CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation by Michael Hudecek, Anna Christina Dragon, Katharina Zimmermann, Thomas Nerreter, Deborah Sandfort, Julia Lahrberg, Stephan Klöß, Christina Kloth, Caroline Mangare, Agnes Bonifacius, Sabine Tischer-Zimmermann, Rainer Blasczyk, Britta Maecker-Kolhoff, Barbara Uchanska-Ziegler, Hinrich Abken, Axel Schambach, Britta Eiz-Vesper

“…Current treatment options do not distinguish between healthy and malignant B cells and are thereby often limited by severe side effects in the already immunocompromised patients. …”
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The Central Role of Inflammation Associated with Checkpoint Inhibitor Treatments by Cristina Vajaitu, Carmen Cristina Draghici, Iulia Solomon, Cristina Victoria Lisievici, Alexandra Victoria Popa, Mihai Lupu, Constantin Caruntu, Maria Magdalena Constantin, Vlad Mihai Voiculescu

“…This review is focused on the association between cancer and inflammation, underlying the mechanisms of action of monoclonal antibodies that are targeting checkpoint inhibitors: ipilimumab against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and pembrolizumab and nivolumab against programmed cell death protein 1 (PD-1), their indications for treatment, and side effects. …”
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Structural information in therapeutic peptides: Emerging applications in biomedicine by Valentín Iglesias, Oriol Bárcenas, Carlos Pintado‐Grima, Michał Burdukiewicz, Salvador Ventura

“…This trend stems from their cost‐effectiveness and reduced immunogenicity, compared to antibodies or recombinant proteins, but also from their ability to dock and interfere with large protein–protein interaction surfaces, and their higher specificity and better biocompatibility relative to organic molecules. …”
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Fine particulate matter (PM2.5) induces microRNA-192–5p causing glomerular damage by Melina Yarbakht, George Sarau, Yanyi Xu, Xinyi Fang, Zeynab Mirzaei, René Krüger, Yalan Xiao, Arslan Usman, Christoph Daniel, Mario Schiffer, Silke Christiansen, Janina Müller-Deile

“…Cultured human podocytes, zebrafish, and mice were exposed to PM2.5 to assess possible effects on glomerular function and ultrastructure. …”
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Developmental programming of tissue-resident macrophages by Maria Francesca Viola, Eliana Franco Taveras, Elvira Mass

“…Understanding these effects can inform targeted interventions or preventive strategies against diseases. …”
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Revisiting the Molecular Mechanism of Neurological Manifestations in Antiphospholipid Syndrome: Beyond Vascular Damage by M. Carecchio, R. Cantello, C. Comi

“…In these cases, alterations of the coagulation system at various levels caused by multiple effects of antiphospholipid antibodies (aPL) have been postulated to explain the vascular damage to the CNS in APS. …”
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The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation by Katarzyna Samelska, Magdalena Kupis, Katarzyna Szymanek, Justyna Izdebska, Anna Zaleska-Żmijewska, Piotr Skopiński

“…Multiple studies have defined molecules important for maintaining the function of LSC including C/EBPδ, Bmi-1, p63α, interleukins (IL-6), epithelial structural proteins – keratins, and antibodies against epidermal growth factor receptor (EGFR). …”
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Phosphatase Dysregulation in Cancer: Signaling Pathways and Therapeutic Opportunities by Maryam Jama, Michael Overduin, Khaled H. Barakat

“…This review highlights current therapeutic strategies, including small molecules and antibodies, and their synergistic effects with kinase inhibitors and immune checkpoint blockade. …”
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The association of intolerance to non-steroidal anti-inflammatory drugs, bronchial asthma and nasal polyps: Clinical aspects and treatment strategies in Poland by Maria Zofia Lisiecka

“… Objective: To investigate the correlation between intolerance to non-steroidal anti-inflammatory drugs (NSAIDs), bronchial asthma, and nasal polyps, and to develop an effective treatment strategy for patients suffering from these conditions simultaneously. …”
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Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model by Zohreh Sharafian, Zohreh Sharafian, Paula T. Littlejohn, Paula T. Littlejohn, Paula T. Littlejohn, Christina Michalski, Christina Michalski, James A. Sousa, James A. Sousa, Janelle Cheung, Mariana Hill, Mariana Hill, Hannah Piper, Kevan Jacobson, Kevan Jacobson, Pascal M. Lavoie, Pascal M. Lavoie, Joannie M. Allaire, Bruce A. Vallance, Bruce A. Vallance

