Harnessing antibody-mediated recognition of the intracellular proteome with T cell receptor-like specificity by Maya Haus-Cohen, Yoram Reiter

“…The clinical success of cancer immunotherapy has driven ongoing efforts to identify novel targets that can effectively guide potent effector functions to eliminate malignant cells. …”
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Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions by Tarikul I. Milon, Titli Sarkar, Titli Sarkar, Yixin Chen, Jordan M. Grider, Feng Chen, Jun-Yuan Ji, Seetharama D. Jois, Konstantin G. Kousoulas, Vijay Raghavan, Wu Xu

“…IntroductionMonoclonal antibody (mAb) drug treatments have proven effective in reducing COVID-19-related hospitalizations or fatalities, particularly among high-risk patients. …”
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Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomisti... by Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Nishank Raisinghani, Gennady Verkhivker

“…According to our results, the E1 and F3 groups of Abs effectively exploit binding hotspot clusters of hydrophobic sites that are critical for spike functions along with the selective complementary targeting of positively charged sites that are important for ACE2 binding. …”
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Effectiveness and safety of BCD180, anti-TRBV9⁺ T-lymphocytes monoclonal antibody in patients with active radiographic axial spondyloarthritis: 36-week results of double... by E. L. Nasonov, V. I. Mazurov, A. M. Lila, T. V. Dubinina, I. Z. Gaydukova, S. A. Lapshina, A. A. Klimenko, D. V. Somov, S. A. Lukianov, D. M. Chudakov, I. V. Zvyagin, O. V. Britanova, M. A. Korolev, D. I. Abdulganieva, D. G. Krechikova, A. A. Kastanayan, L. V. Eliseeva, R. R. Samigullina, T. V. Povarova, O. V. Antipova, S. A. Smakotina, V. N. Soboleva, O. B. Nesmeyanova, T. V. Plaksina, N. F. Soroka, I. B. Vinogradova, A. P. Rebrov, T. V. Kropotina, A. L. Maslyanskiy, A. V. Zinkina-Orikhan, Yu. N. Lin’kova, P. S. Pukhtinskaia, M. A. Morozova, G. A. Vinderskaya

“…The proportion of patients with binding antibodies was 5.1%. However, no neutralizing antibodies were detected.Conclusion. …”
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Everestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effects by Hongchao Pan, Yunnan Su, Yini Xie, Weiyong Wang, Wanli Qiu, Wei Chen, Wenying Lu, Zhao Lu, Weiwei Wang, Anquan Shang

“…Chronic treatment of everestmab to GK and diet induced obese (DIO) rats achieved beneficial effects on weight reducing, HbA1c lowering, glucose tolerance, liver and pancreas islet function impairment. …”
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Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination by Ayae Nishiyama, Takuto Nogimori, Yuji Masuta, Tomoka Matsuura, Tetsuo Kase, Kyoko Kondo, Satoko Ohfuji, Yu Nakagama, Natsuko Kaku, Sachie Nakagama, Yuko Nitahara, Yoshimasa Takahashi, Hiroshi Kakeya, Yasutoshi Kido, Wakaba Fukushima, Takuya Yamamoto

“…Additionally, Fc-mediated functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) are recognized as important protective immune mechanisms. …”
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Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM by Xiaofeng Zhou, Zhifang Liu, Weixiong Zhang, Lin Dai, Tao Chen, Zexiong Lin, Hong Pan, Qi Qi, Henry Wei

“…Despite efforts using anti-EpCAM monoclonal antibodies (mAbs), their anti-tumor effects have been limited. …”
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Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification by Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M

“…Additionally, a phospho-antibody array was utilized to screen over 300 molecules across 16 canonical signaling pathways in ZXF-treated HF models, with Western blot analysis confirming the specific pathways implicated in ZXF’s therapeutic effects.Results: Network pharmacology analysis identified 56 potential active ingredients in ZXF, 47 of which were associated with HF-related targets. …”
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Enzyme-instructed self-assembled supramolecular bi-antibodies for inhibition and imaging of atherosclerosis progression by Shuang Bian, Yangang Zhu, Nanxin Zhao, Yanchen Wang, Zhimou Yang, Jingjing Li

“…Therefore, we designed a peptide 2P with an alkaline phosphatase (ALP) induced self-assembly function and P-selectin targeting function to form a supramolecular bi-antibodies 2P@VLA-4 by coassembling with VLA-4, a CD106 affinity. …”
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The significance of anti-PLA2R antibody in the diagnosis and treatment of primary membranous nephropathy by XU Dong-mei, LIU Yi-peng

