Expression Characteristics and Prognostic Value of KLRG2 in Endometrial Cancer: A Comprehensive Analysis Based on Multi-Omics Data by Xiaoyan Huang, Ailian Li, Dianbo Xu

“…While killer cell lectin-like receptor G2 (KLRG2) exhibits oncogenic properties in other cancers, its clinical significance and mechanistic roles in EC are unknown. This study aims to systematically characterize KLRG2 expression in EC, evaluate its prognostic significance, decipher underlying molecular mechanisms, and explore its role in tumor immune microenvironment regulation. …”
Get full text

Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data by Jialiang Lin, Linjuan Huang, Weiming Li, Haijun Xiao, Mingmang Pan

“…Abstract Background Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). …”
Get full text

Comprehensive analysis of regulatory B Cell related genes in prognosis and therapeutic response in lung adenocarcinoma by Liangyu Zhang, Liangyu Zhang, Jianshen Zeng, Jianshen Zeng, Xun Zhang, Xun Zhang, Menglong Zhang, Menglong Zhang, Yilin Lin, Yilin Lin, Fancai Lai, Fancai Lai

“…This study seeks to investigate the roles of Breg-associated genes in the context of LUAD.MethodsConsensusClusterPlus package was used to characterize LUAD patients into two clusters. …”
Get full text

Enhancing fibroblast–epithelial cell communications: Serpine2 as a key molecule in Fusobacterium nucleatum–promoted colon cancer by Xueke Li, Xueke Li, Simin Luo, Yifang Jiang, Qiong Ma, Fengming You, Fengming You, Qixuan Kuang, Xi Fu, Chuan Zheng

“…Three machine learning algorithms were employed to identify characteristic genes. …”
Get full text

microRNA-497-5p-based screening identifies a novel synthetic lethal-type interaction via PKMYT1 and WEE1 in pleural mesothelioma by Nathanael Pruett, Sierra Wilferd, Anand Singh, Agnes Y. Choi, Shivani Dixit, Vivek Singh, Charlize Nguyen, Olivia Lin, David S. Schrump, Christopher L. Plaisier, Chuong D. Hoang

“…We demonstrate the utility of experimentally deriving the miR-497-5p targetome, explaining its pathophysiological role in DPM and why it is a rational therapeutic for further development.…”
Get full text

Metabolic pathway activation and immune microenvironment features in non-small cell lung cancer: insights from single-cell transcriptomics by Yanru Liu, Yanru Liu, Yanru Liu, Hanmin Liu, Hanmin Liu, Ying Xiong, Ying Xiong

“…WGCNA was utilized to identify gene modules and hub genes closely associated with these four metabolic pathways.ResultsOur analysis showed that DEGs between tumor and normal tissues were predominantly enriched in immune response and cell adhesion pathways. …”
Get full text

Shared pathogenesis in polycystic ovaries and rheumatoid arthritis: an analysis of key genes and pathways by Yingying Ji, Pengcheng Xia, Yan Wang, Yang Liu, Feng Wang, Fenggang Sun, Qiang Feng, Qingbin Ni, Yi Li

“…Protein interaction analysis, machine learning algorithms, and validation analyses were employed to identify core genes with potential diagnostic value. …”
Get full text

Identification of a potential miRNA–mRNA regulatory network for ischemic stroke by using bioinformatics methods: a retrospective study based on the Gene Expression Omnibus database... by Zhaoying Chen, Xiaodan Zhang, Xiangjun Qi, Jiyuan Zheng, Niancai He, Bohui Zheng, Nan Zhong, Chengcheng Ji, Yulan Jin, Hu Yu, Weinv Fan, Guoming Chen

“…We constructed a potential miRNA–mRNA regulatory network and confirmed the differential expression of proteins associated with this network by proteomic validation, suggesting that they play a role in IS pathophysiology. …”
Get full text

The potential crosstalk genes and molecular mechanisms between systemic lupus erythematosus and periodontitis by Kai Zhao, Xiaolong Li, Qingmiao Zhu, Mengyu Zhu, Jinge Huang, Ting Zhao

“…Additionally, using machine learning algorithms and ROC curve analysis, a total of 8 key genes (PLEKHA1, CEACAM1, TNFAIP6, TCN2, GLDC, GNG7, LY96, VCAN) were identified Finally, immune infiltration analysis highlighted the significant roles of neutrophils, monocytes, plasma cells, and gammadelta T cells (γδ T cells) in the pathogenesis of both SLE and PD.ConclusionThis study identifies 8 hub genes that could potentially serve as diagnostic markers for both SLE and PD, highlighting the importance of VCAN and LY96 in diagnosis. …”
Get full text

Immune intrinsic escape signature stratifies prognosis, characterizes the tumor immune microenvironment, and identifies tumorigenic PPP1R8 in glioblastoma multiforme patients by Ran Du, Lijun Jing, Denggang Fu

