The Immune‐Related Gene CD48 Is a Prognostic Biomarker Associated With the Breast Cancer Tumor Microenvironment by Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

“…ABSTRACT Background While tumor cells can affect the biological behavior of malignant tumors, the tumor microenvironment (TME) also plays an important role in the occurrence, development, and metastasis of tumors. …”
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Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E by Junqian Zhang, Xiaobo Zhang, Ruixin Wu, Chang-Sheng Dong

“…Finally, this study identified the singular role of NT5E in the immunosuppression resulting from PM reprogramming in PC. …”
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Role of mass spectrometry-based serum proteomics signatures in predicting clinical outcomes and toxicity in patients with cancer treated with immunotherapy by Young Kwang Chae, Emma Yu, Na Hyun Kim, Min Jeong Kim, Leeseul Kim, Hyung-Gyo Cho, Yeonggyeong Park, Yoonhee Choi, Seung Pyo Daniel Hong

“…Here, we focus on the role of serum-based proteomic tests in predicting the response and toxicity of immunotherapy. …”
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Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease by Daryll Philip, Rebecca Hodgkiss, Swarnima Kollampallath Radhakrishnan, Akshat Sinha, Animesh Acharjee

“…Abstract Introduction Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a crucial role in gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD). …”
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Identification of osteoarthritis-associated chondrocyte subpopulations and key gene-regulating drugs based on multi-omics analysis by Ting Hao, Zhiwei Pei, Sile Hu, Zhenqun Zhao, Wanxiong He, Jing Wang, Liuchang Jiang, jirigala Ariben, Lina Wu, Xiaolong Yang, Leipeng Wang, Yonggang Wu, Xiaofeng Chen, Qiang Li, Haobo Yang, Siqin Li, Xing Wang, Mingqi Sun, Baoxin Zhang

“…To screen for hub genes associated with OA, a combination of 10 machine learning algorithms and 113 algorithm compositions was integrated. …”
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Associations of VEGF-D levels with clinical manifestations in lymphangioleiomyomatosis: a cross-sectional analysis of 631 cases by Luning Yang, Hanghang Wang, Chongsheng Cheng, Miaoyan Zhang, Danjing Hu, Yani Wang, Tengyue Zhang, Xiaoxin Zhang, Song Liu, Wenshuai Xu, Junya Liu, Jinrong Dai, Shuzhen Meng, Yanli Yang, Shao-Ting Wang, Xinlun Tian, Kai-Feng Xu

“…VEGF-D is a valuable biomarker in evaluation of LAM and improve the efficiency of diagnostic algorithm.…”
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Vitellogenin-like A-associated shifts in social cue responsiveness regulate behavioral task specialization in an ant. by Philip Kohlmeier, Barbara Feldmeyer, Susanne Foitzik

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Exploring the multifaceted roles of glutamate oxaloacetate transaminase 1 as a biomarker and therapeutic target in colorectal cancer and pan-cancer analyses by Xi Wang, Longquan Pi, Yuning Chen, Jiangyu Tan, Yingying Wang, Kaiyan Xia, Xianchun Zhou

“…Glutamate oxaloacetate transaminase 1 (GOT1) plays a crucial role in metabolism and is associated with various cancers. …”
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Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review. by Isabelle Cleynen, Peter Jüni, Geertruida E Bekkering, Eveline Nüesch, Camila T Mendes, Stefanie Schmied, Stefan Wyder, Eliane Kellen, Peter M Villiger, Paul Rutgeerts, Séverine Vermeire, Daniel Lottaz

“…We systematically reviewed all published genetic studies on populations of European ancestry (67 studies on Crohn's disease [CD] and 37 studies on ulcerative colitis [UC]) to identify critical genomic regions associated with IBD. We developed a computer algorithm to map the 807 P/PI genes with exact genomic locations listed in the MEROPS database of peptidases onto these critical regions and to rank P/PI genes according to the accumulated evidence for their association with CD and UC. 82 P/PI genes (75 coding for proteases and 7 coding for protease inhibitors) were retained for CD based on the accumulated evidence. …”
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Biomarkers associated with cell-in-cell structure in kidney renal clear cell carcinoma based on transcriptome sequencing by Zehua Wang, Zhongxiao Zhang

