Evaluation of Outgrowth Potential of Rat Pheochromocytoma Cells Supplied with Highly Purified Rapidly Expanding Clones and Potential Application to Trigeminal Nerve Regeneration by Mrunalini Ramanathan, Md. Mahbobur Rahman, Ankhtsetseg Shijirbold, Md. Rashel Mahmod, Hiromi Miyauchi, Yumi Matsuzaki, Takahiro Kanno, Yuki Fujita

“…MSCs are ideal for therapeutic application owing to their numerous advantages; they exhibit limited growth and differentiation abilities, leading to heterogeneous cell populations with inconsistent functions. However, highly purified MSCs, namely, rapidly expanding clones (RECs) that are isolated by single-cell sorting, display uniform functionality. …”
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Adipose Factor ANGPTL4: Its Role in Aging Mechanisms and Associated Diseases by Wang X, Chang HC, Gu X, Zhang Y, Bao Z

“…However, the intricate and sometimes conflicting functions of the two cleavage fragments of ANGPTL4, namely N-terminal fragment (nANGPTL4) and C-terminal fragment (cANGPTL4), in different chronic diseases—exerting inhibitory or stimulatory effects depending on the disease stage—have posed challenges to the progress of ANGPTL4 antibody therapy. …”
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A role for DICAM+ mononuclear phagocytes in controlling neuroinflammation in multiple sclerosis by Marina Rode von Essen, Marie Mathilde Hansen, Sahla El Mahdaoui, Victoria Hyslop Hvalkof, Malene Bredahl Hansen, Sophie Buhelt, Finn Sellebjerg, Finn Sellebjerg

“…Analysing the functional properties of DICAM showed that LPS-induced TNFα-production in mononuclear phagocytes was effectively reduced by signalling through surface-bound DICAM. …”
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Rapid Mental Stress Evaluation Based on Non-Invasive, Wearable Cortisol Detection with the Self-Assembly of Nanomagnetic Beads by Junjie Li, Qian Chen, Weixia Li, Shuang Li, Cherie S. Tan, Shuai Ma, Shike Hou, Bin Fan, Zetao Chen

“…The rapid and timely evaluation of the mental health of emergency rescuers can effectively improve the quality of emergency rescues. …”
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Inhibition of VEGF signaling prevents exhaustion and enhances anti-leukemia efficacy of CAR-T cells via Wnt/β-catenin pathway by Suwan Wu, Yiyi Wei, Yingqi Qiu, Kexin Ai, Mu Chen, Hao Wang, Honghao Zhang, Qingyan Cen, Peiyun Liao, Xiangyang Ding, Xiaoling Xie, Yuhua Li

“…Abstract Background Current challenges in Chimeric Antigen Receptor (CAR) -T cell therapy for hematological cancers include T cell exhaustion and limited persistence, which contribute to cancer relapse. Methods The effects of Axitinib, a VEGFR inhibitor, on the biological functions of CAR-T cells in vitro and in vivo were investigated by comparing CAR-T cells pre-treated ex vivo with Axitinib, as well as utilizing a B-ALL mouse model. …”
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A Novel Biosensor for the Early Detection of <i>Aethina tumida</i> via <i>Kodamaea ohmeri</i> in Honeybee Colonies by Paola Ghisellini, Patrizia Garbati, Marco Pietropaoli, Antonella Cersini, Gabriele Pietrella, Cristina Rando, Luca Giacomelli, Stefano Ottoboni, Giovanni Formato, Roberto Eggenhöffner

“…Its gold-plated surface over quartz was functionalized with an antibody effective in recognizing the peptide associated with <i>Kodamaea ohmeri</i>, a potential warning for detecting <i>Aethina tumida</i>. …”
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Secreted and transmembrane 1A is a novel co-stimulatory ligand. by Duncan Howie, Hugo Garcia Rueda, Marion H Brown, Herman Waldmann

“…Binding of SECTM1A to activated primary T cells was inhibited by either GITRL-Fc or anti GITR antibodies. Thus SECTM1A and SECTM1B represent novel reciprocal alternative ligands which may function to modulate the activation of effector and regulatory T cells. …”
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Cellular immune signatures and differences of four porcine circovirus type 2 vaccines to heterologous PCV2d infection by Shuai Li, Jiawei Liu, Lingbo Meng, Susu Yin, Hua Wu, Jianwen Zou, Dongbo Yuan, Hairong He, Guanghao Yin, Xianfeng Jia, Xiaoli Hao, Shaobin Shang

“…Abstract Multiple PCV2 vaccines originating from different antigens and formula are commercially available and have shown great effectiveness in protecting pigs from clinical disease. …”
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Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies? by Manoj Kumar, Manoj Kumar, Linda Yip, Fangyuan Wang, Saci-Elodie Marty, C. Garrison Fathman

“…Additionally, epigenetic modifications further compound these effects, creating lasting changes in gene expression and immune cell function. …”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…However, the nanoplatform must guarantee both the local production of the protein and the safety of the treatment to allow an effective therapy with reduced systemic toxicity.MethodsIn order to ensure a selective delivery of nucleic acids, we developed poly(lactic-co-glycolic acid) (PLGA)-poly(vinyl alcohol) (PVA) NPs loaded with an Enhanced Green Fluorescent Protein (EGFP)-coding plasmid and covalently coated with antiCD19 recombinant antibody as a targeting mechanism. …”
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion by Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares

