Epigenetic Changes Regulating Epithelial–Mesenchymal Plasticity in Human Trophoblast Differentiation by William E. Ackerman IV, Mauricio M. Rigo, Sonia C. DaSilva-Arnold, Catherine Do, Mariam Tariq, Martha Salas, Angelica Castano, Stacy Zamudio, Benjamin Tycko, Nicholas P. Illsley

“…Characterization of the normal differentiation processes is, thus, essential for the analysis of these pathologies. …”
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The interplay between epigenomic and transcriptomic variation during ecotype divergence in stickleback by Man Luo, Junjie Zhao, Juha Merilä, Rowan D. H. Barrett, Baocheng Guo, Juntao Hu

“…Despite significant genome-wide associations between epigenomic and transcriptomic variation, we found largely non-parallel patterns of ecotype divergence across epigenomic and transcriptomic levels, with predominantly nonoverlapping (ranging from 43.40 to 87.98%) sets of differentially expressed, spliced and methylated genes, and candidate genes targeted by differentially expressed miRNA between the ecotypes. …”
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Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity by Carlos M. Díaz-Domínguez, Hasier Eraña, Francesca Peccati, Enric Vidal, Jorge M. Charco, Cristina Sampedro-Torres-Quevedo, Miguel A. Pérez-Castro, Nuria L. Lorenzo, Samanta Giler, Glenn C. Telling, Mariví Geijo, Jesús R. Requena, Gonzalo Jiménez-Osés, Joaquín Castilla

“…In many cases, specific polymorphisms of the proteins associated with these diseases influence their misfolding. …”
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Epigenetic regulation of bladder cancer in the context of aging by Xuewei Liu, Guofeng Ding, Yifan Liu, Xiaoli Yan, Yan Zhao, Hailin Lv, Xiaojuan Xu

“…At the non-coding RNA level, dysregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in BC contribute to aberrant proliferation, metastatic potential, and immune suppression, with aging-associated declines in miRNA processing further exacerbating these effects. …”
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Management of Local Skin Reactions Caused by 5-FU 4% Cream for the Treatment of Actinic Keratosis: A Delphi Consensus by Gabriella Brancaccio, Giulia Briatico, Zoe Apalla, Reinhard Dummer, Jan Eklind, Nicole Basset Seguin, Brigitte Dreno, Maria Concetta Fargnoli, Pascale Guitera, Markus V. Heppt, Christoph Hoeller, Thomas Jouary, Aimilios Lallas, Ulrikke Lei, Ulrike Leiter, Josep Malvehy, David Moreno Ramirez, John Paoli, Ketty Peris, Susanna Puig, Philippe Saiag, Eggert Stockfleth, Wilhelm Stolz, Alexander J. Stratigos, Class Ulrich, Ann-Marie Wennberg, Iris Zalaudek, Giuseppe Argenziano

“…Objective: We sought to build consensus on management of LSR associated with 4% 5-FU using a Delphi methodology. …”
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Acoustic Detection and Quantification of Fish in Lancang Waters of Seribu Islands, Indonesia by Syahrul Purnawan, Henry M. Manik, Agustina Sartika Manik, La Elson, Myounghee Kang

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From manual clinical criteria to machine learning algorithms: Comparing outcome endpoints derived from diverse electronic health record data modalities. by Shreya Chappidi, Mason J Belue, Stephanie A Harmon, Sarisha Jagasia, Ying Zhuge, Erdal Tasci, Baris Turkbey, Jatinder Singh, Kevin Camphausen, Andra V Krauze

“…Our findings indicate a need for improved data source integration, validation, and revisiting of clinical criteria in parallel to multi-modal ML algorithm development.…”
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SPACO+: a mixed methods protocol to assessing the effectiveness of an educative intervention in patients with Long Covid by Odette Linda Kamdem, Caroline Dupre, Valdez Heugno, Amandine Baudot, Estelle Essangui, Marie Blanquet, Nina Guercon, Marie Fanget, Sasha Bayet, Marie Pierre Vericel, Pauline Oustric, Yves Mbama Biloa, Elie Shikitele Lola, Mabrouk Nekaa, Mario Debellis, François Stierlam, Ronelle Fabiola Mbia, Olivier Tatsilong, Peguy Assomo Ndemba, Williams Bell Ngan, Valérie Ndobo, Clarisse Ayina Ayina, Jerson Mekoulou, Marie Solange Ndom Ebongue, Thomas Celarier, Louise Ruiz, Veronique Regnier, Claude Bika, Françoise Ngo Sack, Judith Laure Ngondi, Nathalie Barth, Samuel Honore Mandengue, Frederic Roche, Elisabeth Botelho-nevers, Carole Else Eboumbou Moukoko, Céline Nguefeu Nkenfou, David Hupin, Bienvenu Bongue, Jessica Guyot

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Utilizing Environmental DNA to Identify Eukaryotic Diversity in Mangrove Sediments at Demak, Central Java, Indonesia by Ni Kadek Dita Cahyani, Jumari Jumari, Riche Hariyati, Rully Rahadian, Aulia Rahim, Enita Setiawati Zega, Rizqi Widya Nur Kholifah, Paul Hendry Barber, Sapto Purnomo Putro, Tri Retnaningsih Soeprobowati

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Study protocol for a national observational cohort investigating frailty, delirium and multimorbidity in older surgical patients: the third Sprint National Anaesthesia Project (SNA... by Peter Martin, Akshay Shah, Jose Lourtie, Judith Partridge, Karen Williams, Tom Poulton, Iain Keith Moppett, Carol Green, Bob Evans, Claire Swarbrick, Laura Cortes, Christine Taylor