“…The accuracy of these biomarkers was verified by using the receiver operating characteristic (ROC) curve as well as in vitro experiments (CCK-8 assay, wound healing assay, Transwell assay, and quantitative real-time PCR). The CIBERSORT algorithm was applied to explore the association between immune infiltration and the biomarkers. …”
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Exploring the association between circadian rhythms and osteoporosis: new diagnostic and therapeutic targets identified via machine learning by Jian Du, Jian Du, Tian Zhou, Ran Meng, Wei Zhang, Jin Zhou, Wei Peng

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Elevated Serum Levels of CCL23 Are Associated with Poor Outcome after Resection of Biliary Tract Cancer by Christoph Roderburg, Simon Labuhn, Jan Bednarsch, Sven A. Lang, Anne T. Schneider, Linda Hammerich, Mihael Vucur, Tom F. Ulmer, Ulf P. Neumann, Tom Luedde, Sven H. Loosen

“…Chemokine (C-C motif) ligand 23 (CCl23) has been associated with tumor progression in hepatocellular carcinoma (HCC), but its role in the context of BTC is largely unknown. …”
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Novel estrogen-related gene variants identified by whole-exome sequencing in pregnancy-associated intrahepatic cholestasis by Hua Lai, Siming Xin, Jinliang Zhang, Yang Hu, Wenjuan Fan, Hong Wan, Bowen Chen, Yang Zou, Xiaoming Zeng, Xianxian Liu

“…Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse fetal outcomes, including fetal morbidity and mortality. …”
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Integrative Analysis of Neutrophil-Associated Genes Reveals Prognostic Significance and Immune Microenvironment Modulation in Cervical Cancer by Ting Hu, Haijing Wu, Xinghan Cheng, Haoyue Gao, Min Yang

“…<b>Background:</b> Tumour-associated neutrophils play an important role in tumour progression and immunomodulation. …”
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Prognostic role of hemostasis-regulating genetic factors and their interaction with conventional risk factors at the early stages of coronary heart disease development by E. Yu. Andreenko, L. M. Samokhodskaya, A. V. Balatskyi, P. I. Makarevich, S. A. Boytsov

“…Increased CHD risk was associated with the TT genotype of GPIa (p=0,0001; OR=10,2). …”
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Novel Insights from Comprehensive Bioinformatics Analysis Utilizing Large-Scale Human Transcriptomes and Experimental Validation: The Role of Autophagy in Periodontitis by Liu F, Zhu Z, Zou H, Huang Z, Xiao S, Li Z

“…Our analysis unveiled an association between these genes and altered immune cell infiltration in periodontitis. …”
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Role of multislice computed tomography in the diagnosis of acute rupture of the thoracic aorta and hepatic artery in a patient with severe concomitant injury by R. Sh. Muslimov, F. A. Sharifullin, N. R. Chernaya, M. S. Novruzbekov, L. S. Kokov

“…Acute traumatic aortic rupture is associated with extremely high mortality rates and requires emergency diagnosis and treatment. …”
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Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision by Chenglong Fan, Guanglin Yang, Cheng Li, Jiwen Cheng, Shaohua Chen, Hua Mi

“…An unsupervised consensus clustering of DN samples from the same dataset was conducted based on differentially expressed GRGs. The hub genes associated with DN and glycolysis-related clusters were identified via weighted gene co-expression network analysis (WGCNA) and machine learning algorithms. …”
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Evaluation of Environmental Factors Influencing Photovoltaic System Efficiency Under Real-World Conditions by Krzysztof Pytel, Wiktor Hudy, Roman Filipek, Malgorzata Piaskowska-Silarska, Jana Depešová, Robert Sito, Ewa Janiszewska, Izabela Sieradzka, Krzysztof Sulkowski

“…Furthermore, the findings highlight the indirect role of air pollution in attenuating irradiance and reducing system efficiency. …”
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Identification of marker genes associated with oxidative stress in hypertrophic cardiomyopathy using bioinformatics analysis and experimental validation by Jian Zhuo, Ding Ding, Mengkang Fan, Weiwei Lu, Xiaochen Lu, Lihong Yao, Hongzhuan Sheng

“…This study aimed to identify HCM-associated oxidative stress genes and evaluate their significance in HCM pathogenesis through bioinformatic analysis of public datasets. …”
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