Immunotherapeutic Blockade of CD47 Increases Virus Neutralization Antibodies by Lamin B. Cham, Thamer A. Hamdan, Hilal Bhat, Bello Sirajo, Murtaza Ali, Khaled Saeed Tabbara, Eman Farid, Mohamed-Ridha Barbouche, Tom Adomati

“…Here, we investigated the vaccinal effect of anti-CD47 antibodies and discussed the possibilities of combining anti-CD47 treatments with vaccines. …”
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Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies by Melanie Märklin, Gundram Jung, Jonas S Heitmann, Helmut R Salih, Martina Svenja Lutz, Boris Klimovich, Stefanie Maurer, Latifa Zekri, Clemens Hinterleitner

“…Together, our findings demonstrate that platelets undermine the efficacy of T cell-recruiting bsAb and identify modulation of platelet function as a means to reinforce the effectiveness of bsAb treatment.…”
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CHALLENGES IN TREATMENT OF RENAL GRAFT ACUTE ANTIBODY-MEDIATED REJECTION by A. I. Sushkov, A. V. Sharshatkin

“…The repeated treatment course (plasmapheresis, antithymocyte globulin, intravenous immunoglobulin and rituximab) was effective. The patient has good and stable graft function in 1 year after transplantation.…”
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Monoclonal Antibodies in Gynecological Cancer: A Critical Point of View by Filippo Bellati, Chiara Napoletano, Maria Luisa Gasparri, Valeria Visconti, Ilaria Grazia Zizzari, Ilary Ruscito, Jlenia Caccetta, Aurelia Rughetti, Pierluigi Benedetti-Panici, Marianna Nuti

“…Catumazumab, a bivalent antibody against CD3 and EpCAM, is effective in the treatment of neoplastic ascites. …”
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Advances of bispecific antibodies using/application in dermatology: a review by Ting Zhang, Yang Liu, Pei Xiong Liew, Yu Zhang, Zuotao Zhao

“…This characteristic endows bispecific antibodies with more functions, regulating multiple signal pathways simultaneously, enhancing the therapeutic effect, and by infusion of targeted tumor antigens and drug carriers in advance, the contact time between the drug and normal tissues is reduced, and the toxic side effects are greatly reduced. …”
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Structural and biochemical differences between non-catalytic and catalytic antibodies by Taizo Uda, Ryuichi Kato, Yasuteru Shigeta, Shun Hirota, Jun Kobayashi, Hisashi Yoshida, Masato Tsuyuguchi, Kowit Hengphasatporn, Moe Tsujita, Hiroaki Taguchi, Emi Hifumi

“…In particular, when His residues in the catalytic region are fully deprotonated, Asp1, His93, and Ser27a transiently come into close proximity, enabling the formation of a functional catalytic triad. Catalytic antibodies can be made starting from just the amino acid sequence of a desired mAb, which may be available in databases such as OAS or IMGT. …”
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Use of polyclonal antibodies in brain-dead donors in kidney transplantation by D. O. Kuzmin, V. A. Manukovsky, S. F. Bagnenko, O. N. Reznik, A. N. Ananiev, O. A. Vorobyeva, S. L. Vorobyev, D. V. Gogolev, V. S. Daineko, A. A. Kutenkov, N. A. Chichagova, I. V. Uliankina

“…Fifteen (75%) recipients of kidneys obtained from donors with ATG had immediate graft function; in the control group – 10 (50%) recipients.Conclusion. …”
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Flow Cytometric Assessment of FcγRIIIa-V158F Polymorphisms and NK Cell Mediated ADCC Revealed Reduced NK Cell Functionality in Colorectal Cancer Patients by Phillip Schiele, Stefan Kolling, Stanislav Rosnev, Charlotte Junkuhn, Anna Luzie Walter, Jobst Christian von Einem, Sebastian Stintzing, Wenzel Schöning, Igor Maximilian Sauer, Dominik Paul Modest, Kathrin Heinrich, Lena Weiss, Volker Heinemann, Lars Bullinger, Marco Frentsch, Il-Kang Na

“…Fc gamma receptor IIIa (FcγRIIIa) polymorphisms impact ADCC, yet their clinical relevance in NK cell functionality remains debated. We developed two complementary flow cytometry assays: one to predict the FcγRIIIa-V158F polymorphism using a machine learning model, and a 15-color flow cytometry panel to assess antibody-induced NK cell functionality and cancer-immune cell interactions. …”
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Theragnostic Imaging Using Radiolabeled Antibodies and Tyrosine Kinase Inhibitors by Mitsuyoshi Yoshimoto, Hiroaki Kurihara, Hirofumi Fujii

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Bispecific antibodies: unleashing a new era in oncology treatment by Lin Shui, Dan Wu, Kaixuan Yang, Chuntang Sun, Qingli Li, Rutie Yin

“…Compared with the combination of two monoclonal antibodies, BsAbs represent the physical integration of dual specificities, demonstrating superior binding efficacy, reducing the risk of drug resistance, and enabling unique biological functions such as bridging tumor cells and T cells to achieve precise cytotoxicity. …”
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The dengue-specific immune response and antibody identification with machine learning by Eriberto Noel Natali, Alexander Horst, Patrick Meier, Victor Greiff, Mario Nuvolone, Lmar Marie Babrak, Katja Fink, Enkelejda Miho

“…Broadly neutralizing antibodies recognizing all serotypes may be an effective treatment. …”
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Antibodies with specificity to glycan motifs that decorate OMV cargo proteins by Hyun Young Kim, Christina M. Rothenberger, Mary E. Davey, Manda Yu

