Heart crosstalk with other organs and pharmacological strategies for cardioprotection by Zizhuo TU, Yaozu XIANG

“…Drugs targeting the regulation of pathways related to hepatic lipid metabolism, intestinal flora, renal sodium excretion and hypoglycemia, bone marrow clonal hematopoiesis and immune inflammation, such as Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, Sodium-glucose Cotransporter-2 (SGLT2) inhibitors, IL-1β monoclonal antibodies and Chimeric antigen receptor (CAR) -T therapy, have been shown to have significant protective effects in the prevention and treatment of cardiovascular disease, especially ischemic heart disease and HF. …”
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Immune Profile of COVID-19 Survivors and Contacts During 9 Months: A Cohort Study by Valentina V. Tatarnikova, Natalya O. Kiseleva, Valentina I. Dubrovina, Vladimir A. Vishnyakov, Darya D. Bryukhova, Anna B. Pyatidesyatnikova, Konstantin M. Korytov, Munko B. Sharakshanov, Sergey V. Balakhonov, Haijuan Wang

“…Little is known about the possible long-term effects of COVID-19 on circulating leukocyte kinetics and functional T-cell activity after recovery. …”
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Role of the cellular immunity in the formation of the immune response in coronavirus infections by I. A. Ivanova, N. D. Omelchenko, A. V. Filippenko, A. A. Trufanova, A. K. Noskov

“…The data obtained during previous epidemics caused by coronaviruses, and current pandemic indicate that assessing the role of certain immune interactions between these viruses and the microorganism is the main pre-requisite for development of diagnostic test systems as well as effective medical drugs and preventive measures. The review summarizes the results of studying patho– and immunogenesis of SARSCoV, MERS-CoV, and SARS-CoV-2 infections. …”
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Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence by Pujan Engels, Andras Szolek, Sebastian Hörner, Georgios Vavouras Syrigos, Kim Hebbel, Michelle Schmidtke, Min Zhou, Maria Mateo-Tortola, Caroline Schönfeld, Sylwia Anna Stefanczyk, Katharina Wolter, Sepideh Babaei, Michael Schindler, Manfred Claassen, Daniel Dauch, Lars Zender, Ana Tapía-Abellán, Alexander N. R. Weber

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How breastfeeding affects immunity? by Dawid Piecuch, Weronika Sobota, Katarzyna Zemsta, Przemysław Piskorz, Michał Zwoliński, Edyta Hańczyk, Aleksandra Sędek

“…Mechanisms that cause side effects that cause effects not only in the aftermath of life, but also in the aftermath of health in the aftermath of life. …”
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Features of the formation of specific immunity after vaccination against viral hepatitis B in children and young people by E. O. Kochetova, O. V. Shamsheva, I. V. Polesko, A. V. Semenenko, O. A. Maiorova, V. V. Belyakova, V. V. Gorev

“…Thus, due to the weak response to the recombinant hepatitis B vaccine and the high medical and social significance of hepatitis B infection, various approaches are currently being developed to enhance the effectiveness of vaccination: changes in the vaccination regimen; correction of immune system functions to restore an adequate response to vaccine preparations, the use of various adjuvants, including recombinant interferons.…”
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Potential biomarker and composite efficacy readout for human clinical trials of schistosomiasis vaccine in Africa by Desalegn W. Kifle, Aravindan Kalyanasundaram, Adebayo J. Molehin, Mumtaz Y. Balkhi, Aryandra Arya, Weidong Zhang, Gul Ahmad, Workineh Torben, David Carey, James F. Papin, Lisa A. Jackson, Sean A. Gray, Darrick Carter, Afzal A. Siddiqui

“…This reproducible functional assay has the potential to serve as one of the biomarkers for the effectiveness of the SchistoShield vaccine in human trials in Africa.…”
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Revisiting the role of cancer-associated fibroblasts in tumor microenvironment by Xiaolei Lan, Wenyang Li, Kai Zhao, Jianpeng Wang, Shifang Li, Hai Zhao

“…However, challenges persist in understanding their heterogeneity, origin, and functional diversity. One major obstacle is the lack of standardized naming conventions for CAF subpopulations, with current systems failing to capture their full complexity. …”
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HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway by Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang

“…While pre-clinical investigations have effectively showcased significant anti-cancer effects of HER3-targeted therapies, these therapies have had little impact on cancer patient outcomes in the clinic, except for patients with rare NRG1 fusion mutations. …”
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Hirsutella sinensis polysaccharides and Parabacteroides goldsteinii reduce lupus severity in imiquimod-treated mice by Shih-Hsin Chang, Yun-Fei Ko, Jian-Ching Liau, Cheng-Yeu Wu, Tsong-Long Hwang, David M. Ojcius, John D. Young, Jan Martel

