Monoclonal antibodies in severe asthma: outcomes from real-world data by Silvia del-Barrio-Buesa, Silvia del-Barrio-Buesa, Álvaro Narrillos-Moraza, Álvaro Narrillos-Moraza, Julia García-de-Pedro, Julia García-de-Pedro, Julia García-de-Pedro, Francisco Javier de-Castro-Martínez, Francisco Javier de-Castro-Martínez, María Esther Durán-García, María Esther Durán-García, Vicente Escudero-Vilaplana, Vicente Escudero-Vilaplana, Elena Lobato-Matilla, Elena Lobato-Matilla, Rosa Romero-Jimenez, Rosa Romero-Jimenez, Esther Chamorro-de-Vega, Esther Chamorro-de-Vega, Paula Ruiz-Briones, Paula Ruiz-Briones, Félix Jesús Garcia-Moreno, Félix Jesús Garcia-Moreno, María Martín-Bartolomé, María Martín-Bartolomé, Ana Herranz, Ana Herranz, María Sanjurjo, María Sanjurjo

“…BackgroundUncontrolled severe asthma represents a substantial clinical and economic burden, particularly in patients with comorbidities and poor response to high-dose inhaled corticosteroids. Monoclonal antibodies targeting type 2 (T2) inflammation have become key therapeutic options, but their real-world performance remains insufficiently characterized.ObjectiveTo evaluate the real-world effectiveness, adherence, and persistence of benralizumab, mepolizumab, omalizumab, and reslizumab in adults with uncontrolled severe asthma after 12 months of treatment.MethodsA retrospective real-world observational study was conducted in patients with uncontrolled severe asthma who initiated treatment with benralizumab, mepolizumab, omalizumab, and reslizumab between January 2015 and December 2022. …”
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ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES by M. S. Drutskaya, E. A. Gorshkova, A. S. Zhdanova, K.-S. Atretkhany, V. S. Gogoleva, R. V. Zvartsev, A. A. Kruglov, S. A. Nedospasov

“…This study revealed systemically increased levels of IL-6 in developing arthritis caused by transfer of pathogenic antibodies, as well as the effects of IL-6 neutralization by monoclonal antibodies against murine IL-6. …”
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Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice by Masaya Yamamoto, Takahide Itokazu, Hiroki Uno, Takakuni Maki, Nao Shibuya, Toshihide Yamashita

“…In this study, we explored the involvement of RGMa and the therapeutic effects of an anti-RGMa neutralizing antibody in a mouse model of vascular dementia (VaD). …”
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Dual vs. isolated anti-Ro antibody positivity in rheumatoid arthritis by Yan Ma, Chaoyu Gu, Qianqian Li, Liangjing Lu

“…Conversely, patients with isolated Ro60 positivity exhibited lower IgG levels, fewer systemic complications, and reduced reliance on biological therapies, indicating a less severe disease phenotype.ConclusionAnti-Ro antibody subtyping effectively identifies distinct clinical and immunological RA subgroups. …”
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Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression. by Marloes Grobben, Margreet Bakker, Angela I Schriek, Liesbeth J J Levels, Jeffrey C Umotoy, Khadija Tejjani, Mariëlle J van Breemen, Ryan N Lin, Steven W de Taeye, Gabriel Ozorowski, Neeltje A Kootstra, Andrew B Ward, Stephen J Kent, P Mark Hogarth, Bruce D Wines, Rogier W Sanders, Amy W Chung, Marit J van Gils

“…However, the properties underlying the potential beneficial effects of antibodies during HIV-1 infection are poorly understood. …”
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PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages by Deyou Kong, Yongzhen Chen, Yajuan Yin, Zhikun Liu, Fang Yang, Xiaohong Li, Dongxing Shen, Jun Zhang

“…Abstract To investigate how PD-L1 monoclonal antibodies (mAbs) affect the left ventricular function in mice with myocardial infarction (MI) and through what mechanisms they exert their effects. …”
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Effect of streptococcal arginine deiminase on the function of CD4⁺ and CD8⁺T lymphocytes by E. A. Starikova, J. T. Mammedova, A. Ozhiganova, A. M. Lebedeva, T. A. Leveshko, L. A. Burova, I. V. Kudryavtsev

