Intracerebral Transplantation of Mesenchymal Stromal Cell Compounded with Recombinant Peptide Scaffold against Chronic Intracerebral Hemorrhage Model by Soichiro Takamiya, Masahito Kawabori, Tsukasa Kitahashi, Kentaro Nakamura, Yuki Mizuno, Hironobu Yasui, Yuji Kuge, Aki Tanimori, Yasuyuki Takamatsu, Kohei Yuyama, Hideo Shichinohe, Miki Fujimura

“…Background. Due to the lack of effective therapies, stem cell transplantation is an anticipated treatment for chronic intracerebral hemorrhage (ICH), and higher cell survival and engraftment are considered to be the key for recovery. …”
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Nanotechnology-based paper microfluidics for rapid point-of-care detection and differentiation of snake venom types by Lakshmi Narashimhan Ramana, Nitin Salvi, M.V. Khadilkar, Tarun Kumar Sharma

“…The primary treatment involves administering antivenom, which consists of polyclonal antibodies developed against various snake venoms. However, antivenom therapy can lead to serum-related complications, reducing its effectiveness. …”
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Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics by Xiaofeng Dai, Yuting Fan, Xing Zhao

“…Diversified types of medications have been shown effective for alleviating SLE syndromes, ranging from cytokines, antibodies, hormones, molecular inhibitors or antagonists, to cell transfusion. …”
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Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies by Ewelina Musielak, Violetta Krajka-Kuźniak

“…Lipid and inorganic nanoparticles can enhance brain delivery while minimizing side effects. These formulations may include epitopes—small antigen fragments that bind directly to free antibodies, B cell receptors, or T cell receptors—that interact with transport systems and enable BBB crossing, thereby boosting therapeutic efficacy. …”
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Transcranial electrical stimulation in the treatment of peptic ulcer by Dariya N. Tarasova, Vsevolod V. Skvortsov, Boleslav N. Levitan

“…The use of transcranial electrical stimulation as part of the complex treatment of gastrointestinal diseases has beneficial effects: analgesic (effective anesthesia), vegetocorregulating (accelerating the processes of repair of erosive processes), reduces the secretory activity of the stomach. …”
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A novel HVEM-Fc recombinant protein for lung cancer immunotherapy by Yuanshan Yao, Bin Li, Jing Wang, Chunji Chen, Wen Gao, Chunguang Li

“…Abstract Background The ubiquitously expressed transmembrane protein, Herpesvirus Entry Mediator (HVEM), functions as a molecular switch, capable of both activating and inhibiting the immune response depending on its interacting ligands. …”
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Portable cotton swab biosensor for rapid naked-eye detection of Helicobacter pylori by Ghadeer.A.R.Y. Suaifan, Asmaa Alnajajrah, Ward Abu Jbara, Amr A. El-Mousa, Fahid Abu Jbara, Doha A.I. Al-Omari, Mayadah B. Shehadeh

“…The biosensor utilizes a lactoferrin-functionalized cotton platform for bacterial capture, followed by signal generation using polymeric nanobeads conjugated to specific anti-H. pylori antibodies. …”
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Mucosal immune response in biology, disease prevention and treatment by Xiaoxue Zhou, Yuchen Wu, Zhipeng Zhu, Chu Lu, Chunwu Zhang, Linghui Zeng, Feng Xie, Long Zhang, Fangfang Zhou

“…A comprehensive understanding of mucosal immunity is essential for developing treatments that can effectively target diseases at their entry points, thereby minimizing the overall impact on the body. …”
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Optimized NaYF₄: Er³⁺/Yb³⁺ Upconversion Nanocomplexes via Oleic Acid for Biomedical Applications by Ha Thi Phuong, Le Thi Vinh, Tong Quang Cong, Tran Quoc Tien, Nguyen Duc Van, Vu Thi Hong Ha, Vu Ngoc Phan, Le Thi Hoi, Pham Duc Thang, Do Thi Thao, Tran Thu Huong

“…Subsequently, the nanoparticles were coated with a silica shell, functionalized with amine groups, and conjugated with IgG antibodies via glutaraldehyde (GA) to form the bio-nano complex β-NaYF₄: Er³⁺/Yb³⁺@SNGA-IgG. …”
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Management of severe pediatric Guillain-Barré syndrome in a low-income country: efficacy and safety of therapeutic plasma exchange in pediatric patients: a retrospective study by Tahani Ali, Faihaa Hkima Abou Fakher, Malek Alawir, Abdulsater Allababidi, Aya Sheikh Hasan

“…Therapeutic plasma exchange (TPE), which involves the selective removal of pathological molecules, such as auto-antibodies, from plasma, has proven to be safe and effective in adults with GBS. …”
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Nanoplatforms Targeting Intrinsically Disordered Protein Aggregation for Translational Neuroscience Applications by Chih Hung Lo, Lenny Yi Tong Cheong, Jialiu Zeng

“…These nanomedicine strategies offer compelling paths forward for developing more effective and targeted therapies for neurodegenerative diseases.…”
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SYSTEMIC MECHANISMS OF CHRONIC OPISTHORCHIASIS by N. V. Karbysheva, E. A. Bobrovskij, I. P. Saldan

