Prospects for 3D Bioprinting Research and Transdisciplinary Application to Preclinical Animal Models by HU Min, DONG Lexuan, GAO Yi, XI Ziqi, SHEN Zihao, TANG Ruiyang, LUAN Xin, TANG Min, ZHANG Weidong

“…To promote more efficient and cost-effective drug research and development, the United States passed the Food and Drug Administration (FDA) Modernization Act 2.0 in September 2022, which removed the federal mandate requiring animal testing in preclinical drug research. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs). …”
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Features of Cell-Mediated Immunity in Children with Congenital Ichthyosis and Their Role in the Pathogenetic Management by Karine O. Avetisyan, Nikolay N. Murashkin, Svetlana G. Makarova, Svetlana S. Petrichuk, Daria G. Kuptsova

“…Typical clinical symptoms of this disease, regardless of the form, are generalized erythroderma, peeling, itching, hyperkeratosis, severe structural and functional disorders of the epidermal barrier, other organs and systems. …”
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Assessment of some cytokines levels in a pauci-immune crescentic glomerulonephritis patients by Dina A. A. Al-Roubaey, Hawraa Ghaleb Idreess, Eman Hasani AL-Salami, Nadia Habeeb Sarhan, Ibtihal Riyadh Najeeb

“…Moreover, anti-neutrophil cytoplasmic antibodies (ANCA), and pro-inflammatory cytokines play a damaging role in a crescent glomerulonephritis. …”
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Spectrum of Cortactin Isoforms in the Urine of Patients with Liver Cirrhosis and Their Diagnostic Value as a Potential Molecular Marker of its Severity by Fayura O., Starikovych M., Abrahamovych O., Abrahamovych M., Stoyka R., Kit Yu.

“…Since the protein content of human urine is closely related to the peculiarity of the functioning of biological systems, its qualitative and quantitative characteristics are promising markers for control of various processes in organism. …”
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Dynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine by Xiuwen Wang, Xiuwen Wang, Xiaodong Yang, Xin Zhang, Hongxia Yan, Junyan Jin, Zhenglai Ma, Junyi Duan, Guanghui Zhang, Tao Huang, Yongzheng Li, Hao Wu, Tong Zhang, Aiwei Zhu, Cong Jin, Xiangrong Song, Bin Su, Bin Su

“…Additionally, the percentages of activated T cells, exhausted T cells and SARS-CoV-2-specific T cells with enhanced functional activity were increased following the administration of inactivated SARS-CoV-2 vaccine. …”
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COMPARATIVE EVALUATION OF THE EFFICACY AND SAFETY OF ABATACEPT IN PATIENTS WITH DIFFERENT DURATION OF RHEUMATOID ARTHRITIS by M. A. Borisova, G. V. Lukina, Ya. A. Sigidin, E. L. Luchikhina, D. E. Karateev, E. S. Aronova, S. I. Glukhova

“…Every 3 months, disease activity was assessed with DAS28; functional status was evaluated with the Health Assessment Questionnaire (HAQ).Results and discussion. …”
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B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma by Hong Li, Shu Li, Jun Yan, Yongling Ning, Hongying Hao, Qian Zhong, Chuanlin Ding, Xiaoling Hu, Kelly M McMasters

“…Additionally, tumor-specific antibodies (Abs) also exhibit antitumor and protumor functions dependent on the Ab isotype. …”
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Magnitude of antigen-specific T-cell immunity the month after completing vaccination series predicts the development of long-term persistence of antitumor immune response by Mary L Disis, John B Liao, Jessica L Reichow, Lupe G Salazar, Sasha E Stanton, Katie M Hitchcock-Bernhardt, James Y Dai, Jong-Baeck Lim, Theodore A Gooley

“…The magnitude and differentiation of effective, durable immune responses depend on antigen-specific precursor frequencies. …”
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Production of immunoregulatory cytokines in clinically asymptomatic periapical lesions depends on the lesions size by Duka Miloš, Gazivoda Dragan, Marković Milan, Majstorović Ivana, Tatomirović Željka, Mihajlović Dušan, Čolić Miodrag

“…In these processes proinflammatory cytokines are involved in stimulation of inflammation and osteodestructive mechanisms, whereas anti-inflammatory cytokines, with the immunoregulatory functions, have the opposite effects. How this balance is controlled is still the subject of numerous studies. …”
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Pathogenetic Mechanisms of the Occurrence of Rheumatoid Arthritis and Ankylosing Spondylitis with the Activation-Enzymatic and Phenotypic Features of Lymphocytes by Lychkovska N., Chopyak V., Vorobets Z.

“…Studies of biochemistry and physiology in recent decades have shown that precision control (NO) and (Ca2+) and the functioning of cellular enzymatic systems are provided. …”
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