Elucidating the role of KLRD1 in coronary atherosclerosis: harnessing bioinformatics and machine learning to advance understanding by Huan Liang, Xiao Liang, Man Zheng, Shoudong Wang

“…The relationship between KLRD1 expression and immune processes was examined using CIBERSORT and ESTIMATE algorithms to assess tumor microenvironment characteristics, suggesting increased immune cell infiltration associated with higher KLRD1 expression. …”
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Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs. by Frans J Walther, Alan J Waring, Jose M Hernandez-Juviel, Larry M Gordon, Zhengdong Wang, Chun-Ling Jung, Piotr Ruchala, Andrew P Clark, Wesley M Smith, Shantanu Sharma, Robert H Notter

“…Surface plasmon resonance (SPR), predictive aggregation algorithms, and molecular dynamics (MD) and docking simulations further suggested a preliminary model for dimeric Super Mini-B, in which monomers self-associate to form a dimer peptide with a "saposin-like" fold. …”
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Empowering Sustainability: The Crucial Role of IoT-Enabled Distributed Learning Systems in Reducing Carbon Footprints by Anjana M S, Aryadevi Remanidevi Devidas, Maneesha Vinodini Ramesh

“…Electrical energy plays a pivotal role in modern society by powering homes, industries, and transportation systems. …”
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Mitochondrial autophagy-related gene signatures associated with myasthenia gravis diagnosis and immunity by Shan Jin, Junbin Yin, Wei Li, Ni Mao

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Identifying key palmitoylation-associated genes in endometriosis through genomic data analysis by Jinyan Kai, Jiaqi Su, Yinping You, Xiaoliang Liang, Haitao Huang, Jie Fang, Qiong Chen

“…Results Through a rigorous screening process, VRK1, GALNT12, and RMI1 emerged as key genes associated with palmitoylation, exhibiting significant downregulation in endometriosis samples (P < 0.05), indicative of a potential protective role. …”
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Characterization of immune microenvironment associated with medulloblastoma metastasis based on explainable machine learning by Fengmao Zhao, Xiangjun Liu, Jingang Gui, Hailang Sun, Nan Zhang, Yun Peng, Ming Ge, Wei Wang

“…The tumor microenvironment (TME) plays a critical role in driving metastasis; however, the mechanisms underlying TME alterations in MB metastasis remain poorly understood. …”
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Integrative analysis of crotonylation-associated genes reveals prognostic and therapeutic targets in gliomas by Bowen Yin, Bowen Yin, Zhuoyang Fan, Panpan Yu, Panpan Yu, Jin Li, Jin Li, Yilin Wang, Yilin Wang, Minfeng Shu, Minfeng Shu

“…ChIP-seq and qPCR demonstrated that reduced crotonylation suppressed CXCL1 expression and promoted GZMB expression in the glioma microenvironment.ConclusionCrotonylation-associated genes play a pivotal role in glioma progression and prognosis. …”
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Identification of cancer-associated fibroblast signature genes for prognostic prediction in colorectal cancer by Wei Jin, Yuchang Lu, Jingen Lu, Zhenyi Wang, Yixin Yan, Biao Liang, Shiwei Qian, Jiachun Ni, Yiheng Yang, Shuo Huang, Changpeng Han, Haojie Yang

“…BackgroundCancer-associated fibroblasts are an essential part of the tumor immunoenvironment, playing key roles in malignancy progression and treatment response. …”
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Genomic Patterns are Associated with Different Sequelae of Patients with Long‐Term COVID‐19 by Nan Zhang, Xizi Luo, Xiangwen Ji, Tian Tian, Runze Wu, Shishun Zhao, Guoqing Wang

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Identification and analysis of the endoplasmic reticulum stress hub genes in sepsis-associated ARDS by Ling Gao, Tingting Liu, Xiaoyan Li

“…Endoplasmic reticulum stress (ERS) plays an important role in the pathophysiologic process of sepsis-associated ARDS. …”
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A deep learning model for predicting systemic lupus erythematosus-associated epitopes by Jiale He, Zixia Liu, Xiaopo Tang

