Phosphorylation of Bok at Ser-8 blocks its ability to suppress IP3R-mediated calcium mobilization by Caden G. Bonzerato, Katherine R. Keller, Richard J. H. Wojcikiewicz

“…Results Our results confirm that Ser-8 of Bok is phosphorylated by cAMP-dependent protein kinase, and remarkably that phosphorylation can be detected with Bok specific antibodies. Also, we find that Bok has suppressive effects on IP3R-mediated Ca2+ mobilization in a variety of cell types. …”
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Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B by Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung

“…BoNTs comprise three functional domains: a light-chain enzymatic domain (LC), a heavy-chain translocation domain (HC_N), and a heavy-chain receptor-binding domain (HC_C). …”
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Safety, pharmacokinetics, and potential benefits of TSH-receptor-specific monoclonal autoantibody K1-70TM in Japanese Graves’ disease patients: results of a phase 1 trial by Jaeduk Yoshimura Noh, Natsuko Watanabe, Koichi Ito, Mika Tsuiki, Yuki Ishihara, Tetsuya Tagami, Ichiro Yamauchi, Ai Kozaki, Toshu Inoue, Bernard Rees Smith

“…The primary objective was to assess safety and tolerability, and the secondary objectives were evaluation of PK and thyroid function. Exploratory analyses focused on the dynamics of the anti-TSH receptor antibodies and Thyroid eye disease (TED). …”
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Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets by Akhmed Aslam, Bassem Refaat, Riyad A. Almaimani, Ahmad A. Obaid, Abdulrahman Mujalli, Wesam F. Farrash, Mohamed E. Elzubier, Shakir Idris, Afnan Salaka, Ahmed H. Almalki, Mofareh Y. Alkhaldi, Hassan A. Asiri, Mohammad A. Baqassi, Ali M. Alhanash, Othman M. Hakmi, Faisal Minshawi

“…The data were then stratified according to clinical stages (early-stage I/II vs. late-stage III/IV) and tumour sites (right-sided cancers; RSCs vs. left-sided cancers; LSCs). Functional effects of biologically active IL-10 protein (0.1, 1, and 40 ng/ml), anti-IL10Rα monoclonal antibody (0.1, 1, and 40 ng/ml), and a single concentration of a specific STAT3 inhibitor (2 µM) on cell cycle and apoptosis were assessed in HT29 and SW620 CRC cell lines, along with the expression of key regulatory molecules. …”
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Syk inhibitors reduce tau protein phosphorylation and oligomerization by Tomohisa Yamaguchi, Tadanori Hamano, Kiyonao Sada, Rei Asano, Nicholas M. Kanaan, Hirohito Sasaki, Shu-Hui Yen, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Koji Aoki, Hironobu Naiki, Maho Morishima, Yuko Saito, Shigeo Murayama, Yasunari Nakamoto

“…In this model of neuronal tauopathy, the effects of the Syk inhibitors—BAY 61–3606 and R406—on tau phosphorylation and oligomerization were explored using several phosphorylated tau-specific antibodies and an oligomeric tau antibody, and the effects of these Syk inhibitors on autophagy were examined using western blot analyses. …”
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Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies by Venkata Lokesh Battula, Abhishek Maiti, Adishwar Rao, Akriti Agrawal, Gautam Borthakur

“…Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. In this review, we discuss γδ T cells’ biology, roles in cancer and AML, and mechanisms of immune escape and antileukemia effect; we also discuss recent clinical advances related to γδ T cells in the field of AML therapeutics.…”
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Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell r... by Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin

“…Finally, combination MG1 and programmed cell death protein-1 antibody (αPD-1) therapy was investigated in advanced 4434 tumors.Results MG1 effectively supported priming of functional cytotoxic T cells (CTLs) against tumor-associated antigens as well as virus-derived peptides, as assessed using peptide recall and T2 killing assays, respectively. …”
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

“…Importantly, we found that timing is crucial, as administration of IL-2cx after (but not before) ICIs led to profound antitumor effects. Mechanistically, CD25-biased IL-2cx selectively stimulated expansion and effector functions of tumor-specific CD8+ T cells in a CD25-dependent manner, overcoming Treg cell-mediated suppression. …”
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Single-center experience in kidney transplantation: outcomes, conclusions, and perspectives by M. Sh. Khubutia, I. V. Dmitriev, A. G. Balkarov, Yu. A. Anisimov, N. V. Shmarina, N. V. Zagorodnikova, N. V. Borovkova, M. G. Minina, D. V. Lonshakov, V. O. Aleksandrova, V. Smirnova, A. U. Rustambek

