Altered actin centripetal retrograde flow in physically restricted immunological synapses. by Cheng-han Yu, Hung-jen Wu, Yoshihisa Kaizuka, Ronald D Vale, Jay T Groves

“…Dynamical assembly of cytoskeletal network is believed to play an important role in driving these assembly processes. In one experimental strategy, the APC is replaced with a synthetic supported membrane. …”
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A GC-MS-Based Metabolomics Investigation of the Protective Effect of Liu-Wei-Di-Huang-Wan in Type 2 Diabetes Mellitus Mice by Jian-hua Huang, Dan He, Lin Chen, Qing Du, Rong Yu, Ping Cai, Shui-han Zhang

“…Metabolomics approach coupled with gas chromatography-mass spectrometry (GC-MS) and random forest (RF) algorithm was proposed to discover the metabolic differences among model group and control group as well as to examine the therapeutic efficacy of traditional Chinese medicine, Liu-Wei-Di-Huang-Wan (LWDHW), in diabetes and associated kidney failure. …”
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Artificial intelligence driven innovations in biochemistry: A review of emerging research frontiers by Mohammed Abdul Lateef Junaid

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Integration of graph neural networks and transcriptomics analysis identify key pathways and gene signature for immunotherapy response and prognosis of skin melanoma by Maodong Ye, Shuai Ren, Huanjuan Luo, Xiumin Wu, Hongwei Lian, Xiangna Cai, Yingchang Ji

“…Abstract Objective The assessment of immunotherapy plays a pivotal role in the clinical management of skin melanoma. …”
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The potential of ME1 in guiding immunotherapeutic strategies for ovarian cancer: insights from pan-cancer research by Jiahui Wei, Ming Wang, Shuiqing Xu, Paizigul Tusufuhan, Yumei Wu

“…ObjectiveME1 catalyzes the conversion of malic acid into acetic acid, thereby linking glucose metabolism to the citric acid cycle. In recent years, the role of ME1 in various tumors has only been superficially explored. …”
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From Biopsy to Diagnosis: Navigating Aggressive B-Cell Lymphomas in Practice by Georgian Halcu, Anca Evsei-Seceleanu, Mihai Cerbu, Marina Alina Bara, Andrei Turbatu, Mihail Constantin Ceausu

“…It highlights vital diagnostic tools, including CD45, B/T-cell markers, germinal center markers, and the Hans algorithm, as well as the role of FISH in identifying rearrangements of key genes MYC, BCL2, and BCL6, which are significant for recognizing double-hit and triple-hit lymphomas. …”
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Hydrogen production efficiency: A critical factor in integrated planning of distribution and transmission system for large-scale centralized offshore wind-hydrogen system by Rongsen Jin, Peng Hou, Yuanhang Qi, Zili Huang, Tongle Wu, Xiaoqiang Cai

“…Green hydrogen plays a pivotal role in decarbonizing our energy system and achieving the Net-Zero Emissions goal by 2050. …”
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Capacity Estimation and Knee Point Prediction Using Electrochemical Impedance Spectroscopy for Lithium Metal Battery Degradation via Machine Learning by Qianli Si, Shoichi Matsuda, Yasunobu Ando, Toshiyuki Momma, Yoshitaka Tateyama

“…Conversely, high‐frequency features related to charge transfer resistance play a dominant role in the KP detection. To reduce data complexity and improve model efficiency, the input by selecting specific frequency points based on SHAP values is further optimized. …”
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Molecular features and diagnostic modeling of synovium- and IPFP-derived OA macrophages in the inflammatory microenvironment via scRNA-seq and machine learning by Chao Lin, Yue Wan, Yong Xu, Qingsong Zou, Xiaoxiao Li

“…Machine learning (ML) algorithms identified feature genes of OA-macrophages. …”
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A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer by Li Tang, Matthew C. Hill, Mingxing He, Junhao Chen, Zirui Wang, Patrick T. Ellinor, Min Li

“…To investigate the effects of variants in the context of 3D organization, a two‐phase scoring algorithm, 3DFunc, is developed to evaluate the pathogenicity of variant–gene pairs in cancer. …”
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Computational Identification of Milk Trait Regulation Through Transcription Factor Cooperation in Murciano-Granadina Goats by Muhammad Imran Khan, Hendrik Bertram, Armin Otto Schmitt, Faisal Ramzan, Mehmet Gültas

