Anti-IL-5 and anti-IL-5 receptor therapy significantly improves quality of life and FEV1 values in patients with severe asthma by Anaiza Odalis Villalobos Alfaro, Haydee Carolina Gutiérrez Vargas, Juan Manuel Díaz, Jonathan Alvarez Pinto, Diana Cristina García Cambero, Eduardo Hernandez Cuellar, Julio Augusto Palma Zapata, Alondra Esthefanía Llamas Domínguez, Juliana Palma Zapata, Silvia Denise Ponce-Campos

“…Abstract In recent years, the use of monoclonal antibodies directed against interleukin-5 (anti-IL-5) and its receptor alpha (anti-IL-5R) has proven to be an effective therapeutic option for patients with severe asthma by reducing the number of eosinophils, which may promote disease remission. …”
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Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review by Jiann-Jy Chen, Chih-Wei Hsu, Yen-Wen Chen, Tien-Yu Chen, Bing-Yan Zeng, Ping-Tao Tseng

“…<b><i>Conclusions:</i></b> Clinicians are encouraged to remain vigilant about the possibility of APS and its complex audiovestibular manifestations, as prompt intervention could stabilize audiovestibular function effectively.…”
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The use of “Acellbia” – a biosimilar of rituximab in systemic sclerosis by L. P. Ananyeva, L. A. Garzanova, O. V. Desinova, R. U. Shayakhmetova, M. N. Starovoytova, O. A. Koneva, O. B. Ovsyannikova, S. I. Glukhova, E. L. Nasonov

“…A significant decrease of skin fibrosis and improvement of lung functions have been proven. The clinical effect of ACB manifested by the 6th month from the start of therapy and reached its maximum one year after its initiation. …”
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Acute hepatitis in a paediatric patient: immune-mediated drug-induced liver injury or albendazole-induced autoimmune hepatitis? by Nataša Dragutinović, Aleksandra Barać, Goran Stevanović, Irena Đorđić, Bianca Paglietti, Jelena Micić, Ema Aleksić, Jelena Stojnić, Jelena Martinov Nestorov

“…Corticosteroid therapy resulted in the complete normalization of liver function, as well as IgG. With the cessation of corticosteroid therapy, transaminases, bilirubin and gamma-glutamyl transferase (GGT) remained within normal levels, but an increase in anti-smooth muscle antibodies (SMA) was noted in immunological analyses after one year of follow-up. …”
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The evolution of the therapeutic concept ‘GIP receptor antagonism’ by Frederikke Koefoed-Hansen, Frederikke Koefoed-Hansen, Mads Marstrand Helsted, Hüsün Sheyma Kizilkaya, Asger Bach Lund, Asger Bach Lund, Asger Bach Lund, Mette Marie Rosenkilde, Lærke Smidt Gasbjerg, Lærke Smidt Gasbjerg

“…Today, GIP receptor antagonists are not only used as scientific tools but due to significant metabolic effects, they also have a therapeutic purpose. The beneficial clinical effects of GIP receptor antagonism are supported by comparable phenotypic traits of individuals with loss-of-function genetic receptor variants. …”
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Presence and Location of CatSper 1–4, Opioid (μ, δ and κ) and CD44 Receptors in Spermatozoa from Aoudad, Iberian Ibex and Mouflon by Alejandro Vicente‐Carrillo, Manuel Álvarez‐Rodríguez, Cristina Castaño, Adolfo Toledano‐Díaz, Eva Martínez‐Nevado, Heriberto Rodríguez‐Martínez, Julián Santiago‐Moreno

“…Acquiring a sound knowledge of the molecular basis of most functional aspects of spermatozoa will improve the effectiveness of reproductive techniques and optimise conservation programs for threatened species. …”
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Beyond insulin: advancing frontiers in cell-based and genetic therapies for type 1 diabetes management by Tamer A. Addissouky

“…Parallel progress in immunomodulatory approaches includes both antigen-specific (oral insulin, GAD65, and proinsulin peptide therapies) and non-antigen-specific interventions (anti-CD3 monoclonal antibodies, engineered regulatory T cells). Combination immunotherapies and the advent of Teplizumab have demonstrated potential for delaying disease progression and preserving beta cell function. …”
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Influence of Interleukin-8 and Neutrophil Extracellular Trap (NET) Formation in the Tumor Microenvironment: Is There a Pathogenic Role? by Manuela Gonzalez-Aparicio, Carlos Alfaro

“…However, the extent to which NETs affect the function of other cells of the immune system in the tumor context has not been directly demonstrated. …”
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HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…Our results also suggest that HDAC1-3 inhibitors potentiate the antitumor effects of anti-programmed cell death protein 1 antibodies. …”
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Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-c... by Ruiling Zhao, Zhangyao Su, Junjie Gu, Hang Zhao, Lingling Bian, Yin Jiang, Yun Cai, Tao Yang, Yong Gu, Xinyu Xu

