Direct Detection of <i>Orthoflavivirus</i> via Gold Nanorod Plasmon Resonance by Erica Milena de Castro Ribeiro, Bruna de Paula Dias, Cyntia Silva Ferreira, Samara Mayra Soares Alves dos Santos, Rajiv Gandhi Gopalsamy, Estefânia Mara do Nascimento Martins, Cintia Lopes de Brito Magalhães, Flavio Guimarães da Fonseca, Luiz Felipe Leomil Coelho, Cristiano Fantini, Luiz Orlando Ladeira, Lysandro Pinto Borges, Breno de Mello Silva

“…In this study, we investigated the effectiveness of gold nanorods (GNRs) functionalized with specific anti-dengue and anti-orthoflavivirus antibodies in detecting viral particles. …”
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A review on surface modification of nanofibrous textiles for diverse applications: Focus on medical uses by Rasool Shabanloo, Majid Montazer, Ali Farahani, Nesa Karimi

“…Chemical modification includes functionalization with chemical groups, while biological modification involves coating with proteins, enzymes, or antibodies. …”
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Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease by Rukshan Ahamed Mohamed Rafeek, Natkunam Ketheesan, Michael F. Good, Manisha Pandey, Ailin Lepletier

“…In animals injected with rM5 and treated with LD-IL-2, no cardiac functional or histological changes was observed. LD-IL-2 therapy effectively reduced the production of cross-reactive antibodies raised against host proteins and significantly increased regulatory T cells in the mediastinal lymph nodes. …”
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Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically... by Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A Harrison, Stuart Ainsworth, Nicholas R Casewell

“…Although snakebite can cause a variety of pathologies in victims, haemotoxic effects are particularly common and are typically characterised by haemorrhage and/or venom-induced consumption coagulopathy. …”
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Immunogenicity and Safety of 13-valent Conjugated Pneumococcal Vaccine in Patients with Rheumatoid Arthritis by B. T. Batozhargalova, M. P. Kostinov, A. D. Shmitko, G. V. Lukina, D. A. Murtazalieva, E. N. Koltsova, E. V. Zhilyaev

“…Methotrexate (MTX) in RA patients reduced the pneumococcal response and the functional activity of antibodies.…”
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Adenoviral-vectored vaccine against Bordetella pertussis fimbrial antigen induces partial protection in a mouse model by Alexa Dierig, Martina Kristof, Christina Dold, Elodie Lesne, Catpagavalli Asokanathan, Luke Blackwell, Barbara Bolgiano, Andrew R. Gorringe, Andrew J. Pollard, Kevin Markey, Christine S. Rollier

“…As a first step to address these issues we developed novel Bordetella pertussis vaccine candidates using viral-vectored vaccine technology with the aim of producing durable functional antibodies that prevent nasal colonization. …”
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SARS-CoV-2 Assembly: Gaining Infectivity and Beyond by Harshita Katiyar, Ariana Arduini, Yichen Li, Chen Liang

“…While much attention has been paid to the structure and functions of the viral spike protein and the entry step of viral infection, partly because these are targets for neutralizing antibodies and COVID-19 vaccines, the later stages of SARS-CoV-2 replication, including the assembly and egress of viral progenies, remain poorly characterized. …”
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Early Epcoritamab Administration Revives CAR‐T Cells in Relapsed/Refractory B‐Cell Lymphomas by Kensuke Yanashima, Yoshiki Furukawa, Midori Ishii, Shintaro Kinoshita, Yasuharu Hamano, Naoki Watanabe, Yutaka Tsukune, Hajime Yasuda, Jun Ando, Miki Ando

“…ABSTRACT Background Bispecific antibodies are effective for relapsed/refractory B‐cell lymphoma patients even after CAR‐T therapy. …”
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Targeting Death Receptor 5 (DR5) for the imaging and treatment of primary bone and soft tissue tumors: an update of the literature by Zakareya Gamie, Anja Krippner-Heidenreich, Craig Gerrand, Kenneth Samora Rankin

“…Currently, clinical trials are investigating the effectiveness of DR5 activation using new biological agents, such as bi-specific or tetravalent antibodies, in improving the survival of patients with relapsed or refractory cancers. …”
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Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection by Qi Yan, Nan Duan, Mingqun Lin, Wenqing Zhang, Stephen Denton, Yichen Zhong, Yizhou Dong, Yasuko Rikihisa

“…Abstract Background Rickettsiosis is among the deadliest vector-borne infectious diseases worldwide, in part because rickettsiae replicate within human cells, where antibodies and most drugs cannot effectively reach this obligatory intracellular pathogen. …”
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Harnessing the Therapeutic Potential of Th17 Cells by Jonas Bystrom, Taher E. Taher, M. Sherwan Muhyaddin, Felix I. Clanchy, Pamela Mangat, Ali S. Jawad, Richard O. Williams, Rizgar A. Mageed

“…In addition, treatment with antibodies to IL-17 is effective in treating patients with psoriasis, psoriatic arthritis, and refectory rheumatoid arthritis. …”
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Immunotherapy of malignant gliomas: a modern view on the problem by А. А. Pichugin, R. R. Kovyazina, А. Trondin, А. G. Alekseev, P. B. Kopnin, T. V. Gessel, S. V. Boichuk

