Parasitic infections during pregnancy in Gabon affect glycosylation patterns of maternal and child antibodies by Yabo J. Honkpehedji, Anna O. Kildemoes, Koen A. Stam, Dieu L. Nguyen, Tom Veldhuizen, Angela van Diepen, Meral Esen, Peter G. Kremsner, Manfred Wuhrer, Ayôla A. Adegnika, Cornelis H. Hokke, Maria Yazdanbakhsh

“…Abstract Antibody glycosylation patterns can affect antibody functionality and thereby contribute to protection against invading pathogens. …”
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Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention by Juan C Becerra, Lauren Hitchcock, Khoa Vu, Johannes S Gach

“…Continual advancements in identifying more potent bnAbs, along with their capacity to trigger antibody-mediated effector functions, coupled with modifications to extend their half-life, position them as promising candidates for both HIV-1 treatment and prevention. …”
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Unlocking the potential of antibody-drug conjugates in cervical cancer: emerging targets and clinical trials by Yue Zhang, Yao Ding, Yiran Liao, Jin Shu, Yi Gong

“…There persists a substantial unmet clinical need for novel therapeutic strategies that are both effective and well-tolerated. In recent years, antibody-drug conjugate (ADC) have gained increasing attention as an emerging form of precision chemotherapy with targeted delivery capabilities, offering a promising therapeutic approach for r/mCC. …”
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Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features by Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei

“…In this work, we show two machine learning approaches – one with pre-trained language models (PTLM) capturing functional effects of sequence variation, and second, a supervised convolutional neural network (CNN) trained with Rosetta energetic features – to better classify thermostable scFv variants from sequence. …”
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Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response. by Diana S Smith, Kejun Guo, Bradley S Barrett, Karl J Heilman, Leonard H Evans, Kim J Hasenkrug, Warner C Greene, Mario L Santiago

“…The underlying mechanism does not involve a direct effect of Apobec3 on B cell function. Here we show that while Apobec3 decreased titers of infectious virus during acute FV infection, plasma viral RNA loads were maintained, indicating substantial release of noninfectious particles in vivo. …”
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Supervised fine-tuning of pre-trained antibody language models improves antigen specificity prediction. by Meng Wang, Jonathan Patsenker, Henry Li, Yuval Kluger, Steven H Kleinstein

“…Antibodies play a crucial role in the adaptive immune response, with their specificity to antigens being a fundamental determinant of immune function. …”
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Case Report: Subcutaneous ofatumumab for patients with immunosuppressant-dependent or ineffective primary membranous nephropathy by Jie Chen, De-tian Li, Xin Feng, Bei-Ru Zhang

“…After ofatumumab therapy, Case 1 achieved PLA2R antibody negativity, and Case 2 showed improvements in renal function and hypoproteinemia. …”
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Neutralizing and enhancing monoclonal antibodies in SARS-CoV-2 convalescent patients: lessons from early variant infection and impact on shaping emerging variants by Frédéric Coutant, Franck Touret, Jean-Jacques Pin, Marina Alonzo, Cécile Baronti, Sandie Munier, Mikaël Attia, Xavier de Lamballerie, Tristan Ferry, Pierre Miossec

“…Serological studies of COVID-19 convalescent patients have identified polyclonal lineage-specific and cross-reactive antibodies (Abs), with varying effector functions against virus variants. …”
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Immunoglobulin Y antibodies against colonization-related genes block the growth and infection of Helicobacter pylori by Shiyuan Deng, Xiaoling Luo, Yunxiao Du, Rania G. Elbaiomy, Weihan He, Rong Guo, Ahmed H. El-Sappah, Xiaohong Jian, Yongmei Xie, Mohammed Bakeer, Mohammed Bakeer, Zaixin Li, Zhi Zhang

“…Interestingly, combination treatment with these IgY antibodies, based on their different roles, enhances antibacterial benefits and significantly promotes the recovery of gastrointestinal function.ConclusionOur results indicate that IgY antibodies against colonization-related genes can directly block the growth and infection of H. pylori, and combination treatment with these antibodies offers more advantages in combating H. pylori.…”
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Development of novel neutralizing single-chain fragment variable antibodies against S100A8 by Hamideh Raeisi, Masoumeh Azimirad, Alexandru Schiopu, Amir-Hassan Zarnani, Hamid Asadzadeh Aghdaei, Elham Abdemohamadi, Mohammad Reza Zali, Abbas Yadegar

