Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism by Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli, Farhad Motavalli Khiavi

“…The cancerous plasma cells produce immunoglobulins (antibodies) uncontrollably which consequently damage the tissues and organs and break the immune system function. …”
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Dual CD47 and PD‐L1 blockade elicits anti‐tumor immunity by intratumoral CD8+ T cells by Susan N Christo, Keely M McDonald, Thomas N Burn, Nadia Kurd, Jessica Stanfield, Megan M Kaneda, Ruth Seelige, Christopher P Dillon, Timothy S Fisher, Bas Baaten, Laura K Mackay

“…Abstract Objectives Bispecific antibodies targeting CD47 and PD‐L1 (CD47 × PD‐L1 BisAb) demonstrate efficacy against a range of solid cancers. …”
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The overview and role of heat shock proteins (HSP) especially HSP 60 and 70 in reproduction and other pathologies (a literature review) by V.O. Berestoviy, Ahmad Mahmood, I.B. Venckivska, V.G. Ginzburg, I.V. Sokol, O.O. Berestoviy, D.O. Govsieiev

“…ELISA, western blotting, immunofluorescence, and affinity chromatography were the most common methods researchers used to determine and separate HSP 60 and antibodies related to it. Heat shock proteins are responsible for normal folding of other proteins and prevent its abnormal folding and cause degradation of abnormally folded proteins, mitochondrial protein transport, DNA metabolism, regulation of apoptosis are their significant functions. …”
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PO80 | Heparin-induced thrombocytopenia (HIT): a monocentric experience with danaparoid

“…This mismatch confirmed danaparoid effect on immune complex disruption. Conclusions: Danaparoid is an effective and safe drug for HIT. …”
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The dynamics of the content of immunoglobulins in the blood serum of piglets according to the actions of immunostimulating agents by N. Yu. Krempa, O. V. Kozenko, B. V. Gutyj, I. V. Dvyliuk, N. V. Magrelo, H. V. Sus, V. V. Voroniak, A. O. Vysotskyi, U. M. Vus, T. V. Martyshuk

“…We believe that the increase in the content of class A immunoglobulins, most likely the secretory form of the piglets themselves, when using Globigen® Jump Start, which reached the mark of 1.48 mg/ml, indicates the formation of immune resistance mechanisms. The effectiveness, specificity, and mechanism of action of these agents is based on the ability of their components, particularly Ig Y, to bind to pathogens or their fragments, to neutralize and safely remove them from the body, which helps to increase the barrier function of the intestinal mucosa. …”
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Immunoglobulins G from Patients with Systemic Sclerosis Modify the Molecular Signatures of Endothelial Cells by Eric Hachulla, David Launay, Alain Lescoat, Valérie Lecureur, Vincent Sobanski, Sylvain Dubucquoi, Martin Figeac, Aurélien Chepy, Solange Vivier, Fabrice Bray, Clément Chauvet, Abderrahmane Elhannani, Lucile Guilbert, Frédéric Leprêtre, Louisa Bourel, Christian Rolando

“…Functional antibodies (FA) might be implicated in vasculopathy, in which endothelial cells (EC) are key players. …”
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Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1β and TNF-α by Isela Martínez-Reza, Lorenza Díaz, David Barrera, Mariana Segovia-Mendoza, Sigifredo Pedraza-Sánchez, Giovanny Soca-Chafre, Fernando Larrea, Rocío García-Becerra

“…In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1β and TNF-α through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.…”
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Development of an <i>in vitro</i> model to study the role of disulfide bonds in the largest extracellular domain of the sodium-dependent phosphate transporter NaPi2b in OVCAR-8 ova... by V. S. Skripova, D. A. Firsova, A. V. Kilunov, L. F. Bulatova, M. A. Poputsky, R. G. Kiyamova

“…There is the largest extracellular domain (ECD) containing a cryptic MX35 epitope, against which therapeutic antibodies have been developed and are undergoing preclinical and clinical trials. …”
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STUDY OF THE CELLULAR COMPONENT OF IMMUNE SYSTEM IN CASES OF TRAUMATIC MANDIBULAR FRACTURE IN PATIENTS OF DIFFERENT PSYCHOSOMATIC PERSONALITY TYPES by Ya.P. Nahirniy, V. L. Fesyk

“…This influence occurs due to different degree of the effect of psyche on immune system that is crucial in purulent complications development. …”
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LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria by A. Benitez-Amaro, E. Garcia, M.T. LaChica Lhoëst, A. Polishchuk, I. Zegri-Reiriz, D. Vilades, J.M. Guerra, L. Fernández-del-Rio, S. Mirabet, V. Samouillan, O. Shirihai, M. Liesa, C. Enrich, V. Llorente-Cortés