“…At the same time, arginine deiminase did not exert cytotoxic effects upon lymphocytes. L-arginine applied at the doses exceeding physiological levels caused restoration of the cellular functions. …”
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Investigating Associations between Subclinical Hypothyroidism and Pregnancy Outcomes and Effects of Levothyroxine Therapy on Improving Maternal and Infant Prognosis by Chen Li, Xia Li

“…However, little is known on the impacts and effectiveness of levothyroxine (LT4) therapy on pregnancy outcomes in women with SCH. …”
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NK cell immunopotentiators-loaded nanoliposomes enhance ADCC effect for targeted therapy against HER2-positive breast cancer by Ruoxin Du, Changqing Cao, Dong Fan, Guodong Li, Shuangpeng Pu, Xinyao Xu, Mengmeng Liu, Gege Shi, Yuxin Wu, Qiang Hao, Yuan Gao, Juliang Zhang, Huadong Zhao, Cun Zhang

“…Through in vitro experiments, we substantiated that bolstering the tumor infiltration and activity of NK cells can lead to an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) effect, thereby amplifying the anti-tumor activity of trastuzumab. …”
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PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic framework with effective nanozyme performance and cuproptosis induction efficacy for enhanced PD-L1-based immunotherapy by Xufeng Lu, Wenhai Deng, Shuaibin Wang, Shengsheng Zhao, Bingzi Zhu, Binglong Bai, Yiwen Mao, Ji Lin, Yongdong Yi, Zuoliang Xie, Xiang Wang, Yongyong Lu, Xiufeng Huang, Tao You, Xiaolei Chen, Weijian Sun, Xian Shen

“…Furthermore, combining ES@Cu(Ⅱ)-MOF with an anti-programmed cell death-ligand 1 (PD-L1) antibody converted the immunosuppressive tumor microenvironment to an immunogenic microenvironment, thus effectively inhibiting breast tumor growth. …”
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Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects by Maria Jure-Kunkel, Christina Yu, Nora Pencheva, Mark Fereshteh, Alexander Muik, Aras Toker, Özlem Türeci, Tahamtan Ahmadi, Ugur Sahin, Brandon W Higgs, Jordan M Blum, Saskia M Burm, Vanessa M Spires, Angelica Sette, Sina Fellermeier-Kopf, Andrea Imle, Michela Capello, Kristin Strumane, Theo Plantinga, Craig J Thalhauser, Kristina B Nürmberger, Patricia Garrido Castro, Carol Costa Sa, Bruna de Andrade Pereira

“…Since 4-1BB is coexpressed with programmed cell death protein-1 (PD-1) on CD8+ T cells, PD-1 blockade and simultaneous costimulation through 4-1BB may synergistically enhance T-cell effector functions. We hypothesized that combining acasunlimab with PD-1 blockade to fully disrupt PD-1 interactions with both PD-L1 and PD-L2 would amplify the depth and duration of antitumor immunity.Methods The effect of acasunlimab and pembrolizumab combination was analyzed in vitro using functional immune cell assays, including mixed-lymphocyte reactions and antigen-specific T-cell proliferation and cytotoxicity assays. …”
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Effects of Vitamin and Mineral Supplementation During Gestation in Beef Heifers on Immunoglobulin Concentrations in Colostrum and Immune Responses in Naturally and Artificially Rea... by Jennifer L. Hurlbert, Friederike Baumgaertner, Kerri A. Bochantin-Winders, Isabella M. Jurgens, Kevin K. Sedivec, Carl R. Dahlen

“…Two experiments assessed the effects of providing a vitamin and mineral supplement to gestating beef heifers on concentrations of immunoglobulins (Ig) in colostrum and calf serum 24 h after feeding maternal colostrum (Exp. 1) or a colostrum-replacement product (Exp. 2). …”
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Experience in the use of neutralizing monoclonal antibodies in kidney transplant recipients with COVID-19 by I. G. Kim, M. A. Lysenko, N. F. Frolova, L. Yu. Artyukhina, T. A. Buruleva, A. M. Nikitina, V. E. Vinogradov, E. V. Volodina, V. I. Chervinko, E. V. Kryukov, M. L. Zubkin

