Adverse events associated with vismodegib: insights from a real-world pharmacovigilance study using the FAERS database by Bingqing Wang, Kaidi Zhao, Ningyi Xian, Landong Ren, Jiashu Liu, Chen Tu, Dewu Zhang

“…Disproportionality analysis was conducted using four algorithms: Reporting odds ratio, proportional reporting ratio, multi-item gamma Poisson shrinker, and Bayesian confidence propagation neural network to assess the safety profile of vismodegib in clinical practice. …”
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USING ARTIFICIAL INTELLIGENCE AND COMPETITIVE ADVANTAGE IN OPERATIONS MANAGEMENT: A CASE STUDY OF ISLAMIC BANKS IN AMMAN, JORDAN by Khaled Abdulwahab Alzeaideen, Ala’a Abdulkarim Hamdan, Hazem Khaled Shehadeh, Majed Abdel-Mohdi Masadeh, Hala Alsabatin, Abdalmuttaleb Al-Sartawi, Waleed Nureldeen

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USING ARTIFICIAL INTELLIGENCE AND COMPETITIVE ADVANTAGE IN OPERATIONS MANAGEMENT: A CASE STUDY OF ISLAMIC BANKS IN AMMAN, JORDAN by Khaled Abdulwahab Alzeaideen, Ala’a Abdulkarim Hamdan, Hazem Khaled Shehadeh, Majed Abdel-Mohdi Masadeh, Hala Alsabatin, Abdalmuttaleb Al-Sartawi, Waleed Nureldeen

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Artificial intelligence-based radiogenomics reveals the potential immunoregulatory role of COL22A1 in glioma and its induced autoimmune encephalitis by Bingchao Yan, Bingchao Yan, Qian Chen, Dacheng Wang, Leili Ding, Leili Ding, Jingfeng Qu, Renfei Du, Renfei Du, Wenjie Shi, Ulf D. Kahlert, Zhengquan Yu

“…COL22A1 was also positively correlated with immune checkpoints and immune-regulated genes.ConclusionOur study highlights the critical role of COL22A1 in gliomas and glioma-Induced Autoimmune Encephalitis, demonstrating its strong association with poor prognosis and its significant involvement in tumor immune regulation.…”
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Interpretable machine learning approaches for predicting prostate cancer by using multiple heavy metal exposures based on the data from NHANES 2003–2018 by Zu-Ming You, Yuan-Sheng Li, Fan-Shuo Meng, Rui-Xiang Zhang, Chen-Xi Xie, Zhijiang Liang, Ji-Yuan Zhou

“…Environmental pollution plays a major role in the development of prostate cancer (PCA). …”
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Exploring the Role of Peritumoral Edema in Predicting Lung Cancer Subtypes Through T2-FLAIR Digital Subtraction Imaging of Metastatic Brain Tumors by Okan Dilek, Emin Demırel, Zeynel Abidin Tas, Emre Bılgın

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Daily time-use compositions of physical behaviours and its association with evaluative and experienced wellbeing: a multilevel compositional analysis by Anantha Narayanan, Scott Duncan, Conal Smith, Flora Le, Lisa Mackay, Julia McPhee, Basile Chaix, Tom Stewart

“…Time-use data were processed using UK Biobank machine learning algorithms. We employed Bayesian multilevel compositional analysis to investigate how time-use behaviours, and reallocating time between behaviours, were associated with both life satisfaction and momentary affective states. …”
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Ocular markers of microangiopathy and their possible association with cardiovascular risk in patients with systemic inflammatory rheumatic diseases: a systematic review by Bengta Sturm, Anna-Lena Zang, Julia Stingl, Rebecca Hasseli-Fräbel, Antonis Fanouriakis, Andreas Schwarting, Andreas Schwarting, Christian Geber, Julia Weinmann-Menke, Mohammed Alhaddad, Konstantinos Triantafyllias, Konstantinos Triantafyllias

“…Additionally, various cross-sectional and follow-up studies in patients with ARDs have demonstrated associations between ocular vessel changes, traditional CV risk scores, and disease-related characteristics, suggesting a potential role for ocular assessments in CV risk screening. …”
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Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction by Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng

“…Functional enrichment analyses delineated the dysregulation of pathways, while weighted gene co-expression network analysis identified hub genes within ribosome biogenesis-associated modules. A multi-algorithm machine learning framework was employed to optimize predictive performance, with model interpretability achieved through SHapley Additive exPlanations and diagnostic accuracy validated by receiver operating characteristic curves. …”
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Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component. by Diana Mechtcheriakova, Yury Sobanov, Gabriele Holtappels, Erika Bajna, Martin Svoboda, Markus Jaritz, Claus Bachert, Erika Jensen-Jarolim