“…In this study, we investigated the genetic architecture of seven milk traits in MUGs, employing a two-step computational analysis to examine genotype–phenotype associations. Initially, a random forest algorithm identified the relative importance of each single-nucleotide polymorphism (SNP) in determining the traits of interest. …”
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Influence of geomagnetic disturbances on myocardial infarctions in women and men from Brazil by Luiz Felipe C. Rezende, Eurico R. De Paula, Marcio T. A. H. Muella, Severino L. G. Dutra, Reinaldo R. Rosa, Paulo H. N. Saldiva, Jean P. H. B. Ometto

“…Using the unsupervised K-Means algorithm, the results indicate that the group associated with disturbed geomagnetic conditions has a higher incidence of MIs in women. …”
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Size and vitality characteristics of bilberry (Vaccinium myrtillus L.) populations in the Central Bohemian region of the Czech Republic: A case study of non-timber forest products by Maryna Sherstiuk, Viktoria Skliar, Jan Kašpar, Zohreh Mohammadi

“…Bilberry (Vaccinium myrtillus L.) is a key non-timber forest product that plays an important role in forest biodiversity and ecosystem function. …”
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Identification and validation of hub m7G-related genes and infiltrating immune cells in osteoarthritis based on integrated computational and bioinformatics analysis by Zhenhui Huo, Chongyi Fan, Kehan Li, Chenyue Xu, Yingzhen Niu, Fei Wang

“…Abstract Background Osteoarthritis (OA) is a joint disease closely associated with synovial tissue inflammation, with the severity of synovitis impacting disease progression. m7G RNA methylation is critical in RNA processing, metabolism, and function, but its role in OA synovial tissue is not well understood. …”
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FMCW Radar-Aided Navigation for Unmanned Aircraft Approach and Landing in AAM Scenarios: System Requirements and Processing Pipeline by Paolo Veneruso, Luca Manica, Enrico Miccio, Roberto Opromolla, Carlo Tiana, Giacomo Gentile, Giancarmine Fasano

“…The radar is designed to detect high-reflectivity targets placed in the landing area and uses a matching algorithm to associate these detections with their known positions, enabling reliable corrections to the aircraft navigation state. …”
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A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma by Jiale Fang, Siyuan Yu, Wei Wang, Wei Wang, Cheng Liu, Xiaojia Lv, Jiaqi Jin, Xiaomin Han, Xiaomin Han, Xiaomin Han, Fang Zhou, Yukun Wang

“…IntroductionTumor-infiltrating B lymphocytes (TILBs) play a pivotal role in shaping the immune microenvironment of tumors (TIME) and in the progression of lung adenocarcinoma (LUAD). …”
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PathNetDRP: a novel biomarker discovery framework using pathway and protein–protein interaction networks for immune checkpoint inhibitor response prediction by Dohee Lee, Jaegyoon Ahn, Jonghwan Choi

“…Results We introduce PathNetDRP, a novel biomarker discovery approach that applies the PageRank algorithm to prioritize ICI-associated genes, maps them to relevant biological pathways, and calculates PathNetGene scores to quantify their contribution to immune response. …”
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A Full-Profile Measurement Method for an Inner Wall with Narrow-Aperture and Large-Cavity Parts Based on Line-Structured Light Rotary Scanning by Zhengwen Li, Changshuai Fang, Xiaodong Zhang

“…As a special component, inner-wall-shaped parts with a narrow aperture and large cavity play an important role in the field of industrial manufacturing. It is of great significance to accurately measure the full profile of the inner surface of such parts. …”
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Reconstructing the dynamics of HIV evolution within hosts from serial deep sequence data. by Art F Y Poon, Luke C Swenson, Evelien M Bunnik, Diana Edo-Matas, Hanneke Schuitemaker, Angélique B van 't Wout, P Richard Harrigan

“…The subsequent emergence of HIV variants that use the CXCR4 coreceptor in roughly half of all infections is associated with an accelerated decline of CD4+ T-cells and rate of progression to AIDS. …”
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Integration of mitochondrial gene expression and immune landscape in acute kidney injury prediction by Xiaoping Xia, Renyang Liu, Xiaohui Jiang

“…Immune infiltration was assessed using the xCell algorithm to explore the relationship between MRS and immune cell dynamics in AKI. …”
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