“…TIME analysis was carried out using multiple deconvolution algorithms. Additionally, functional assays including CCK8, cell cycle, and apoptosis assays were conducted on PPP1R8-silenced U251 cells using CRISPR/Cas9 technologyResultsThirty-six IERGs were associated with GBM outcomes, with 20 linked to poor survival and 16 to better outcomes. …”
Get full text

Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genes by Shoupeng Ding, Chunxiao Huang, Jinghua Gao, Chun Bi, Yuyang Zhou, Zihan Cai

“…We identified T-cell-associated metabolic differentially expressed genes (TCM–DEGs) through integrated differential expression analysis and machine learning algorithms (XGBoost, SVM–RFE, and Boruta). …”
Get full text

Sodium Propionate Alleviates Atopic Dermatitis by Inhibiting Ferroptosis via Activation of LTBP2/FABP4 Signaling Pathway by Xie A, Li W, Ye D, Yin Y, Wang R, Wang M, Yu R

“…Analysis using three algorithms identified potential therapeutic targets of SP. …”
Get full text

Constructing a Glioblastoma Prognostic Model Related to Fatty Acid Metabolism Using Machine Learning and Identifying F13A1 as a Potential Target by Yushu Liu, Hui Deng, Ping Song, Mengxian Zhang

“…We also conducted a multifaceted analysis of F13A1, which plays an important role in the best model. <b>Results:</b> C2, with the worst prognosis, may be associated with an immunosuppressive phenotype, which may be related to positive regulation of cell adhesion and lymphocyte-mediated immunity. …”
Get full text

Identification of lactylation-related biomarkers in osteoporosis from transcriptome and single-cell data by Jiafeng Peng, Hongxing Zhang, Huaize Wang, Ting Jiang, Minglei Gao, Xingfu Ma, Yingzong Xiong, Yingchun Li, Ran Xu, Junchen Zhu

“…First, the biomarkers associated with OP were identified through differential gene expression analysis, machine learning algorithms, expression validation, and receiver operating characteristic (ROC) curve analysis. …”
Get full text

ATP6V0A4 as a novel prognostic biomarker and potential therapeutic target in oral squamous cell carcinoma by Xiaopu Gao, Jiamin Zhou, Yu Qiao, Chuyin Lin, Guanxiong Zhang, Qiuyu Wu, Zhikang Su, Qianji Zhang, Songkai Huang

“…Nevertheless, the exact role and molecular mechanisms of ATP6V0A4 in oral squamous cell carcinoma (OSCC) are not yet fully understood. …”
Get full text

Identification and validation of CKAP2 as a novel biomarker in the development and progression of rheumatoid arthritis by Qiongbing Zheng, Qiongbing Zheng, Youmian Lan, Jiexin Chen, Ling Lin, Ling Lin

“…Immune infiltration analysis showed these genes were associated with plasma cells and T cell infiltration. …”
Get full text

Treatment Strategies and Prognostic Outcomes in Acute Limb Ischemia: A Systematic Review and Meta-Analysis Comparing Thrombolytic Therapy and Open Surgical Interventions by Mircea Cătălin Coșarcă, Nicolae Alexandru Lazăr, Suzana Vasilica Șincaru, Bogdan Corneliu Bandici, Eduard Costin Argatu, Cosmin Carașca, Ráduly Gergő, Dorin Constantin Dorobanțu, Cristian Trâmbițaș, Adrian Vasile Mureșan

“…Future research should focus on refining treatment algorithms, investigating novel thrombolytic agents, and expanding the role of minimally invasive techniques to improve long-term outcomes while mitigating complications such as bleeding and reperfusion injuries.…”
Get full text

DAF-Net: Dual-Aperture Feature Fusion Network for Aircraft Detection on Complex-Valued SAR Image by Qingbiao Meng, Youming Wu, Yuxi Suo, Tian Miao, Qingyang Ke, Xin Gao, Xian Sun

“…Aircraft detection in synthetic aperture radar (SAR) images plays a crucial role in supporting essential tasks, such as airport management and airspace monitoring. …”
Get full text

Petrological controls on the engineering properties of carbonate aggregates through a machine learning approach by Javid Hussain, Tehseen Zafar, Xiaodong Fu, Nafees Ali, Jian Chen, Fabrizio Frontalini, Jabir Hussain, Xiao Lina, George Kontakiotis, Olga Koumoutsakou

“…Abstract Rock aggregates have been extensively exploited in the construction sector, and the associated engineering features play a critical role in their application. …”
Get full text

Enhanced identification of Morganella spp. using MALDI-TOF mass spectrometry by Mathilde Duque, Cécile Emeraud, Rémy A. Bonnin, Quentin Giai-Gianetto, Laurent Dortet, Alexandre Godmer

Get full text