“…Subjects and methods: We studied 312 chronic opisthorchiasis patients with the laboratory-confirmed diagnosis. The functional status of humoral immunity was assessed in 312 patients before the course of treatment and during the residual period of the invasion (2 weeks, 3 and 6 months after the course of treatment) together with the dynamics of specific markers (IgM and IgG antibodies and antigen Op. felineus CICs). …”
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Loss of cadherin 17 downregulates LGR5 expression, stem cell properties and drug resistance in metastatic colorectal cancer cells by Ruben A. Bartolomé, Laura Pintado-Berninches, Javier Robles, Tania Calvo-López, Issam Boukich, Pablo Otero-Núñez, Jose Manuel Gonzalez-Sancho, J. Ignacio Casal

“…Treatment with CDH17/integrin blocking antibodies produced similar effects, decreasing both, LGR5 expression and Wnt signaling. …”
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Anti-DAMP therapies for acute inflammation by Russell Hollis, Russell Hollis, Russell Hollis, Megan Tenet, Megan Tenet, Monowar Aziz, Monowar Aziz, Monowar Aziz, Ping Wang, Ping Wang, Ping Wang

“…This review explores the pivotal role of DAMPs in the pathogenesis of acute inflammation and shock, highlighting cutting-edge therapeutic strategies aimed at mitigating their effects. Emerging approaches include monoclonal antibodies, decoy receptors, small molecule inhibitors, and scavengers designed to neutralize or inhibit DAMP activity. …”
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Cell-targeted PD-1 agonists are potent NK-cell inhibitors by Harriet C. Pope, Harriet C. Pope, Ana L. Chiodetti, Alice Newey, Guillaume Rieunier, David X. Overton, Eduardo Mateos-Diaz, Tara M. Mahon, Giovanna Bossi, Hussein Al-Mossawi, Charlotte Viant

“…Suppressive effects of the β-cell tethered bispecific PD-1 agonist molecule on NK cells and NK92-PD-1 cell line activation were assessed through gene expression, cell surface expression of the CD107a degranulation marker, intracellular IFNγ production and Granzyme B secretion. …”
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Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough. by Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Carla Zimmerman, Kunho Choi, Stephane Flibotte, Michel Roberge

“…Unexpectedly, Y-320 increased cellular protein levels and protein synthesis, measured by SYPRO Ruby protein staining and puromycin labeling, as well as ribosome biogenesis measured using antibodies to rRNA and ribosomal protein S6. Y-320 did not increase the rate of translation elongation and it exerted its effects independently of mTOR signaling. …”
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Cardiovascular risk management beyond statins: review of new therapies available in Italy by Maurizio Capuozzo, Alessandro Ottaiano, Claudia Cinque, Stefania Farace, Francesco Ferrara

“…In addition, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, including monoclonal antibodies and siRNA-based therapies, have shown robust LDL-C-lowering effects by preventing LDL receptor degradation, leading to a significant reduction in cardiovascular risk. …”
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Characteristics of the Autonomic Nervous System State in Patients with Systemic Lupus Erythematosus with the Different Activity Degree According to the Indices of Heart Rate Variab... by Abrahamovych U.

“…Vegetative disorders are a term that unites varieties of origin and manifestations of the violation of vegetative functions of the organism, which are caused by the disorders of their neurogenic regulation. …”
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Deficient of glycosylation site in the envelop protein attenuated Zika virus replication in mosquito cells by Wen-Jing Wang, Wen-Jing Wang, Zi-Han Wang, Zi-Han Wang, Jing Li, Jing Li, Sai-Ya Ma, Sai-Ya Ma, Mei He, Mei He, Meng-Xuan Liu, Meng-Xuan Liu, Yu-Fei Zhan, Yu-Fei Zhan, Feng Jin, Feng Jin, Guosheng Qu, Guosheng Qu, Chunhong Yin, Chunhong Yin, Jie Tong, Jie Tong

“…Although glycosylation of the E protein is known to influence viral infectivity and immune evasion, the specific functional roles of E protein glycosylation in ZIKV infectivity in mosquito cells remain unclear.MethodsIn this study, we generated a deglycosylation mutant ZIKV with a T156I substitution in the E protein and investigated its effects on viral replication and viral-host interactions in mosquito C6/36 cells.ResultsOur results demonstrated that the T156I mutant exhibited attenuated replication compared to the wild-type virus during the early stages (0-24 hours) post-virus infection in mosquito C6/36 cells. …”
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Molecularly imprinted polymer technology for electrochemical detection of diabetes-related biomarkers by Launa Silky Karenindra Rokhmat, Irkham, Serly Zuliska, Adisyahputra, Yohanes Susanto Ridwan, Retna Putri Fauzia, Putra Rafli Ramdani, Yeni Wahyuni Hartati

“…As an alternative, Molecularly Imprinted Polymers (MIPs) have emerged as a promising solution due to their exceptional specificity in biomarker recognition, mimicking the selective binding properties of natural antibodies. MIPs-based electrochemical sensors offer significant advantages, including high stability, selectivity, reproducibility, and cost-effectiveness, making them highly suitable for rapid and portable biomarker detection. …”
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