabolite-protein interactions (MPIs) are crucial regulators of cancer metabolism; however, their roles and coordination within the esophageal squamous cell carcinoma (ESCC) microenvironment remain largely unexplored. …”
Get full text

IL-6R blockade combined with immunosuppressants alleviates adult-onset Still’s disease through immune remodeling: a mass cytometry study by Ruru Guo, Ting Zhang, Yixuan Li, Xuesong Liu, Xinyu Meng, Lei Tong, Xiaoxiang Chen, Xianting Ding, Liangjing Lu

“…Abstract Background Early administration of IL-6R blockade is effective in adult-onset Still’s disease (AOSD), but the underlying immune alterations during combined immunotherapy remain unclear. …”
Get full text

Predictive value of self-prioritized mobility factors on gait speed and life space in older nigerians: A cross-sectional study by Divine Esohe Eghomwanre, Freeman Ojeikere Ahonsi, Isreal Adandom, Tyler Sun, Daniel Rayner, Francis Kolawole, Henrietta Fawole, Soroush Shirazi, Michael Kalu

“…Background and Objectives: Eighty-two cognitive, environmental, financial, personal, physical, psychological, and social factors significantly influence mobility decline following hospital discharge. …”
Get full text

Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study by Muhammed Manzoor, Jaakko Leskelä, Milla Pietiäinen, Nicolas Martinez-Majander, Eija Könönen, Teemu Niiranen, Leo Lahti, Juha Sinisalo, Jukka Putaala, Pirkko J. Pussinen, Susanna Paju

“…However, its exact link to the oral microbiota remains unclear.Methods In a case-control study involving 120 participants, comprising 60 cases and 60 controls (mean age (SD) 36.6 (7.6) years; 50% males), nested within a prospective multicentre cohort study, we examined the oral microbiome composition of gingivitis patients and their controls using shotgun metagenomic sequencing of saliva samples. …”
Get full text

Long-Term Exercise Mitigates Energy Expenditure and Inflammatory Responses Induced by Sleep Deprivation in Mice by Tian-Shu Zheng, Xin-Ran Gao, Chen Gu, Yu-Ning Ru, Rui-Ping Xu, Yu-Hang Yang, De-Hua Wang

“…<b>Background</b>: Sleep deprivation (SD), defined as the disruption or loss of normal sleep, negatively affects energy metabolism, immune function, and gut microbiota in both humans and animals. …”
Get full text

Heat-health messaging in Canada: A review and content analysis of public health authority webpages and resources by Emily J. Tetzlaff, Katie E. Wagar, Sarah J.I. Johnson, Melissa Gorman, Glen P. Kenny

“…Background: With the growing threat posed by extreme heat, heat-health messaging communicated by public health authorities is critical for raising community awareness and action. …”
Get full text

Optimal Network Design for Municipal Waste Management: Application to the Metropolitan City of Rome by Marco Boresta, Anna Livia Croella, Claudio Gentile, Laura Palagi, Diego Maria Pinto, Giuseppe Stecca, Paolo Ventura

“…<i>Background:</i> This work is part of the regional research project PIPER—Intelligent Platform for the Optimization of Recycling Operations, which aims to develop a network design model for waste collection in the metropolitan city of Rome, Italy. …”
Get full text

Psychophysiological effects of a supervised home-based resistance band exercise program in pre-frail older patients with type 2 diabetes mellitus: a randomized controlled trial by Lin Hu, Haixia Feng, Jing Han, Qing Han, Yumin Zhang

“…Abstract Background Frailty is a syndrome as with aging in the population of type 2 diabetes mellitus (T2DM) and exercise has become an essential non-pharmacological tool especially in the pre-frail stage. …”
Get full text

The effect of Hydrogen-rich „Truskavetska” bottled water on the swimming stress test in female rats by Walery Zukow, Igor Popovych

“… Background and aim. Despite the use of drinking hydrogen rich water both in clinical and sports medicine, further research into the mechanisms of its beneficial effect remains relevant. …”
Get full text

The mechanism of Ningxin-Tongyu-Zishen formula regulating probdnf/mbdnf balance through PAI-1/tPA signaling pathway in the treatment of premature ovarian insufficiency by Jiawen Ma, Chaofan Zhu, Lifang Xie, Shuaiqi An, Zaiyang Zhang, Keying Wang, Yizhou Zhang

“…Abstract Background Premature ovarian insufficiency (POI) is a refractory gynecological endocrine disorder. …”
Get full text

Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK/STAT3 signaling and intestinal flora by Yingyin Liu, Nachuan Chen, Huaxing He, Lulin Liu, Suxia Sun

