Trehalose-loaded LNPs enhance mRNA stability and bridge in vitro in vivo efficacy gap by Xu-Han Liu, Hui-Ping Song, Ling-Ling Tao, Zhe Zhai, Jin-Xing Huang, Yong-Xian Cheng

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Enhancing the potency of 5T4 mRNA vaccine by CD70 mRNA-LNPs through ADCC and T cell boosting in prostate cancer therapy by Fei Cao, Yuandong Xu, Yupeng Guan, Kexin Zhang, Haowei Qiu, Zhen Xu, Yunru He, Ze Xiu Xiao, Gao-feng Zha, Jun Pang

“…Mechanistically, these LNPs increased the immune responses, including elevated 5T4-specific antibodies, enhanced CD8 + T cell activity, and more active natural killer (NK) cells. …”
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Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications by Kai Yuan Leong, Seng Kong Tham, Chit Laa Poh

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Lignin-based nanoencapsulation for sustainable herbicide delivery: controlled release and bioactivity of 2,4-D and MCPA compared to commercial formulations by Somayeh Ghaffari Ganzagh, Ali Reza Yousefi, Abbas Rahdar, Mehdi Mohammadi

“…LNPs were synthesized via solvent-free nanoprecipitation, achieving high entrapment efficiencies of 90.7% (2,4-D) and 97.4% (MCPA), confirmed by ultraviolet–visible spectroscopy. …”
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Advancing gene editing therapeutics: Clinical trials and innovative delivery systems across diverse diseases by Mozhghan Raigani, Zohre Eftekhari, Ahmad Adeli, Fatemeh Kazemi-Lomedasht

“…These delivery platforms have enabled promising early-phase clinical trials demonstrating feasibility, safety, and durable gene modification in patient populations. For example, LNPs have been pivotal in delivering mRNA editors for liver-targeted metabolic diseases. …”
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Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways by Sofie Rennen, Victor Bosteels, Clint De Nolf, Sandra Maréchal, Jessica Vetters, Karo Van Lil, Greta Webb, Janne Swinnen, Evelien Van De Velde, Farzaneh Fayazpour, Ria Roelandt, Niels Vandamme, Kevin Verstaen, Stefaan C. De Smedt, Karine Breckpot, Stijn Vanhee, Philippe Gevaert, Eric Hoste, Bruno G. De Geest, Rein Verbeke, Ine Lentacker, Sophie Janssens

“…The data corroborate that uptake of empty (or peptide-containing) LNPs induces homeostatic maturation in DCs, while uptake of Toll-like receptor ligand-adjuvanted (or mRNA-containing) LNPs induces immunogenic maturation, yielding distinct T cell outputs. …”
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Self-assembled extracellular matrix-lipid nanoparticle composite for site-specific siRNA delivery to improve cardiac repair post-myocardial infarction by Xinming Wang, Yiming Zhong, Bei Qian, Shixing Huang, Qiang Long, Haonan Zhang, Qiang Zhao, Xiaofeng Ye

“…To address this, an extracellular matrix (ECM)-LNP composite is developed for targeted RNA delivery to the myocardium. The LNPs are conjugated to the ECM scaffold to enhance RNA retention. …”
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MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer by Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio

“…Finally, LNPs‐miR‐182‐3p were able to cross the blood–brain barrier and reduce intracranial tumors representing a possible therapeutic option for metastatic brain lesions.…”
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Research progress of mRNA vaccines for infectious diseases by Zhen Zhang, Jingli Du, Danyang Zhang, Rui Han, Xueqiong Wu, Yan Liang

“…In particular, during the 2019 Coronavirus Disease (COVID-19) pandemic, the mRNA vaccines delivered with lipid nanoparticles (LNPs) have been developed by BioNTech and Moderna, their exceptional protective efficacy and extensive clinical application further proved the rapid responsiveness of mRNA vaccines in addressing emerging infectious diseases. …”
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Targeting Wnt-driven metabolic adaptations in cancer: integrating glycolysis, glutaminolysis, IDO1-mediated immune evasion, and therapeutic delivery strategies by Eric Flores-Hernández, Grace Binder, Kuo-Ching Mei, Kuo-Ching Mei, Nydia Tejeda-Muñoz, Nydia Tejeda-Muñoz

“…Additionally, advanced drug delivery systems, including lipid nanoparticles (LNPs), polymeric nanocarriers, and exosome-based platforms, enhance the targeted accumulation of metabolic inhibitors and immunomodulatory agents while minimizing systemic toxicity. …”
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Targeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma by Sophie G. Shifman, Jennifer L. O’Connor, Daniel P. Radin, Aryan Sharma, Laura Infante, Francesca Ferraresso, Christian J. Kastrup, Daniel A. Lawrence, Stella E. Tsirka

“…In culture, glioma cell lines were challenged with MDI-2268, lucanthone, mitoxantrone, or siRNA-LNPs targeting PAI-1, and assessed by MTT assay, q-RT-PCR, ELISA, invasion assay, immunoblot, and immunocytochemistry. …”
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