“…Use of mAbs significantly reduced mortality from 19.7% in KTRs in group 2 to 3% in group 1 without adverse effect on graft function. Conclusion. The use of mAbs therapy in the early stages of COVID-19 in KTRs is safe, it prevents severe COVID-19, and reduces the incidence of adverse outcomes.…”
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Current status and future perspectives of antibody-drug conjugates in breast cancer therapy by LIN Jialin, WANG Wenna, XU Binghe

“…HER2-targeting ADCs present specific adverse events, including interstitial lung disease (ILD) associated with T-DXd, thrombocytopenia, and liver function abnormalities observed with T-DM1, while Trop-2-targeting ADCs such as SG are linked to hematologic toxicity and gastrointestinal side effects. …”
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Tocilizumab, but not dexamethasone, prevents CRS without affecting antitumor activity of bispecific antibodies by Hans-Georg Rammensee, Melanie Märklin, Gundram Jung, Jonas S Heitmann, Joseph Kauer, Helmut R Salih, Latifa Zekri, Lukas Osburg, Sebastian Hörner, Stefanie Müller

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A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis by Wenlu Ouyang, Yuchen Chen, Tao Tan, Yujing Song, Tao Dong, Xin Yu, Kyung Eun Lee, Xinyu Zhou, Zoe Tetz, Sophia Go, Xindi Zeng, Liujiazi Shao, Chao Quan, Ting Zhao, Yuzi Tian, Katsuo Kurabayashi, Hua Jin, Jichun Ma, Jingdong Qin, Brandon Williams, Qingtian Li, Gui-dong Zhu, Hasan B. Alam, Kathleen A. Stringer, Yongqing Li, Jianjie Ma

“…The hCitH3-mAb treatment effectively disrupts this cycle and restores macrophage function under septic conditions. …”
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Antibody signatures elicited by potent and subpotent whole-cell pertussis vaccines in mice by Yetunde Adewunmi, Jennifer Doering, Prashant Kumar, Jozelyn V. Pablo, Andy A. Teng, Vu Huynh, Kathryn Secrist, David B. Volkin, Sangeeta B. Joshi, Joseph J. Campo, Nicholas J. Mantis

“…We then screened immune sera on a limited B. pertussis Tahoma I proteome array and identified >30 antigens whose antibody reactivity profiles either increased, decreased, or were unchanged as a function of wP potency. …”
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Effect of immunization during pregnancy and pre-existing immunity on diphtheria-tetanus-acellular pertussis vaccine responses in infants by Aapo Knuutila, Alex-Mikael Barkoff, Lauri Ivaska, Elina Tenhu, Johanna Teräsjärvi, Pieter van Gageldonk, Annemarie Buisman, Jussi Mertsola, Qiushui He

“…Immunization during pregnancy (IP) against pertussis is recommended in many countries to protect infants. Although maternal antibodies can influence the infants’ antibody responses to primary vaccinations, their effect on the development of functional antibodies and B cells remain poorly studied. …”
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Bispecific antibodies and CLEM: an analytical approach to advanced cell imaging for therapeutic strategies by Han-ul Kim, Young Kwan Kim

“…This synergy not only deepens our understanding of BsAbs’ mechanisms of action but also provides critical insights into their spatial distribution, binding kinetics, and functional dynamics in live cells. In this review, the integration of BsAbs and CLEM paves the way for targeted therapeutic strategies, fostering the development of more effective treatments that can adapt to the complexities of disease pathology.…”
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The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases by Diego E. Sastre, Stylianos Bournazos, Maros Huliciak, Barbara Ann C. Grace, E. Josephine Boder, Jonathan Du, Nazneen Sultana, Tala Azzam, Trenton J. Brown, Maria W. Flowers, Pete Lollar, Ting Xu, Tatiana A. Chernova, Alasdair D. Keith, Meredith Keen, Abigail Saltzman, Ana Martinez Gascueña, Beatriz Trastoy, Marcelo E. Guerin, Filipp Frank, Eric A. Ortlund, Jeffrey V. Ravetch, Eric J. Sundberg

“…Moreover, we demonstrate that CU43 treatment is highly effective in abrogating Fc effector functions in humanized mouse models, while preserving the neutralizing capacity of anti-influenza IgG antibodies, thereby conferring protection against lethal influenza challenge.…”
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