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    Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology by Huifen Ma, Zhiyang Yu, Qiong Qiao, Wenpan Wang, Zhonghua Li, Pan Wang, Junying Song, Xiaowei Zhang, Yunfang Su, Yiran Sun, Zhishen Xie, Zhenqiang Zhang

    Published 2025-07-01
    “…Kai-Xin-San (KXS) has been commonly employed in ancient and modern Chinese clinical trials for the treatment of dementia; however, whether the protective effect of KXS in AD is related to the gut microbiota remains elusive. APP/PS1 mice were used as the model of AD. 43 key metabolites influenced by KXS were screened using untargeted metabolomics. …”
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    Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a by YANG Hongyan, LIAO Qirong, HOU Mingliang

    Published 2025-01-01
    “…Methods‍ ‍Six-month-old APP/PS1 mouse model of AD and wild type (WT) mice were subjected and then randomly divided into WT group, WT+ circ-Olfm1 knockout group, AD group (transgenic APP/PS1 mice), AD+ circ-Olfm1 knockout group, AD+FOXO3a knockout group, with 3 mice in each group. ① The total RNA of mouse brain was extracted, and the differential expression of circRNAs and mRNAs between the AD mice and WT mice was detected, and the obtained circRNAs and mRNAs were analyzed with gene ontology (GO) analysis. ② RT‐qPCR was used to detect the expression of the top 10 up-regulated and down-regulated circRNAs, as well as the expression of circ-Olfm1 and miR-330-5p. ③ Lentiviral vectors were prepared and stereotaxically injected into the cortex or hippocampus of WT and AD mice to knock out circ-Olfm1 gene. …”
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    ANGPTL4-mediated microglial lipid droplet accumulation: Bridging Alzheimer's disease and obesity by Nan Li, Xiaojun Wang, Ruilang Lin, Fuxia Yang, Hung-Chen Chang, Xuchao Gu, Jun Shu, Guidong Liu, Yongfu Yu, Wenshi Wei, Zhijun Bao

    Published 2024-12-01
    “…Subsequently, animal models and clinical data were employed to further explore alterations in circulating ANGPTL4 levels in AD. …”
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