Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. by Lei Zheng, Kelly Foley, Lanqing Huang, Ashley Leubner, Guanglan Mo, Kelly Olino, Barish H Edil, Masamichi Mizuma, Rajni Sharma, Dung T Le, Robert A Anders, Peter B Illei, Jennifer E Van Eyk, Anirban Maitra, Daniel Laheru, Elizabeth M Jaffee

“…The aggressiveness of pancreatic ductal adenocarcinoma (PDA) is characterized by its high metastatic potential and lack of effective therapies, which is the result of a lack of understanding of the mechanisms involved in promoting PDA metastases. …”
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Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia by Yu-Zhong Feng, Hao Cheng, Guo-Qing Xiong, Jia-Zhen Cui, Zhi-Li Chen, Yuan-Yuan Lu, Zhi-Xin Meng, Chen Zhu, Hao-Long Dong, Xiang-Hua Xiong, Gang Liu, Qing-Yang Wang, Hui-Peng Chen

“…However, the current clinically applied uricases, despite their potent urate-lowering capacity, tend to form anti-drug antibodies because of their immunogenicity, leading to increased risk of anaphylaxis, faster drug clearance and reduced or even complete loss of therapeutic effect, limiting their clinical application. …”
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Cellular reactions of CD3+ CD4+ CD45RO+ T-lymphocytes on dexamethason in in normal patients and in patients with with rheumatoid arthritis in vitro by L. S. Litvinova, N. M. Todosenko, O. G. Khaziakhmatova, I. P. Malinina, K. A. Yurova

“…We assume that the resistance of CD4+CD45RO+CD95+HLA-DR+ T cells in RA patients to the suppressor effect of GC generally leads to the preservation and enhancement of the functionality of autoreactive cells in the pathogenesis of RA.…”
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Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocar... by Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Guang-Yin Shen, Yonggu Lee, Jeong Hun Shin, Hyuck Kim, Kyung-Soo Kim

“…Moreover, the VEGF-containing BM-MSC supernatant inhibited miRNA-23a and miRNA-92a expression and reduced apoptotic signaling in cardiomyocytes under hypoxia. These effects were inhibited when the supernatant was treated with neutralizing antibodies against VEGF. …”
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New immunomodulatory treatment protocol for canine leishmaniosis reduces parasitemia and proteinuria. by Guadalupe Miró, Sergi Segarra, José Joaquín Cerón, Lluís Ferrer, Laia Solano-Gallego, Laia Montell, Ester Costa, Joan Teichenne, Roger Mariné-Casadó, GALILEI trial Group, Xavier Roura

“…The current standard treatment for canine leishmaniosis (CanL), N-methylglucamine antimoniate (MGA) given with allopurinol, is not fully effective and may cause adverse effects and drug resistance. …”
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The clinical and pathological histology efficacy of biological therapy for severe asthma with a phenotype of type 2 inflammation - systematic review by Junhui Ma, Qiang Ma, Jing Yang, Panpan Liang, Jiaxin Zhou, Jiarui Ma, Fuhua Ma, Bing Zhuan, Wei Zhou

“…Several well-verified biological agents, such as anti-immunoglobulin E (IgE) monoclonal antibodies, anti-interleukin (IL)-4 monoclonal antibodies, anti-IL-5 monoclonal antibodies, and anti-thymic stromal lymphopoietin (TSLP) monoclonal antibodies, have shown outstanding effectiveness. …”
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Structural Virology: The Key Determinants in Development of Antiviral Therapeutics by Tanuj Handa, Ankita Saha, Aarthi Narayanan, Elsa Ronzier, Pravindra Kumar, Jitin Singla, Shailly Tomar

“…This review highlights the significance of structure-based investigations for bridging the gap between structure and function, thus facilitating the development of effective antiviral therapeutics, vaccines, and antibodies for tackling emerging viral threats.…”
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NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer by Jian Huang, Bo Wang, Dong Yan, Tianxin Lin, Lu Pei, Hao Yu, Wang He, Kaiwen Li, Meihua Yang, Weibin Hou, Honghui Zeng, Xin-Ke Zhang, Long Huang, Haide Qin

“…Targeting NNMT using the inhibitor 5-Amino-1-methylquinolinium iodide significantly reduced tumor growth and enhanced the apoptotic effects of the anti-PD-L1 antibody in UBC mouse models. …”
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Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage by Natalia Lazzarin, Costanzo Moretti, Giovanna De Felice, Elena Vaquero, Dario Manfellotto

“…It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. …”
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Preclinical development of an immunoassay for the detection of TREM2: a new biomarker for Alzheimer’s disease by Jie Hu, Huimei Zeng, Jiaqi Lu, Tianpeng Li, Xue Liu, Yang Liu, Weihuan Wen, Weijun Shen, Hongying Chen, Zhicheng Chen