“…Methods: We examined the effects of the prebiotics, H. sinensis polysaccharides, and probiotic, P. goldsteinii, in a mouse model of imiquimod-induced systemic lupus erythematosus. …”
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Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors by Xiaowei Bian, Minna Piipponen, Zhuang Liu, Lihua Luo, Jennifer Geara, Yongjian Chen, Traimate Sangsuwan, Monica Maselli, Candice Diaz, Connor A. Bain, Evelien Eenjes, Maria Genander, Michael Crichton, Jenna L. Cash, Louis Archambault, Siamak Haghdoost, Julie Fradette, Pehr Sommar, Martin Halle, Ning Xu Landén

“…Targeting this maladaptive epigenetic memory could mitigate RT’s late-onset adverse effects, improving the quality of life for cancer survivors.…”
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Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by Parvulan by Beniamino Palmieri, Antonio Manenti, Francesca Galotti, Maria Vadalà

“…The asymptomatic SARS-CoV-2 patients who were incidentally enrolled in our survey were tested at the sixth month for antibodies against SARS-CoV-2, and 14 patients had high levels of SARS-CoV-2 antibodies. …”
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Pain mediator NGF improves chondrocyte extracellular matrix synthesis via PI3K/AKT pathway by Mengling Wang, Jie Lian, Maoqing Ye, Bingchen An

“…Clinical studies revealed that anti-NGF antibodies are often accompanied by progressively worsening cartilage degeneration, although they exhibit significant analgesic effects. …”
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Boron delivery agents in BNCT: A mini review of current developments and emerging trends by Rolemae M. Murilla, Gladys G. Edilo, Marco Laurence M. Budlayan, Eulogio S. Auxtero, Jr.

“…This review provides a comprehensive analysis of current developments in boron delivery systems, offering insights into their potential to transform BNCT into a more effective and accessible cancer therapy.…”
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Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives by Sarkar Sardar Azeez, Raya Kh. Yashooa, Shukur Wasman Smail, Abbas Salihi, Azhin Saber Ali, Sami Mamand, Christer Janson

“…Furthermore, combination therapies, including chemotherapy, radiotherapy, antibodies, small molecule inhibitors, cancer vaccines, oncolytic viruses, and multi-CAR cell combination therapy, offer synergistic potential by modulating the TME and improving CAR-cell functionality. …”
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Role of Tumor Necrosis Factor in Tuberculosis by Fedor D. Kireev, Julia A. Lopatnikova, Alina A. Alshevskaya, Sergey V. Sennikov

“…Understanding the pleiotropic functions of TNF in tuberculosis pathogenesis is crucial for developing safe immunomodulatory strategies and optimizing the clinical management of patients at risk of latent TB reactivation.…”
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Multi-Antigen Viral-Vectored Vaccine Protects Against SARS-CoV-2 and Variants in a Lethal hACE2 Transgenic Mouse Model by Shannon Stone, Amany Elsharkawy, J. D. Burleson, Mary Hauser, Arban Domi, Pratima Kumari, Zainab Nabi, Janhavi P. Natekar, Maciel Porto, Brian Backstedt, Mark Newman, Sreenivasa Rao Oruganti, Mukesh Kumar

“…GEO-CM02 vaccine efficacy studies also demonstrated a complete level of vaccine-induced protection with a single dose against the original B.1 virus and B.1.1.529 variant. GEO-CM02 effectively elicited functional T-cell responses in both prime and prime–boost groups. …”
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In Vivo and In Vitro Evaluation of the Feasibility and Safety Profiles of Intraarticular Transplantation of Mitochondria for Future Use as a Therapy for Osteoarthritis by Carlos Vaamonde-Garcia, Tamara Hermida-Gómez, Sara Paniagua-Barro, Elena F. Burguera, Francisco J. Blanco, Mercedes Fernández-Moreno

“…We established an efficient, reproducible, effective, and rapid protocol for isolating mitochondria from liver. …”
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Pathogenetic Relationship of Immunological Disorders in Chronic Generalized Periodontitis and Rheumatoid Arthritis by G. V. Poryadin, A. N. Zakhvatov, A. Y. Parshina

“…The pathogenetic mechanisms of progression of chronic periodontitis accompanied with rheumatoid arthritis is confirmed by the common parts of immune-inflammatory reactions.Damage to periodontal tissues is indirectly made by cytotoxic effects of enzymes and their metabolites produced by Porphyromonas gingivalis bacteria. …”
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Toxicity and biodistribution of the serotype 2 recombinant adeno-associated viral vector, encoding Aquaporin-1, after retroductal delivery to a single mouse parotid gland. by Dariya Momot, Changyu Zheng, Hongen Yin, Reem H Elbekai, Molly Vallant, John A Chiorini

“…There were no significant adverse effects due to treatment noted by clinical chemistry and pathology evaluations. …”
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