Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences by Muhammad Ali, Pierre Garcia, Laetitia P. Lunkes, Alessia Sciortino, Melanie H. Thomas, Tony Heurtaux, Kamil Grzyb, Rashi Halder, Alexander Skupin, Luc Buée, David Blum, Manuel Buttini, Enrico Glaab

“…To validate the most robust findings across distinct mouse models and species, the results were compared with cortical scRNA-seq data from the transgenic hAPP-based Tg2576 mouse model and human AD. …”
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Long-read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons by Jishu Xu, Michaela Hörner, Elena Buena Atienza, Kalaivani Manibarathi, Maike Nagel, Stefan Hauser, Jakob Admard, Nicolas Casadei, Stephan Ossowski, Rebecca Schuele

“…In this study, we employed nanopore long-read RNA sequencing to profile the transcriptomes of three cell types commonly used to model brain disorders, human fibroblasts, induced pluripotent stem cells and stem cell-derived cortical neurons, identifying extensive transcript diversity with 15 072 transcripts in stem cell-derived cortical neurons, 13 048 in fibroblasts and 12 759 in induced pluripotent stem cells. …”
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Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes by Ying-Chieh Wu, Šárka Lehtonen, Kalevi Trontti, Riitta Kauppinen, Pinja Kettunen, Ville Leinonen, Markku Laakso, Johanna Kuusisto, Mikko Hiltunen, Iiris Hovatta, Kristine Freude, Hiramani Dhungana, Jari Koistinaho, Taisia Rolova

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Research on an Intelligent Sedimentary Microfacies Recognition Method Based on Convolutional Neural Networks Within the Sequence Stratigraphy of Well Logging Curve Image Groups by Xinyi Yuan, Xidong Wang, Shutian Wang, Feng Tian, Zichun Yang

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Stock Market Bubble Warning: A Restricted Boltzmann Machine Approach Using Volatility–Return Sequences by Mauricio A. Valle, Jaime Lavín, Felipe Urbina

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Enrichment of Z-DNA-Forming Sequences Within Super-Enhancers: A Computational and Population-Based Study by Yulia V. Makus, German A. Ashniev, Alexey V. Orlov, Petr I. Nikitin, Zoia G. Zaitseva, Natalia N. Orlova

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Validation of a microRNA profile in urine liquid biopsy with diagnostic and stratification value for bladder cancer classification, available through the open app BladdermiRaCan by Julia Oto, Raquel Herranz, Emma Plana, Javier Pérez-Ardavín, David Hervás, Fernando Cana, Patricia Verger, David Ramos-Soler, Manuel Martínez-Sarmiento, César D. Vera-Donoso, Pilar Medina

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Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer by Hongwei Lan, Hui Liu, Helei Hou, Chuantao Zhang, Jingjuan Zhu, Na Zhou, Xiaochun Zhang

“…Peripheral blood mononuclear cell-derived patient-derived xenograft (PBMC-PDX) model was established from drug-resistant recurrent HGSOC patient-derived tumor cells, and single-cell RNA sequencing (scRNA-seq) was conducted to dissect the TME following treatment with anlotinib, anlotinib + aPD-L1 and anlotinib + aPD-1.ResultsClinical analysis revealed a disease control rate (DCR) of 71.43% for anlotinib monotherapy, which improved to 100% when combined with aPD-L1/aPD-1. …”
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Adaptive Graph Convolutional Network with Deep Sequence and Feature Correlation Learning for Porosity Prediction from Well-Logging Data by Long Hao, Xun Wang, Yunlong Dong, Peizhi Zhao, Peifu Han, Xue Li, Fengrui Jing, Chuchu Zhai

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Impact of the Spatiotemporal Relationship Between Blast Source and Protected Area on Wave Arrival Sequence and Vibration Control Methods in Bench Blasting by Sijie Wang, Haojun Wu, Min Gong, Xiaodong Wu

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Revealing the Next Word and Character in Arabic: An Effective Blend of Long Short-Term Memory Networks and ARABERT by Fawaz S. Al-Anzi, S. T. Bibin Shalini

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Astronomical Orbital Cycle-Driven Coevolution of Paleoclimate and Sea Level with Sedimentary Response: A Case Study from the Upper Member of the Miocene Zhujiang Formation in the E... by Shangfeng Zhang, Chenjun Zeng, Enze Xu, Yaning Wang, Rui Zhu, Rui Han, Gaoyang Gong

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NeuroTIS+: An Improved Method for Translation Initiation Site Prediction in Full-Length mRNA Sequence via Primary Structural Information by Wenqiu Xiao, Chao Wei

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Data Analysis of Globular Cluster Harris Catalogue in View of the King Models and Their Dynamical Evolution. I. Theoretical model by Marco Merafina, Daniele Vitantoni

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Language Models for Predicting Organic Synthesis Procedures by Mantas Vaškevičius, Jurgita Kapočiūtė-Dzikienė

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RoPT: Route-Planning Model with Transformer by Zuyun Xiong, Yan Wang, Yuxuan Tian, Lijuan Liu, Shunzhi Zhu

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Inter-Turn Fault Diagnosis of Induction Motors Based on Current Vector Pattern Analysis in Stationary Coordinate Frame by Inyeol Yun, Hyunwoo Kim, Ju Lee, Sung-Gu Lee

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Classification of Diabetic Retinopathy Based on Efficient Computational Modeling by Jiao Xue, Jianyu Wu, Yingxu Bian, Shiyan Zhang, Qinsheng Du

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Large-Language-Model-Enabled Text Semantic Communication Systems by Zhenyi Wang, Li Zou, Shengyun Wei, Kai Li, Feifan Liao, Haibo Mi, Rongxuan Lai

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Research on Wellbore Trajectory Prediction Based on a Pi-GRU Model by Hanlin Liu, Yule Hu, Zhenkun Wu

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