“…Abstract Background The accurate prediction of epitopes associated with Systemic Lupus Erythematosus (SLE) plays a vital role in advancing our understanding of autoimmune pathogenesis and in designing effective immunotherapeutics. …”
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Experimental validation of cuproptosis-associated molecular signatures and their immunological implications in pulmonary tuberculosis by Xiaofang Liu, Xiaofang Liu, Qianqian Ma, Zhiming Li, Yong Xue, Jie Mi, Yuxi Li, Chunfeng Bai, Donglin Guo, Yinping Liu, Yan Liang, Jianqin Liang, Xueqiong Wu

“…PTB-associated DEGs were intersected with CRGs to identify PTB-related CRGs. …”
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Association between age and lung cancer risk: evidence from lung lobar radiomics by Yuwei Li, Chengting Lin, Lei Cui, Chao Huang, Liting Shi, Shiyang Huang, Yue Yu, Xianglan Zhou, Qian Zhou, Kun Chen, Lei Shi

“…Abstract Background Previous studies have highlighted the prominent role of age in lung cancer risk, with signs of lung aging visible in computed tomography (CT) imaging. …”
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Identification of immune-related biomarkers linked to systemic lupus erythematosus and dilated cardiomyopathy through integrated bioinformatics analysis and multiple machine learni... by Gaijie Li, Liwen Lin, Shushu Wang, Kachun Lu, KaMan Szeto, Guiting Zhou, Xianwen Tang, Chuanjin Luo, Chuanjin Luo

“…Additionally, we performed single-gene set enrichment analysis (GSEA) on key genes to elucidate their potential roles in SLE-related DCM. Finally, we applied the CIBERSORT algorithm to assess immune cell infiltration in both DCM and SLE patients.ResultsThrough DEG and WGCNA in the DCM and SLE datasets, we identified a total of 141 key module genes and 24 commonly expressed differentially expressed genes. …”
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Establishment of predictive models for postoperative delirium in elderly patients after knee/hip surgery based on total bilirubin concentration: machine learning algorithms by Shuhui Hua, Chuan Li, Yuanlong Wang, YiZhi Liang, Shanling Xu, Jian Kong, Hongyan Gong, Rui Dong, Yanan Lin, Xu Lin, Yanlin Bi, Bin Wang

“…This study further investigated whether cerebrospinal fluid plays some role in the relationship between bilirubin and POD using mediated causal analysis. …”
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The moderating role of professional grief in the relationship between job stress dimensions and turnover intention among nurses by Xue Liang, Jue Wang

“…Abstract Background Nurses, as the largest workforce in healthcare, play a crucial role in achieving universal health coverage. However, they continually face both physical and emotional burdens. …”
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Investigation of Underlying Biological Association and Targets between Rejection of Renal Transplant and Renal Cancer by Yinwei Chen, Zhanpeng Liu, Qian Yu, Xu Sun, Shuai Wang, Qingyi Zhu, Jian Yang, Rongjiang Jiang

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The Systemic Immune‐Inflammation Index and Its Association With Biologic Therapy Switching and Response in Psoriasis by Gregg Murray, Niamh Kearney, Conor Smith, Kieran Carty, Yasmine Safta, Olwyn Conlon, Brian Kirby, Ali Alsharqi

“…The systemic immune‐inflammation index (SII) is a novel biomarker for systemic inflammation. Its role in biologic switching in psoriasis remains unexplored. …”
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Association of Mediterranean, high-quality, and anti-inflammatory diet with dementia in UK Biobank cohort by Ji-eun Youn, Yu-Jin Kwon, Yae-Ji Lee, Seok-Jae Heo, Ji-Won Lee

“…Dementia incidence was identified using algorithmically defined outcomes based on ICD codes. Fine–Gray subdistribution hazard models adjusted for sociodemographic, genetic, and lifestyle factors were applied to examine the association between dietary indices and dementia risk. …”
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Pore size classification and prediction based on distribution of reservoir fluid volumes utilizing well logs and deep learning algorithm in a complex lithology by Hassan Bagheri, Reza Mohebian, Ali Moradzadeh, Behnia Azizzadeh Mehmandost Olya

“…Pore size analysis plays a pivotal role in unraveling reservoir behavior and its intricate relationship with confined fluids. …”
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