Enhancing Cardiovascular Risk Prediction with a Simplified Carotid IMT Protocol: Evidence from the IMPROVE Study by Fabrizio Veglia, Anna Maria Malagoni, Mauro Amato, Rona J. Strawbridge, Kai Savonen, Philippe Giral, Antonio Gallo, Matteo Pirro, Bruna Gigante, Per Eriksson, Douwe J. Mulder, Beatrice Frigerio, Daniela Sansaro, Alessio Ravani, Daniela Coggi, Roberta Baetta, Nicolò Capra, Elena Tremoli, Damiano Baldassarre

“…<b>Background/Objectives</b>: Carotid intima-media thickness (CIMT) has long been used as an index of subclinical atherosclerosis, but its role as a risk modifier in cardiovascular (CV) risk optimization has recently been questioned due to methodological problems, such as lack of protocol standardization and scanning difficulties. …”
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WGCNA-ML-MR integration: uncovering immune-related genes in prostate cancer by Jing Lv, Jing Lv, Yuhua Zhou, Yuhua Zhou, Shengkai Jin, Shengkai Jin, Chaowei Fu, Chaowei Fu, Yang Shen, Yang Shen, Bo Liu, Bo Liu, Menglu Li, Yuwei Zhang, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…Furthermore, a machine learning algorithm was used to screen for core genes and construct a diagnostic model, which was then validated in an external validation dataset. …”
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HPV-negative oropharyngeal carcinoma as a separate prognostkally unfavorable form of cancer, requiring new approaches to treatment (case report) by A. R. Gevorkov, A. V. Boyko, A. P. Polyakov, L. V. Bolotina, N. N. Volchenko, I. V. Rebrikova, A. М. Lemeshko, S. V. Shashkov

“…The study objective is to demonstrate the difficulties associated with treatment of HPV-negative oropharyngeal cancer.Material and methods. …”
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Development of a high-spatial-resolution annual emission inventory of greenhouse gases from open straw burning in Northeast China from 2001 to 2020 by Z. Song, Z. Song, L. Zhang, C. Tian, Q. Fu, Q. Fu, Z. Shen, R. Zhang, D. Liu, D. Liu, S. Cui, S. Cui

“…The enforcement of straw-burning bans since 2018 has played a pivotal role in curbing open straw burning and has reduced fire spots by 51.7 % on an annual basis compared to 2013–2017. …”
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RESULTS OF USTEKINUMAB TREATMENT IN PATIENTS WITH PSORIATIC ARTHRITIS IN THE RUSSIAN FEDERATION ACCORDING TO THE DATA OF PSUMMIT 1 AND PSUMMIT 2 by Yu. L. Korsakova, A. A. Godzenko, A. O. Pchelintseva, O. Yu. Grigoryeva, L. N. Denisov, E. L. Nasonov

“…Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, vertebral column,  and entesises, which is associated with psoriasis. T helper type 17 cells (Th-17)  play a leading role in the development of inflammation in psoriasis and PsA so different biologicals affecting interleukins (IL) 17 and 23 are being intensively investigated. …”
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Assessing the causal effect of inflammation‐related genes on myocarditis: A Mendelian randomization study by Huazhen Xiao, Hongkui Chen, Wenjia Liang, Yucheng Liu, Kaiyang Lin, Yansong Guo

“…Five algorithms [MR‐Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode regression] were employed for the MR analysis, with IVW as the primary method, and sensitivity analysis was conducted. …”
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Comprehensive analysis of senescence-related genes identifies prognostic clusters with distinct characteristics in glioma by Wenyuan Wei, Ying Dang, Gang Chen, Chao Han, Siwei Zhang, Ziqiang Zhu, Xiaohua Bie, Jungang Xue

“…To uncover the role of senescence in gliomas, we collected senescence-related genes for integrated analysis. …”
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Integrated single-cell and transcriptome sequencing data reveal the value of IL1RAP in gastric cancer microenvironment and prognosis by Weifeng Yang, Xiaohua Wu, Jian Wang, Wenquan Ou, Xing Huang

“…Three machine learning algorithms identified distinct sets of prognostic genes in gastric cancer patients. …”
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Investigating immune cell infiltration and gene expression features in pterygium pathogenesis by Ji Yang, Ya-Nan Chen, Chen-Yan Fang, Yan Li, Hong-Qin Ke, Rui-Qin Guo, Ping Xiang, Yun-Ling Xiao, Li-Wei Zhang, Hai Liu