“…These drugs might be effective in treatment of malignant gliomas overexpressing the molecules that suppress immune cells functions. …”
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Intradermal delivery of SARS-CoV-2 RBD3-Fc mRNA vaccines via a needle-free injection system induces robust immune responses in rats by Cenrong Wang, Xin Tang, Xin Tang, Chenghan Jiang, Yu Zhang, Bo Han, Yi Sun, Jianfeng Guo, Hanyu Peng, Zihan Wang, Yipeng Wang, Jialu Zhang, Yong Zhang, Yong Zhang, Chunlai Jiang, Chunlai Jiang, Chunlai Jiang

“…Naked mRNA vaccines were functional, but less effective than mRNA-LNP vaccines.DiscussionThe above results suggest that RBD3-Fc vaccines are safe and immunogenic and NFIS can be used as an alternative to needles/syringes for the inoculation of mRNA-LNP vaccines to elicit robust systematic immune responses.…”
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Size-dependent aggregation of erythrocytes by low molecular weight hyaluronic acids of different sizes: bioactivity and quality control potential by Xinyue Ma, Xiao Wang, XiaoXiao Jia, Jessica H. Hui, Joshua H. Shofaro, Ran Tao, Mizhou Matthew Hui

“…IntroductionHyaluronic acid (HA) is a crucial biological molecule whose diverse functions are strongly influenced by its molecular weight. …”
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CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy by Yu Chen, Wancheng Liu, Qiaomei Cai, Chaohu Pan, Zhenghao Yin, Yijiao Tang, Zhixu He, Genhong Cheng, Liping Shu, Liping Shu

“…DiscussionThis study not only suggests that CDK2 inhibition improves the outcome of chemotherapy by enhancing the type-1 interferon response but also investigates the synergistic effects of CDK2 inhibition with MTX or anti-PD-1 antibodies in immunocompetent mice.…”
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Duck plague virus UL47 gene affects the release and cell-to-cell spread of the virus and its deletion strains can provide strong protection for ducks by Yuxi Cui, Siyu Chen, Mingshu Wang, Wei Zhang, Qiao Yang, Xumin Ou, Di Sun, Yu He, Bin Tian, Zhen Wu, Shaqiu Zhang, Juan Huang, Ying Wu, Xinxin Zhao, Dekang Zhu, Shun Chen, Mafeng Liu, Renyong Jia, Anchun Cheng

“…The absence of the DPV UL47 gene significantly reduced the virulence of the virus but maintained immunogenicity and immune efficacy, thereby inducing the production of DPV-specific antibodies to resist strong attack by DP. These findings offer valuable insights into the functional characterization of the UL47 gene and the development of an attenuated vaccine based on this gene. …”
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Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine. by Natalie C Silmon de Monerri, Ye Che, Joshua A Lees, Jayasankar Jasti, Huixian Wu, Matthew C Griffor, Srinivas Kodali, Julio Cesar Hawkins, Jacqueline Lypowy, Christopher Ponce, Kieran Curley, Alexandre Esadze, Juan Carcamo, Thomas McLellan, David Keeney, Arthur Illenberger, Yury V Matsuka, Suman Shanker, Laurent Chorro, Alexey V Gribenko, Seungil Han, Annaliesa S Anderson, Robert G K Donald

“…Novel inhibitory epitopes in the lectin binding FimH were identified, revealing diverse functional mechanisms of FimH-directed antibodies with relevance to FimH-targeted UTI vaccines.…”
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Dynamic maternal synthesis and segregation of the germ plasm organizer, Bucky ball, in chicken oocytes and follicles by Sabine Klein, Roland Dosch, Sven Reiche, Wilfried A. Kues

“…Previously, we proposed the chicken-specific Bucky ball (cBuc) as a functional equivalent of the zebrafish germ plasm organizer. …”
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Foot-and-mouth disease dynamics in multi-species livestock systems at the interface of African protected areas by Oriane Ploquin, Vladimir Grosbois, Mthabisi Ndlovu, Simbarashe Ndozore, Martin Munzamba, Emildah Porovha, Khanyile Nkomo, Oriane Basso, Gaelle Corbel, Richard Shumba, Masocha D. Mhlanga, Ellen Mwandirigana, Benjamin Musekiwa, Elijah Takayindisa, Anais Loisier, Hervé Fritz, Florian Liégeois, Alexandre Caron, Franck Prugnolle, Eve Miguel

“…Multi-species epidemiological systems are characterized by populations that interact and perform different functions in pathogen transmission and maintenance. …”
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Aptamers Binding to c-Met Inhibiting Tumor Cell Migration. by Birgit Piater, Achim Doerner, Ralf Guenther, Harald Kolmar, Bjoern Hock

“…In normal conditions, the c-Met receptor is activated by its bivalent ligand hepatocyte growth factor (HGF). Also bivalent antibodies can activate the receptor by cross linking, limiting therapeutic applications. …”
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