Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases by Tian Tian, Monan Liu, Peter J. Little, Hans Strijdom, Jianping Weng, Suowen Xu

“…The GFRAL receptor is central to its function, mediating the anorexigenic and metabolic effects of GDF15. …”
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Genome and Pathogenicity Analysis of an NADC30-like PRRSV Strain in China’s Xinjiang Province by Honghuan Li, Wei Zhang, Yanjie Qiao, Wenxing Wang, Wenxiang Zhang, Yueli Wang, Jihai Yi, Huan Zhang, Zhongchen Ma, Chuangfu Chen

“…Serum biochemical tests indicated significant impairment of liver and kidney function. PRRSV antibodies began to appear gradually after 10 days post infection. …”
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Adeno-associated virus-based gene therapy for hemophilia–addressing the gaps by Wolfgang Miesbach, Paul Batty, Pratima Chowdary, Sylvia Fong, Radoslaw Kaczmarek, Frank W.G. Leebeek, Brian Long, Johnny Mahlangu, Mike Makris, Glenn F. Pierce, Steven W. Pipe, Alok Srivastava, Jan Voorberg, Flora Peyvandi

“…This manuscript follows literature reviews and structured discussions by the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee Working Group on Gene Therapy that identified specific areas requiring standardization of methods, including viral vector production, liver function assessment, quantification of factor (F)VIII and FIX expression levels, assessment of antiadeno-associated viral antibodies, and genomic integration detection methods. …”
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Decrease in Intracellular Perforin Levels and IFN-γ Production in Human CD8+ T Cell Line following Long-Term Exposure to Asbestos Fibers by Naoko Kumagai-Takei, Yasumitsu Nishimura, Hidenori Matsuzaki, Suni Lee, Kei Yoshitome, Takemi Otsuki

“…Therefore, we examined the effects of long-term exposure to asbestos on CD8+ T cell functions by comparing long-term cultures of the human CD8+ T cell line EBT-8 with and without exposure to chrysotile (CH) asbestos as an in vitro model. …”
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Case series of dermopathy in autoimmune thyroid disease by Janić Tamara, Stojković Mirjana, Marković Bojan, Đurković Ivana, Babić Jovana, Joksimović Nata, Nedeljković-Beleslin Biljana, Ćirić Jasmina, Žarković Miloš

“…Our patients had different thyroid function disorders (hypo/hyperthyroidism), different forms of dermopathy, and varying times of onset during the disease. …”
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T-Follicular Helper Cells and Their Role in Autoimmune Diseases by Michalis Christodoulou, Eleni Moysidou, Georgios Lioulios, Stamatia Stai, Christina Lazarou, Aliki Xochelli, Asimina Fylaktou, Maria Stangou

“…Tfh cell-related biomarkers can be used to assess disease activity and transform autoimmune disease treatment, leading to more personalized and effective care for patients with chronic autoimmune conditions.…”
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Interrelation of indicators of oxygen metabolism of neutrophils and antiendotoxin immune as a marker of the postoperative period in patients with acute colonic obstruction by A. V. Pikuza, A. M. Zakirov

“…The article reflects effective approaches to monitoring the course of the postoperative period in 157 patients operated on for acute colonic obstruction. …”
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The partial clinical remission phase of type 1 diabetes: early-onset dyslipidemia, long-term complications, and disease-modifying therapies by Benjamin Udoka Nwosu, Benjamin Udoka Nwosu

“…These therapies are focused on mitigating β-cell apoptosis by reducing autoimmune attacks on surviving β-cells through several pathways; as well as improving β-cell function to enable the production of functional endogenous insulin and C-peptide through the reduction of proinsulin to C-peptide ratios and other measures. …”
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The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT by Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo

“…Patients who completely discontinued immunosuppression and maintained stable allograft function underwent protocol liver biopsies at 12 and 24 months after immunosuppression withdrawal. …”
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1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expression by Julie Petry, Han Mai, Maria Shoykhet, Ali Bashiri Dezfouli, Barbara Wollenberg

“…Consequently, targeting platelet-leukocyte aggregate (PLA) formation represents a promising pharmacological strategy to interfere with platelet-mediated pro-tumorigenic effects. 1,8-cineole, a plant-derived metabolite found in several botanical sources, has shown potent anti-platelet effects through modulation of the adenosine A2A receptor signaling. …”
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Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer by Benjamin N. Christopher, Lena Golick, Ashton Basar, Leticia Reyes, Reeder M. Robinson, Aaron O. Angerstein, Carsten Krieg, G. Aaron Hobbs, Denis C. Guttridge, John P. O’Bryan, Nathan G. Dolloff

