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    Integrated analyses and a novel nomogram for the prediction of significant fibrosis in patients by Mengxin Lu, Shuai Tao, Xinyan Li, Qunling Yang, Cong Du, Weijia Lin, Shuangshuang Sun, Conglin Zhao, Neng Wang, Qiankun Hu, Yuxian Huang, Qiang Li, Yi Zhang, Liang Chen

    Published 2025-01-01
    “…The hub genes were explored using the CytoHubba plugin app and validated in GEO datasets and cell models. …”
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    Hippocampal CA1 neuron, a crucial regulator for chronic stress exacerbating Alzheimer’s disease progression by Qing-Lin Gao, Hai-Wei Zha, Zi-Jie Liu, Miao-Miao Wang, Yu-Qing Zhang, Jia-Rui Bi, Tian-Yang Wu, Zhen-Jiang Liu, Hui Wu, Dong Sun

    Published 2025-05-01
    “…Here, we provide evidence for chronic restraint stress (CRS), a widely used stress model in rodents, to regulate AD pathology. CRS not only induces prolonged depressive-like behaviors and cognitive deficits in young adult wild type (WT) mice, but also exacerbates a series of AD-related phenotypes in APP/PS1 mice, including impaired spatial learning and memory, increased β-amyloid plaques, promoted glial cells (astrocyte and microglial cell) activation and decreased dendritic spines in CA1 neurons. …”
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