Sm16, A Schistosoma mansoni Immunomodulatory Protein, Fails to Elicit a Protective Immune Response and Does Not Have an Essential Role in Parasite Survival in the Definitive Host by Wilma Patrícia de Oliveira Santos Bernardes, Juliano Michel de Araújo, Gardênia Braz Carvalho, Clarice Carvalho Alves, Aline Thaynara de Moura Coelho, Isabela Thamara Sabino Dutra, Sueleny Silva Ferreira Teixeira, Rosy Iara Maciel de Azambuja Ribeiro, Marina de Moraes Mourão, Rosiane Aparecida da Silva-Pereira, Cristina Toscano Fonseca

“…In order to explore the biological function of Sm16 during the course of experimental infection, RNA interference was also employed. …”
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CQD-based electrochemical immunosensor for sensitive D-dimer detection in thrombosis and COVID-19 by Jillian Gamboa, Carmen Linares, Virginia Cebrián, Hamidreza Enshaei, Óscar Ahumada, Francesc Estrany, Juan Torras

“…Emerging point-of-care (POCT) biosensors offer faster, cost-effective alternatives, utilizing electrochemical or optical detection and nanostructured films. …”
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Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Genetic or pharmacological inhibition of HDAC7 effectively enhanced astrocytic clearance of tau with improved cognitive functions in PS19 mice. …”
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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

“…Administration of an IL6R functional blocking antibody failed to alter accelerated symptom onset and disease progression. …”
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Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

“…RAPA-201 recipients had preservation of T cell counts and Th1 cytokine secretion yet had increased T cell receptor clonality that associates with antitumor responses in the setting of monoclonal antibody checkpoint therapy. RAPA-201 therapy overcomes previous barriers to effective autologous polyclonal T-cell therapy, as it is feasible to manufacture, exquisitely safe to administer, and mediates remission in patients with RRMM.Trial registration number ClinicalTrials.gov: NCT04176380.…”
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Alternative splicing in ovarian cancer by Liwei Wei, Yisheng Li, Jiawang Chen, Yuanmei Wang, Jianmin Wu, Huanming Yang, Yi Zhang

“…In clinical settings, bevacizumab, a humanized monoclonal antibody that specifically targets the VEGF-A isoform, has demonstrated beneficial effects in the treatment of patients with advanced epithelial ovarian cancer. …”
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Mechanistic study of CTHRC1 in promoting Wilms’ tumor progression by regulating M2-type tumor-associated macrophages polarization by Yingquan Zhuo, Xiaoyun Feng, Wenqi Zhang, Jun Du, Xu Sun, Xi Luo, Wei Wang, Hua Jiang, Huajian Gu

“…In vitro and in vivo experiments were performed to investigate the biological functions of CTHRC1 in WT and its effects on M2-TAMs polarization. …”
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Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab by Nicole Osborne, Amit Rupani, Vladimir Makarov, Timothy A. Chan, Raghvendra M. Srivastava

“…We show a robust enhancement in NK-cell effector function, DC maturation, reciprocal NK:DC crosstalk and DC editing that is unique to avelumab treatment using multiple functional immune assays. …”
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Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin by Can Wang, Hongfeng Cheng, Xiaoying Dong, Yue Zhan, Ying Liu, Nianhong Wu, Rui Tang, Hongye He, Yuting Cao, Liping Yang, Jianli Ren, Xingsheng Li, Pan Li

“…This innovative approach combines supersaturated oxygen therapy with the multitarget therapeutic effect of CCK-8 and dynamic monitoring via DMCE to offer an integrated strategy for early detection and comprehensive VR treatment. …”
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Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases by Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann

“…Modification of RG7716's FcRn and FcγR binding sites disabled the antibodies' Fc‐mediated effector functions. This resulted in increased systemic, but not ocular, clearance. …”
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PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer by Laura Conforti, Edith M Janssen, Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Trisha M Wise-Draper

“…The purpose of this study was to elucidate the effects of pembrolizumab on potassium (K+) channel (KCa3.1 and Kv1.3) activity, Ca2+ fluxes, and chemotaxis in the cytotoxic T cells of patients with HNSCC and to determine their correlation with treatment response.Methods Functional studies were conducted in CD8+ peripheral blood T cells (PBTs) and tumor infiltrating lymphocytes (TILs) from patients with HNSCC treated with pembrolizumab. …”
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Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer by Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen

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The state of the immunophenotype of blood lymphocytes in patients with newly diagnosed type 2 diabetes in the post-COVID period by V.V. Popova, N.V. Het’man, Ya.I. Labanets, H.V. Kulikovska, O.E. Lavrinenko, O.V. Furmanova, O.I. Kovzun, M.D. Tronko

“…Today, the indicators of the subpopulation blood composition are one of the key characteristics of immune function. These parameters are of particular importance in patients with newly diagnosed type 2 diabetes mellitus (T2DM) in the post-COVID period. …”
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Simultaneous treatment with benralizumab and ustekinumab in a patient with severe asthma and ulcerative colitis by Lorenzo Carriera, Roberto Barone, Simone Ielo, Angelo Coppola

“…Since benralizumab was administered, the patient has not experienced any exacerbations requiring oral corticosteroids, emergency department visits, or hospital admissions, and the control of asthma symptoms and respiratory function considerably improved. Twelve months after the initiation of the combination, both diseases are well controlled, without any side effects or blood test abnormalities. …”
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Faecalibacterium prausnitzii enhances intestinal IgA response by host-microbe derived inecalcitol in colitis by Wenfei Qin, Nuoming Yin, Binqiang Xu, Qixiang Mei, Yang Fu, Junjie Fan, Yingying Lu, Guangqiang Wang, Lianzhong Ai, Zhanjun Lu, Yue Zeng, Chunlan Huang

“…To present evidence of sIgA involved in the anti-inflammatory effects of F. prausnitzii, we further applied immunoglobulin A (IgA) knockout mice and secretory IgA (sIgA) depletion mouse models using polymeric immunoglobulin receptor (pIgR) neutralizing antibody. …”
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Galectin‐1‐Induced Tumor Associated Macrophages Repress Antitumor Immunity in Hepatocellular Carcinoma Through Recruitment of Tregs by Xizhi Yu, Junjie Qian, Limin Ding, Caixu Pan, Xi Liu, Qinchuan Wu, Shuai Wang, Jianpeng Liu, Mingge Shang, Rong Su, Danjing Guo, Haiyang Xie, Shengyong Yin, Lin Zhou, Shusen Zheng

“…Inhibition of Gal1 improves the effectiveness of anti‐PD1 therapy, shedding important new light on the combination immunotherapy of HCC.…”
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Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products by Suzanne M. Castenmiller, Nandhini Kanagasabesan, Aurélie Guislain, Benoît P. Nicolet, Marleen M. van Loenen, Kim Monkhorst, Alexander A.F.A. Veenhof, Egbert F. Smit, Koen J. Hartemink, John B.A.G. Haanen, Rosa de Groot, Monika C. Wolkers

“…Adoptive transfer of tumor infiltrating lymphocytes (TIL therapy) has proven highly effective for treating solid cancers, including non-small cell lung cancer (NSCLC). …”
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Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations by Peleg Rider, Yaron Carmi, Idan Cohen

“…Here, we review some of the most recent approaches of cytokine targeting, focusing on anti-TNF antibodies or recombinant TNF decoy receptor, recombinant IL-1 receptor antagonist (IL-1Ra) and anti-IL-1 antibodies, anti-IL-6 receptor antibodies, and TH17 targeting antibodies. …”
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SARS-CoV-2 immune responses in patients with multiple myeloma and lenalidomide maintenance therapy by Ioana Martac, Sina A. Beer, Aileen Schenk, Osama Ahmad, Claus-Philipp Maier, Claus-Philipp Maier, Gülay Demirel, Beate Preuß, Reinhild Klein, Anna M. P. Stanger, Britta Besemer, Luca Hensen, Claudia Lengerke

“…Here, immunomodulatory drugs (IMiDs) like Lenalidomide (Lena) become interesting, as they may have stimulatory effects on T-cell functioning.MethodsIn this study we investigated immune responses elicited by COVID-19 vaccine or infection comparing 43 healthy volunteers (avg. 35y, 72.1% female, 81.4% previously COVID-19 infected), with 41 MM patients under Lena maintenance therapy (avg. 63.8y, 51.2% female, 61% previously COVID-19 infected). …”
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The role of E-cadherin in neoplastic evolution of epithelial cells by N. A. Gloushankova, I. Yu. Zhitnyak, D. V. Ayollo, S. N. Rubtsova

“…It was shown that transformed epithelial cells in vitro form dynamic adherens junctions that are essential for the effective collective migration of these cells.…”
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