“…In order to support objective decision-making for patients, services and national guidance, accurate, contemporary data are needed to describe the impact and associations between frailty, multimorbidity and healthcare processes with patient and service-level outcomes.Methods and analysis The study is comprised of an observational cohort study of approximately 7500 patients; an organisational survey of perioperative services and a clinician survey of the unplanned, medical workload generated from older surgical patients. …”
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HPA system in anxiety disorder patients treated with cognitive behavioural therapy: A review by Jennifer Lange, Angelika Erhardt-Lehmann

“…Furthermore, low cortisol levels elicited in relation to exposure interventions are repeatedly associated with risk for non-response. Additionally, some evidence suggests that successful CBT containing exposure sessions as well as cognitive techniques induces normalization of the HPA system by reducing acute response to fear related stimuli in parallel to normalizing basal cortisol levels. …”
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Evidence of Gold Mineralization Using Geoelectrical Methods (ERT and IP) in Bindiba Village, East Cameroon: A Case Study by Fotso Nde André Ledoux, Ngoumou Paul Claude, Owono Amougou Olivier Ulrich Igor, Ngoa Embeng Steve Barthélémy, Meying Arsène, Ndougsa-Mbarga Théophile

“…The complexity of tectonic processes in this area has resulted in geological structures favorable to the presence of gold mineralization. …”
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Effects of facilitated family case conferencing for advanced dementia: A cluster randomised clinical trial. by Meera Agar, Tim Luckett, Georgina Luscombe, Jane Phillips, Elizabeth Beattie, Dimity Pond, Geoffrey Mitchell, Patricia M Davidson, Janet Cook, Deborah Brooks, Jennifer Houltram, Stephen Goodall, Lynnette Chenoweth

“…<h4>Methods</h4>A two arm parallel cluster randomised controlled trial was conducted. …”
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Helium Pickup Ion Velocity Distributions Observed in Interplanetary Coronal Mass Ejection Structures by Keiichi Ogasawara, Maher A. Dayeh, Robert W. Ebert, Berndt Klecker, Harald Kucharek

“…For an ICME accompanied by a quasi-parallel shock, (a) localized heating and acceleration were found around the shock location; (b) power-law suprathermal tail distributions were found near the shock, suggesting diffusive shock acceleration processes; (c) weak or no sheath heating was observed; and (d) pitch angle scattering was correlated with magnetic field power spectral density. …”
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The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization. by Yirong He, Debin Zeng, Qiongling Li, Lei Chu, Xiaoxi Dong, Xinyuan Liang, Lianglong Sun, Xuhong Liao, Tengda Zhao, Xiaodan Chen, Tianyuan Lei, Weiwei Men, Yanpei Wang, Daoyang Wang, Mingming Hu, Zhiying Pan, Haibo Zhang, Ningyu Liu, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Sha Tao, Qi Dong, Yong He, Shuyu Li

“…However, during this period, the developmental process of multiscale structural architecture, its association with cortical morphological changes, and its role in the maturation of functional organization remain largely unknown. …”
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Deep Learning and Methods Based on Large Language Models Applied to Stellar Light Curve Classification by Yu-Yang Li, Yu Bai, Cunshi Wang, Mengwei Qu, Ziteng Lu, Roberto Soria, Jifeng Liu

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Benchmarking with a Language Model Initial Selection for Text Classification Tasks by Agus Riyadi, Mate Kovacs, Uwe Serdült, Victor Kryssanov

“…The LMDFit approach draws parallels from the organizational personnel selection process, where job candidates are first evaluated by conducting a number of basic skill assessments before they would be hired, thus mitigating the consequences of hiring unfit candidates for the organization. …”
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Network toxicology combined with molecular docking technology to explore the molecular mechanism of amatoxin causing liver injury by Chenglin Wang, Xin Wang, Yaxing Deng, Yingchun Hu, Li Hu

“…PPI network topology revealed critical nodal connections, while functional enrichment analyses delineated key biological processes and signaling pathways associated with these targets. …”
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Allochrony in Atlantic Lumpfish: Genomic and Otolith Shape Divergence Between Spring and Autumn Spawners by Mathilde Horaud, Núria Raventós, Kim Præbel, Carles Galià‐Camps, Cinta Pegueroles, Carlos Carreras, Marta Pascual, Victor M. Tuset, Shripathi Bhat, Arve Lynghammar

“…Genomic differences between the two groups were concentrated in three chromosomes, with a region of chromosome 1 encompassing the same single nucleotide polymorphisms (SNPs) driving differential season spawning for both localities, suggesting parallel responses. The functional analysis of the SNPs in this region revealed genes associated with responses to environmental stressors, possibly adaptations to seasonal variations at high latitudes. …”
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The Effect of a Nature-Based Gel on Gingival Inflammation and the Proteomic Profile of Crevicular Fluid: A Randomized Clinical Trial by Luciene Cristina Figueiredo, Bruno Bueno-Silva, Giovanna Denúncio, Nathalia Freitas Figueiredo, Daniele Ferreira da Cruz, Jamil A. Shibli, Maria Helena R. Borges, Valentim A. R. Barão, Doron Haim, Thabet Asbi, João Gabriel S. Souza

“…However, the nature-based gel markedly changed the proteomic profile of GCF after treatment, showing a profile associated with a host response.…”
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