“…We assessed morphological changes and conducted transcriptomics profiling via RNAseq.ResultsExposing enteroids to neonatal Th17-cells-derived conditioned media led to enhanced growth, maturation, and differentiation as compared to control media. These effects were ablated when an IL-22 neutralizing antibody was used, while conversely, supplementing with recombinant IL-22 mimicked the Th17 effects, increasing intestinal epithelial cell proliferation and inducing marked differentiation of secretory cells. …”
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Influence of VEGF deprivation upon vascular formation by endothelium in the presence of macrophages by A. R. Kozyreva, T. Yu. Lvova, K. L. Markova, A. S. Simbirtsev, A. M. Ischenko, S. A. Selkov, D. I. Sokolov

“…The aim of our study was to investigate the effect of VEGF deprivation using monoclonal antibodies on angiogenesis under conditions of co-cultivation of endothelium and macrophages. …”
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ANTI-IGE THERAPY FOR SEVERE ASTHMA IN CHILDREN: TWO-YEAR TRIAL by T.Yu. Kulichenko, L.S. Namazova-Baranova, R.M. Torshkhoeva, O.F. Lukina, E.A. Vishneva

“…Thanks to treatment, lung function parameters improve, particularly in children with low bronchial patency parameters even after administration of broncholytics. …”
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Mechanistic Exploration of Yiqi Zengmian in Regulating the Microenvironment as an Immunopotentiator with the Beijing Bio-Institute of Biological Products Coronavirus Vaccine Based... by Zeyue Yu, Yudong Wang, Jianhui Sun, Xiaotong Zheng, Liyu Hao, Yurong Deng, Jianliang Li, Zongyuan Li, Zhongchao Shan, Weidong Li, Yuling Qiao, Ruili Huo, Yibai Xiong, Hairu Huo, Hui Li, Longfei Lin, Hanhui Huang, Guimin Liu, Aoao Wang, Hongmei Li, Luqi Huang

“…<b>Results</b>: YQZM significantly enhanced antigen-specific antibody titers, immune cell proportions, cytokine levels, and memory lymphocyte functions. …”
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OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics by Kristien Van Belle, Jean Herman, Mark Waer, Ben Sprangers, Thierry Louat

“…Surprisingly, knockout of ILK in murine B cells did not affect B cell function as assessed by several in vivo and ex vivo B cell assays and did not alter the B cell immunosuppressive activity of OSU-T315. …”
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Lymphocytic RNA stimulates physiological regeneration and enhances microcirculation in the thyroid gland by N. V. Tishevskaya, E. S. Golovneva, R. V. Takhaviev

“…Follicular epithelium and vascular structures were analyzed using morphometry, VEGF content was quantified via immunohistochemistry with specific antibodies, and thyroid microvascular function was assessed using laser flowmetry.Results. …”
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Immunotherapies: Exploiting the Immune System for Cancer Treatment by Jeffrey Koury, Mariana Lucero, Caleb Cato, Lawrence Chang, Joseph Geiger, Denise Henry, Jennifer Hernandez, Fion Hung, Preet Kaur, Garrett Teskey, Andrew Tran

“…However, not until recent decades have biological therapeutics been developed and refined enough to safely and effectively combat cancer. Three unique immunotherapies have gained traction in recent decades: adoptive T cell transfer, checkpoint inhibitors, and bivalent antibodies. …”
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Natural phytochemicals as small-molecule proprotein convertase subtilisin/kexin type 9 inhibitors by Je-Wen Liou, Pei-Yi Chen, Wan-Yun Gao, Jui-Hung Yen

“…Currently, monoclonal antibodies are used as PCSK9 inhibitors in clinical practice. …”
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Frequency of thyroid dysfunctions during interferon alpha treatment of single and combination therapy in hepatitis C virus-infected patients: a systematic review based analysis. by Chandrasekharan Nair Kesavachandran, Frank Haamann, Albert Nienhaus

“…Variations in IFN dosage, treatment duration of IFN, definition/criteria followed in each study for thyroid dysfunction and irregular thyroid function testing during treatment in different studies influence the outcome of the single studies and jeopardise the validity of a pooled risk estimate of side effects of thyroid dysfunction. …”
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Mechanisms Underlying the Impact of Interleukin Family on Acute Kidney Injury: Pathogenesis, Progression, and Therapy by Yuwei Ji, Zhenkai Zhao, Yan Yang, Xiaochen Wang, Ruifeng Qiao, Xiang Yu, Xinyan Gong, Zhe Feng, Quan Hong

“…As core components of the cytokine network, interleukins (ILs) exert pleiotropic effects in the development of AKI, participating in processes such as inflammation, fibrosis, tissue damage repair, and remote organ injury. …”
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Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates. by Duncan N Ndegwa, Prasun Kundu, Jessica B Hostetler, Alejandro Marin-Menendez, Theo Sanderson, Kioko Mwikali, Lisa H Verzier, Rachael Coyle, Sophie Adjalley, Julian C Rayner

“…A panel of P. vivax proteins predicted to function in erythrocyte invasion were expressed as full-length recombinant ectodomains in a mammalian expression system. …”
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