“…Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest 5-year survival rates of all cancers, and limited treatment options exist. Immunotherapy is effective in some cancer types, but the immunosuppressive tumor microenvironment (TME) of PDAC is a barrier to effective immunotherapy. …”
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Clarification of a unique mucosal vaccination route for improved systemic and mucosal immune response in broiler by Rupa Akter, Md Abdul Masum, Subrato Biswas, Md Zahir Uddin Rubel, Sujan Kumar Sarkar, Mohammad Saiful Islam, Hossain M. Golbar, Md Emtiaj Alam, Md Abdur Rakib, Md Zahirul Isalm Khan

“…Cloacal-vaccinated chickens showed less damage to the follicle and epithelium of the bursa of Fabricius compared to other groups, indicating its lower cytotoxic effect. Therefore, the cloaca-associated mucosal vaccination route produces more antibodies than other mucosal vaccination routes, which will protect the chickens on the farm to a greater extent.…”
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Radioiodine Thyroid Ablation in Graves′ Hyperthyroidism: Merits and Pitfalls by J. Nwatsock, D. Taieb, L. Tessonnier, J. Mancini, F. Dong-A-Zok, O. Mundler

“…The aim of this study was to evaluate thyroid function, TSH-receptor antibodies (TRAb) and Graves′ ophthalmopathy (GO) occurrence after radioiodine thyroid ablation in GD. …”
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Clinical outcomes of surgical management for rare types of progressive familial intrahepatic cholestasis: a case series by Kazunori Masahata, Takehisa Ueno, Kazuhiko Bessho, Tasuku Kodama, Ryo Tsukada, Ryuta Saka, Yuko Tazuke, Shuji Miyagawa, Hiroomi Okuyama

“…LDLT accompanied by total biliary diversion may not be as effective for patients with FIC1 deficiency.…”
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Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy by Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot

“…Abstract Collagen is critical to the structure and function of skin tissues, with the collagen I/III ratios influencing fibrillogenesis, fiber organization, and skin mechanics. …”
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From infection to infertility: a review of the role of human papillomavirus-induced oxidative stress on reproductive health and infertility by Omid Salahi Ardekani, Arash Letafati, Sepehr Ebrahimi Dehkordi, Ali Vasheghani Farahani, Mahshid Bahari, Bahar Mahdavi, Negar Ariamand, Mahdie Taghvaei, Moein Kohkalani, Angila Ataei Pirkooh, Seyed Mohammad Jazayeri, Luciano Saso

“…HPV may also affect ovarian reserve by causing chronic inflammation, which can impair granulosa cell function and lower serum anti-Müllerian hormone (AMH) levels. …”
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SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy by Amelia Fox, Jonathan Oliva, Rajanikanth Vangipurapu, Francis M. Sverdrup

“…To assess reciprocal effects of DUX4 on SIX1, 2, and 4 expression, we utilized a doxycycline-inducible DUX4 myoblast cell line. …”
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Treadmill Exercise Impact on Brain Electrophysiological and Glial Immunoreactivity in Cuprizone-Treated Rats by Cássia Borges Lima-de-Castro, Noranege Epifânio Accioly, Geórgia de Sousa Ferreira Soares, Catarina Nicácio dos-Santos, Sonia Carolina Guerrero Prieto, Rubem Carlos Araujo Guedes

“…Physical exercise benefits central neural functions that depend on the brain’s electrophysiological and glial activity. …”
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Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report by Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu

“…BackgroundSjögren’s syndrome (SS) is a systemic autoimmune disease, with major symptoms including dry mouth and dry eyes, for which there is no effective treatment. Recent studies have demonstrated that mesenchymal stem cells (MSCs) are effective in the treatment of SS, but the efficacy of allogeneic MSCs is affected by variability among different cell donors, and they are easily cleared by the immune system of the recipient. …”
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Marine medaka heat shock protein 90ab1 is a receptor for red-spotted grouper nervous necrosis virus and promotes virus internalization through clathrin-mediated endocytosis. by Wanwan Zhang, Kuntong Jia, Peng Jia, Yangxi Xiang, Xiaobing Lu, Wei Liu, Meisheng Yi

“…Inhibition of MmHSP90ab1 by HSP90-specific inhibitors or MmHSP90ab1 siRNA caused significant inhibition of viral binding and entry, whereas its overexpression led to the opposite effect. The binding of RGNNV to cultured marine medaka hMMES1 cells was inhibited by blocking cell surface-localized MmHSP90ab1 with anti-HSP90β antibodies or pretreating virus with recombinant MmHSP90ab1 or MmHSP90ab1-NM protein, indicating MmHSP90ab1 was an attachment receptor for RGNNV. …”
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