“…Our data demonstrate the class switch recombination and somatic hypermutation events likely taking place locally in the airways and in addition to the previously highlighted markers and/or targets as IL5 and IgE suggest novel candidate genes to be considered for treatment of nasal polyposis including among others IL13 and CD23. Thus, the algorithm presented herein including the multigene signature approach, analysis of co-regularities and creation of AID-associated functional network gives an integrated view of biological processes and might be further applied to assess role of altered AID expression in etiology of other diseases, in particular, aberrant immunity and cancer.…”
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Influence of multi-species data on gene-disease associations in substance use disorder using random walk with restart models. by Everest U Castaneda, Sharon Moore, Jason A Bubier, Stephen K Grady, Michael A Langston, Elissa J Chesler, Erich J Baker

“…A major challenge lies in discovering, emphasizing, and characterizing human gene-disease and gene-gene associations. The limitations of data on the role of human gene products in substance use disorder (SUD) makes it challenging to transition from genetic associations to actionable insights. …”
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Village-level climate and weather variability, mediated by village-level crop yield, is associated with linear growth in children in Uganda by Vernon M Chinchilli, Paddy Ssentongo, Djibril M Ba, Claudio Fronterre

“…Normalised rainfall anomaly and total precipitation were derived from the African Rainfall Estimation Algorithm Version 2 product. Linear regression models were used to associate total annual precipitation and anomalies with height-for-age z-scores and to explore the mediating role of crop yield qualitatively. …”
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Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis by Jian Liu, Meng Pu, Di Guo, Ying Xiao, Jin-zhu Yin, Dong Ma, Cun-gen Ma, Qing Wang

“…Abstract Objective The present study aimed to investigate the potential role and molecular mechanism of procyanidin B2 (PCB2) in the treatment of multiple sclerosis (MS), with the hope of providing novel strategies for the precision treatment of MS. …”
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Prognostic model of lung adenocarcinoma from the perspective of cancer-associated fibroblasts using single-cell and bulk RNA-sequencing by Jiarui Zhao, Chuanqing Jing, Rui Fan, Wei Zhang

“…Abstract Cancer-associated fibroblasts (CAFs) play important roles in the progression of lung adenocarcinoma (LUAD). …”
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VSIG4 as a tumor-associated macrophage marker predicting adverse prognosis in diffuse large B-cell lymphoma by Dongshen Ma, Yubo Wang, Qingqing Shen, Qingqing Shen, Xinyu Liu, Xinyu Liu, Wenxin Lu, Shaoqi Li, Qianqian Yin, Lei Xia, Guangzhen Liu, Yuhong Chen, Chenxi Xiang, Hui Liu, Hui Liu

“…IntroductionDiffuse large B-cell lymphoma (DLBCL) exhibits heterogeneous tumor microenvironment. However, the role of tumor-associated macrophages (TAMs) in the DLBCL tumor microenvironment remains unclear. …”
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Identification and validation of efferocytosis-related biomarkers for the diagnosis of metabolic dysfunction-associated steatohepatitis based on bioinformatics analysis and machine... by Chenghui Cao, Chenghui Cao, Wenwu Liu, Xin Guo, Shuwei Weng, Yang Chen, Yonghong Luo, Shuai Wang, Botao Zhu, Botao Zhu, Yuxuan Liu, Yuxuan Liu, Daoquan Peng

“…Efferocytosis, a process implicated in a broad spectrum of chronic inflammatory disorders, has been reported to be associated with the pathogenesis of MASH; however, its precise role remains obscure. …”
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GULP. II. Hierarchical Distribution and Evolution of Young Stellar Structures in NGC 4449 by Beena Meena, Elena Sabbi, Peter Zeidler, Bruce G. Elmegreen, Jan J. Eldridge, Varun Bajaj, Mario Gennaro, Anna Pasquali, Debra M. Elmegreen, Ralf S. Klessen, Linda J. Smith, Luciana Bianchi, Aida Wofford, Pietro Facchini, John S. Gallagher III, Daniela Calzetti, Eva K. Grebel, Angela Adamo, (GULP)

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A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. by Olivia Adams, Félice A Janser, Bastian Dislich, Sabina Berezowska, Magali Humbert, Christian A Seiler, Dino Kroell, Julia Slotta-Huspenina, Marcus Feith, Katja Ott, Mario P Tschan, Rupert Langer

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The canine gut microbiome is associated with higher risk of gastric dilatation-volvulus and high risk genetic variants of the immune system. by Meredith A J Hullar, Johanna W Lampe, Beverly J Torok-Storb, Michael A Harkey

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Multi-Omics and Experimental Validation Identify GPX7 and Glutathione-Associated Oxidative Stress as Potential Biomarkers in Ischemic Stroke by Tianzhi Li, Sijie Zhang, Jinshan He, Hongyan Li, Jingsong Kang

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