“…Serum anti-PLA2R levels can predict therapeutic effect, and the anti-PLA2R levels after treatment can predict long-term prognosis of PMN. …”
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GENERALIZED ANALYSIS OF MONOCLONAL ANTIBODIES TO IGE IN THE TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN IN RUSSIAN FEDERATION by T.V. Kulichenko, A.A. Baranov, M.M. Abelevich, E.V. Balashova, E.A. Vishneva, A.N. Galustyan, S.Yu. Elizarova, I.V. Koroleva, A.G. Manvelyan, L.S. Namazova-Baranova, Yu.V. Peshekhonova, E.V. Timofeeva, R.M. Torshhoeva, N.V. Tursina, T.E. Chashina

“…Full control of the disease or marked improvement can be achieved in 73% patients, the effect in most cases significantly increases during the first 6 months of treatment and becomes stable in the future, providing a good quality of life and normal lung function.Key words: bronchial asthma, anti-IgE-therapy, treatment, adolescents, children, quality of life, omalizumab.…”
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Low Serum Vitamin D Is Associated with Anti-Thyroid-Globulin Antibody in Female Individuals by Xinling Wang, Jazyra Zynat, Yanying Guo, Reziwan Osiman, Aihemaitjan Tuhuti, Hongli Zhao, Munira Abdunaimu, Huili Wang, Xiaoping Jin, Shuqing Xing

“…A total of 1714 Chinese adults were analyzed. 25(OH)D, anti-thyroid antibodies, and thyroid function were measured. Results. …”
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Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…Currently, the identification of effective therapies for KRAS-mutant NSCLC is difficult for reasons of the structural and biochemical characteristics of the KRAS protein. …”
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Building a potent TREM2 agonistic, biparatopic, common light chain antibody by Ana da Silva Almeida, Melissa L. Geddie, Anil Bhate, Chao Quan, Joseph W. Arndt, Yang Jiao, Joseph C. Santoro, Liron Noiman, Ramya Vijayakumar, Jorge Sanchez-Salazar, Abhishek Datta, Giovanna Antognetti, Ciputra Adijaya Hartana, Xue Fan Wang, Benjamin A. Smith, Dan Bartlett, Danté Duncan, Chia-Chen Liu, Karel Otero Gutierrez, Thomas O. Cameron, Samir Koirala, Heather A. Cooke

“…Activation of TREM2 signaling may contribute to protection against neurotoxic effects of amyloid. Numerous TREM2 activating antibodies have been shown to modulate downstream microglial functions to different degrees, with mixed results in preclinical models and in the clinic. …”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…T-cell engaging (TCE) bispecific antibodies are potent drugs that trigger the immune system to eliminate cancer cells, but administration can be accompanied by toxic side effects that limit dosing. …”
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Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed. by Michael I Falola, Howard W Wiener, Nathan E Wineinger, Gary R Cutter, Robert P Kimberly, Jeffrey C Edberg, Donna K Arnett, Richard A Kaslow, Jianming Tang, Sadeep Shrestha

“…Anthrax vaccine is highly effective, but vaccine-induced IgG antibody responses vary widely following required doses of vaccinations. …”
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Comparison of sequence- and structure-based antibody clustering approaches on simulated repertoire sequencing data. by Katharina Waury, Stefan Lelieveld, Sanne Abeln, Henk-Jan van den Ham

“…Repertoire sequencing allows us to investigate the antibody-mediated immune response. The clustering of sequences is a crucial step in the data analysis pipeline, aiding in the identification of functionally related antibodies. …”
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Mechanism of modified mRNA structure in COVID-19 vaccines for inducing neutralizing antibodies by Sabighoh Zanjabila, Beti Ernawati Dewi

“…While mRNA vaccines have proven effective in neutralizing SARS-CoV-2, challenges remain, including the decline in neutralizing antibody titers over time and the emergence of new viral variants. …”
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Understanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies by Bo Zhao, Joy Yoon, Bojie Zhang, Youmi Moon, Yue Fu, Yinyin Li, Yunlong Zhao, Hui Xiao, Ning Li

“…Methionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs). …”
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Cellulose-Based Colorimetric Test Strips for SARS-CoV-2 Antibody Detection by Mariana P. Sousa, Ana Cláudia Pereira, Bárbara Correia, Anália do Carmo, Ana Miguel Matos, Maria Teresa Cruz, Felismina T. C. Moreira

“…Glutaraldehyde reacts with amino groups to generate a brown color, enabling detection of SARS-CoV-2 antibodies. Wathman filter paper was functionalized with (3-aminopropyl)triethoxysilane (APTES) to immobilize virus-like particles (VLPs) and nucleocapsid protein (N-protein) as biorecognition elements. …”
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