“…Induction immunosuppressive therapy (IST) with monoclonal antibodies was administered to 859 (77.7%) recipients, with polyclonal antibodies to 122 recipients (11%), and induction without antibodies to 125 recipients (11.3%). …”
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The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy. by Pablo F Barcelona, Alba Galan, Hinyu Nedev, Yifan Jian, Marinko V Sarunic, H Uri Saragovi

“…Many neurodegenerative retinal diseases are treated with monoclonal antibodies (mAb) delivered by invasive intravitreal injection (IVT). …”
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Future perspectives on immunotherapy for hepatocellular carcinoma by Landon L. Chan, Stephen L. Chan

“…These agents have demonstrated potential for synergistic effects with existing ICIs, with initial studies yielding positive outcomes. …”
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Long-term survival of a kidney transplant patient with advanced renal cancer after combination therapy: a case report and literature review by Chao Peng, Weihao Wang, Jiajun Chen, Shouhua Pan, Gang Xu, Mengyao Li, Lulu Zhang, Yulei Li, Keyuan Zhao, Jing Jin

“…The patient underwent cytoreductive nephrectomy followed by sequential treatment with tyrosine kinase inhibitors (TKI) and anti-PD-1 monoclonal antibodies. After 2 years, the patient showed excellent graft function with no evidence of cancer progression. …”
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The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats by T.A. Voroshylova, V.I. Shepitko, Ye.V. Stetsuk, N.V. Boruta, O.V. Vilkhova, M.V. Rud, G.S. Puzyryov, O.V. Sych, А.A. Miahkokhlib

“…The heart is unique in its structure and function, yet it is subject to changes under the influence of various factors. …”
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rhIL-7-hyFc and hIL-2/TCB2c combination promotes an immune-stimulatory tumor microenvironment that improves antitumor efficacy of checkpoint inhibitors by Miyoung Kim, Eun Ju Lee, Donghoon Choi, Sara Ferrando-Martinez, Minji Lee, Sun-Kyoung Im, Seungtae Baek, Mankyu Ji, Seung Taek Ji, Daeun Kim, Jun-Young Lee, Alexandra Wolfarth

“…Anti-PD-1 monoclonal antibody was administered intraperitoneally three times at 3-day intervals at a dose of 5 mg/kg. …”
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An efficient bivalent vaccine against duck Tembusu and duck plague viruses based on ribosomal skipping of DHAV-1 2A1 and abundant expression of DPV protein by Liping Wu, Xuewen Deng, Mingshu Wang, Anchun Cheng

“…In this study, a recombinant virus DPV-(UL49-2A1-E) expressing the DTMUV E protein was successfully constructed and evaluated for its immunological effects using a duck-derived viral protein with ribosome jumping function, duck hepatitis A virus type 1 (DHAV-1) 2A1, to ligate a DTMUV -truncated E protein positioned before the termination codon of the DPV high-abundance expression protein pUL49. …”
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Complete Blood Count-Derived Biomarkers’ Association with Risk of PD-1 or PD-1/CTLA-4 Inhibitor-Induced Hypothyroidism in Patients with Solid Tumors by Ketevan Lomidze, Nino Kikodze, Marine Gordeladze, Nino Charkviani, Tinatin Chikovani

“…Background: A novel and highly effective strategy for tumor immunotherapy involves enhancing host immune responses against tumors through the blockade of checkpoint molecules. …”
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B7-H3 in glioblastoma and beyond: significance and therapeutic strategies by Davor Babič, Ivana Jovčevska, Alja Zottel

“…A methodology involves CAR-T cells, monoclonal antibodies, ADCC and nanobodies sourced from camelids. …”
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PCSK9 Inhibitors: Focus on Evolocumab and Its Impact on Atherosclerosis Progression by Maram H. Abduljabbar

“…This paper investigates the therapeutic use of PCSK9 inhibitors, particularly Evolocumab, as monoclonal antibodies for the treatment of atherosclerosis based on recent literature reviews. …”
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Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages by Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue

“…Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. …”
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Impaired mucosal IgA response in patients with severe COVID-19 by Melyssa Yaugel-Novoa, Blandine Noailly, Fabienne Jospin, Andrés Pizzorno, Aurélien Traversier, Bruno Pozzetto, Louis Waeckel, Stéphanie Longet, Sylvie Pillet, Elisabeth Botelho-Nevers, Manuel Rosa-Calatrava, Thomas Bourlet, Stéphane Paul

“…However, even if SIgA levels were high, mucosal IgA antibodies could not control the infection effectively in patients with severe disease. …”
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