Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6 by Ankit Joshi, Zhousheng Xiao, Shreya Suman, Connor Cooper, Khanh Ha, James A. Carson, Leigh Darryl Quarles, Jeremy C. Smith, Madhulika Gupta

“…The top 20 scoring ligands from the in silico studies after post analysis were subjected to in vitro functional assays. Among these compounds, the ligand with the second-highest calculated binding affinity experimentally showed an ~84% inhibitory effect on IL6-induced STAT3 reporter activity at 10 μM concentration. …”
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Morphofunctional features of isthmocele complicated by abnormal uterine bleeding by Z.I. Hladchuk, N.M. Rozhkovska, V.O. Sytnikova, S.M. Syvyi

“…Conclusions. Accounting the functional, morphological and immunohistochemical features of isthmocoele complicated by abnormal uterine bleeding will improve the effectiveness of treatment of symptomatic isthmocoele.…”
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AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model by Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt

“…We further demonstrate that a single systemic dose of AAV‐VHH‐B9 produces positive long‐term (12 months plus) effects on amyloid load, neuroinflammation, synaptic function, and cognitive performance, in the AppNL‐G‐F Alzheimer’s mouse model. …”
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Activated NK cells reprogram MDSCs via NKG2D-NKG2DL and IFN-γ to modulate antitumor T-cell response after cryo-thermal therapy by Peng Peng, Lisa X Xu, Yue Lou, Shicheng Wang, Junjun Wang, Zelu Zhang, Peishan Du, Jiamin Zheng

“…Targeting MDSCs to alleviate their protumor functions and immunosuppressive activities is intimately associated with cancer immunotherapy. …”
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Quality of Life in Breast Cancer Patients in Saudi Arabia: A Systematic Review by Aljadani FF, Nughays RO, Alharbi GE, Almazroy EA, Elyas SK, Danish HE, Alanazi RT, Aldrees BA, Jadkarim GA, Mikwar Z

“…Chemotherapy and monoclonal antibodies can make the patients stressed and more tired. …”
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HISTOGENETIC ASPECTS OF PNEUMOFIBROSIS DURING CONIOTIC CHANGES IN KUZBASS MINERS by Олег Иванович Бондарев, Сергей Николаевич Филимонов

“…Immunohistochemical study was performed using monoclonal antibodies (proliferation marker Ki-67; oncogene of proapoptotic activity Vcl-2; endothelial function factors CD-31 and CD-34, macrophage factor NAM 56). …”
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Impact of pancreatic cell-engineered constructs on the islet apparatus in recipient rats with type I diabetes mellitus by N. V. Baranova, L. A. Kirsanova, G. N. Bubentsova, A. S. Ponomareva, A. O. Nikolskaya, Yu. B. Basok, V. I. Sevastianov

“…Morphological examination of the pancreatic islet apparatus in the experimental animals revealed that implantation of the PCEC had a be- neficial effect on restoration of the recipient’s pool of functionally active beta cells, serving as a trigger for the regenerative process.…”
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Current opportunities to improve outcomes of COVID-19 infection prevention and course in patients with lymphoproliferative diseases (regional analysis) by Ch. Kh. Valiakhmetova, E. I. Siraeva

“…Impaired immune response in patients with lymphoproliferative diseases (LPD) can lead to severe COVID-19 infection and significantly affect survival by increasing the risk of death. The effectiveness of vaccines may be reduced in people with compromised immune system function. …”
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Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy by Lanfang Ren, Zeda Zhao, Yuqing Chao, Panting Yu, Zhoufang Mei, Bing Du, Yiyun Cheng

“…Optimized LNPs efficiently deliver various proteins, including antibodies, enzymes, toxins, and Cas9 into living cells with reserved functions. …”
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IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma by Xiaoying Hu, Viktor Umansky, Peter Altevogt, Jochen S Utikal, Alina Siebenmorgen, Christopher Groth, Carsten Sticht, Rebekka Weber, Zeno Riester, Laura Hüser