“…This study examines (i) whether HFHC induces cholesterol accumulation in mitochondria, and impacts cardiac bioenergetics, and (ii) the effectiveness of anti-P3 Abs in mitigating HFHC-induced mitochondrial alterations. …”
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POLYMORPHISM OF THE TP53 GENE IN PATIENTS WITH GASTRIC CANCER IN PROSPECTIVE AND CLINICAL CASE-CONTROL STUDIES by A. V. Belkovets, S. A. Kurilovich, V. N. Maksimov, Yu. I. Ragino, L. V. Scherbakova, O. V. Cheremisina, N. V. Cherdyntseva, M. V. Parulikova, M. I. Voevoda

“…Background. A functionally significant TP53Arg72Pro polymorphism can contribute to the development of gastric cancer (GC).The aim: to study the associations of genotypes and alleles of the TP53Arg72Pro 4 polymorphism with GC and biomarkers of gastric ucosal atrophy in population-based prospective and case-control clinical trials among the population of Siberia.Material and methods. …”
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ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment by Xinyue Dong, Hao Wang, Jinxuan Cai, Yichun Wang, Dezhi Chai, Zichen Sun, Jie Chen, Mengxia Li, Tianxia Xiao, Chunhua Shan, Jian V. Zhang, Ming Yu

“…An in vitro implantation model was conducted to evaluate the effects of ST6GALNAC1/sTn on the receptivity of human endometrial AN3CA cells to JAR spheroids. …”
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VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway by Liu-liu Shi, Yu-ting Sun, Jia-nan Sun, Jing Yue, Wei Chen, Kun Meng, Long Chen, Chang-qing Hu, Rui Chen, Dong-sheng Sun, Cheng-bao Xu, Wei Yuan, Xin-li Li, Dan Zhao, Yan Wu, Shi-bing Xi, Xiao-ying Zhao, Jun-ming Tang

“…Furthermore, high-dose VEGF-B186 decreased the expression of glucose transporter type 4, glucose utilization, and mitochondrial function in a unique myoblast cell model, effects that were reversed by PKA activators and NFATc1/c2 overexpression. …”
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The state of NOergic homeostasis in experimental autoimmune glomerulonephritis against the background of the use of cell-free cryopreserved biological agents by F.V. Hladkykh, T.I. Lіadova

“…Materials and methods. Research on the effectiveness of CfBA in autoimmune nephritis (AIN) was conducted on 42 male rats. …”
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PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer by Tian Fang, Yu Xia, Ying Li, Sen Xu, Huayi Li, Siyuan Wang, Pu Huang, Yiyu Qian, Ping Jin, Ning Jin, Cheng Xu, Zhen Wang, Xiaoming Xiong, Mengjie Wang, Dongchen Zhou, Ya Wang, Xiaoting Li, Tao Xu, Qi Zhang, Dan Liu, Yong Fang, Guang-Nian Zhao, Qinglei Gao

“…Importantly, neutralizing B7-H3 antibodies had synergistic effects with PARPis and achieved superior therapeutic efficacy than PARPis plus PD-1 blockade in a syngeneic mouse ovarian cancer model. …”
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CD99: A Key Regulator in Immune Response and Tumor Microenvironment by Maria Cristina Manara, Valentina Fiori, Angelo Sparti, Katia Scotlandi

“…Anti-CD99 antibodies effectively eliminate tumors and attract immune cells to the tumor area. …”
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Small but Mighty: Nanobodies in the Fight Against Infectious Diseases by Wenning Jiang, Chundong Huang, Serge Muyldermans, Lingyun Jia

“…Nanobodies (Nbs), a novel class of affinity reagents derived from unique heavy chain-only antibodies in camelids, represent the smallest intact and fully functional antigen-binding fragments. …”
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Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment by Kin Man Au, Siqing Li, Tian Zhang, Andrew Z. Wang

“…More importantly, the MINP formulation effectively prevented the hepatotoxicity associated with the systemic administration of immune checkpoint agonistic antibodies. …”
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C1-inactivator is upregulated in glioblastoma. by Karolina Förnvik, Aida Maddahi, Oscar Persson, Kurt Osther, Leif G Salford, Henrietta Nittby Redebrandt

“…This could be demonstrated both at the gene level from patients with glioblastoma, on mRNA level and with immunohistochemistry. Treatment with antibodies against C1-IA had beneficial effects on survival when tested in vivo.…”
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Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes by Mikolaj Piotr Zaborowski, Slawomir Michalak

“…The evaluation of onconeural and neuronal surface antibodies was recommended in current guidelines. The link between PNS emergence and antitumor responses may result from more active CTLs and less functional Treg lymphocytes.…”
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