“…Impairment of TREM2 function aggravates the toxic effects of amyloid plaques, and its activation has been shown to reduce Aβ burden and memory deficits. …”
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Unraveling the immunomodulatory role of TIM-3 in head and neck squamous cell carcinoma: implications for targeted therapy by Shuang Xu, Yang Luo, Yuzhu He, Yuxiang Chen, Fengfeng Qin, Wenjian Hu

“…With increased research in immunotherapy, antibodies against various immune checkpoints like programmed death receptor 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 (CTLA-4) have been shown to be effective against a wide range of tumors. …”
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Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis by Jing Chen, Shenghua Zhang, Xinmei Huang, Qianqian Wang, Weiyan Xu, Jing Huang, Yuming Su, Qinkun Sun, Xiaojuan Du, Baocai Xing, Xiaoyan Qiu

“…Notably, anti-sialylated IgG antibody effectively blocks colorectal cancer liver metastasis in mouse models. …”
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Nanobody-Based Immunoassays for the Detection of Food Hazards—A Review by Wenkai Li, Zhihao Xu, Qiyi He, Junkang Pan, Yijia Zhang, El-Sayed A. El-Sheikh, Bruce D. Hammock, Dongyang Li

“…In immunoassays, antibodies function as the primary recognition elements. …”
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Hashimoto’s Thyroiditis and Graves’ Disease in One Patient: The Extremes of Thyroid Dysfunction Associated with Interferon Treatment by R. H. Bishay, R. C. Y. Chen

“…This raises the need to monitor thyroid function closely in patients both during and following completion of interferon treatment.…”
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Differentiated thyroid carcinoma in children: Clinical characteristics and long-term follow-up by Muge Tamam, Ercan Uyanik, Nurcan Edís, Mehmet Mulazimoglu, Tevfik Ozpacaci

“…The follow-up protocol consisted of detailed clinical examination, testing of thyroid function, determination of serum thyroglobulin (Tg), and anti-Tg antibodies, and neck ultrasonography application. …”
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Splenomegaly and thrombocytopenia in patients with liver cirrhosis by Đorđević Jelena, Svorcan Petar, Vrinić Dušica, Dapčević Branka

“…One is central which involves either myelosuppression because of hepatitis viruses or the toxic effects of alcohol abuse on the bone marrow. The second one involves the presence of antibodies against platelets. …”
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Active Immunization Against Inhibin Impaired Spermatogenesis, Plasma Luteinizing Hormone, Pituitary Prolactin mRNA, and Hypothalamic Vasoactive Intestinal Peptide mRNA Expressions... by Muhammad Faheem Akhtar, Muhammad Umar, Ejaz Ahmad, Mingxia Zhu, Ying Han, Changfa Wang

“…Immunization against INH in male geese leads to the production of antibodies to neutralize the INH activity that enhances testicular function and gonadotropin production. …”
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The influence of identity-oriented psychotrauma therapy on Hashimoto disease activity: a randomised controlled trial by Maria-Magdalena Macarenco, Cristian Opariuc-Dan, Teodora Georgescu

“…Background: Childhood adversity and trauma have been linked to altered thyroid function and hypothyroidism, yet few randomised controlled trials (RCTs) have examined the effectiveness of trauma-focused psychological interventions in patients with Hashimoto’s thyroiditis (HT).Objective: This study aimed to evaluate the effectiveness of Identity-Oriented Psychotrauma Therapy (IOPT) in adults with HT, focusing on both immunological and psychological outcomes.Method: This parallel-group RCT randomised 70 adults with HT (93.94% women; age 25–57) to receive treatment as usual (TAU) or TAU plus IOPT. …”
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Valvular Heart Disease In Antiphospholipid Syndrome (Review) by G. A. Ignatenko, G. G. Taradin, L. V. Kononenko, I. V. Rakitskaya, Y. S. Kagitina, B. D. Prendergast

“…The main pathogenetic events of VHD are caused by the effects of antiphospholipid antibodies, local platelet aggregation, migration of inflammatory cells and deposition of immune complexes. …”
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Comparison of the Efficacy and Safety of PD‐1/PD‐L1 Inhibitors in the Treatment of Small Cell Lung Cancer by Qichen Zhang, Xiaojuan Han, Jiayi Liu, Hui Qiao

“…Median survival times were 21.0 months for PD‐L1 and 17.0 months for PD‐1, with no statistically meaningful difference (p = 0.180). Adverse effects were comparable between the groups in terms of thyroid function (p = 0.898), but bone marrow suppression and gastrointestinal reactions were significantly less severe in the PD‐L1 group (p = 0.047 and p = 0.002). …”
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