“…There were 52 co-DEGs shared by both datasets, and four candidate biomarkers (FN1, SPRR1B, SERPINB13, EGR2) with potential diagnostic value were identified through machine learning algorithms. Single-sample GSEA demonstrated increased Th2 cell infiltration and decreased CD8 + T cell presence in pterygium tissues, suggesting a crucial role of the immune microenvironment in pterygium pathogenesis. …”
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Cancer risk in HIV patients with incomplete viral suppression after initiation of antiretroviral therapy. by Jennifer S Lee, Stephen R Cole, Chad J Achenbach, Dirk P Dittmer, David B Richardson, William C Miller, Christopher Mathews, Keri N Althoff, Richard D Moore, Joseph J Eron, Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS)

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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…The molecular characteristics of Hub PCD-DEGs, their role in synovial immune inflammation, and their association with the immune microenvironment were investigated through functional enrichment analysis and ssGSEA immune infiltration analysis. …”
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Characterizing Duodenal Immune Microenvironment in Functional Dyspepsia: An AutoML-Driven Diagnostic Framework by Zhang X, Fan X, Hu X, Qian Z, Li J, Wu W, Chen L, Wu S, Ma L, Yang C, Zhang T, Su X, Wei W

“…Recent studies suggest that duodenal immune activation plays a pivotal role in its development.Methods: Mendelian randomization analysis using genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data identified genes associated with FD. …”
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Autonomic nervous system development-related signature as a novel predictive biomarker for immunotherapy in pan-cancers by Cunen Wu, Cunen Wu, Cunen Wu, Cunen Wu, Weiwei Xue, Yuwen Zhuang, Dayue Darrel Duan, Dayue Darrel Duan, Zhou Zhou, Zhou Zhou, Xiaoxiao Wang, Zhenfeng Wu, Jin-yong Zhou, Xiangkun Huan, Ruiping Wang, Haibo Cheng, Haibo Cheng

“…Seven machine learning (ML) methods were applied to identify vital genes associated with both cancer and immune characteristics. …”
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Causal estimation of the relationship between reproductive performance and the fecal bacteriome in cattle by Yutaka Taguchi, Haruki Yamano, Yudai Inabu, Hirokuni Miyamoto, Koki Hayasaki, Noriyuki Maeda, Yoshiro Kanmera, Seiji Yamasaki, Noboru Ota, Kenji Mukawa, Atsushi Kurotani, Shigeharu Moriya, Teruno Nakaguma, Chitose Ishii, Makiko Matsuura, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Motoaki Udagawa, Satoshi Wada, Jun Kikuchi, Hiroshi Ohno, Hideyuki Takahashi

“…The relationship of the fecal bacteriome at 150 and 300 days of age and reproductive performance was visualized using statistical structural equation modelling between traits based on four types of machine-learning algorithms (linear discriminant analysis, association analysis, random forest, and XGBoost). …”
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Future projection of East Asian atmospheric rivers in high-resolution climate models by Yeeun Kwon, Seok-Woo Son

“…ARs are also projected to become more intense and persistent with a considerable increase in extreme precipitation, although the quantitative change slightly differs depending on the AR detection algorithms. Such changes are primarily driven by thermodynamic processes, with dynamic processes playing a secondary role. …”
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Forecasting Spatiotemporal Dynamics of Daytime Surface Urban Cool Islands in Response to Urbanization in Drylands: Case Study of Kerman and Zahedan Cities, Iran by Mohammad Karimi Firozjaei, Naeim Mijani, Solmaz Fathololoumi, Jamal Jokar Arsanjani

“…Urban micro-climate plays an important role in human activities and in ensuring public health. …”
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Tensor-FLAMINGO unravels the complexity of single-cell spatial architectures of genomes at high-resolution by Hao Wang, Jiaxin Yang, Xinrui Yu, Yu Zhang, Jianliang Qian, Jianrong Wang

“…We develop a data-driven algorithm, Tensor-FLAMINGO, based on a low-rank tensor completion strategy. …”
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Log-Based Analysis of Creativity in the Context of Computational Thinking by Rotem Israel-Fishelson, Arnon Hershkovitz

“…We developed a Python algorithm to automatically analyze the logged solutions across four creativity measures. …”
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The Significance of Cellular Senescence Hub Genes in the Diagnosis and Subtype Classification of a Comprehensive Database of Gene Expression in Intervertebral Disc Degeneration by Fei Liu, Silong Gao, Ji Yin, Chao Song, Yongliang Mei, Zhaoqiang Wang, Zongchao Liu

“…ABSTRACT Background Intervertebral disc degeneration (IVDD) is a complex age‐related physiological process, with cellular senescence (CS) being a primary contributing factor. However, the precise role of CS and its associated genes in IVDD remains unclear. …”
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Re-emergence of thiamine deficiency disease in the Pacific islands (2014-15): A case-control study. by Eric J Nilles, Atarota Manaia, Bineta Ruaia, Clare Huppatz, Catherine Ward, Peter George, Christiaan Sies, Alessio Cangiano, James Sejvar, André Reiffer, Teatoa Tira

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