“…MDSC differentiated in the presence of IL-6 strongly inhibited CD8+ T cell functions compared with MDSC differentiated without IL-6. …”
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Efficacy of anti-LAG3 and anti-PD-1 combination checkpoint inhibitor therapy against head and neck squamous cell carcinoma in a genetically engineered mouse model by Felipe F. Lamenza, Peyton Roth, Puja Upadhaya, Suvekshya Shrestha, Sushmitha Jagadeesha, Natalie Kazmierowicz, Natalie Horn, Hasan Pracha, Sonali Dasari, Steve Oghumu

“…Combined anti-LAG-3/anti-PD-1 therapy was effective at decreasing the tumor burden and lymphatic metastasis compared to anti-LAG-3 treatment but not when compared to the anti-PD-1 treatment alone. …”
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Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy? by Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis

“…However, translating these promising findings into safe and effective clinical therapies presents substantial challenges. …”
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Rituximab Administration to Treat Nephrotic Syndrome in Children: 2-Year Follow-Up by Dmytro Ivanov, Lutz T. Weber, Elena Levtchenko, Liudmyla Vakulenko, Mariia Ivanova, Iryna Zavalna, Yelizaveta Lagodych, Ninel Boiko

“…Further studies should focus on long-term cost-effectiveness and deferred side effects.…”
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THE TIME COURSE OF CHANGES IN B LYMPHOCYTE SUBPOPULATIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS DURING THERAPY WITH BIOLOGICAL AGENTS by A. A. Mesnyankina, S. K. Solovyev, E. N. Aleksandrova, A. P. Aleksankin, E. V. Suponitskaya, A. V. Elonakov, E. A. Aseeva, E. L. Nasonov

“…Assessment of the time course of changes in peripheral blood B lymphocyte subpopulations provides new opportunities to identify impaired function and regulation of cellular immunity in patients with SLE, it may be a useful diagnostic parameter to monitor an autoimmune disease and a valuable tool to assess and predict a response.…”
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Enzymatic hydrolysis of silkworm pupa and its allergenicity evaluation by animal model with different immunization routes by Yan Dai, Meijia Huang, Yujuan Xu, Lixia Mu, Jingyan Gao, Hongbing Chen, Zhihua Wu, Anshu Yang, Yong Wu, Xin Li

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An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV by Hailong Guo, Bomsoo Cho, Paul R. Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W. Botten, Stephen F. Carroll, Bruce A. Keyt, Andrew W. Womack, William R. Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W. Shiver, Tong-Ming Fu

“…The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. …”
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Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy by Yogesh Godiyal, Drishti Maheshwari, Hiroaki Taniguchi, Shweta S. Zinzuwadia, Yanelys Morera-Díaz, Devesh Tewari, Anupam Bishayee

“…Furthermore, it controls the phenotype and functionality of innate and adaptive immune components. …”
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Active immunization with inhibin DNA vaccine promotes spermatogenesis and testicular development in rats by Jinzhu Meng, Jian Hao Feng, Lilin Xiao, Wanfeng Zhou, Hongliang Zhang, Xianyong Lan, Shuilian Wang

“…INH immunization may have a positive effect on spermatogenesis and testicular development in male rats.…”
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Histomorphometric changes in pituitary gonadotropic endocrinocytes when exposed to dark deprivation by L. I. Kondakova, S. A. Kalashnikova

“…Aim. To assess the effect of 30-day dark deprivation on functional and histomorphometric changes in adenohypophysis gonadotropic endocrinocytes and their reversibility in mature male rats.Materials and methods. …”
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Abstract 087: Cocaine‐Induced Acute Spinal Cord Ischemia Syndrome by Tyler Kendall, Alexander Besser, Harsh Gupta

“…Other studies on outcomes of spinal cord ischemia have shown that ASIA Impairment Scale (AIS) score, lesion level, and patient age were the strongest predictors of neurologic and functional outcomes, whereas etiology of the ischemia had no effect on outcomes [10].…”
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