“…Mitochondrial division inhibitor 1 (Mdivi-1) enhanced the therapeutic effect of anti-CD3 mAb treatment by promoting the development of more TEX cells. …”
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Identification of Potential <i>Amblyomma americanum</i> Antigens After Vaccination with Tick Extracellular Vesicles in White-Tailed Deer by Adela Oliva Chávez, Julia Gonzalez, Cristina Harvey, Cárita de Souza Ribeiro-Silva, Brenda Leal-Galvan, Kelly A. Persinger, Sarah Durski, Pia U. Olafson, Tammi L. Johnson

“…Conclusions: Proteins within tick salivary and midgut vesicles are recognized by antibodies from vaccinated white-tailed deer. These proteins can be further evaluated for their function and potential as vaccine candidates against ticks.…”
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Comparisons of efficacy and safety of immunotherapies for Alzheimer’s disease treatment: A network meta-analysis of randomised controlled trials by Ching-Hui Su, Ying-Tzu Chang, Huan-Shu Tseng, Chan-Yen Kuo, Jin-Hua Chen, Po-Yu Chien, Yao-Jen Chang, Chin-Chuan Hung

“…Donanemab and lecanemab ranked among the most effective treatments for improving cognitive function (Clinical Dementia Rating Scale – Sum of Boxes P-scores: 0.88 and 0.77) and daily activities (Alzheimer’s Disease Cooperative Study – Activities of Daily Living P-scores: 0.85 and 0.90), based on network meta-analysis findings. …”
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The expression and significance of p53 protein and Ki-67 protein in pterygium by Ljubojević Vesna, Gajanin Radoslav, Amidžić Ljiljana, Vujković Zoran

“…Inactivation of p53 function removes an obstacle to increased proliferation. …”
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Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens. by Emma T Crooks, Francisco Almanza, Alessio D'Addabbo, Erika Duggan, Jinsong Zhang, Kshitij Wagh, Huihui Mou, Joel D Allen, Alyssa Thomas, Keiko Osawa, Bette T Korber, Yaroslav Tsybovsky, Evan Cale, John Nolan, Max Crispin, Laurent K Verkoczy, James M Binley

“…Selection criteria included i) high expression and ii) infectious function, so that trimer neutralization sensitivity can be profiled in pseudovirus (PV) assays. …”
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MODERN APPROACHES TO ANTIVIRULENT THERAPY OF DISEASES ASSOCIATED WITH STAPHYLOCOCCUS AUREUS by T.O. Kryuchko, O.Ya. Tkachenko, N.V. Kuzmenko, I.N. Nesina, S.M. Tanianska, I.A. Kolenko, M.O. Melnyk

“…Staphylococcus aureus is a universal bacterial pathogen, which is able to develop the resistance to new antibiotics, by means of virulence factors, whose main function is the spread of diseases by inhibiting the immune factors of host defense. …”
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Backgrounds of origin and character of structural changes in testicles of coalminers of Donbass region by Yu. V. Danilov, T. I. Shevchenko, K. V. Motkov

“…Pathohistological research was conducted according to standard methodology. Mice monoclonal antibodies were used to CD34, collаgen type IV, PCNA, chromogranin A and synaptophysine (DAKO). …”
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Balance Between Pro- and Anti-Inflammatory Cytokines in Mice Treated With Centruroides noxius Scorpion Venom by Vera L. Petricevich

“…CSV consists of a very complex of molecules and demonstrates significant cellular activities capable of stimulating immune functions in vivo. The purpose of this study was to analyze the effects of CSV on sex, weight, route of injection and the balance of pro- and anti-inflammatory cytokines in mice. …”
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Approach to Hyperthyroidism by Raisa Chowdhury, Sena Turkdogan, Jennifer A. Silver, Jessica Hier, Stuart Bursey, Danah Quttaineh, Mark Khoury, Lamiae Himdi

“…Management strategies include beta-blockers for symptomatic relief, though side effects such as bradycardia and fatigue may occur. …”
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Adaptive immune response in pathogenesis and treatment of head and neck squamous cell carcinoma: the influence of immunosuppression factors and gender by A. I.  Stukan, R.  A. Murashko, N. A. Tsygan, A. Yu. Goryainova, O. N. Nefedov, V. A. Porkhanov

“…It has been shown that the use of immune response checkpoint inhibitors is more effective in improving survival rates in men, and the use of these drugs in combination with chemotherapy is more effective in women. …”
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Critical Role of p38&alpha; MAPK Subclass in the Development of Pain Hypersensitivity After Hind Paw Incision by Ishikawa D, Yamakita S, Oh-Hashi K, Amaya F

“…Localization of p38 MAPK expression was analyzed by immunohistochemistry using subclass-selective antibodies. The effects of a p38α MAPK inhibitor on plantar incision-induced pain hypersensitivity was assessed using behavioral tests to measure mechanical and thermal sensitivity. …”
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