“…Notably, therapeutic targeting of IL‐11RA with a neutralising antibody demonstrated significant anti‐tumour efficacy in a PDX model. …”
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A Phase II Study of Denileukin Diftitox in Patients with Advanced Treatment Refractory Breast Cancer by William R. Gwin, Lupe G. Salazar, James Y. Dai, Doreen Higgins, Andrew L. Coveler, Jennifer S. Childs, Rosie Blancas, Yushe Dang, Jessica Reichow, Meredith Slota, Hailing Lu, Mary L. Disis

“…This Phase II study aimed to assess the safety of denileukin diftitox and its effect on Tregs and tumor growth in patients with advanced breast cancer. …”
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TreC_Metha: A Digital Application to Enhance Patient Agency, Therapy Compliance and Quality of Life in Metastatic Breast Cancer Patients by Antonella Ferro, Maria Chiara Pavesi, Lucia Pederiva, Claudio Eccher

“…This paper aims to delineate the fundamental functionalities and objectives of TreC_Metha, a technologically advanced instrument to provide effective support during all care process of patients diagnosed with HR+HER2-negative mBC able to proactively change its configuration depending on the treatment line or on the intra-line treatment phase the patient undergoes, as set by the healthcare team. …”
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Mediating role of triglyceride-glucose index and its derivatives in the relationship between central obesity and Hashimoto thyroiditis in type 2 diabetes by Ya-Jie Zhai, Chen-Ying Lin, Jing-Bo Li, Hui-Na Qiu, Fan Wu, Yu-Lun Wang, Jing-Na Lin

“…Mediation analysis revealed that high IR, as assessed by the TyG-body mass index (TyG-BMI), significantly mediated the effects of WC, WHtR, and WHR on the risk of HT. Among them, the TyG-BMI had the highest proportion of mediating effect of WC on HT risk, reaching 74.08%. …”
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Association between a low baseline level of gene expression of energy metabolism in the blood and the development of clinical remission in response to tofacitinib therapy in patien... by E. V. Chetina, A. M. Satybaldyev, G. A. Markova, E. Yu. Samarkina, M. V. Cherkasova

“…Currently it is not possible to predict JAKi efficacy in every patient, while some patients are non-responsive to the drug, other develop adverse effects. JAKi effect in RA patients has been recently associated with alterations in mitochondrial function and ATP production. …”
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The Role of Macrophages in the Pathogenesis of Celiac Disease by A. I. Khavkin, E. V. Loshkova, E. I. Kondratieva, N. S. Shapovalova, I. R. Grishkevich, I. V. Doroshenko, G. N. Yankina

“…Impaired macrophage function/differentiation results in either inadequate, excessive immune activation or failure to mount effective protective immune responses against pathogens, which may result in the development of gastrointestinal diseases. …”
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A protease-cleavable liposome for co-delivery of anti-PD-L1 and doxorubicin for colon cancer therapy in mice by Yixuan Liu, Ying Xie, Yuling Chen, Jialun Duan, Chunjie Bao, Jinling Wang, Hexuan Feng, Mengjie Wang, Yuxin Ren, Peishan Li, Qian Luo, Jiarui Xu, Min Jiang, Yanchen Men, Yang Wu, Jianwei Li, Guiling Wang, Wanliang Lu

“…In vivo, eLipo anti-PD-L1 is cleaved by legumain at colon cancer site into pegylated anti-PD-L1 and cancer-homing doxorubicin liposome. Functional assessments show cancer-targeting, legumain-responding, tumor-penetrating, and immune-activating effects, as well as efficacy in treating colon cancer-bearing mice in vivo. …”
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Establishment and validation of a population pharmacokinetic model for apatinib in patients with tumors by Li’an Zuo, Jing Ling, Nan Hu, Rong Chen

“…Covariates, such as age, gender, body weight, and indices of liver and renal function, were examined to assess their influence on the pharmacokinetic parameters of apatinib. …”
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Eosinophilic Pneumonia Triggered by <i>Toxocara canis</i> in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report by Kacper Packi, Wanda Fugiel, Violetta Gołąbek, Alicja Rudek, Agnieszka Śliwińska

“…Patients with PCD are prone to recurrent respiratory infections due to impaired ciliary function, which hinders effective mucus clearance and promotes pathogen colonization. …”
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Novel transferrin receptor-mediated enzyme replacement therapy efficiently treats myogenic and neurogenic aspects of Pompe disease in mice by Kelly George, Raquel Riley, Shan Zhou, Elizabeth Allen, Laurie Smith, Elena Kistanova, Sofia Kinton, Lilu Guo, Dinesh Bangari, Ayman Ismail, Jayaprakash Thummapudi, Fawzi Boumezbeur, Erwan Selingue, Dorothée Tamarelle, Cecile Capdevila, Tuan-Minh Do, Dominique Lesuisse, Nina Leksa, Pablo Sardi, Arjan van der Flier

“…These data support the theory that the neurogenic and myogenic manifestations of PD can be effectively treated by anti-TfR-GAA.…”
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