“…P. gingivalis has a variety of immune evasion mechanisms and exhibits highly variable cell surface characteristics that are strain dependent, complicating the development of effective vaccines and therapeutics. Here, we show that a subset of immunoglobulin M (IgM) antibodies in antiserum raised against P. gingivalis strain W83 selectively recognize the outer membrane vesicles (OMVs). …”
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Effect of anti-CD4 mAb induced by inhibiting B cell disorder on immune reconstruction of HIV-infected immunological non-responders by Yi Ouyang, Kang Wu, Lei Fu, Panpan Yi, Da Cheng, Xiaoyu Fu

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Modern possibilities of effective cough therapy in acute respiratory infections in children by N. A. Geppe, E. G. Kondyurina, T. E. Pak

“…Its meaning consists in relief of infectious inflammation using preparations with anti-inflammatory effect. One of promising directions is studying efficiency and implementation of complex antitussive preparations in clinical practice. …”
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Effect of Free Radical-Mediated Conjugation with Rosmarinic Acid on Allergenicity and Functional Properties of Egg White Protein by LIU Ying, CHEN Shiyun, GUO Xiao, HAO Yacheng, FANG Min, LIU Xin, GONG Zhiyong, YANG Qing

“…In this study, egg white protein (EWP) was covalently coupled with rosmarinic acid (RA) by a free radical method, and the coupling effect was verified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and RA binding equivalent. …”
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Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Res... by Yu. O. Shulpekova, I. V. Maev, V. B. Grinevich, I. B. Khlynov, Yu. G. Shvarts, V. T. Ivashkin

“…The aim of the study was to evaluate the efficacy and safety of Kolofort® (a complex medicine containing technologically processed forms of antibodies to S-100 protein, tumor necrosis factor-α and histamine) in the management of functional dyspepsia (FD) in outpatient clinical practice.Methods: Outpatients (N = 309) at the age of 18–45 in whom FD was diagnosed according to the Rome IV criteria were enrolled in a multicenter, double-blind, placebo-controlled, randomized clinical trial. …”
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Effects of renal replacement therapy combined with immune adsorption on inflammatory factors and immune function in patients with lupus nephritis by GAO Yang, RUAN Xiu-fang, AN Ling-chun

“…Objective To investigate the effect of renal replacement therapy combined with immune adsorption on inflammatory factors and immune function in patients with lupus nephritis.Methods Ninety-four patients with lupus nephritis were selected and randomly divided into the observation group and the control group(n=47 each group).The patients in two groups were treated with conventional hormone and immunosuppressant.The patients in the control group were treated with PH-350,and those in the observation group were treated with renal replacement therapy combined with immune adsorption for 4 courses(one week of one course).The inflammatory factors(TNF-alpha,IL-6,IL-8),immune function(IgG,IgA,IgM,C3,C4),systemic lupus erythematosus activity index(SLEDAI)and antibody levels(anti C1 q antibody,anti nucleosome antibody and anti ds-DNA antibody)were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in the serum levels of TNF-alpha,IL-6 and IL-8 between the two groups(P>0.05).After treatment,TNF-alpha,IL-6 and IL-8 levels in two groups were decreased significantly as compared with those before treatment,and the levels of TNF-alpha,IL-6 and IL-8 in the observation group were significantly lower than those in the control group(P<0.05).Before treatment,the levels of IgG,IgA,IgM,C3 and C4 in the two groups were not statistically significant(P>0.05).After treatment,the IgG,IgA and IgM levels in two groups were significantly reduced,but C3,C4 complement levels were increased significantly.The levels of IgG,IgA and IgM in the observation group were significantly lower than those in the control group,but the levels of C3 and C4 were significantly higher than those in the control group(P<0.05).Before treatment,there was no significant difference between the two groups in SLEDAI score and anti C1 q antibody,anti nucleosome antibody and anti ds-DNA antibody(P>0.05).After treatment,SLEDAI scores and the levels of anti ds-DNA antibody and anti C1 q antibody,anti nucleosome antibody in the two groups were significantly decreased,and those in the observation group were significantly lower those in the control group(P<0.05).Conclusions Renal replacement therapy combined with immune adsorption can help reduce inflammation,improve immune function and reduce systemic lupus activity index and antibody level.…”
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Stability Analysis of a Fractional Epidemic Model Involving the Vaccination Effect by Sümeyye Çakan

“…This paper, by constructing a fractional epidemic model, analyzes the transmission dynamics of some infectious diseases under the effect of vaccination, which is one of the most effective and common control measures. …”
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Effect of rituximab on the manifestations of activity and pulmonary function in patients with systemic sclerosis: one-year follow-up evaluation by L. P. Ananyeva, O. A. Koneva, O. V. Desinova, L. A. Garzanova, S. I. Glukhova, M. N. Starovoitova, O. B. Ovsyannikova, A. V. Volkov, A. P. Aleksankin, E. L. Nasonov

“…Of these, upper respiratory tract infections developed in 7 patients; plantar phlegmon occurred in one case; urinary tract infection and herpes zoster were detected in two and one cases, respectively.The results of this study confirm data from other studies that have demonstrated that RTM exerts a positive effect on SS-associated ILD. We were the first to show the association of positive changes in the measures of pulmonary function tests with the dose of RTM.…”
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TRADITIONAL AND CASCADE PLASMAPHERESIS IN ANTIBODY TITERS’ REDUCTION IN RENAL TRANSPLANT RECIPIENTS by A.V. Vatazin, A.B. Zulkarnayev, R.O. Kantarija, M. Krstich

“…The concentration of antibodies may be effectively reduced with DFPF. Total IgM and IgG antibodies were reduced by 30–55% of the original level. …”
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