“…Therefore, targeting the S100A8 function may alleviate the pathogenic process in various diseases. …”
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In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay by Ágnes Kovács, Ágnes Kovács, Zoltán Hérincs, Krisztián Papp, Jakub Zbigniew Kaczmarek, Daniel Nyberg Larsen, Daniel Nyberg Larsen, Pernille Stage, László Bereczki, Eszter Ujhelyi, Tamás Pfeil, Tamás Pfeil, József Prechl

“…We obtained equilibrium affinity constants and concentrations for distinct antibody classes. These variables reflect the quality and the effective quantity of serum antibodies, respectively. …”
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Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination by Masayoshi Aosasa, Md Saddam Hossain, Tomoko Sakata, Keita Koga, Takanari Shigemitsu, Yuji Shoya, Motonori Yamaguchi, Kenji Saito, Mujo Kim

“…These antibodies can aid in understanding the extracellular PAD2 function and treating diseases associated with aberrant citrullination.…”
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AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity by Aditya A. Agarwal, James Harrang, David Noble, Kerry L. McGowan, Adrian W. Lange, Emily Engelhart, Miranda C. Lahman, Jeffrey Adamo, Xin Yu, Oliver Serang, Kyle J. Minch, Kimberly Y. Wellman, David A. Younger, Randolph M. Lopez, Ryan O. Emerson

“…These models enable efficient in silico prescreening and optimization of antibody candidates. By focusing experimental efforts on the most promising candidates guided by deep learning predictions, antibodies with optimal properties can be designed more quickly and effectively. …”
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Anti-idiotypic antibodies specific to steroid hormones and proliferative activity of tumor in breast cancer patients by A. N. Glushkov, E. G. Polenok, S. A. Mun, L. A. Gordeeva, A. V. Antonov, P. V. Bairamov, N. E. Verzhbitskaya, G. I. Kolpinsky

“…Nongenomic effects of antibodies specific to membrane steroid receptors are well known. …”
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Protocol to measure the impact of Clostridioides difficile toxins on antibody responses using ELISA, ELISPOT, and toxin-neutralization assays by Kaylee M. Norman, Gillian A. Lang, Jimmy D. Ballard, Mark L. Lang

“…Summary: To determine the effects of bacterial toxins on the humoral immune response, accurate measurement of antibody quantity, specificity, and function is critical. …”
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Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies by Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu, Gilad Kaplan

“…Some of the most promising therapies are neutralizing antibodies against SARS-CoV-2. In order to maximize the therapeutic effectiveness of such neutralizing antibodies, Fc engineering to modulate effector functions and to extend half-life is desirable. …”
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Pioneer: a synthetic human antibody phage display library for rapid therapeutic lead generation by Mateusz Putyrski, Christian Hentrich, Manuel Cavada, Melissa Wich, Sarah-Jane Kellmann, Sarah Hanselka, Michaela Eick-Werner, Hanh Hanuschka, Waldemar Preis, Christina Werkmeister, Martina Klee, Achim Knappik, Francisco Ylera

“…In this study, we introduce Pioneer, one of the largest synthetic human antibody libraries developed to date, with approximately 2.2 × 1011 functional members. …”
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Passive Anti-amyloid Beta Monoclonal Antibodies: Lessons Learned over Past 20 Years by Alexandra Wicker, Jahnavi Shriram, Boris Decourt, Marwan Noel Sabbagh

“…Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder that significantly impairs cognitive and functional abilities, placing a substantial burden on both patients and caregivers. …”
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Development of a sensitive antibody-based label-free electrochemical immunosensors for breast cancer diagnosis by Saiedeh Agh Atabay, Hossein Ahmadzadeh, Parviz Norouzi, Somayeh Dianat, Kheibar Dashtian

“…The sensor employs a gold electrode functionalized with carboxylic acid molecules (11-mercaptoundecanoic acid, 3-mercaptopropionic acid), activated by coupling agents and modified with anti-HER2 antibodies. …”
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The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies by Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan, Mingjuan Du, Anqi Zhou, Huanzhen Liu, Yujia He, Wei Wang, Yuchi Lu, Xiaoyu Zhang, Haofeng Wang, Xiuna Yang, Hongkai Zhang, Xinwen Chen, Zihe Rao, Haitao Yang

“…Currently, effective antiviral treatments against this virus are limited. …”
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