“…Background Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), can seriously impact patients’ quality of life. …”
Get full text

Overweight and obesity combined with low physical function and non-communicable diseases among older adults in nursing homes represent a group with nutritional risk, malnutrition,... by Tenna Christoffersen, Inge Tetens, Anja Weirsøe Dynesen, Margit Dall Aaslyng, Janne Kunchel Lorenzen, Anne Marie Beck

“…Background &amp; Aims: Older adults with overweight and obesity (overnutrition) may be overlooked in terms of nutritional risk. …”
Get full text

Dysbiosis and Metabolic Dysregulation of Salivary Microbiota in Schizophrenia by Wang J, Lu L, Ren L, Zhu R, Jiang Y, Qiao Y, Li Y

“…However, fewer studies have directly investigated the potential links between oral microbiota and SZ.Purpose: This study aimed to explore the relationship between salivary microbiota dysbiosis and SZ, examining microbial and metabolic alterations that may contribute to SZ pathophysiology.Methods: Salivary samples from 30 hospitalized patients diagnosed with SZ and 10 healthy controls were collected. …”
Get full text

Association of specific microbiota taxa in the amniotic fluid at birth with severe acute and longer-term outcomes of very preterm infants: a prospective observational study by Birte Staude, Silvia Gschwendtner, Tina Frodermann, Frank Oehmke, Thomas Kohl, Susanne Walch, Michael Schloter, Harald Ehrhardt

“…Abstract Background Dysbiotic microbial colonization predisposes to severe outcomes of prematurity, including mortality and severe morbidities like necrotizing enterocolitis (NEC), late-onset infection (LOI) and bronchopulmonary dysplasia (BPD). …”
Get full text

Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol. by Hui Liu, Fuliang Shangguan, Fen Liu, Yu Guo, Huixi Yu, Hanbing Li, Yinhua Su, Zhongyu Li

“…<h4>Background</h4>Time-restricted eating (TRE) manages weight effectively, but choosing how long and what time window remain debatable. …”
Get full text

Insights into infraspecific differentiation of the medicinally important species Bupleurum Chinense revealed by morphological and molecular evidence by Fang Li, Kaiying Ge, Rong Huang, Yi Lu, Huihui Lin, Yanfengyang Jiang, Enwei Tian, Zhi Chao

“…Abstract Background Radix Bupleuri, derived from the dried roots of Bupleurum chinense DC., is a well-documented phytomedicine in global pharmacopoeias and a common constituent in herbal formulations. …”
Get full text

Papain Affects the Percentage and Morphology of Microglia in Hippocampal Neuron–Glial Cultures by Ivan A. Tumozov, Valentina N. Mal’tseva, Sergei A. Maiorov, Artem M. Kosenkov, Sergei G. Gaidin

“…<b>Background.</b> Microglia, accounting for 5–15% of total brain cells, represent an essential population of glial cells in the cultures used for modeling neuroinflammation in vitro. …”
Get full text

Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia by Tiantian Xia, Ziqiao Yan, Pan Shen, Mingyang Chang, Nan Zhang, Yunan Zhang, Qi Chen, Rui Wang, Li Tong, Wei Zhou, Zhexin Ni, Yue Gao

“…<b>Background/Objectives</b>: High-altitude environments have a significant detrimental impact on the cognitive functions of the brain. …”
Get full text

Effect of Acoustic Pressure on Temozolomide-Loaded Oleic Acid-Based Liposomes and Its Safety to Brain Tissue by Vasilisa D. Dalinina, Vera S. Shashkovskaya, Iman M. Khaskhanova, Daria Yu. Travnikova, Nelly S. Chmelyuk, Dmitry A. Korzhenevskiy, Vsevolod V. Belousov, Tatiana O. Abakumova

“…In this study, we developed liposomal formulations with optimized temozolomide (TMZ)’s loading and analyze its response to focused ultrasound (FUS). <b>Methods</b>: We synthetized OA-based liposomes with different lipid composition, performed physicochemical characterization (DLS, TEM) and analyzed the TMZ loading efficiency. …”
Get full text

Long-read 16S rRNA amplicon sequencing reveals microbial characteristics in patients with colorectal adenomas and carcinoma lesions in Egypt by Asmaa A. El Leithy, Amira Salah El-Din Youssef, Auhood Nassar, Ramy K. Aziz, Nadin M. Khaled, Mina T. Mahrous, Ghobrial N. Farahat, Aya H. Mohamed, Yasser Mabrouk Bakr

“…Abstract Background Colorectal cancer (CRC) is among the five leading causes of cancer incidence and mortality. …”
Get full text